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Contact Details

Phone
64 3 364 1117
Email
mark.richards@cdhb.health.nz
Position
Professor
Department
Department of Medicine (Christchurch)
Qualifications
MBChB MD PhD (Otago) FRACP
Research summary
Cardioendocrinology

Research

Mark Richards is the director of the Christchurch Heart Institute. He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.

He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.

Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies. He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute. His research interests include:

  • Neurohormonal physiology and pathophysiology in cardiovascular health and disease
  • Heart Failure
  • Acute Coronary Syndromes
  • Hypertension
  • Vasoactive Hormones
  • The Cardiac Natriuretic Peptides

Publications

Iyer, N. R., Chan, S.-P., Liew, O. W., Chong, J. P. C., Bryant, J. A., Le, T.-T., … Richards, A. M., … and on behalf of the ATTRaCT investigators. (2024). Global longitudinal strain and plasma biomarkers for prognosis in heart failure complicated by diabetes: A prospective observational study. BMC Cardiovascular Disorders, 24, 141. doi: 10.1186/s12872-024-03810-5

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Verryt, T., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. Journal of Applied Laboratory Medicine. Advance online publication. doi: 10.1093/jalm/jfae001

Richards, A. M., Wang, P., & Wong, L. L. (2024). 'Micro'-managing heart failure: Restoring that which was lost in translation [Invited]. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.3188

Dib, M.-J., Levin, M. G., Zhao, L., Diab, A., Wang, Z., Ebert, C., … Richards, A. M., Doughty, R., … Chirinos, J. A. (2024). Proteomic associations of adverse outcomes in human heart failure. Journal of the American Heart Association, 13, e031154. doi: 10.1161/jaha.123.031154

Sim, H. W., Koh, K. W. L., Poh, S.-C., Chan, S. P., Marchesseau, S., Singh, D., … Richards, A. M., & Chan, M. Y. (2024). Remote intensive management to improve antiplatelet adherence in acute myocardial infarction: A secondary analysis of the randomized controlled IMMACULATE trial. Journal of Thrombosis & Thrombolysis. Advance online publication. doi: 10.1007/s11239-023-02931-6

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Chapter in Book - Research

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Chapter in Book - Research

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Chapter in Book - Research

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Chapter in Book - Research

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Chapter in Book - Research

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Chapter in Book - Research

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Chapter in Book - Research

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Chapter in Book - Research

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Chapter in Book - Research

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Chapter in Book - Research

Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Chapter in Book - Research

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

Chapter in Book - Research

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Chapter in Book - Other

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Appleby, S., Aitken-Buck, H. M., Holdaway, M. S., Byers, M. S., Frampton, C. M., Paton, L. N., Richards, A. M., Lamberts, R. R., & Pemberton, C. J. (2024). Cardiac effects of myoregulin in ischemia-reperfusion. Peptides, 174, 171156. doi: 10.1016/j.peptides.2024.171156

Journal - Research Article

Azzo, J. D., Dib, M.-J., Zagkos, L., Zhao, L., Wang, Z., Chang, C.-P., … Richards, A. M., … Chirinos, J. A. (2024). Proteomic associations of NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide) in heart failure with preserved ejection fraction. Circulation: Heart Failure, 17(2), e011146. doi: 10.1161/circheartfailure.123.011146

Journal - Research Article

Dib, M.-J., Levin, M. G., Zhao, L., Diab, A., Wang, Z., Ebert, C., … Richards, A. M., Doughty, R., … Chirinos, J. A. (2024). Proteomic associations of adverse outcomes in human heart failure. Journal of the American Heart Association, 13, e031154. doi: 10.1161/jaha.123.031154

Journal - Research Article

Iyer, N. R., Chan, S.-P., Liew, O. W., Chong, J. P. C., Bryant, J. A., Le, T.-T., … Richards, A. M., … and on behalf of the ATTRaCT investigators. (2024). Global longitudinal strain and plasma biomarkers for prognosis in heart failure complicated by diabetes: A prospective observational study. BMC Cardiovascular Disorders, 24, 141. doi: 10.1186/s12872-024-03810-5

