Research interests
At the Centre for Neuroendocrinology, our research focuses on understanding how the excitability of corticotropin-releasing hormone (CRH) neurons is regulated. CRH neurons are activated in response to stress and are responsible for controlling the levels of stress hormones in the body.
We are particularly interested in determining how changes in synaptic inputs and dendritic excitability regulate CRH neuron activity and function.
Clinical conditions
- Stress
- Depression
Dr Karl Iremonger's researcher profile
List of publications for Karl Iremonger (Google Scholar)
Iremonger Laboratory staff & students
Dharshini Ganeshan, Assistant Research Fellow
Molecular regulation of CRH neurons
Email dharshini.ganeshan@otago.ac.nz
Joon Kim, Postdoctoral Fellow
Regulation of CRH neuron activity dynamics in vivo
Email joon.kim@otago.ac.nz
Emmet Power, Postdoctoral Fellow
Understanding sex differences in neural circuits controlling stress
Email emmet.power@otago.ac.nz
Shaojie Zheng, PhD student
Control of ultradian stress hormone rhythms by hypothalamic CRH neurons
Email: zhesh339@student.otago.ac.nz
Jamie Paul, Honours student
Isaac Tripp, Honours student
Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.
Publications
Power, E. M., & Iremonger, K. J. (2021). Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons. Scientific Reports, 11(1), 16700. doi: 10.1038/s41598-021-96341-4
Perkinson, M. R., Kim, J. S., Iremonger, K. J., & Brown, C. H. (2021). Visualising oxytocin neurone activity in vivo: The key to unlocking central regulation of parturition and lactation [Invited review]. Journal of Neuroendocrinology, e13012. Advance online publication. doi: 10.1111/jne.13012
Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972
Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2020). Characterisation of an oxytocin-ires-cre mouse model for recording oxytocin neuron bursts in behaving mice. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03560
Abbasi, M., Perkinson, M., Brown, C., & Iremonger, K. (2020). Kisspeptin regulation of oxytocin neuron activity in late pregnancy. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.02418
