Professor Paul Smith

2024

Chapter in Book - Research

Zheng, Y., & Smith, P. F. (2024). Translating animal findings to humans in tinnitus research. In W. Schlee, B. Langguth, D. De Ridder, S. Vanneste, T. Kleinjung & A. R. Møller (Eds.), Textbook of tinnitus. (2nd ed.) (pp. 301-312). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-35647-6_24

Journal - Research Article

Yuan, S., Tan, H. T., Smith, P. F., & Zheng, Y. (2024). Lack of amino acid alterations within the cochlear nucleus and the auditory cortex in acoustic trauma-induced tinnitus rats using In vivo microdialysis. Audiology Research, 14(6), 1000-1013. doi: 10.3390/audiolres14060083

Tan, H. T., Smith, P. F., & Zheng, Y. (2024). Time-dependent effects of acoustic trauma and tinnitus on extracellular levels of amino acids in the inferior colliculus of rats. Hearing Research, 443, 108948. doi: 10.1016/j.heares.2024.108948

Journal - Research Other

Smith, P. F., Darlington, C. L., & Zheng, Y. (2024). Animal studies linking the vestibular system and memory: Aotearoa/New Zealand’s contribution. Journal of the Royal Society of New Zealand. Advance online publication. doi: 10.1080/03036758.2024.2412085

Searchfield, G., Adhia, D., Barde, A., De Ridder, D., Doborjeh, M., Doborjeh, Z., … Smith, P. F., & Zheng, Y. (2024). A scoping review of tinnitus research undertaken by New Zealand researchers: Aotearoa–an international hotspot for tinnitus innovation and collaboration. Journal of the Royal Society of New Zealand, 2363424. Advance online publication. doi: 10.1080/03036758.2024.2363424

Smith, P. F. (2024). Aging of the vestibular system and its relationship to dementia. Current Opinion in Neurology, 37, 83-87. doi: 10.1097/wco.0000000000001231

2023

Journal - Research Article

Tashakori-Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2023). Vestibular modulation of the tail of the rat striatum. Scientific Reports, 13, 4443. doi: 10.1038/s41598-023-31289-1

Journal - Research Other

Smith, P. F. (2023). Interpreting the meaning of changes in hippocampal volume associated with vestibular loss. Frontiers in Integrative Neuroscience, 17, 1254972. doi: 10.3389/fnint.2023.1254972

Singh, A., Smith, P. F., & Zheng, Y. (2023). Targeting the limbic system: Insights into its involvement in tinnitus. International Journal of Molecular Sciences, 24, 9889. doi: 10.3390/ijms24129889

McLaren, R., Smith, P. F., Taylor, R. L., Niazi, I. K., & Taylor, D. (2023). Scoping out noisy galvanic vestibular stimulation: A review of the parameters used to improve postural control. Frontiers in Neuroscience, 17, 1156796. doi: 10.3389/fnins.2023.1156796

Conference Contribution - Published proceedings: Abstract

Kelly, G., Singh, A., Smith, P. F., & Zheng, Y. (2023). Effects of chronic tinnitus on long-term potentiation in the rat hippocampus. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Sabzevar, F., Zheng, Y., Vautrelle, N., & Smith, P. (2023). Vestibular projections to the striatum: The mechanism of galvanic vestibular stimulation effects in Parkinson’s disease? Brain Stimulation, 16(1), (pp. 151-152). doi: 10.1016/j.brs.2023.01.114

Conference Contribution - Poster Presentation (not in published proceedings)

Tashakori Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2023, August). Vestibular modulation of the tail of the rat striatum. Poster session presented at the Brain Health Research Centre (BHRC) Annual Conference, Dunedin, New Zealand.

Blakeman, K., Smith, P., & Zheng, Y. (2023, August). Effect of galvanic vestibular stimulation on the rat striatum before and after inactivation of the parafascicular nucleus of the thalamus. Poster session presented at the Brain Health Research Centre (BHRC) Annual Conference, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Tan, H.-T., Zheng, Y., Smith, P., & Reynolds, J. (2023, August). Investigating the changes in stimulation-evoked dopamine release within the nucleus accumbens shell and the auditory cortex of acoustic trauma-induced tinnitus rats. Verbal presentation at the Brain Health Research Centre (BHRC) Annual Conference, Dunedin, New Zealand.

Taylor, D., Smith, P., McLaren, R., Chaudhary, S., Zheng, Y., & Lord, S. (2023, October). Is it feasible to combine nGVS with balance rehabilitation in older adults? Verbal presentation at the Combined Neuro-Otology Society of Australia (NOTSA) and the New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) Meeting, Auckland, New Zealand.

Tashakori-Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2023, October). Electrical vestibular stimulation evokes electrophysiological activity in the rat striatum. Verbal presentation at the Combined Neuro-Otology Society of Australia (NOTSA) and the New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) Meeting, Auckland, New Zealand.

2022

Journal - Research Article

Rana, Z., Rosengren, R., & Smith, P. (2022). Exploring the mechanism and suggesting combination therapies for HDAC inhibitors in androgen receptor-null prostate cancer using multivariate statistical analysis and data mining techniques. Bioinformatics & Biology Insights, 11, 1-11. doi: 10.1177/11779322221145428

McLaren, R., Smith, P. F., Taylor, R. L., Ravindran, S., Rashid, U., & Taylor, D. (2022). Efficacy of nGVS to improve postural stability in people with bilateral vestibulopathy: A systematic review and meta-analysis. Frontiers in Neuroscience, 16, 1010239. doi: 10.3389/fnins.2022.1010239

Journal - Research Other

Curthoys, I. S., Smith, P. F., & Ramos de Miguel, A. (2022). Why should constant stimulation of saccular afferents modify the posture and gait of patients with bilateral vestibular dysfunction? The saccular substitution hypothesis. Journal of Clinical Medicine, 11(4), 1132. doi: 10.3390/jcm11041132

Smith, P. F. (2022). Hearing loss versus vestibular loss as contributors to cognitive dysfunction. Journal of Neurology, 269, 87-99. doi: 10.1007/s00415-020-10343-2

Conference Contribution - Published proceedings: Abstract

Tan, H.-T., Smith, P., Zheng, Y., & Reynolds, J. (2022). Stimulation-evoked dopamine release in the auditory cortex of anaesthetised rats. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from https://www.queenstownresearchweek.org

Conference Contribution - Poster Presentation (not in published proceedings)

Telang, R. S., Suzuki-Kerr, H., Vlajkovic, S. M., Smith, P. F., Zheng, Y., & Thorne, P. R. (2022, August-September). Insight into hearing loss through a metabolomics approach: A pilot comparison of inner ear fluid, cochlea and blood plasma. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Tashakori Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2022, September). Effects of electrical vestibular stimulation on the local field potential in rat striatum. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

2021

Chapter in Book - Research

Searchfield, G. D., Zhang, J., Biswas, R., De Ridder, D., Deutsch, B., Hall, D. A., … Kleinstäuber, M., … Smith, P. F., … Zheng, Y. (2021). Emerging topics in the behavioral neuroscience of tinnitus. In G. D. Searchfield & J. Zhang (Eds.), The behavioral neuroscience of tinnitus: Current topics in behavioral neurosciences (Vol. 51). (pp. 461-484). Cham, Switzerland: Springer. doi: 10.1007/7854_2021_217

Zheng, Y., McTavish, J., & Smith, P. F. (2021). Pharmacological evaluation of drugs in animal models of tinnitus. In G. D. Searchfield & J. Zhang (Eds.), The behavioral neuroscience of tinnitus: Current topics in behavioral neurosciences (Vol. 51). (pp. 51-82). Cham, Switzerland: Springer. doi: 10.1007/7854_2020_212

He, J., Aa, J.-Y., Sun, J.-G., Smith, P. F., De Ridder, D., Wang, G.-J., & Zheng, Y. (2021). Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 399-430). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.09.002

Journal - Research Article

Smith, P. F., & Zheng, Y. (2021). Applications of multivariate statistical and data Mining analyses to the search for biomarkers of sensorineural hearing loss, tinnitus, and vestibular dysfunction. Frontiers in Neurology, 12, 627294. doi: 10.3389/fneur.2021.627294

Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., Zheng, Y., & Smith, P. F. (2021). Stratification of hippocampal electrophysiological activation evoked by selective electrical stimulation of different angular and linear acceleration sensors in the rat peripheral vestibular system. Hearing Research, 403, 108173. doi: 10.1016/j.heares.2021.108173

Journal - Research Other

McLaren, R., Smith, P. F., Lord, S., Kaur, P. K., Zheng, Y., & Taylor, D. (2021). Noisy galvanic vestibular stimulation combined with a multisensory balance program in older adults with moderate to high fall risk: Protocol for a feasibility study for a randomized controlled trial. JMIR Research Protocols, 10(10), e32085. doi: 10.2196/32085

Conference Contribution - Published proceedings: Abstract

Smith, P. F., Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., & Zheng, Y. (2021). The implications of vestibular and auditory dysfunction for dementia. New Zealand Medical Journal, 134(1539), (pp. 92). Retrieved from https://www.nzma.org.nz/journal

2020

Chapter in Book - Research

Agrawal, Y., Smith, P. F., & Merfeld, D. M. (2020). Dizziness, imbalance and age-related vestibular loss. In J. Stein (Ed.), Reference module in neuroscience and biobehavioral psychology. Elsevier. doi: 10.1016/B978-0-12-809324-5.23818-2