Journal - Research Article

Ling, S. S. M., Lilyanna, S., Ng, J. Y. X., Chong, J. P. C., Lin, Q., Yong, X. E., … Richards, A. M., & Liew, O. W. (2024). Multiple circulating forms of neprilysin detected with novel epitope-directed monoclonal antibodies. Cellular & Molecular Life Sciences, 81, 42. doi: 10.1007/s00018-023-05083-1

Journal - Research Article

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Verryt, T., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. Journal of Applied Laboratory Medicine. Advance online publication. doi: 10.1093/jalm/jfae001

Journal - Research Article

Sim, H. W., Koh, K. W. L., Poh, S.-C., Chan, S. P., Marchesseau, S., Singh, D., … Richards, A. M., & Chan, M. Y. (2024). Remote intensive management to improve antiplatelet adherence in acute myocardial infarction: A secondary analysis of the randomized controlled IMMACULATE trial. Journal of Thrombosis & Thrombolysis. Advance online publication. doi: 10.1007/s11239-023-02931-6

Journal - Research Article

van Essen, B. J., Tharshana, G. N., Ouwerkerk, W., Yeo, P. S. D., Sim, D., Jaufeerally, F., … Richards, A. M. (2024). Distinguishing heart failure with reduced ejection fraction from heart failure with preserved ejection fraction: A phenomics approach. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.3156

Journal - Research Article

Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082

Journal - Research Article

Chin, Y., Lim, J., Kong, G., Ng, C. H., Goh, R., Muthiah, M., … Richards, A. M., … Chew, N. W. S. (2023). Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long-term mortality in acute myocardial infarction. Diabetes, Obesity & Metabolism, 25, 1032-1044. doi: 10.1111/dom.14950

Journal - Research Article

Doudesis, D., Lee, K. K., Boeddinghaus, J., Bularga, A., Ferry, A. V., Tuck, C., … Pickering, J. W., Than, M. P., … CoDE-ACS Investigators, including Richards, A. M., Pemberton, C., Troughton, R. W., & Aldous, S. J. (2023). Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations. Nature Medicine, 29, 1201-1210. doi: 10.1038/s41591-023-02325-4

Journal - Research Article

Earle, N. J., Poppe, K. K., Rolleston, A., Pilbrow, A., Aish, S., Bradbury, K., … Troughton, R. W., … Richards, A. M., Cameron, V. A., … Doughty, R. N. (2023). Prognostic modelling of clinical outcomes after first-time acute coronary syndrome in New Zealand. Heart. Advance online publication. doi: 10.1136/heartjnl-2022-322010

Journal - Research Article

Ji, F., Chai, Y. L., Liu, S., Kan, C. N., Ong, M., Richards, A. M., … Zhou, J. H. (2023). Associations of blood cardiovascular biomarkers with brain free water and its relationship to cognitive decline: A diffusion-MRI study. Neurology. Advance online publication. doi: 10.1212/wnl.0000000000207401

Journal - Research Article

Kalailingam, P., Mohd-Kahliab, K.-H., Ngan, S. C., Iyappan, R., Melekh, E., Lu, T., … Richards, A. M., … Sze, S. K. (2023). Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation. EMBO Molecular Medicine, e18526. Advance online publication. doi: 10.15252/emmm.202318526

Journal - Research Article

Koh, H. W. L., Pilbrow, A. P., Tan, S. H., Zhao, Q., Benke, P. I., Burla, B., … Pickering, J. W., Troughton, R., Pemberton, C., … Richards, A. M., & Chan, M. Y. (2023). An integrated signature of extracellular matrix proteins and a diastolic function imaging parameter predicts post-MI long-term outcomes. Frontiers in Cardiovascular Medicine, 10, 1123682. doi: 10.3389/fcvm.2023.1123682

Journal - Research Article

Koo, C.-Y., Zheng, H., Tan, L.-L., Foo, L.-L., Shih, E., Hausenloy, D. J., … Richards, A. M., … Chan, M. Y. (2023). Global Registry of Acute Coronary Events score underestimates post-acute coronary syndrome mortality among cancer patients. Cancers, 15, 5222. doi: 10.3390/cancers15215222

Journal - Research Article

Lawson, C. A., Tay, W. T., Bernhardt, L., Richards, A. M., Zaccardi, F., Tromp, J., … on behalf of the ASIAN-HF investigators. (2023). Association between diabetes, chronic kidney disease, and outcomes in people with heart failure from Asia. JACC: Asia, 3(4), 611-621. doi: 10.1016/j.jacasi.2023.03.005

