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Anderson Laboratory

Research interests

My research group’s interests are focused on the regulation of fertility by hormones such as leptin, insulin that provide the brain with information about the body’s nutritional status, and on the effects of a recently discovered group of brain cells called RFRP neurons on fertility and stress responses (such as anxiety). Beyond our focused basic research projects, our ‘big picture’ goal is the development of new and improved treatments for infertility and anxiety-related disorders; both of which are unseen conditions experienced by a large proportion of modern societies. For example, we are currently developing drugs that combat the anxiety-promoting effects of RFRP neurons. The Anderson Research Group is based in the Department of Anatomy and forms one of the laboratories that make up University of Otago's Centre for Neuroendocrinology.

Clinical conditions

  • Infertility
  • Metabolic syndrome
  • Chronic anxiety disorders

Professor Anderson's researcher profile

List of publications for Greg Anderson (Google Scholar)

Anderson Laboratory staff and students

Dr Caroline Ancel, Assistant Research FellowCaroline Ancel_web
RFRP neuron actions on stress and reproduction, and characterization of novel RFRP-3 antagonists
Email caroline.ancel@otago.ac.nz

Maggie EvansDr Maggie Evans, Postdoctoral Fellow
Metabolic hormone effects on feeding, reward, and reproduction
Email maggie.evans@otago.ac.nz

Megan InglisMegan Inglis, Research Technician
Email megan.inglis@otago.ac.nz

Romy Kerbus_webRomy Kerbus, PhD student
Metabolic and reproductive consequences of PCOS
Email kerro860@student.otago.ac.nz

India Sawyer_webIndia Sawyer, PhD student
RFRP neuron actions on stress and reproduction, and characterization of novel RFRP-3 antagonists
Email india.sawyer@otago.ac.nz

Cassie Clark, Honours student
Role of GALP neurons in conveying leptin signals for reproduction

Asha Mamgain, Masters student
Identifying the role of RFRP neurons in stress induced infertility

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

McCallum-Loudeac, J., Anderson, G., & Wilson, M. J. (2019). Age and sex-related changes to gene expression in the mouse spinal cord. Journal of Molecular Neuroscience. Advance online publication. doi: 10.1007/s12031-019-01371-3

Evans, M. C., & Anderson, G. M. (2018). Metabolic regulation of GnRH neurons. In A. E. Herbison & T. M. Plant (Eds.), The GnRHS neuron and its control. (pp. 386-410). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119233275

Evans, M. C., Kumar, N. S., Inglis, M. A., & Anderson, G. M. (2018). Leptin and insulin do not exert redundant control of metabolic or emotive function via dopamine neurons. Hormones & Behavior, 106, 93-104. doi: 10.1016/j.yhbeh.2018.10.001

Evans, M. C., & Anderson, G. M. (2018). Integration of circadian and metabolic control of reproductive function. Endocrinology, en.2018-00691. Advance online publication. doi: 10.1210/en.2018-00691

Ancel, C., Plate, M., Decourt, C., Inglis, M. A., & Anderson, G. M. (2018). Using genetic manipulations to understand the role of RFRP-3 in the regulation of reproduction. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 247-248). Retrieved from http://www.icn2018.org/

Chapter in Book - Research

Evans, M. C., & Anderson, G. M. (2018). Metabolic regulation of GnRH neurons. In A. E. Herbison & T. M. Plant (Eds.), The GnRHS neuron and its control. (pp. 386-410). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119233275

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Journal - Research Article

McCallum-Loudeac, J., Anderson, G., & Wilson, M. J. (2019). Age and sex-related changes to gene expression in the mouse spinal cord. Journal of Molecular Neuroscience. Advance online publication. doi: 10.1007/s12031-019-01371-3

Evans, M. C., Kumar, N. S., Inglis, M. A., & Anderson, G. M. (2018). Leptin and insulin do not exert redundant control of metabolic or emotive function via dopamine neurons. Hormones & Behavior, 106, 93-104. doi: 10.1016/j.yhbeh.2018.10.001

Evans, M. C., & Anderson, G. M. (2018). Integration of circadian and metabolic control of reproductive function. Endocrinology, en.2018-00691. Advance online publication. doi: 10.1210/en.2018-00691

Evans, M. C., & Anderson, G. M. (2017). Dopamine neuron-restricted leptin receptor signaling reduces some aspects of food reward but exacerbates the obesity of leptin receptor-deficient male mice. Endocrinology, 158(12), 4246-4256. doi: 10.1210/en.2017-00513

Egan, O. K., Inglis, M. A., & Anderson, G. M. (2017). Leptin signalling in AgRP neurons modulates puberty onset and adult fertility in mice. Journal of Neuroscience, 37(14), 3875-3886. doi: 10.1523/jneurosci.3138-16.2017

Ancel, C., Inglis, M. A., & Anderson, G. M. (2017). Central RFRP-3 stimulates LH secretion in male mice and has cycle stage-dependent inhibitory effects in females. Endocrinology, 158(9), 2873-2883. doi: 10.1210/en.2016-1902