Journal - Research Article

Smith, P. F. (2020). Why the cerebellar shutdown/clampdown hypothesis of vestibular compensation is inconsistent with neurophysiological evidence. Journal of Vestibular Research, 30(5), 295-303. doi: 10.3233/ves-200715

Smith, P. F. (2020). Why dizziness is likely to increase the risk of cognitive dysfunction and dementia in elderly adults. New Zealand Medical Journal, 133(1522), 112-127. Retrieved from https://www.nzma.org.nz/journal

Jacob, A., Tward, D. J., Resnick, S., Smith, P. F., Lopez, C., Rebello, E., … Agrawal, Y. (2020). Vestibular function and cortical and sub-cortical alterations in an aging population. Heliyon, 6(8), e04728. doi: 10.1016/j.heliyon.2020.e04728

Logerot, P., Smith, P. F., Wild, M., & Kubke, M. F. (2020). Auditory processing in the zebra finch midbrain: Single unit responses and effect of rearing experience. PeerJ, 8, e9363. doi: 10.7717/peerj.9363

Kumari, N., Taylor, D., Rashid, U., Vandal, A. C., Smith, P. F., & Signal, N. (2020). Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial. Scientific Reports, 10(1), 11853. doi: 10.1038/s41598-020-68825-2

Journal - Research Other

Smith, P. F., Truchet, B., Chaillan, F. A., Zheng, Y., & Besnard, S. (2020). Vestibular modulation of long-term potentiation and NMDA receptor expression in the hippocampus. Frontiers in Molecular Neuroscience, 13, 140. doi: 10.3389/fnmol.2020.00140

Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., Zheng, Y., & Smith, P. F. (2020). The effects of selective electrical stimulation of the rat cochlea on hippocampal field potentials. Hearing Research, 395, 108023. doi: 10.1016/j.heares.2020.108023

Agrawal, Y., Merfeld, D. M., Horak, F. B., Redfern, M. S., Manor, B., Westlake, K. P., … Smith, P. F., … Lipsitz, L. A. (2020). Aging, vestibular function, and balance: Proceedings of a National Institute on Aging/National Institute on Deafness and Other Communication Disorders Workshop. Journals of Gerontology Series A, 75(12), 2471-2480. doi: 10.1093/gerona/glaa097

Agrawal, Y., Smith, P. F., & Rosenberg, P. B. (2020). Vestibular impairment, cognitive decline and Alzheimer's disease: Balancing the evidence. Aging & Mental Health, 24(5), 705-708. doi: 10.1080/13607863.2019.1566813

2019

Chapter in Book - Research

Smith, P. F. (2019). Vestibular compensation as a distributed process. In J. P. Stein (Ed.), Reference module in neuroscience and biobehavioral psychology. Elsevier. doi: 10.1016/B978-0-12-809324-5.23820-0

Journal - Research Article

Martey, O. N. K., Greish, K., Smith, P. F., & Rosengren, R. J. (2019). A multivariate statistical analysis of the effects of styrene maleic acid encapsulated RL71 in a xenograft model of triple negative breast cancer. Journal of Biological Methods, 6(4). doi: 10.14440/jbm.2019.306

Machado, M. L., Lefèvre, N., Philoxene, B., Le Gall, A., Madeleine, S., Fleury, P., Smith, P. F., & Besnard, S. (2019). New software dedicated to virtual mazes for human neurocognitive investigations. Journal of Neuroscience Methods, 327, 108388. doi: 10.1016/j.jneumeth.2019.108388

Le Gall, A., Hilber, P., Chesneau, C., Bulla, J., Toulouse, J., Machado, M. L., … Smith, P. F., & Besnard, S. (2019). The critical role of vestibular graviception during cognitivo-motor development. Behavioural Brain Research, 372, 112040. doi: 10.1016/j.bbr.2019.112040

Truchet, B., Benoit, A., Chaillan, F., Smith, P. F., Philoxene, B., Guillamin, M., … Besnard, S. (2019). Hippocampal LTP modulation and glutamatergic receptors following vestibular loss. Brain Structure & Function, 224, 699-711. doi: 10.1007/s00429-018-1792-0

Journal - Research Other

Smith, P. F. (2019). The growing evidence for the importance of the otoliths in spatial memory. Frontiers in Neural Circuits, 13, 66. doi: 10.3389/fncir.2019.00066

Smith, P. F., Agrawal, Y., & Darlington, C. L. (2019). Sexual dimorphism in vestibular function and dysfunction. Journal of Neurophysiology, 121, 2379-2391. doi: 10.1152/jn.00074.2019

Besnard, S., Tighilet, B., Chabbert, C., Hitier, M., Toulouse, J., Le Gall, A., … Smith, P. F. (2019). Reply to Micarelli et al. Commentary on the balance of sleep: Role of the vestibular sensory system. Sleep Medicine Reviews, 44, 87-88. doi: 10.1016/j.smrv.2018.12.003

Zheng, Y., & Smith, P. F. (2019). Cannabinoid drugs: Will they relieve or exacerbate tinnitus? Current Opinion in Neurology, 32, 131-136. doi: 10.1097/wco.0000000000000631

Conference Contribution - Published proceedings: Abstract

Smith, P. F., & Zheng, Y. (2019). Application of discriminant and principal component analyses to analysis of metabolomics data obtained from brain tissue. Proceedings of the New Zealand Statistical Association Conference. (pp. 37-38). Retrieved from https://www.otago.ac.nz/nzsa/programme-and-speakers/

Kumaria, N., Taylor, D., Rashid, U., Vandal, A. C., Smith, P. F., & Signal, N. (2019). Can cerebellar transcranial direct current stimulation influence motor learning in healthy adults? In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 66). Retrieved from http://www.otago.ac.nz/awcbr

Zheng, Y., Castro, S., Tan, H.-T., Jones, O., Smith, P. F., & Reynolds, J. N. (2019). Increased synaptic plasticity in the inferior colliculus of rats following acoustic trauma. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 38). Retrieved from http://www.otago.ac.nz/awcbr

2018

Journal - Research Article

Smith, P. F. (2018). Vestibular functions and Parkinson’s Disease. Frontiers in Neurology, 9, 1085. doi: 10.3389/fneur.2018.01085

Stiles, L., Zheng, Y., & Smith, P. F. (2018). The effects of electrical stimulation of the peripheral vestibular system on neurochemical release in the rat striatum. PLoS ONE, 13(10), e0205869. doi: 10.1371/journal.pone.0205869

Hitier, M., Sato, G., Zhang, Y.-F., Zheng, Y., Besnard, S., & Smith, P. F. (2018). Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. Journal of Comparative Physiology A, 204, 835-847. doi: 10.1007/s00359-018-1286-9

Stiles, L., Reynolds, J. N., Napper, R., Zheng, Y., & Smith, P. F. (2018). Single neuron activity and c-Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system. Physiological Reports, 6(13), e13791. doi: 10.14814/phy2.13791

Benoit, A., Besnard, S., Guillamin, M., Philoxene, B., Sola, B., Le Gall, A., … Smith, P. F. (2018). Differential regulation of NMDA receptor-expressing neurons in the rat hippocampus and striatum following bilateral vestibular loss demonstrated using flow cytometry. Neuroscience Letters, 683, 43-47. doi: 10.1016/j.neulet.2018.06.035

Hitier, M., Sato, G., Zhang, Y.-F., Besnard, S., & Smith, P. F. (2018). Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neuroscience Letters, 677, 60-64. doi: 10.1016/j.neulet.2018.04.041

Benoit, A., Guillamin, M., Aitken, P., Smith, P. F., Sola, B., Poulain, L., … Besnard, S. (2018). Flow cytometry for receptor analysis from ex-vivo brain tissue in adult rat. Journal of Neuroscience Methods, 304, 11-23. doi: 10.1016/j.jneumeth.2018.04.005

Aitken, P., Zheng, Y., & Smith, P. F. (2018). The modulation of hippocampal theta rhythm by the vestibular system. Journal of Neurophysiology, 119(2), 548-562. doi: 10.1152/jn.00548.2017

Journal - Research Other

Besnard, S., Tighilet, B., Chabbert, C., Hitier, M., Toulouse, J., Le Gall, A., … Smith, P. F. (2018). The balance of sleep: Role of the vestibular sensory system. Sleep Medicine Reviews, 42, 220-228. doi: 10.1016/j.smrv.2018.09.001

Smith, P. F. (2018). On the application of multivariate statistical and data mining analyses to data in neuroscience. Journal of Undergraduate Neuroscience Education, 16(2), R20-R32. [Review].