Journal - Research Article

Lawson, C. A., Tay, W. T., Richards, M., Zaccardi, F., Tromp, J., Teng, T.-H. K., … on behalf of the ASIAN-HF investigators. (2023). Patient-reported status and heart failure outcomes in Asia by sex, ethnicity, and socioeconomic status. JACC: Asia, 3(3), 349-362. doi: 10.1016/j.jacasi.2023.03.015

Journal - Research Article

Lim, X. C., Huang, C., Yatim, S. M. J. M., Chong, S. Y., Tan, S. H., Yang, X., … Richards, A. M., Charles, C. J., … Wang, J.-W. (2023). Temporal changes in extracellular vesicle hemostatic protein composition predict favourable left ventricular remodeling after acute myocardial infarction. International Journal of Molecular Sciences, 24, 327. doi: 10.3390/ijms24010327

Journal - Research Article

Michaëlsson, E., Lund, L. H., Hage, C., Shah, S. J., Voors, A. A., Saraste, A., … Richards, A. M., … Lam, C. S. P. (2023). Myeloperoxidase inhibition reverses biomarker profiles associated with clinical outcomes in HFpEF. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2023.03.002

Journal - Research Article

Neumann, J. T., Twerenbold, R., Ojeda, F., Aldous, S. J., Allen, B. R., Apple, F. S., … Pickering, J. W., Pemberton, C. J., … Richards, A. M., … Than, M. P., … Troughton, R. W., … the ARTEMIS study group. (2023). Personalized diagnosis in suspected myocardial infarction. Clinical Research in Cardiology. Advance online publication. doi: 10.1007/s00392-023-02206-3

Journal - Research Article

Ong, C. W., Wee, I. J. Y., Toma, M., Cui, F., Xu, X. Y., Richards, A. M., … Choong, A. M. T. L. (2023). Haemodynamic changes in visceral hybrid repairs of type III and type V thoracoabdominal aortic aneurysms. Scientific Reports, 13, 13760. doi: 10.1038/s41598-023-40323-1

Journal - Research Article

Pua, C. J., Loo, G., Kui, M., Moy, W. L., Hii, A.-A., Lee, V., … Richards, A. M., … Chin, C. W. L. (2023). Impact of diabetes on myocardial fibrosis in patients with hypertension: The REMODEL study. Circulation: Cardiovascular Imaging, 16, e015051. doi: 10.1161/circimaging.123.015051

Journal - Research Article

Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2023). Combined inhibition of phosphodiesterases 5 and 9 in experimental heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2023.08.028

Journal - Research Article

Sazzad, F., Kuzemczak, M., Jason, C. Z., Tan, J. F., Ong, Z. X., Richards, A. M., & Kofidis, T. (2023). Transcatheter, targeted, myocardial restoration using hydrogel-based cell-free compound: Toward an adoptable clinical protocol. JTCVS Open. Advance online publication. doi: 10.1016/j.xjon.2022.12.008

Journal - Research Article

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2022.11.006

Journal - Research Article

Tan, E. S. J., Chan, S. P., Liew, O. W., Chong, J. P. C., Leong, K. T. G., Yeo, P. S. D., … Richards, A. M. (2023). Differential associations of A-/B-type natriuretic peptides with cardiac structure, function, and prognosis in heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2023.09.011

Journal - Research Article

Tan, E. S. J., Chan, S.-P., Choi, Y. C., Pemberton, C. J., Troughton, R., Poppe, K., … Richards, A. M. (2023). Regional handling and prognostic performance of circulating insulin-like growth factor binding protein-7 in heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2023.01.016

Journal - Research Article

Tan, E. S. J., Jin, X., Oon, Y. Y., Chan, S. P., Gong, L., Lunaria, J. B., … Richards, A. M. (2023). Prognostic value of left atrial strain in aortic stenosis: A competing risk analysis. Journal of the American Society of Echocardiography, 36(1), 29-37. doi: 10.1016/j.echo.2022.10.011

Journal - Research Article

Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290

Journal - Research Article

Teng, T.-H. K., Tay, W. T., Ouwerkerk, W., Tromp, J., Richards, A. M., Gamble, G., … Troughton, R., … Doughty, R. N. (2023). Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.14275

