University of Otago, Christchurch, MRI expert Dr Tracy Melzer has been awarded $500,000 from the Health Research Council (HRC) to study changes in the brain that could predict dementia.
A recipient of a prestigious Sir Charles Hercus Health Research Fellowship, Dr Melzer is one of fourteen Otago health researchers and students to receive funding through the HRC career development awards for 2017. A full list appears below.
Dr Melzer is part of the New Zealand Brain Research Institute and has spent the past few years scanning and studying the brains of people with Parkinson's disease. The disease is the second most common form of neurodegeneration, behind Alzheimer's disease, and often can lead to dementia.
Dr Melzer says recently clinicians and scientists have acknowledged that cognitive problems associated with Parkinson's disease can be more debilitating than physical symptoms such as tremor and slowed movements. Much international effort is now focused on developing new preventative treatments for dementia. Identifying people at highest risk of developing dementia is an essential part of this effort.
The ultimate aim of Dr Melzer's work is to provide a better understanding of the dementia process and provide clear direction to those developing new therapies for the debilitating and widespread condition.
“If we know who is at imminent risk of developing dementia, we can target these individuals and include them in trials of new drug therapies for cognitive issues. If you can target them before they develop cognitive impairments you have a better chance of delaying the onset, or even preventing it.''
Dr Melzer's study will be the first to combine advanced blood flow imaging and a method to measure the accumulation of an abnormal protein, called tau, in the brain. Tau is associated with the development of Alzheimer's disease and may play an important role in the development of dementia in Parkinson's.
Over four years, Dr Melzer will study the brain scans of 25 healthy participants and 70 people with Parkinson's disease who have varying levels of cognitive impairment. He will look for patterns or differences in tau build-up and blood flow between people with dementia and others.
Otago's HRC career development award recipients:
Sir Charles Hercus Health Research Fellowship
Dr Tracy Melzer
University of Otago, Christchurch
Dementia and Parkinson's disease: Tau pathology and cerebrovascular health
$500,000 over 48 months
Many people with Parkinson's develop cognitive problems and, eventually, dementia. We need to identify suitable objective tools that measure the underlying brain changes associated with cognitive decline. Such tools are important clinically and for assessing new preventative treatments. Here, two novel brain imaging approaches will be used. First, we will measure accumulation in the brain of an abnormal protein, tau, which is associated with the development of Parkinson's dementia. Second, we will use a new brain imaging technique to measure blood flow in the brain. Both measures will be acquired in 25 healthy control participants and 70 people with Parkinson's disease with varying levels of cognitive impairment, including dementia, to show how tau burden and blood flow in the brain reflect degree of cognitive decline.
Clinical Research Training Fellowship
Dr Andrea Teng
University of Otago, Wellington
Impact of sugar-sweetened beverage taxation in the Pacific
$250,000 over 36 months
Given the scale of the global obesity epidemic it is critical to understand if interventions to control obesity are effective. The primary aim of this study is to examine the impact of sugar-sweetened beverage (SSB) tax on consumption in Pacific Island Countries and Territories (PICTs). The Pacific region is an excellent site from with which to examine this topic as 13 of 22 PICTs have introduced SSB taxes. The impact of such taxes can be studied before and after using income and expenditure surveys and importation data from PICTs that do not produce SSBs. Findings from regression and panel estimation, are likely to have international implications and inform interventions to protect the health of New Zealanders. The Clinical Training Fellowship will allow Dr Teng to develop skills in time-series and economic analysis, establish a career as an epidemiologist in non-communicable disease control and contribute to strengthened New Zealand-Pacific links.
Pacific Health Research Postdoctoral Fellowship
Dr Jesse Kokaua
University of Otago
Health implications from education for Pasifika people and their families
$329,116 over 36 months
This study contains two projects and will seek to investigate to what extent health outcomes, particularly mental health outcomes, among Pasifika are related to education and to tease out whether this is a direct or indirect association. The first project will look at health outcomes of graduates from University study in New Zealand. The second will look at health outcomes for Pasifika families associated with education. While studies have looked at the socio-economic or health benefits associated with education, few have looked at health in the context of the former. And none have been found that seek to view these from behind a Pasifika lens to investigate generational differences in health outcomes and their association with education.
Pacific Health Research Summer Studentships
(10 weeks, $5,000)
Miss Toni Anitelea, University of Otago
Follow up of hip and knee arthroplasty patients returned to GP
Miss Tumanu Futi, University of Otago
Effects of uric acid on beta cell function
Miss Mary Kivalu, University of Otago
A review of New Zealand district health board policies about translation services
Miss Brooke Marsters, University of Otago, Wellington
Antibiotic prophylaxis and the progression of acute rheumatic fever to rheumatic heart disease
Miss Johanna Nee-Nee, University of Otago
Raising awareness or creating confusion? Media coverage of cancer issues in New Zealand
Ms Meaalofa Pupi, University of Otago
The economic cost of diabetes among Pacific Islanders
Miss Ashleigh Raikuna, University of Otago
Effects of severe early childhood caries on Pacific Island families
Mr Tevita Vaipuna, University of Otago
Does sleep differ according to ethnicity in children?
Māori Health Summer Studentships
(10 weeks, $5,000)
Miss Mairarangi Haimona, University of Otago
Otago Māori medical student perspectives on cultural development
Miss Nadine Houia-Ashwell, University of Otago
A survey of non-Māori health professional students at Te Whare Wānanga o Otāgo
Mr Jordan Tewhaiti-Smith, University of Otago
Tāne in the health workforce: A students' experience of supporting factors
Mr Daniel Thompson, University of Otago
A qualitative look at Tikanga best practice guidelines in New Zealand district health boards
A list of Otago experts available for media comment is available elsewhere on this website.Electronic addresses (including email accounts, instant messaging services, or telephone accounts) published on this page are for the sole purpose of contact with the individuals concerned, in their capacity as officers, employees or students of the University of Otago, or their respective organisation. Publication of any such electronic address is not to be taken as consent to receive unsolicited commercial electronic messages by the address holder.