Conference Contribution - Published proceedings: Abstract

Smith, P. F., Truchet, B., Benoit, A., Chaillan, F., Philoxene, B., Guillamin, M., … Besnard, S. (2018). The neurobiological basis of spatial memory deficits following vestibular dysfunction: Modulation of hippocampal long-term potentiation and NMDA receptors. Proceedings of the Combined New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) and the Neuro-Otology Society of Australia (NOTSA) Clinical and Scientific Meeting. (pp. 34). Retrieved from http://vertigosociety.nz/

Machado, M. L., Lefèvre, N., Philoxene, B., Le Gall, A., Madeleine, S., Fleury, P., Smith, P. F., & Besnard, S. (2018). New software dedicated to virtual mazes for human neurocognitive investigations. Proceedings of the Combined New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) and the Neuro-Otology Society of Australia (NOTSA) Clinical and Scientific Meeting. (pp. 33). Retrieved from http://vertigosociety.nz/

Le Gall, A., Chesneau, C., Hilber, P., Philoxene, B., Bulla, J., Besnard, S., & Smith, P. F. (2018). Evidence that the otoliths are critical for early development in mice. Proceedings of the Combined New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) and the Neuro-Otology Society of Australia (NOTSA) Clinical and Scientific Meeting. (pp. 32). Retrieved from http://vertigosociety.nz/

Zheng, Y., Aa, J., He, J., Wang, G., & Smith, P. F. (2018). Can metabolic changes in the blood predict changes in the brain in rats following acoustic trauma? In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 26). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr

Other Research Output

Smith, P. (2018, May). Lost in space: The significance of the vestibular system for space exploration. Department of Pharmacology & Toxicology, University of Otago, Dunedin, New Zealand. [Department Seminar].

2017

Journal - Research Article

Smith, P. F. (2017). Is hippocampal neurogenesis modulated by the sensation of self-motion encoded by the vestibular system? Neuroscience & Biobehavioral Reviews, 83, 489-495. doi: 10.1016/j.neubiorev.2017.09.013

Smith, P. F. (2017). Bionic balance organs: Progress in the development of vestibular prostheses. New Zealand Medical Journal, 130(1461), 56-65. Retrieved from http://www.nzma.org.nz/journal

Zheng, Y., Gliddon, C. M., Aitken, P., Stiles, L., Machado, M.-L., Philoxene, B., … Smith, P. F., & Besnard, S. (2017). Effects of acute altered gravity during parabolic flight and/or vestibular loss on cell proliferation in the rat dentate gyrus. Neuroscience Letters, 654, 120-124. doi: 10.1016/j.neulet.2017.06.033

Aitken, P., Zheng, Y., & Smith, P. F. (2017). Ethovision™ analysis of open field behaviour in rats following bilateral vestibular loss. Journal of Vestibular Research, 27, 89-101. doi: 10.3233/VES-170612

He, J., Zhu, Y., Aa, J., Smith, P. F., De Ridder, D., Wang, G., & Zheng, Y. (2017). Brain metabolic changes in rats following acoustic trauma. Frontiers in Neuroscience, 11, 148. doi: 10.3389/fnins.2017.00148

Aitken, P., Zheng, Y., & Smith, P. F. (2017). Effects of bilateral vestibular deafferentation in rat on hippocampal theta response to somatosensory stimulation, acetylcholine release, and cholinergic neurons in the pedunculopontine tegmental nucleus. Brain Structure & Function, 222(7), 3319-3332. doi: 10.1007/s00429-017-1407-1

Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience, 348, 273-287. doi: 10.1016/j.neuroscience.2017.02.033

Smith, P. F. (2017). The vestibular system and cognition. Current Opinion in Neurology, 30(1), 84-89. doi: 10.1097/wco.0000000000000403

Abouzayd, M., Smith, P. F., Moreau, S., & Hitier, M. (2017). What vestibular tests to choose in symptomatic patients after a cochlear implant? A systematic review and meta-analysis. European Archives of Oto-Rhino-Laryngology, 274(1), 53-63. doi: 10.1007/s00405-016-4007-4

Journal - Research Other

Smith, P. F. (2017). A guerilla guide to common problems in 'neurostatistics': Essential statistical topics in neuroscience. Journal of Undergraduate Neuroscience Education, 16(1), R1-R12. [Review].

Conference Contribution - Published proceedings: Abstract

Tan, H., Smith, P. F., & Zheng, Y. (2017). Neurotransmitter changes in the auditory and non-auditory brain regions of rats following tinnitus-inducing acoustic trauma. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 54). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Smith, P. F., Hitier, M., Zhang, Y., Sato, G., Besnard, S., & Zheng, Y. (2017). Effects of selective electrical stimulation of semi-circular canal and otolithic vestibular receptors on field potential activity in the rat hippocampus. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 25). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Zheng, Y., Tan, H., & Smith, P. F. (2017). Effects of tinnitus-inducing acoustic trauma on neurotransmitter release in response to sound stimulation in the inferioir colliculus of rats: Preliminary results. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 24). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Tan, H. T., Smith, P. F., & Zheng, Y. (2017). Neurotransmitter changes in the auditory and non-auditory brain regions of rats following tinnitus-inducing acoustic trauma. New Zealand Medical Journal, 130(1461), (pp. 91). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Aitken, P., Zheng, Y., & Smith, P. F. (2017, September). Effects of bilateral vestibular loss in the rat on the cholinergic theta pathways into the hippocampus. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

Smith, P. (2017, September). Neurostatistics: Common problems arising in statistical analyses in neuroscience. Verbal presentation at the Symposium in Honour of Associate Professor John Harraway, Dunedin, New Zealand.

2016

Journal - Research Article

Aitken, P., Benoit, A., Zheng, Y., Philoxene, B., Le Gall, A., Denise, P., … Smith, P. F. (2016). Hippocampal and striatal M₁-muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats. Hippocampus, 26(12), 1509-1514. doi: 10.1002/hipo.22651

Smith, P. F., Renner, R. M., & Haslett, S. J. (2016). Compositional data in neuroscience: If you've got it, log it! Journal of Neuroscience Methods, 271, 154-159. doi: 10.1016/j.jneumeth.2016.07.008

Tranter-Entwistle, I., Dawes, P., Darlington, C. L., Smith, P. F., & Cutfield, N. (2016). Video head impulse in comparison to caloric testing in unilateral vestibular schwannoma. Acta Oto-Laryngologica, 136(11), 1110-1114. doi: 10.1080/00016489.2016.1185540

Hitier, M., Sato, G., Zhang, Y.-f., Zheng, Y., Besnard, S., Smith, P. F., & Curthoys, I. S. (2016). Anatomy and surgical approach of rat’s vestibular sensors and nerves. Journal of Neuroscience Methods, 270, 1-8. doi: 10.1016/j.jneumeth.2016.05.013

Smith, P. F. (2016). Age-related neurochemical changes in the vestibular nuclei. Frontiers in Neurology, 7, 20. doi: 10.3389/fneur.2016.00020

Balabhadrapatruni, S., Zheng, Y., Napper, R., & Smith, P. F. (2016). Basal dendritic length is reduced in the rat hippocampus following bilateral vestibular deafferentation. Neurobiology of Learning & Memory, 131, 56-60. doi: 10.1016/j.nlm.2016.03.009

Smith, P. F., & Zheng, Y. (2016). Cannabinoids, cannabinoid receptors and tinnitus. Hearing Research, 332, 210-216. doi: 10.1016/j.heares.2015.09.014

Conference Contribution - Published proceedings: Abstract

Zheng, Y., Aa, J., He, J., Zhu, Y., Vagal, S., Wang, G., & Smith, P. F. (2016). Long-term brain metabolic changes in rats following tinnitus-inducing acoustic trauma: A pilot study. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 25). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

2015

Chapter in Book - Research

Vidal, P. P., Cullen, K., Curthoys, I. S., Du Lac, S., Holstein, G., Idoux, E., … Smith, P. (2015). The vestibular system. In G. Paxinos (Ed.), The rat nervous system. (4th ed.) (pp. 805-864). London, UK: Academic Press. doi: 10.1016/B978-0-12-374245-2.00028-0

Journal - Research Article

Zheng, Y., Smithies, H., Aitken, P., Gliddon, C., Stiles, L., Darlington, C. L., & Smith, P. F. (2015). Cell proliferation in the cochlear nucleus following acoustic trauma in rat. Neuroscience, 303, 524-534. doi: 10.1016/j.neuroscience.2015.07.033

Zheng, Y., McPherson, K., Reid, P., & Smith, P. F. (2015). The anti-inflammatory selective melanocortin receptor subtype 4 agonist, RO27-3225, fails to prevent acoustic trauma-induced tinnitus in rats. European Journal of Pharmacology, 761, 206-210. doi: 10.1016/j.ejphar.2015.05.007

Zheng, Y., Reid, P., & Smith, P. F. (2015). Cannabinoid CB₁ receptor agonists do not decrease, but may increase, acoustic trauma-induced tinnitus in rats. Frontiers in Neurology, 6, 60. doi: 10.3389/fneur.2015.00060

Stiles, L., & Smith, P. F. (2015). The vestibular-basal ganglia connection: Balancing motor control. Brain Research, 1597, 180-188. doi: 10.1016/j.brainres.2014.11.063

Zheng, Y., Dixon, S., McPherson, K., & Smith, P. F. (2015). Glutamic acid decarboxylase levels in the cochlear nucleus of rats with acoustic trauma-induced chronic tinnitus. Neuroscience Letters, 586, 60-64. doi: 10.1016/j.neulet.2014.11.047

Journal - Research Other

Besnard, S., Lopez, C., Brandt, T., Denise, P., & Smith, P. F. (2015). The vestibular system in cognitive and memory processes in mammalians. Frontiers in Integrative Neuroscience, 9, 55. doi: 10.3389/fnint.2015.00055

Conference Contribution - Published proceedings: Abstract

Gliddon, C. M., Zheng, Y., Aitken, P., Stiles, L., Hitier, M., Machado, M.-L., … Smith, P., Darlington, C., & Besnard, S. (2015). Effects of vestibular loss and parabolic flight on cell proliferation in the rat dentate gyrus. Proceedings of the Society for Neuroscience 45th Annual Meeting. 335.02/T13. SfN. Retrieved from https://www.sfn.org

