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Iremonger Laboratory

Research interests

At the Centre for Neuroendocrinology, our research focuses on understanding how the excitability of corticotropin-releasing hormone (CRH) neurons is regulated. CRH neurons are activated in response to stress and are responsible for controlling the levels of stress hormones in the body.

We are particularly interested in determining how changes in synaptic inputs and dendritic excitability regulate CRH neuron activity and function.

Clinical conditions

  • Stress
  • Depression

Dr Karl Iremonger's researcher profile

List of publications for Karl Iremonger (Google Scholar)

Iremonger Laboratory staff & students

Dharshini Ganeshan_webDharshini Ganeshan, Assistant Research Fellow
Molecular regulation of CRH neurons 
Email dharshini.ganeshan@otago.ac.nz

Joon Kim_webJoon Kim, Research Fellow
Regulation of CRH neuron activity dynamics in vivo
Email joon.kim@otago.ac.nz

Emmet Power_webEmmet Power, Research Fellow
Understanding sex differences in neural circuits controlling stress
Email emmet.power@otago.ac.nz

Calvin Young_webCalvin Young, Research Fellow
Probing neural stress circuit function in rodents and fish
Email calvin.young@otago.ac.nz

Shaojie Zheng_webShaojie Zheng, PhD student
Control of ultradian stress hormone rhythms by hypothalamic CRH neurons
Email: zhesh339@student.otago.ac.nz

Jamie Paul, Masters student

William Stewart, Honours student

Isaac Tripp, Masters student

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Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Abbasi, M., Perkinson, M. R., Seymour, A. J., Piet, R., Campbell, R. E., Iremonger, K. J., & Brown, C. H. (2022). Local kisspeptin excitation of rat oxytocin neurones in late pregnancy. Journal of Physiology. Advance online publication. doi: 10.1113/jp282531

Jamieson, B. B., Kim, J. S., & Iremonger, K. J. (2022). Cannabinoid and vanilloid pathways mediate opposing forms of synaptic plasticity in corticotropin-releasing hormone neurons. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13084

Power, E. M., & Iremonger, K. J. (2021). Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons. Scientific Reports, 11(1), 16700. doi: 10.1038/s41598-021-96341-4

Perkinson, M. R., Kim, J. S., Iremonger, K. J., & Brown, C. H. (2021). Visualising oxytocin neurone activity in vivo: The key to unlocking central regulation of parturition and lactation [Invited review]. Journal of Neuroendocrinology, e13012. Advance online publication. doi: 10.1111/jne.13012

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972