Profile

Contact Details

Email: marina.kazantseva@otago.ac.nz

University Links

Position

Research Fellow

Department

Department of Pathology (Dunedin)

Qualifications

BSc(Hons)(Otago) PhD (Otago)

Research summary

Precision oncology, genetic and epigenetic mechanisms in cancer

Teaching

MINC301, Early Leaning in Medicine, Integrated cases, Medicine 3rd Year (2023-present)
ELM2, ELM3 (Pathology and Chemical Pathology) (2020-2022)
Māori ELM2 (Physiology) (2020)

Memberships

Maurice Wilkins Centre for Molecular Biodiscovery, New Zealand, 2016-present
European Association for Cancer Research: Young Investigator, 2018-present
Australian Epigenetics Alliance AEpiA – member, 2019-present

Research

My interests are in precision medicine with a special focus on the discovery and utility of cancer epigenetic biomarkers.

My current research is exploring the potential of the noncoding genome in lung cancer diagnostics, novel concepts of the genome regulation including the regulatory sequences carried by transposable elements, and DNA methylation as a therapeutic target in cancer.

I am a KiwiNet Emerging Innovator and I am involved in a number of collaborative projects involving national and international collaborators (Sweden, France and Australia).

Postgraduate research opportunities

There are several research projects available, ranging from honours and master’s to PhD. Interested graduate and postgraduate students are encouraged to make contact to further discuss these projects.

Exploring emerging roles of p53 isoforms in epigenetic dysregulation in cancer. Using dCas9/CRISPR system to reactivate tumour suppressor genes in cancer cells. Level: Honours or masters'
Identification of transposable elements contributing to cancer specific expression and function of long noncoding RNAs. Level: Honours, masters' or PhD
Investigating the roles of p53 isoforms in regulation of long noncoding RNAs. Level: Masters' or PhD
Engineering 3D cancer models for high-throughput drug screening. Level: Masters' or PhD

Funding

Funding of my research has been provided by:

Otago Innovation Ltd
A University of Otago Research Grant
The Cancer Research Trust NZ 2019 recipients
Maurice Wilkins Centre
Otago Medical School Foundation Trust
Royal Society of New Zealand Marsden Fund 2018 awards

Publications

Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8 Journal - Research Article

Kazantseva, M. (2022, August). The Δ133p53 isoform regulates tyrosine kinase AXL expression through epigenetic mechanisms. Poster session presented at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

Polwatta, S. N., Boix De Jesús, A. N., Wang, D., Taha, A., Kazantseva, M., Zhou, J., Mehta, S., Saraiva, A. M., … Royds, J., … Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2022, August). The Δ 133p53 isoform enhances cell-surface trafficking to promote metastasis. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2 Journal - Research Article

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472 Journal - Research Article

2023

Journal - Research Article

2022

Conference Contribution - Poster Presentation (not in published proceedings)

Conference Contribution - Verbal presentation and other Conference outputs

2021

Journal - Research Article

2020

Journal - Research Article

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na⁺ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

2019

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

2018

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Conference Contribution - Poster Presentation (not in published proceedings)

Eiholzer, R. A., Kazantseva, M., Mehta, S., Roth, I., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018, August). The role of the p53 isoform Δ133TPP53 in treatment resistance. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Slatter, T. L., Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., … Royds, J. A., Zhou, J., Hung, N. A., & Braithwaite, A. W. (2018, August). The TP53 isoform Δ133p53β in glioblastoma development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Conference Contribution - Published proceedings: Abstract

Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio

Kazantseva, M., Mehta, S., Eiholzer, R. A., Roth, I., Bowie, S., Joruiz, S., Royds, J. A., Taha, A., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2017). Elevated Δ133p53β in prostate tumours correlates with an immune suppressive signature and poorer outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 29). Retrieved from http://www.uib.no/en/ccbio

Wiles, A., Kazantseva, M., Li, K., Williams, M., Bowie, S., Jo, S., Millier, M., Hessian, P., Stamp, L., Baird, M. A., Slatter, T., & Braithwaite, A. (2017). The presence of Δ133p53β in the autoimmune disease rheumatoid arthritis. Proceedings of the 3rd International p53 Isoform Conference. P10. Retrieved from http://www.uib.no/en/ccbio

Working Paper; Discussion Paper; Technical Report

Knoepp, F., Ashley, Z., Barth, D., Kazantseva, M., Szczesniak, P. P., Clauss, W. G., … Fronius, M. (2017). Mechanical activation of epithelial Na⁺ channel relies on an interdependent activity of the extracellular matrix and extracellular N-glycans of αENaC. bioRxiv. doi: 10.1101/102756

2016

Conference Contribution - Verbal presentation and other Conference outputs

Kazantseva, M., Hung, N., Mehta, S., Roth, I., Baird, M., Braithwaite, A., & Slatter, T. (2016, October). Mutant p53 promotes incorrect B cell differentiation and adverse outcome in DLBCL. Verbal presentation at the 7th International Mutant p53 Workshop, Melbourne, Australia.

Kazantseva, M., Hung, N., Mehta, S., Baird, M., Slatter, T., & Braithwaite, A. (2016, August-September). Investigating the association of Δ133p53 isoform expression and the inflammatory microenvironment in prostate tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Conference Contribution - Verbal presentation and other Conference outputs

Kazantseva, M., Slatter, T., Hung, N., & Braithwaite, A. (2015, September). Altered regulation of Δ133p53 isoforms expression in prostate tumours. Verbal presentation at the 2nd International p53 Isoform Workshop, Aix-en-Provence, France.

2013

Journal - Research Article

Kazantseva, M. G., Hung, N. A., Highton, J., & Hessian, P. A. (2013). MMP expression in rheumatoid inflammation: The rs11568818 polymorphism is associated with MMP-7 expression at an extra-articular site. Genes & Immunity, 14(3), 162-169. doi: 10.1038/gene.2012.65

2012

Journal - Research Article

Kazantseva, M. G., Highton, J., Stamp, L. K., & Hessian, P. A. (2012). Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. Arthritis Research & Therapy, 14, R208. doi: 10.1186/ar4046

Awarded Doctoral Degree

Kazantseva, M. (2012). Smoking, genes and inflammation (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/2496

2011

Conference Contribution - Published proceedings: Abstract

Kazantseva, M. G., Stamp, L., Highton, J., & Hessian, P. (2011). Tobacco smoking and the HLA-DR shared epitope (SE) combine to influence matrix metalloproteinase (MMP)-9 expression in rheumatoid inflammation. Inflammation Research. 60(Suppl. 1), (pp. S176). doi: 10.1007/s00011-011-0341-6

2010

Conference Contribution - Published proceedings: Abstract

Kazantseva, M., Highton, J., Stamp, L. K., & Hessian, P. A. (2010). Dendritic cells and continued smoking in rheumatoid arthritis. Arthritis & Rheumatism, 62(Suppl. 10). doi: 10.1002/art.30166

2009

Conference Contribution - Published proceedings: Abstract

Kazantseva, M., Highton, J., & Hessian, P. (2009). A genetic predisposition underlies increased matrix metalloproteinase-7 (MMP-7) expression in rheumatoid inflammation. European Journal of Immunology, 39(Suppl. 1), (pp. S476). doi: 10.1002/eji.200990184

Kazantseva, M., Highton, J., Stamp, L. K., & Hessian, P. A. (2009). Smoking and aryl hydrocarbon receptor function in rheumatoid arthritis. Arthritis & Rheumatism, 60(Suppl. 10), (pp. S143-S144). doi: 10.1002/art.27423