Stiles, L., Zheng, Y., Napper, R. M., & Smith, P. F. (2015). Changes in c-Fos expression in the striatum following electrical stimulation of the peripheral vestibular system. Proceedings of the Society for Neuroscience 45th Annual Meeting. 236.02/L21. SfN. Retrieved from https://www.sfn.org/

Aitken, P., Zheng, Y., & Smith, P. F. (2015). Bilateral vestibular lesions increase sensitivity to non-vestibular induced theta rhythm in rats. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 68). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

2014

Journal - Research Article

Smith, P. F., Darlington, C. L., & Zheng, Y. (2014). The effects of complete vestibular deafferentation on spatial memory and the hippocampus in rat: The Dunedin experience. Multisensory Research, 28(5-6), 461-485. doi: 10.1163/22134808-00002469

Smith, P. F., & Zheng, Y. (2014). Cannabis, cannabinoids and tinnitus. Journal of Pharmacology & Drug Metabolism, 1, 1-6. Retrieved from http://www.jscholaronline.org/journals/journal-of-pharmacology-and-drug-metabolism/jhome.php

Zheng, Y., Stiles, L., Chien, Y.-T., Darlington, C. L., & Smith, P. F. (2014). The effects of acute stress-induced sleep disturbance on acoustic trauma-induced tinnitus in rats. BioMed Research International, 2014, 724195. doi: 10.1155/2014/724195

Hitier, M., Besnard, S., & Smith, P. F. (2014). Vestibular pathways involved in cognition. Frontiers in Integrative Neuroscience, 8, 59. doi: 10.3389/fnint.2014.00059

Rivers-Auty, J. R., Smith, P. F., & Ashton, J. C. (2014). The cannabinoid CB₂ receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. Neuroscience Letters, 569, 104-109. doi: 10.1016/j.neulet.2014.03.077

Zheng, Y., Geddes, L., Sato, G., Stiles, L., Darlington, C. L., & Smith, P. F. (2014). Galvanic vestibular stimulation impairs cell proliferation and neurogenesis in the rat hippocampus but not spatial memory. Hippocampus, 24(5), 541-552. doi: 10.1002/hipo.22247

Zheng, Y., McPherson, K., & Smith, P. F. (2014). Effects of early and late treatment with L-baclofen on the development and maintenance of tinnitus caused by acoustic trauma in rats. Neuroscience, 258, 410-421. doi: 10.1016/j.neuroscience.2013.11.032

Journal - Research Other

Hornibrook, J., & Smith, P. F. (2014). Dizziness caused by medications. New Zealand Medical Journal, 127(1388). Retrieved from http://www.nzma.org.nz/journal

Journal - Professional & Other Non-Research Articles

Ashton, J. C., Zheng, Y., Darlington, C., Baek, J.-H., & Smith, P. F. (2014). Cannabinoid CB2 receptor immunolabelling in the healthy brain—still a live possibility. Naunyn-Schmiedeberg's Archives of Pharmacology, 387(3), 301. doi: 10.1007/s00210-013-0948-y

Conference Contribution - Published proceedings: Abstract

Zheng, Y., Smithies, H., Aitken, P., Darlington, C. L., & Smith, P. F. (2014). Neurogenesis in the rat cochlear nucleus and the effects of acoustic trauma. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 78). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

Cutfield, N., Tranter-Entwistle, I., Smith, P., Darlington, C., & Dawes, P. (2014). Video head impulse testing in comparison to caloric testing in pre-surgical vestibular Schwannoma University of Otago, Dunedin, New Zealand. Journal of Vestibular Research, 24(2-3 (Special Issue)), (pp. 224-225). doi: 10.3233/VES-140514

2013

Journal - Research Article

Smith, P. F., & Zheng, Y. (2013). From ear to uncertainty: Vestibular contributions to cognitive function. Frontiers in Integrative Neuroscience, 7, 84. doi: 10.3389/fnint.2013.00084

Smith, P. F., Ganesh, S., & Liu, P. (2013). A comparison of random forest regression and multiple linear regression for prediction in neuroscience. Journal of Neuroscience Methods, 220(1). doi: 10.1016/j.jneumeth.2013.08.024

Smith, P. F., & Zheng, Y. (2013). Principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, 548, 265-268. doi: 10.1016/j.neulet.2013.05.036

Baek, J.-H., Darlington, C. L., Smith, P. F., & Ashton, J. C. (2013). Antibody testing for brain immunohistochemistry: Brain immunolabeling for the cannabinoid CB₂ receptor. Journal of Neuroscience Methods, 216(2), 87-95. doi: 10.1016/j.jneumeth.2013.03.021

Smith, P. F., Haslett, S., & Zheng, Y. (2013). A multivariate statistical and data mining analysis of spatial memory–related behaviour following bilateral vestibular loss in the rat. Behavioural Brain Research, 246, 15-23. doi: 10.1016/j.bbr.2013.02.033

Zheng, Y., Wilson, G., Stiles, L., & Smith, P. F. (2013). Glutamate receptor subunit and calmodulin kinase II expression, with and without T maze training, in the rat hippocampus following bilateral vestibular deafferentation. PLoS ONE, 8(2), e54527. doi: 10.1371/journal.pone.0054527

Journal - Research Other

Smith, P. F. (2013). Vestibular dysfunction and Alzheimer’s disease. Medical Hypotheses, 81(6), 1169-1170. doi: 10.1016/j.mehy.2013.09.034

Smith, P. F., & Darlington, C. L. (2013). Personality changes in patients with vestibular dysfunction. Frontiers in Human Neuroscience, 7, 678. doi: 10.3389/fnhum.2013.00678

Conference Contribution - Published proceedings: Abstract

Hitier, M., Zhang, Y. F., Sato, G., Zheng, Y., Denise, P., Besnard, S., & Smith, P. F. (2013). Eye movements during selective electrical vestibular stimulation in rat. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 76). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Zhang, Y. F., Sato, G., Hitier, M., Zheng, Y., Denise, P., Besnard, S., & Smith, P. F. (2013). Functional relations between the vestibular system and hippocampus. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 59). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Sato, G., Sekine, K., Matsuda, K., Takeda, N., & Smith, P. F. (2013). Risk factors for poor outcome of a single Epley maneuver and residual positional vertigo in patients with benign paroxysmal positional vertigo. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 57). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Smith, P. F., Geddes, L. H., Stiles, L., Sato, G., Darlington, C. L., & Zheng, Y. (2013). The effects of galvanic vestibular stimulation on cell proliferation in the rat hippocampus and spatial memory. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 30). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Zheng, Y., McPherson, K., Stiles, L., Darlington, C. L., & Smith, P. F. (2013). Effects of early treatment with L-baclofen on the development of tinnitus induced by acoustic trauma in rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 28). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Zheng, Y., McNamara, E., Aitken, P., & Smith, P. F. (2013). Cell proliferation in the rat cochlear nucleus following noise exposure. Proceedings of the 7th International Tinnitus Research Initiative (TRI) Conference: Tinnitus: A Treatable Disease. (pp. 47). Retrieved from http://www.tinnitusresearch.org/

Zheng, Y., McPherson, K., Stiles, L., Darlington, C. L., & Smith, P. F. (2013). Effect of early treatment with L-baclofen on the development of tinnitus induced by acoustic trauma in rats. Proceedings of the 7th International Tinnitus Research Initiative (TRI) Conference: Tinnitus: A Treatable Disease. (pp. 23). Retrieved from http://www.tinnitusresearch.org/

2012

Journal - Research Article

Zheng, Y., McNamara, E., Stiles, L., Darlington, C. L., & Smith, P. F. (2012). Evidence that memantine reduces chronic tinnitus caused by acoustic trauma in rats. Frontiers in Neurology, 3, 127. doi: 10.3389/fneur.2012.00127

Smith, P. F. (2012). Dyscalculia and vestibular function. Medical Hypotheses, 79(4), 493-496. doi: 10.1016/j.mehy.2012.06.032

Zheng, Y., Cheung, I., & Smith, P. F. (2012). Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs. Behavioural Brain Research, 235(1), 21-29. doi: 10.1016/j.bbr.2012.07.025

Zheng, Y., Balabhadrapatruni, S., Baek, J. H., Chung, P., Gliddon, C., Zhang, M., Darlington, C. L., Napper, R., … Smith, P. F. (2012). The effects of bilateral vestibular loss on hippocampal volume, neuronal number, and cell proliferation in rats. Frontiers in Neurology, 3, 20. doi: 10.3389/fneur.2012.00020

Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2012). The D₂ dopamine receptor and locomotor hyperactivity following bilateral vestibular deafferentation in the rat. Behavioural Brain Research, 227(1), 150-158. doi: 10.1016/j.bbr.2011.11.006

Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2012). The effects of the D₂ dopamine receptor antagonist, eticlopride, on attention following bilateral vestibular deafferentation in the rat. Neuroscience Letters, 506(2), 193-197. doi: 10.1016/j.neulet.2011.11.003

Zheng, Y., Vagal, S., McNamara, E., Darlington, C. L., & Smith, P. F. (2012). A dose–response analysis of the effects of L-baclofen on chronic tinnitus caused by acoustic trauma in rats. Neuropharmacology, 62, 940-946. doi: 10.1016/j.neuropharm.2011.09.027