Journal - Research Article

Teramoto, K., Ouwerkerk, W., Tay, W. T., Tromp, J., Teng, T.-H. K., Chandramouli, C., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2023). Clinical features of heart failure with normal ejection fraction: Insights from the ASIAN-HF Registry. JACC: Asia, 3(5), 739-751. doi: 10.1016/j.jacasi.2023.06.007

Journal - Research Article

Teramoto, K., Tay, W. T., Tromp, J., Teng, T.-H. K., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., & Lam, C. S. P. (2023). Patient-reported versus physician-assessed health status in heart failure with reduced and preserved ejection fraction from ASIAN-HF Registry. Circulation: Cardiovascular Quality & Outcomes, 16(1), e009134. doi: 10.1161/circoutcomes.122.009134

Journal - Research Article

Vinaiphat, A., Pazhanchamy, K., JebaMercy, G., Ngan, S. C., Leow, M. K.-S., Ho, H. H., … Richards, A. M., … Sze, S. K. (2023). Endothelial damage arising from high salt hypertension Is elucidated by vascular bed systematic profiling. Arteriosclerosis, Thrombosis, & Vascular Biology. Advance online publication. doi: 10.1161/atvbaha.122.318439

Journal - Research Article

Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015

Journal - Research Article

Chirinos, J. A., Zhao, L., Reese-Petersen, A. L., Cohen, J. B., Genovese, F., Richards, A. M., … Cappola, T. P. (2022). Endotrophin, a collagen VI formation-derived peptide, in heart failure. NEJM Evidence, 1(10). doi: 10.1056/evidoa2200091

Journal - Research Article

Eggers, K. M., Hammarsten, O., Aldous, S. J., Cullen, L., Greenslade, J., Lindahl, B., … Pemberton, C. J., Pickering, J. W., Richards, A. M., Troughton, R. W., & Than, M. P. (2022). Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain. PLoS ONE, 17(11), e0276645. doi: 10.1371/journal.pone.0276645

Journal - Research Article

Fitzsimons, S., Poppe, K. K., Choi, Y., Devlin, G., Lund, M., Lam, C. S. P., Troughton, R., Richards, A. M., & Doughty, R. N. (2022). Relationship between soluble transferrin receptor and clinical outcomes in patients with heart failure according to ejection fraction phenotype: The New Zealand PEOPLE study. Journal of Cardiac Failure, 28(8), 1255-1263. doi: 10.1016/j.cardfail.2021.12.018

Journal - Research Article

Jin, X., Hung, C.-L., Tay, W. T., Soon, D., Sim, D., Sung, K.-T., … Richards, A. M., … Lam, C. S. P. (2022). Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction. European Journal of Heart Failure, 24, 1346-1356. doi: 10.1002/ejhf.2513

Journal - Research Article

Koo, C. Y., Zheng, H., Tan, L. L., Foo, L.-L., Hausenloy, D. J., Chng, W.-J., … Richards, A. M., … Chan, M. Y. (2022). Prior cancer is associated with lower Atherosclerotic Cardiovascular Disease risk at first acute myocardial infarction. Biomedicines, 10, 2681. doi: 10.3390/biomedicines10112681

Journal - Research Article

Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424

Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry, 68(10), 1292-1301. doi: 10.1093/clinchem/hvac126

Journal - Research Article

Liew, O. W., Fanusi, F., Ng, J. Y. X., Ahidjo, B. A., Ling, S. S. M., Lilyanna, S., … Richards, A. M. (2022). Immunoassay-compatible inactivation of SARS-CoV-2 in plasma samples for enhanced handling safety. ACS Omega, 7(29), 25510-25520. doi: 10.1021/acsomega.2c02585

Journal - Research Article

Liew, O. W., Prickett, T. C. R., Revuelta-López, E., Ling, S. S. M., Cserkóová, A., Lupón, J., … Richards, A. M. (2022). Finding a reliable assay for soluble neprilysin. Clinical Biochemistry, 104, 51-58. doi: 10.1016/j.clinbiochem.2022.03.004

Journal - Research Article

Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639

Journal - Research Article

Robert, C., Ling, L.-H., Tan, E. S. J., Gyanwali, B., Venketasubramanian, N., Lim, S. L., … Richards, A. M., … Hilal, S. (2022). Effects of carotid artery stiffness on cerebral small-vessel disease and cognition. Journal of the American Heart Association, 11, e027295. doi: 10.1161/jaha.122.027295

