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Iremonger Laboratory

Research interests

At the Centre for Neuroendocrinology, our research focuses on understanding how the excitability of corticotropin-releasing hormone (CRH) neurons is regulated. CRH neurons are activated in response to stress and are responsible for controlling the levels of stress hormones in the body.

We are particularly interested in determining how changes in synaptic inputs and dendritic excitability regulate CRH neuron activity and function.

Clinical conditions

  • Stress
  • Depression

Dr Karl Iremonger's researcher profile

List of publications for Karl Iremonger (Google Scholar)

Iremonger Laboratory staff & students

Dharshini Ganeshan_webDharshini Ganeshan, Assistant Research Fellow
Molecular regulation of CRH neurons 
Email dharshini.ganeshan@otago.ac.nz

Joon Kim_webJoon Kim, Postdoctoral Fellow
Regulation of CRH neuron activity dynamics in vivo
Email joon.kim@otago.ac.nz

Emmet Power_webEmmet Power, Postdoctoral Fellow
Understanding sex differences in neural circuits controlling stress
Email emmet.power@otago.ac.nz

Shaojie Zheng_webShaojie Zheng, PhD student
Control of ultradian stress hormone rhythms by hypothalamic CRH neurons
Email: zhesh339@student.otago.ac.nz

Jamie Paul, Honours student

Isaac Tripp, Honours student

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972

Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2020). Characterisation of an oxytocin-ires-cre mouse model for recording oxytocin neuron bursts in behaving mice. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03560

Abbasi, M., Perkinson, M., Brown, C., & Iremonger, K. (2020). Kisspeptin regulation of oxytocin neuron activity in late pregnancy. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.02418

Focke, C. M. B., & Iremonger, K. J. (2020). Rhythmicity matters: Circadian and ultradian patterns of HPA axis activity. Molecular & Cellular Endocrinology, 501, 110652. doi: 10.1016/j.mce.2019.110652

Focke, C. M. B., & Iremonger, K. (2019, September). Do hypothalamic CRH neurons express circadian and ultradian activity patterns? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.