Neo, P., Carter, D., Zheng, Y., Smith, P., Darlington, C., & McNaughton, N. (2012). Septal elicitation of hippocampal theta rhythm did not repair cognitive and emotional deficits resulting from vestibular lesions. Hippocampus, 22(5), 1176-1187. doi: 10.1002/hipo.20963

Journal - Research Other

Smith, P. F. (2012). A note on the advantages of using linear mixed model analysis with maximal likelihood estimation over repeated measures ANOVAs in psychopharmacology: Comment on Clark et al. (2012). Journal of Psychopharmacology, 26(12), 1605-1607. doi: 10.1177/0269881112463471

Smith, P. F. (2012). Statistical analysis in pharmacology is not always BO. Trends in Pharmacological Sciences, 33(11), 565-566. doi: 10.1016/j.tips.2012.08.006

Smith, P. F. (2012). Interactions between the vestibular nucleus and the dorsal cochlear nucleus: Implications for tinnitus [Short communication]. Hearing Research, 292(1-2), 80-82. doi: 10.1016/j.heares.2012.08.006

Smith, P. F., Zheng, Y., & Darlington, C. L. (2012). Revisiting baclofen for the treatment of severe chronic tinnitus. Frontiers in Neurology, 3, 34. doi: 10.3389/fneur.2012.00034

Conference Contribution - Published proceedings: Abstract

Machado, M. L., Lelong-Boulouard, V., Smith, P., Freret, T., Philoxene, B., Denise, P., & Besnard, S. (2012). Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat. Fundamental & Clinical Pharmacology, 26(Suppl. s1), (pp. 61). doi: 10.1111/j.1472-8206.2012.01032.x

2011

Chapter in Book - Research

Smith, P. F. (2011). The endocannabinoid system in the cochlear nucleus and its implications for tinnitus treatment. In A. R. Møller, B. Langguth, D. De Ridder & T. Kleinjung (Eds.), Textbook of tinnitus. (pp. 639-647). New York: Springer. doi: 10.1007/978-1-60761-145-5_79

Journal - Research Article

Zheng, Y., Balabhadrapatruni, S., Masumura, C., Darlington, C. L., & Smith, P. F. (2011). Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory. Current Alzheimer Research, 8(8), 876-882. doi: 10.2174/156720511798192709

Hüfner, K., Strupp, M., Smith, P., Brandt, T., & Jahn, K. (2011). Spatial separation of visual and vestibular processing in the human hippocampal formation. Annals of the New York Academy of Sciences, 1233, 177-186. doi: 10.1111/j.1749-6632.2011.06115.x

Zheng, Y., Hamilton, E., McNamara, E., Smith, P. F., & Darlington, C. L. (2011). The effects of chronic tinnitus caused by acoustic trauma on social behaviour and anxiety in rats. Neuroscience, 193, 143-153. doi: 10.1016/j.neuroscience.2011.07.026

Zheng, Y., Hamilton, E., Begum, S., Smith, P. F., & Darlington, C. L. (2011). The effects of acoustic trauma that can cause tinnitus on spatial performance in rats. Neuroscience, 186, 48-56. doi: 10.1016/j.neuroscience.2011.04.052

Zheng, Y., Hamilton, E., Stiles, L., McNamara, E., de Waele, C., Smith, P. F., & Darlington, C. L. (2011). Acoustic trauma that can cause tinnitus impairs impulsive control but not performance accuracy in the 5-choice serial reaction time task in rats. Neuroscience, 180, 75-84. doi: 10.1016/j.neuroscience.2011.02.040

Zheng, Y., Begum, S., Zhang, C., Fleming, K., Masumura, C., Zhang, M., Smith, P., & Darlington, C. (2011). Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat. Experimental Brain Research, 210(3-4), 477-487. doi: 10.1007/s00221-010-2491-0

Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Cannabinoid CB₁ receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, 487(3), 330-334. doi: 10.1016/j.neulet.2010.10.050

Conference Contribution - Published proceedings: Abstract

McNamara, E. J., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Memantine: A promising treatment for acoustic trauma-induced tinnitus. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29 , 8.7. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Cheung, I. C. W., Smith, P. F., Darlington, C. L., & Zheng, Y. (2011). Do rats with bilateral vestibular lesions experience anxiety? In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.37. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). The effects of D2 dopamine receptor antagonism on behavioural changes in bilateral vestibular deafferented rats. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.36. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Balabhadrapatruni, S., Napper, R., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Effects of bilateral vestibular deafferentation on the dendritic morphology of CA1 pyramidal neurones: A Golgi study. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.35. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Conference Contribution - Verbal presentation and other Conference outputs

Smith, P. (2011, May). Vestibular and auditory influences on the hippocampus. Verbal presentation at the Spring Hippocampal Research Conference, Verona, Italy.

2010

Journal - Research Article

Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiology of Learning & Memory, 94(3), 402-413. doi: 10.1016/j.nlm.2010.08.007

Goddard, M., Smith, P. F., & Ashton, J. C. (2010). Behavioural effects of co-administration of Δ9-tetrahydrocannabinol with fluoxetine in rats. Pharmacology, 86(2), 125-128. doi: 10.1159/000317059

Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019

Zheng, Y., Stiles, L., Hamilton, E., Smith, P. F., & Darlington, C. L. (2010). The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. Hearing Research, 268(1-2), 145-150. doi: 10.1016/j.heares.2010.05.015

Zheng, Y., Mason-Parker, S. E., Logan, B., Darlington, C. L., Smith, P. F., & Abraham, W. C. (2010). Hippocampal synaptic transmission and LTP in vivo are intact following bilateral vestibular deafferentation in the rat. Hippocampus, 20(4), 461-468. doi: 10.1002/hipo.20645

Smith, P. F. (2010). New approaches in the management of spasticity in multiple sclerosis patients: Role of cannabinoids. Therapeutics & Clinical Risk Management, 6, 59-63.

Smith, P. F., & Darlington, C. L. (2010). A possible explanation for dizziness following SSRI discontinuation. Acta Oto-Laryngologica, 130, 981-983. doi: 10.3109/00016481003602082

Zheng, Y., Vagal, S., Zhu, X.-X., de Waele, C., Smith, P. F., Wang, G., Zhang, M., & Darlington, C. L. (2010). The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. Journal of Ethnopharmacology, 128(2), 545-548. doi: 10.1016/j.jep.2010.01.053

Zheng, Y., Masumura, C., Chung, P., Darlington, C. L., & Smith, P. F. (2010). Cell proliferation and survival in the vestibular nucleus following bilateral vestibular deafferentation in the adult rat. Neuroscience Letters, 468(1), 85-88. doi: 10.1016/j.neulet.2009.10.070

Journal - Research Other

Smith, P. F., Geddes, L. H., Baek, J.-H., Darlington, C. L., & Zheng, Y. (2010). Modulation of memory by vestibular lesions and galvanic vestibular stimulation. Frontiers in Neurology, 1, 141. doi: 10.3389/fneur.2010.00141

Smith, P. F., Darlington, C. L., & Zheng, Y. (2010). Move it or lose it: Is stimulation of the vestibular system necessary for normal spatial memory? Hippocampus, 20(1), 36-43. doi: 10.1002/hipo.20588

Conference Contribution - Published proceedings: Full paper

Darlington, C. L., Smith, P. F., & Zheng, Y. (2010). Animal models of tinnitus. New Zealand Medical Journal, 123(1311). Retrieved from http://journal.nzma.org.nz/journal/123-1311/4040/content.pdf

Smith, P. F., Zheng, Y., & Darlington, C. L. (2010). Promising medications for tinnitus. New Zealand Medical Journal, 123(1311). Retrieved from http://journal.nzma.org.nz/journal/123-1311/4040/content.pdf

Conference Contribution - Published proceedings: Abstract

Zheng, Y., Hamilton, E., Stiles, L., Smith, P. F., & Darlington, C. L. (2010). Inducing and assessing chronic tinnitus in rats using unilateral acoustic trauma and a frequency-specific shift in discrimination function with a conditioned lick suppression paradigm. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 45). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Balabhadrapatruni, S., Zheng, Y., Darlington, C. L., Napper, R., & Smith, P. F. (2010). Long-term effects of bilateral vestibular deafferentation on the total number of neurons in the subregions of the hippocampus estimated using the optical fractionator. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 29). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Stiles, L., Zheng, Y., Hamilton, E., Smith, P. F., & Darlington, C. L. (2010). Effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 47). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Vagal, S., Zheng, Y., Hamilton, E., Darlington, C. L., & Smith, P. F. (2010). Effects of baclofen on chronic tinnitus induced by acoustic trauma. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Hamilton, E., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Effects of chronic tinnitus on attention and impulsive behavior in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Baek, J.-H., Zheng, Y., Darlington, C., & Smith, P. (2010). Permanent spatial memory deficits after bilateral vestibular deafferentation and the effects of cannabinoids. New Zealand Medical Journal, 123(1321). Retrieved from http://journal.nzma.org.nz/journal/123-1321/4329/content.pdf

2009

Chapter in Book - Research

Smith, P. F., Darlington, C. L., & Zheng, Y. (2009). Cognitive deficits following complete bilateral loss of vestibular function and their relationship to the hippocampus. In A. Lindqvist & G. Nyman (Eds.), Dizziness: Vertigo, disequilibrium and lightheadedness. New York: Nova Science.