Journal - Research Article

Schillemans, T., Tragante, V., Maitusong, B., Gigante, B., Cresci, S., Laguzzi, F., … Richards, M., Pilbrow, A., Cameron, V., … Leander, K. (2022). Associations of polymorphisms in the peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene with subsequent coronary heart disease: An individual-level meta-analysis. Frontiers in Physiology, 13, 909870. doi: 10.3389/fphys.2022.909870

Journal - Research Article

Sia, C.-H., Tan, S.-H., Chan, S.-P., Marchesseau, S., Sim, H.-W., Carvalho, L., … Richards, A. M., … Chan, M. Y. (2022). Enhanced thrombin generation is associated with worse left ventricular scarring after ST-segment elevation myocardial infarction: A cohort study. Pharmaceuticals, 15, 718. doi: 10.3390/ph15060718

Journal - Research Article

Tan, E. S. J., Oon, Y. Y., Chan, S. P., Liew, O. W., Chong, J. P. C., Tay, E., … Richards, A. M., & Ling, L. H. (2022). Novel predictive role for mid-regional proadrenomedullin in moderate to severe aortic stenosis. Heart, 108, 1319-1327. doi: 10.1136/heartjnl-2021-320707

Journal - Research Article

Tan, S. H., Koh, H. W. L., Chua, J. Y., Burla, B., Ong, C. C., Teo, L. S. L., … Richards, A. M., … Chan, M. Y. (2022). Variability of the plasma lipidome and subclinical coronary atherosclerosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 42, 100-112. doi: 10.1161/ATVBAHA.121.316847

Journal - Research Article

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Journal - Research Article

Tromp, J., Seekings, P. J., Hung, C.-L., Iversen, M. B., Frost, M. J., Ouwerkerk, W., … Richards, A. M., … Ezekowitz, J. A. (2022). Automated interpretation of systolic and diastolic function on the echocardiogram: A multicohort study. Lancet Digital Health, 4, e46-e54. doi: 10.1016/s2589-7500(21)00235-1

Journal - Research Article

Vergaro, G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Passino, C. (2022). Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. Journal of Cardiovascular Medicine, 23(1), 28-36. doi: 10.2459/jcm.0000000000001281

Journal - Research Article

Vergaro, G., Gentile, F., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., … Troughton, R., … Emdin, M. (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure, 9, 2084-2095. doi: 10.1002/ehf2.13883

Journal - Research Article

Ward, Z., Schmeier, S., Pearson, J., Cameron, V. A., Frampton, C. M., Troughton, R. W., … Richards, A. M., & Pilbrow, A. P. (2022). Identifying candidate circulating RNA markers for coronary artery disease by deep RNA-sequencing in human plasma. Cell, 11, 3191. doi: 10.3390/cells11203191

Journal - Research Article

Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Cardiac mesh morphing method for finite element modeling of heart failure with preserved ejection fraction. Journal of the Mechanical Behavior of Biomedical Materials, 126, 104937. doi: 10.1016/j.jmbbm.2021.104937

Journal - Research Article

Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models. Frontiers in Bioengineering & Biotechnology, 10, 1032034. doi: 10.3389/fbioe.2022.1032034

Journal - Research Article

Wu, Z., Pilbrow, A. P., Liew, O. W., Chong, J. P. C., Sluyter, J., Lewis, L. K., Lasse, M., Frampton, C. M., … Cameron, V. A., … Richards, A. M. (2022). Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations. EBioMedicine, 82, 104170. doi: 10.1016/j.ebiom.2022.104170

Journal - Research Article

Wu, Z., Sluyter, J., Liew, O. W., Chong, J. P. C., Waayer, D., Camargo, Jr, C. A., Richards, A. M., & Scragg, R. (2022). Effect of monthly vitamin D supplementation on cardiac biomarkers: A post-hoc analysis of a randomized controlled trial. Journal of Steroid Biochemistry & Molecular Biology, 220, 106093. doi: 10.1016/j.jsbmb.2022.106093

Journal - Research Article

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Lee, L. C., Leo, H. L., & Yap, C. H. (2022). Morphological, functional, and biomechanical progression of LV remodelling in a porcine model of HFpEF. Journal of Biomechanics, 144, 111348. doi: 10.1016/j.jbiomech.2022.111348