Evans, M. C., & Anderson, G. M. (2017). Neuroendocrine integration of nutritional signals on reproduction. Journal of Molecular Endocrinology, 58(2), R107-R128. doi: 10.1530/jme-16-0212

Decourt, C., Anger, K., Robert, V., Lomet, D., Bartzen-Sprauer, J., Caraty, A., … Anderson, G., & Beltramo, M. (2016). No evidence that RFamide-related peptide 3 directly modulates LH secretion in the ewe. Endocrinology, 157(4), 1566-1575. doi: 10.1210/en.2015-1854

McEwen, H. J. L., Inglis, M. A., Quennell, J. H., Grattan, D. R., & Anderson, G. M. (2016). Deletion of suppressor of cytokine signaling 3 from forebrain neurons delays infertility and onset of hypothalamic leptin resistance in response to a high caloric diet. Journal of Neuroscience, 36(27), 7142-7153. doi: 10.1523/jneurosci.2714-14.2016

Kim, J. S., Rizwan, M. Z., Clegg, D. J., & Anderson, G. M. (2016). Leptin signaling is not required for anorexigenic estradiol effects in female mice. Endocrinology, 157(5), 1991-2001. doi: 10.1210/en.2015-1594

Decourt, C., Robert, V., Anger, K., Galibert, M., Madinier, J.-B., Liu, X., … Herbison, A. E., Anderson, G. M., … Beltramo, M. (2016). A synthetic kisspeptin analog that triggers ovulation and advances puberty. Scientific Reports, 6, 26908. doi: 10.1038/srep26908

Kim, J. S., Brown, C. H., & Anderson, G. M. (2016). Anti-opioid effects of RFRP-3 on magnocellular neuron activity in morphine-naïve and morphine-treated female rats. Endocrinology, 157(10), 4003-4011. doi: 10.1210/en.2016-1374

Zuure, W. A., Quennell, J. H., & Anderson, G. M. (2016). Leptin responsive and GABAergic projections to the rostral preoptic area in mice. Journal of Neuroendocrinology, 28(3). doi: 10.1111/jne.12357

Evans, M. C., Rizwan, M. Z., & Anderson, G. M. (2015). Insulin does not target CamkIIα neurones to critically regulate the neuroendocrine reproductive axis in mice. Journal of Neuroendocrinology, 27(12), 899-910. doi: 10.1111/jne.12330

Kim, J. S., Brownjohn, P. W., Dyer, B. S., Beltramo, M., Walker, C. S., Hay, D. L., … Tyndall, J. D. A., & Anderson, G. M. (2015). Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14. Endocrinology, 156(11), 4152-4162. doi: 10.1210/en.2015-1532

Evans, M. C., Rizwan, M. Z., & Anderson, G. M. (2014). Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice. Endocrinology, 155(11), 4368-4379. doi: 10.1210/en.2014-1412

Evans, M. C., Rizwan, M., Mayer, C., Boehm, U., & Anderson, G. M. (2014). Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. Journal of Neuroendocrinology, 26(7), 468-479. doi: 10.1111/jne.12166

Rizwan, M. Z., Harbid, A. A., Inglis, M. A., Quennell, J. H., & Anderson, G. M. (2014). Evidence that hypothalamic RFamide related peptide-3 neurones are not leptin-responsive in mice and rats. Journal of Neuroendocrinology, 26(4), 247-257. doi: 10.1111/jne.12140

Poling, M. C., Quennell, J. H., Anderson, G. M., & Kauffman, A. S. (2013). Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. Journal of Neuroendocrinology, 25(10), 876-886. doi: 10.1111/jne.12084

Harbid, A. A., McLeod, B. J., Caraty, A., & Anderson, G. M. (2013). Seasonal changes in RFamide-related peptide-3 neurons in the hypothalamus of a seasonally breeding marsupial species, the brushtail possum (Trichosurus vulpecula). Journal of Comparative Neurology, 521(13), 3030-3041. doi: 10.1002/cne.23328

Zuure, W. A., Roberts, A. L., Quennell, J. H., & Anderson, G. M. (2013). Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function. Journal of Neuroscience, 33(45), 17874-17883. doi: 10.1523/jneurosci.2278-13.2013

Singireddy, A. V., Inglis, M. A., Zuure, W. A., Kim, J. S., & Anderson, G. M. (2013). Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice. Endocrinology, 154(7), 2434-2445. doi: 10.1210/en.2013-1109

Rizwan, M. Z., Poling, M. C., Corr, M., Cornes, P. A., Augustine, R. A., Quennell, J. H., … Anderson, G. M. (2012). RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology, 153(8), 3770-3779. doi: 10.1210/en.2012-1133

Evans, J. J., & Anderson, G. M. (2012). Balancing ovulation and anovulation: Integration of the reproductive and energy balance axes by neuropeptides. Human Reproduction Update, 18(3), 313-332. doi: 10.1093/humupd/dms004

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