Darlington, C. L., Zheng, Y., & Smith, P. F. (2009). Herbal medicinal products for tinnitus: Perspectives and evaluation. In P. Houghton & P. K. Mukherjee (Eds.), Evaluation of herbal medicinal products. (pp. 314-321). London: Pharmaceutical Press.

Journal - Research Article

Baek, J. h., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009). The CB₁ receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Neuroscience Letters, 464(1), 71-73. doi: 10.1016/j.neulet.2009.08.008

Darlington, C. L., Goddard, M., Zheng, Y., & Smith, P. F. (2009). Anxiety-related behavior and biogenic amine pathways in the rat following bilateral vestibular lesions. Annals of the New York Academy of Sciences, 1164(1), 134-139. doi: 10.1111/j.1749-6632.2008.03725.x

Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2009). Long-term deficits on a foraging task after bilateral vestibular deafferentation in rats. Hippocampus, 19(5), 480-486. doi: 10.1002/hipo.20533

Alexander, A., Smith, P. F., & Rosengren, R. J. (2009). Cannabinoids in the treatment of cancer. Cancer Letters, 285(1), 6-12. doi: 10.1016/j.canlet.2009.04.005

Zheng, Y., Balabhadrapatruni, S., Masumura, C., Munro, O., Darlington, C. L., & Smith, P. F. (2009). Bilateral vestibular deafferentation causes deficits in a 5-choice serial reaction time task in rats. Behavioural Brain Research, 203, 113-117. doi: 10.1016/j.bbr.2009.04.027

Smith, P. F., Brandt, T., Strupp, M., Darlington, C. L., & Zheng, Y. (2009). Balance before reason in rats and humans. Annals of the New York Academy of Sciences, 1164(1), 127-133. doi: 10.1111/j.1749-6632.2008.03726.x

Conference Contribution - Published proceedings: Abstract

Alexander, A., Baek, J., Stuart, E. C., Taurin, S., Smith, P. F., & Rosengren, R. J. (2009). A CB1 specific agonist, JWH-133 accelerates tumor growth in a xenograft model of estrogen receptor negative breast cancer. The Toxicologist. [CD-ROM], 108(1), (pp. 346). [Abstract]

Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009). The effect of the cannabinoid agonist, WIN 55212-2 on object recognition memory in rats. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2009). Aging alters agmatine levels in memory-associated brain structures. Journal of Neurochemistry. 109(Suppl. 1), (pp. 304). doi: 10.1111/j.1471-4159.2009.05927.x

Conference Contribution - Poster Presentation (not in published proceedings)

Vagal, S., Darlington, C. L., Smith, P. F., & Zheng, Y. (2009, September). Effects of a Chinese herbal mixture (EMF01) in an animal model of tinnitus. Poster session presented at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Smith, P. F., Devaraj, R., Zhang, H., Ganesalingham, G., & Liu, P. (2009, September). Multivariate analysis of neurochemical changes in the aging rat brain. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009, September). The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

2008

Journal - Research Article

Liu, P., Smith, P. F., & Darlington, C. L. (2008). Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Synapse, 62, 834-841. doi: 10.1002/syn.20563

Goddard, M., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Synaptic protein expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss. Hippocampus, 18(5), 440-444. doi: 10.1002/hipo.20416

Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2008). Effects of bilateral vestibular deafferentation on anxiety-related behaviours in Wistar rats. Behavioural Brain Research, 193(1), 55-62. doi: 10.1016/j.bbr.2008.04.018

Goddard, M., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Monoamine transporter and enzyme expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss. Neuroscience Letters, 437(2), 107-110. doi: 10.1016/j.neulet.2008.03.073

Goddard, M., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation. Behavioral Neuroscience, 122(2), 448-459. doi: 10.1037/0735-7044.122.2.448

Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei. Acta Oto-Laryngologica, 128(9), 961-967. doi: 10.1080/00016480701796944

Ashton, J. C., Smith, P. F., & Darlington, C. L. (2008). The effect of Δ⁹-tetrahydrocannabinol on the extinction of an adverse associative memory. Pharmacology, 81(1), 18-20. doi: 10.1159/000107663

Smith, P. F. (2008). Inflammation in Parkinson's disease: An update. Current Opinion in Investigational Drugs, 9(5), 478-484.

Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856. doi: 10.1002/hipo.20448

Zheng, Y., Hooton, K., Smith, P. F., & Darlington, C. L. (2008). Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatments in rats. Acta Oto-Laryngologica, 128(1), 48-52. doi: 10.1080/00016480701361939

Conference Contribution - Published proceedings: Abstract

Zhang, C., Zheng, Y., Smith, P., & Zhang, M. (2008). Increased cell proliferation in the cochlear nucleus following bilateral cochlear lesions. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf

Zheng, Y., Balabhadrapatruni, S., Masumura, C., Darlington, C. L., & Smith, P. F. (2008). Effects of CX717 on attentional performance in rats with bilateral vestibular deafferentation. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Darlington, C., Zhang, C., Zhang, M., Fleming, K., Smith, P. F., & Zheng, Y. (2008). Cell proliferation in the cochlear nucleus following bilateral cochlear lesions. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Smith, P. F., Goddard, M., Masumura, C., Chung, P., Darlington, C. L., & Zheng, Y. (2008). Balance before reason. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Zheng, Y., Chung, P., Masumura, C., Darlington, C. L., Brandt, T., Strupp, M., Zhang, M., & Smith, P. F. (2008). Time course changes in hippocampal cell proliferation following bilateral vestibular damage in rats. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 61). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Balabhadrapatruni, S., Zheng, Y., Masumura, C., Darlington, C. L., & Smith, P. F. (2008). Effects of bilateral vestibular deafferentation on attentional performance in a five-choice serial reaction time task in rats. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 68). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Changes in hippocampal cannabinoid CB2 receptor expression following the bilateral vestibular deafferentation. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Ashton, J., Goddard, M., & Smith, P. (2008). Interaction between 5-HT pathways and the endocannabinoid system in the regulation of anxiety. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 54). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Masumura, C., Hooton, K., Horii, A., Zheng, Y., Smith, P. F., & Darlington, C. L. (2008). Evaluating cannabinoid receptor agonist for the treatment of salicylate induced tinnitus in rats. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 32). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008, June-July). Aging alters agmatine levels in memory-associated brain structures. Poster session presented at the Third International Society for Neurochemistry Special Neurochemistry Conference: 8th International Meeting on Brain Energy Metabolism, Beijing, China.

2007

Chapter in Book - Research

Smith, P. F., Zheng, Y., Goddard, M., & Darlington, C. L. (2007). Cognitive impairment due to inner ear damage. In H. C. Sentowski (Ed.), Cognitive Disorders Research Trends. (pp. 231-243). New York: Nova Science.

Ashton, J. C., & Smith, P. F. (2007). Bcl-2 and mitochondrial control of apoptosis as a mechanism for regulating neural plasticity. In L. B. Shultz (Ed.), Cell Apoptosis: Regulation and Environmental Factors. (pp. 1-23). New York: Nova Science.

Journal - Research Article

Smith, P. F. (2007). Will medicinal cannabinoids prove to be useful clinically? Current Drug Therapy, 2(2), 143-150.

Ashton, J. C., & Smith, P. F. (2007). Cannabinoids and cardiovascular disease: The outlook for clinical treatments. Current Vascular Pharmacology, 5(3), 175-184.

Darlington, C. L., & Smith, P. F. (2007). Drug treatments for tinnitus. Progress in Brain Research, 166, 249-262. doi: 10.1016/s0079-6123(07)66023-3

Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2007). Bilateral vestibular deafferentation impairs performance in a spatial forced alternation task in rats. Hippocampus, 17, 253-256.

Zheng, Y., Baek, J.-H., Smith, P. F., & Darlington, C. L. (2007). Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus. Hearing Research, 228, 105-111.

Smith, P. F. (2007). Symptomatic treatment of multiple sclerosis using cannabinoids: Recent advances. Expert Review of Neurotherapeutics, 7(9), 1157-1163.

Conference Contribution - Published proceedings: Abstract

Masumura, C., Horii, A., Darlington, C. L., & Smith, P. F. (2007). The effects of a calcineurin inhibitor on vestibular compensation. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 38). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

Darlington, C. L., Hooton, K., Smith, P. F., & Zheng, Y. (2007). Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 56). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

Smith, P. F., Goddard, M., Darlington, C. L., & Zheng, Y. (2007). Neurochemical changes in the hippocampus following bilateral vestibular damage. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 55). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2007). Effects of bilateral vestibular deafferentation on open field activity in rats. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 55). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2007). Expression of cannabinoid receptors in the hindbrain. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 51). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

Baek, J.-H., Zheng, Y., Ashton, J. C., Darlington, C. L., & Smith, P. F. (2007). Abundant expression of the cannabinoid CB₂ receptors in the rat cerebellum. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp

Liu, P., Devaraj, R., Collie, N. D., Chary, S., Bilkey, D. K., Smith, P. F., Darlington, C. L., & Zhang, H. (2007). Effects of aging on agmatine levels in memory-associated brain structures. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 26). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

2006

Journal - Research Article

Zheng, Y., Darlington, C. L., & Smith, P. F. (2006). Impairment and recovery on a food foraging task following unilateral vestibular deafferentation in rats. Hippocampus, 16, 368-378.

