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Iremonger Laboratory

Research interests

At the Centre for Neuroendocrinology, our research focuses on understanding how the excitability of corticotropin-releasing hormone (CRH) neurons is regulated. CRH neurons are activated in response to stress and are responsible for controlling the levels of stress hormones in the body.

We are particularly interested in determining how changes in synaptic inputs and dendritic excitability regulate CRH neuron activity and function.

Clinical conditions

  • Stress
  • Depression

Dr Karl Iremonger's researcher profile

List of publications for Karl Iremonger (Google Scholar)

Iremonger Laboratory staff & students

Dharshini Ganeshan_webDharshini Ganeshan, Assistant Research Fellow
Molecular regulation of CRH neurons 
Email dharshini.ganeshan@otago.ac.nz

Joon Kim_webJoon Kim, Research Fellow
Regulation of CRH neuron activity dynamics in vivo
Email joon.kim@otago.ac.nz

Emmet Power_webEmmet Power, Research Fellow
Understanding sex differences in neural circuits controlling stress
Email emmet.power@otago.ac.nz

Calvin Young_webCalvin Young, Research Fellow
Probing neural stress circuit function in rodents and fish
Email calvin.young@otago.ac.nz

Shaojie Zheng_webShaojie Zheng, PhD student
Control of ultradian stress hormone rhythms by hypothalamic CRH neurons
Email: zhesh339@student.otago.ac.nz

Jamie Paul, Masters student


Isaac Tripp, Masters student

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Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Power, E. M., & Iremonger, K. J. (2022, August-September). Estrous cycle differences in hypothalamic CRH neuron activity. Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kim, J. S., Ganeshan, D., Grattan, D. R., & Iremonger, K. J. (2022, August-September). Hyothalamic CRH neuron activity in motherhood is not altered during stress but can be suppressed by pup exposure. Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2022, August-September). In vivo monitoring of oxytocin neuron activity in freely-behaving, lactating mice. Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022, August-September). Altered membrance properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer's disease. Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Paul, J., Johnson, S., & Iremonger, K. (2022, August-September). Developing a zebrafish (Danio rerio) model to study behavioural and neuroendocrine responses to stress. Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.