Journal - Research Article

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Sampath, S., Ali, A. A. B., … Yap, C. H. (2022). Effects of hypertrophic and dilated cardiac geometric remodeling on ejection fraction. Frontiers in Physiology, 13, 898775. doi: 10.3389/fphys.2022.898775

Journal - Research Article

Zhou, Y., Ng, D. Y. E., Richards, A. M., & Wang, P. (2022). Loss of full length pumilio 1 abrogates miRNA-221-induced gene p27 silencing–mediated cell proliferation in the heart. Molecular Therapy: Nucleic Acids, 27, 456-470. doi: 10.1016/j.omtn.2021.12.012

Journal - Research Article

Aung, T., Qin, Y., Tay, W. T., Bamadhaj, N. S. B. S., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., … Lam, C. S. P. (2021). Prevalence and prognostic significance of frailty in Asian patients with heart failure: Insights from ASIAN-HF. JACC: Asia, 1(3), 303-313. doi: 10.1016/j.jacasi.2021.09.006

Journal - Research Article

Fadil, H., Totman, J. J., Hausenloy, D. J., Ho, H.-H., Joseph, P., Low, A. F.-H., Richards, A. M., … Marchesseau, S. (2021). A deep learning pipeline for automatic analysis of multi-scan cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 23, 47. doi: 10.1186/s12968-020-00695-z

Journal - Research Article

Fitzsimons, S., Yeo, T. J., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R., … Richards, A. M., & Doughty, R. N. (2021). Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype. ESC Heart Failure, 8, 4572-4583. doi: 10.1002/ehf2.13617

Journal - Research Article

Koh, C. Y., Shih, N., Yip, C. Y. C., Li, A. W. L., Chen, W., Amran, F. S., … Richards, A. M., … Chan, M. Y. (2021). Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors. Nature Communications, 12, 6912. doi: 10.1038/s41467-021-27275-8

Journal - Research Article

Koo, C. Y., Zheng, H., Tan, L. L., Foo, L. L., Seet, R., Chong, J.-H., … Richards, A. M., … Chan, M. Y. (2021). Lipid profiles and outcomes of patients with prior cancer and subsequent myocardial infarction or stroke. Scientific Reports, 11, 21167. doi: 10.1038/s41598-021-00666-z

Journal - Research Article

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Journal - Research Article

Liew, O. W., Ling, S. S. M., Lilyanna, S., Zhou, Y., Wang, P., Chong, J. P. C., … Richards, A. M. (2021). Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. Communications Biology, 4, 441. doi: 10.1038/s42003-021-01965-x

Journal - Research Article

Lim, S. L., Liu, X., Gao, Q., Nyunt, S. Z., Gong, L., Lunaria, J. B., … Richards, A. M., … Ng, T. P. (2021). Subclinical vasculopathy and skeletal muscle metrics in the Singapore longitudinal ageing study. Aging, 13(11), 14768-14784. doi: 10.18632/aging.203142

Journal - Research Article

Lin, Z., Lim, S. H., Yap, Q. V., Tan, C. H. C., Chan, Y. H., Wong, H. C., … Richards, A. M., & Chua, T. S. J. (2021). Comparing conventional and high sensitivity troponin T measurements in identifying adverse cardiac events in patients admitted to an Asian emergency department chest pain observation unit. IJC Heart & Vasculature, 34, 100758. doi: 10.1016/j.ijcha.2021.100758

Journal - Research Article

Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206

Journal - Research Article

Park, J. E., JebaMercy, G., Pazhanchamy, K., Guo, X., Ngan, S. C., Liou, K. C. K., … Richards, A. M., … Sze, S. K. (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis, 324, 58-68. doi: 10.1016/j.atherosclerosis.2021.03.020

Journal - Research Article

Poh, K. K., Shabbir, A., Ngiam, J. N., Lee, P. S. S., So, J., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2021). Plasma clearance of B-type natriuretic peptide (BNP) before and after bariatric durgery for morbid obesity. Clinical Chemistry, 67(4), 662-671. doi: 10.1093/clinchem/hvaa308

Journal - Research Article

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Journal - Research Article

Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2021). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research, 117, 508-519. doi: 10.1093/cvr/cvaa052

Journal - Research Article

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