Zheng, Y., Lee, H. S., Smith, P. F., & Darlington, C. L. (2006). Neuronal nitric oxide synthase expression in the cochlear nucleus in a salicylate model of tinnitus. Brain Research, 1123, 201-206.

Smith, P. F., Ashton, J. C., & Darlington, C. L. (2006). The endocannabinoid system: A new player in the neurochemical control of vestibular function? Audiology & Neurotology, 11, 207-212.

Ashton, J. C., Darlington, C. L., & Smith, P. F. (2006). Co-distribution of the cannabinoid CB₁ receptor and the 5-HT transporter in the rat amygdale. European Journal of Pharmacology, 537, 70-71.

Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2006). Lesions of the vestibular system disrupt hippocampal theta rhythm in the rat. Journal of Neurophysiology, 96, 4-14.

Fergusson, D. M., Poulton, R., Smith, P. F., & Boden, J. M. (2006). Cannabis and psychosis. BMJ, 332, 172-175. doi: 10.1136/bmj.332.7534.172

Ashton, J. C., Friberg, D., Darlington, C. L., & Smith, P. F. (2006). Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study. Neuroscience Letters, 396, 113-116.

Conference Contribution - Published proceedings: Abstract

Liu, P., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2006). Effects of perirhinal nitric oxide synthase inhibition in the water maze task. Acta Pharmacologica Sinica. 27(Suppl.), (pp. 371). [Abstract]

Liu, P., Smith, P. F., & Darlington, C. L. (2006). Effects of aging on NMDA receptor subunits in memory-associated brain structures. In J. G. Anson (Ed.), Proceedings of the 24th International Australasian Winter Conference on Brain Research. 24, (pp. 57). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2006Abstracts.pdf

2005

Chapter in Book - Research

Smith, P. F. (2005). Medicinal use of cannabis: Implications for lung cancer. In R. L. Carafaro (Ed.), Focus on lung cancer research. (pp. 193-209). New York, NY: Nova Science Publishers.

Smith, P. F. (2005). Cannabis and cannabinoids for the symptomatic treatment of multiple sclerosis. In F. Columbus (Ed.), Treatment and management of multiple sclerosis. (pp. 155-167). New York, NY: Nova Science Publishers.

Journal - Research Article

Brandt, T., Schautzer, F., Hamilton, D. A., Brüning, R., Markowitsch, H. J., Kalla, R., Darlington, C., Smith, P., & Strupp, M. (2005). Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain, 128(11), 2732-2741. doi: 10.1093/brain/awh617

Ashton, J. C., Little, E., Muir, M., Smith, P. F., & Darlington, C. L. (2005). Mitochondrial ultrastructure and apoptotic protein expression in the vestibular nucleus complex following unilateral labyrinthectomy. Brain Research, 1055, 165-170.

Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2005). GABA_A receptor subunit expression in the guinea pig vestibular nucleus complex during the development of vestibular compensation. Experimental Brain Research, 166, 71-77. doi: 10.1007/s00221-005-2344-4

Zhang, R., Smith, P. F., & Darlington, C. L. (2005). Immunocytochemical and stereological study of glucocorticoid receptors in rat medial vestibular nucleus neurons and the effects of unilateral vestibular deafferentation. Acta Oto-Laryngologica, 125, 1258-1264.

Smith, P. F., Zheng, Y., & Darlington, C. L. (2005). Ginkgo biloba extracts for tinnitus: More hype than hope? Journal of Ethnopharmacology, 100, 95-99.

Ashton, J. C., Khalessi, A., Kapoor, M., Clarkson, A., Sammut, I. A., Darlington, C. L., & Smith, P. F. (2005). Characterization of mitochondrial respiratory chain energetics in the vestibular nucleus complex [Short Communication]. Acta Oto-Laryngologica, 125, 422-425.

Smith, P. F. (2005). The safety of cannabinoids for the treatment of multiple sclerosis. Expert Opinion on Drug Safety, 4(3), 443-456.

Smith, P. F., & Darlington, C. L. (2005). Drug treatments for subjective tinnitus: Serendipitous discovery versus rational drug design. Current Opinion in Investigational Drugs, 6(7), 712-716.

Smith, P. F. (2005). Cannabinoids as potential anti-epileptic drugs. Current Opinion in Investigational Drugs, 6(7), 680-685.

Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2005). Effects of chronic infusion of a GABA_A receptor agonist or antagonist into the vestibular nuclear complex on vestibular compensation in the guinea pig. Journal of Pharmacology & Experimental Therapeutics, 313(3), 1126-1135. doi: 10.1124/jpet.104.082172

Zhang, R., Smith, P. F., & Darlington, C. L. (2005). Immunocytochemical and stereological studies of the rat vestibular nucleus: Optimal research methods using glucocorticoid receptors as an example. Journal of Neuroscience Methods, 144, 99-106.

Smith, P. F., Zheng, Y., Horii, A., & Darlington, C. L. (2005). Does vestibular damage cause cognitive dysfunction in humans? [Review]. Journal of Vestibular Research, 15, 1-9.

Zhang, R., Ashton, J., Horii, A., Darlington, C. L., & Smith, P. F. (2005). Immunocytochemical and stereological analysis of GABA_B receptor subunit expression in the rat vestibular nucleus following unilateral vestibular deafferentation. Brain Research, 1037(1-2), 107-113. doi: 10.1016/j.brainres.2005.01.018

Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2005). GABAergic systems in the vestibular nucleus and their contribution to vestibular compensation. Progress in Neurobiology, 75, 53-81. doi: 10.1016/j.pneurobio.2004.11.001

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2005). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Hippocampus, 15, 642-655.

Lindsay, L., Liu, P., Gliddon, C., Zheng, Y., Smith, P. F., & Darlington, C. L. (2005). Cytosolic glucocorticoid receptor expression in the rat vestibular nucleus and hippocampus following unilateral vestibular deafferentation. Experimental Brain Research, 162, 309-314. doi: 10.1007/s00221-004-2168-7

Smith, P. F., Horii, A., Russell, N., Bilkey, D. K., Zheng, Y., Liu, P., Kerr, D. S., & Darlington, C. L. (2005). The effects of vestibular lesions on hippocampal function in rats. Progress in Neurobiology, 75, 391-405.

Conference Contribution - Published proceedings: Abstract

Liu, P., Chen, G., Appleton, I., Smith, P. F., & Darlington, C. L. (2005). Regional variations and age-related changes in cyclooxygenase in memory-associated brain structures. Proceedings of the 23rd International Australasian Winter Conference on Brain Research. (pp. 55). [Abstract]

2004

Journal - Research Article

Smith, P. F. (2004). GW-1000 GW Pharmaceuticals. Current Opinion in Investigational Drugs, 5(7), 748-754.

Horii, A., Masumura, C., Smith, P. F., Darlington, C. L., Kitahara, T., Uno, A., … Kubo, T. (2004). Microarray analysis of gene expression in the rat vestibular nucleus complex following unilateral vestibular deafferentation. Journal of Neurochemistry, 91, 975-982.

Zheng, Y., Darlington, C. L., & Smith, P. F. (2004). Bilateral labyrinthectomy causes long-term deficit in object recognition in rat. NeuroReport, 15, 1913-1916.

Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2004). Rapid vestibular compensation in guinea pig even with prolonged anesthesia. Neuroscience Letters, 371, 138-141.

Smith, P. F. (2004). Medicinal cannabis extracts for the treatment of multiple sclerosis. Current Opinion in Investigational Drugs, 5(7), 727-730.

Ashton, J. C., Appleton, I., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical localization of cannabinoid CB₁ receptor in inhibitory interneurons in the cerebellum. Cerebellum, 3, 222-226.

Ashton, J. C., Appleton, I., Darlington, C. L., & Smith, P. F. (2004). Cannabinoid CB1 receptor protein expression in the rat choroid plexus: A possible involvement of cannabinoids in the regulation of cerebrospinal fluid. Neuroscience Letters, 364, 40-42.

Ashton, J. C., Appleton, I., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical localization of cerebrovascular cannabinoid CB1 receptor protein. Journal of Cardiovascular Pharmacology, 44(5), 517-519.

Horii, A., Russell, N. A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2004). Vestibular influences on CA1 neurons in the rat hippocampus: An electrophysiological study in vivo. Experimental Brain Research, 155(2), 245-250.

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Potential involvement of NOS and arginase in age-related behavioural impairments. Experimental Gerontology, 39(8), 1207-1222.

Liu, P., Gliddon, C. M., Lindsay, L., Darlington, C. L., & Smith, P. F. (2004). Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: A link to deficits in object recognition? Journal of Vestibular Research, 14, 411-417.

Ashton, J. C., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation. Brain Research, 1021, 264-271.

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex. Neurobiology of Aging, 25(4), 547-552.

Conference Contribution - Verbal presentation and other Conference outputs

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004, August). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Verbal presentation at the 22nd International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.

Commissioned Report for External Body

Smith, P. F. (2004). Drug Report for: GW-1000. Thomson Current Drugs. 19p.

2003

Journal - Research Article

Zheng, Y., Smith, P. F., Pearce, J. M., Vann, S. D., Good, M., Jenkins, T. A., & Aggleton, J. P. (2003). Using idiothetic cues to swim a path with a fixed trajectory and distance: Necessary involvement of the hippocampus, but not the retrosplenial cortex. Behavioral Neuroscience, 117(6), 1363-1377.

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Neuroscience, 119(3), 679-687.

Zheng, Y., Kerr, D. S., Darlington, C. L., & Smith, P. F. (2003). Unilateral inner ear damage results in lasting changes in hippocampal CA1 field potentials in vitro. Hippocampus, 13, 873-878.

Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Long-term changes in hippocampal N-methyl-D-aspartate receptor subunits following unilateral vestibular damage in rat. Neuroscience, 117, 965-970.

Horii, A., Kitahara, T., Smith, P. F., Darlington, C. L., Masumura, C., & Kubo, T. (2003). Effects of unilateral labyrinthectomy on GAD, GATI and GABA receptor gene expression in the rat vestibular nucleus. NeuroReport, 14, 2359-2363.

Gliddon, C. M., Smith, P. F., & Darlington, C. L. (2003). Interaction between the hypothalamic-pituitary-adrenal axis and behavioural compensation following unilateral vestibular deafferentation. Acta Oto-Laryngologica, 123(9), 1013-1021.

Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal, perirhinal, postrhinal, and temporal cortices: Regional variations and age-related changes. Hippocampus, 13, 859-867.

Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: Regional variations and age-related changes. Brain Research, 979(1-2), 235-239.

Ashton, J. C., Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2003). Effect of low body temperature during unilateral labyrinthectomy on vestibular compensation in the guinea pig. Acta Oto-Laryngologica, 123, 448-452.

Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2003). Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented guinea pig. Brain Research, 964, 306-310.

Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2003). Long-term effects of permanent vestibular lesions on hippocampal spatial firing. Journal of Neuroscience, 23(16), 6490-6498.

Darlington, C. L., & Smith, P. F. (2003). Vestibulotoxicity following aminoglycoside antibiotics and its prevention. Current Opinion in Investigational Drugs, 4(7), 841-846.

Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2003). Bilateral peripheral vestibular lesions produce long-term changes in spatial learning in the rat. Journal of Vestibular Research, 13(1), 9-16.

Smith, P. F. (2003). Cannabinoids for the treatment of multiple sclerosis: No smoke without fire? Expert Review of Neurotherapeutics, 3(3), 327-334.

Smith, P. F. (2003). Therapeutic N-methyl-D-aspartate receptor antagonists: Will reality meet expectation. Current Opinion in Investigational Drugs, 4(7), 826-832.

Smith, P. F. (2003). Neuroprotection against hypoxia-ischemia by insulin-like growth factor-I (IGF-I). IDrugs, 6(12), 1173-1177.

Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Nitric oxide synthase and arginase expression in the vestibular nucleus and hippocampus following unilateral vestibular deafferentation in the rat. Brain Research, 966, 19-25.

Liu, P., Zheng, Y., Smith, P. F., & Bilkey, D. K. (2003). Changes in NOS protein expression and activity in the rat hippocampus, entorhinal and postrhinal cortices after unilateral electrolytic perirhinal cortex lesions. Hippocampus, 13, 561-571.

Maclennan, K. M., Zheng, Y., Sheard, P. W., Williams, S. M., Darlington, C. L., & Smith, P. F. (2003). Adrenalectomy-induced cell death in the dentate gyrus: Further characterisation using TUNEL and effects of the Ginkgo biloba extract, EGb 761 and ginkgolide B. Hippocampus, 13, 212-225.

Conference Contribution - Published proceedings: Abstract

Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Age-related changes in glucocorticoid receptor protein expression in the rat hippocampus and parahippocampal region. In J. G. Anson & J. Wickens (Eds.), Proceedings of the 21st International Australasian Winter Conference on Brain Research. (pp. 53). Queenstown: AWCBR. [Abstract]

Ashton, J. C., Khalessi, A., Kapoor, M., Clarkson, A., Darlington, C. L., Smith, P. F., & Sammut, I. A. (2003). Mitochondria respiratory chain activity in the vestibular nucleus and cerebellum. Proceedings of the 21st International Australasian Winter Conference on Brain Research. 21, (pp. 45). University of Otago, Dunedin: AWCBR. [Abstract]

2002

Authored Book - Research

Smith, P. F. (2002). Cannabis on the Brain. Palmerston North: Dunmore Press, 228p.

Journal - Research Article

Darlington, C. L., Dutia, M. B., & Smith, P. F. (2002). The contribution of the intrinsic properties of vestibular nucleus neurones to recovery from vestibular damage. European Journal of Neuroscience, 15, 1719-1727.

Smith, P. F. (2002). The therapeutic applications of cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Current Opinion in Investigational Drugs, 3, 1472-1477.

Horii, A., Smith, P. F., & Darlington, C. L. (2002). Application of real-time quantitative polymerase chain reaction to quantification of glutamate receptor gene expression in the vestibular brainstem and cerebellum. Brain Research Protocols, 9(1), 77-83. doi: 10.1016/S1385-299X(01)00139-8

King, J., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. NeuroReport, 13(12), 1541-1545.

King, J., Young, C., Highton, J., Smith, P. F., & Darlington, C. L. (2002). Vestibulo-ocular, optokinetic and postural function in humans with rheumatoid arthritis. Neuroscience Letters, 328, 77-80.

Maclennan, K. M., Darlington, C. L., & Smith, P. F. (2002). The CNS effects of Ginkgo biloba extracts and ginkgolide B. Progress in Neurobiology, 67, 235-257.

Nicholson, M., King, J., Smith, P. F., & Darlington, C. L. (2002). Vestibulo-ocular, optokinetic and postural function in diabetes mellitus. NeuroReport, 13(1), 1-5.

Conference Contribution - Published proceedings: Abstract

Ashton, J. C., Smith, P. F., Darlington, C. L., & Gliddon, C. M. (2002). The effect of low body temperature at unilateral deafferentation on vestibular compensation. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 37). Dept of Psychology: AWCBR. [Abstract]

Zheng, Y., Pearce, J., Smith, P. F., & Aggleton, J. P. (2002). Contribution of visual cues and vestibular cues to egocentric spatial memory in the morris water maze. 20th International Australian Winter Conference on Brain Research. 20, (pp. 35). [Abstract]

Smith, P. F., King, J., Zheng, Y., Liu, P., & Darlington, C. L. (2002). Nitric Oxide Synthase and Arginase expression in the rat hippocampus following unilateral vestibular deafferentation. 20th International Australasian Winter Conference on Brain R. 20, (pp. 34). [Abstract]

King, J., Zheng, Y., Darlington, C. L., Smith, P. F., & Liu, P. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. 20th International Australasian Conference on Brain Research. 20, (pp. 37). [Abstract]

Khalessi, A., Ashton, J. C., Sammut, I. A., Smith, P. F., & Darlington, C. L. (2002). Mitochondrial function in the vestibular nucleus complex. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 36). [Abstract]

Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2002). Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented Guinea Pig. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 36). [Abstract]

Darlington, C. L., King, J., Zheng, Y., Liu, P., & Smith, P. F. (2002). Nitric oxide synthase and arginase expression in the rat vestibular nucleus following unilateral vestibular deafferentation. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 38). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Liu, P., Zheng, Y., King, J., Darlington, C., & Smith, P. (2002). NMDA and AMPA receptor subunit protein expression in the rat hippocampus following unilateral labyrinthectomy. Verbal presentation at the Twentieth International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.

2001

Journal - Research Article

Darlington, C. L., Ross, A., King, J., & Smith, P. F. (2001). Menstrual cycle effects on postural stability but not optokinetic function. Neuroscience Letters, 307, 147-150.

Zheng, Y., Horii, A., Appleton, I., Darlington, C. L., & Smith, P. F. (2001). Damage to the vestibular inner ear causes long-term changes in nitric oxide synthase expression in the rat hippocampus. Neuroscience, 105(1), 1-5.

Smith, P. F., Zheng, Y., Paterson, S., & Darlington, C. L. (2001). The contribution of nitric oxide to vestibular compensation: Are there species differences? Acta Oto-Laryngologica, 121(545), 57-60. doi: 10.1080/000164801750388126

Horii, A., Smith, P. F., & Darlington, C. L. (2001). Quantitative changes in gene expression of glutamate receptor subunits/subtypes in the vestibular nucleus, inferior olive and flocculus before and following unilateral labyrinthectomy in the rat: Real-time quantitative PCR method. Experimental Brain Research, 139, 188-200.

Todd, L., King, J., Darlington, C. L., & Smith, P. F. (2001). Optokinetic reflex dysfunction in multiple sclerosis. NeuroReport, 12(7), 1399-1402.

Smith, P. F. (2001). New evidence that nicotine affects eye movement and balance in susceptible individuals. NeuroReport, 12, A31-A32.

Zheng, Y., Horii, A., Smith, P. F., & Darlington, C. L. (2001). Differences in NOS protein expression and activity in the rat vestibular nucleus following unilateral labyrinthectomy. Molecular Brain Research, 88, 166-170.

Conference Contribution - Published proceedings: Abstract

Richmond, J., Liu, P., Bilkey, D., & Smith, P. F. (2001). Changes in NOS activity and protein expression in the rat hippocampus and entorhinal and postrhinal cortoces following unilateral perirhinal lesions. Society for Neuroscience Abstracts. 27. [Abstract]

Zheng, Y., Horii, A., Darlington, C. L., Kerr, D. S., & Smith, P. F. (2001). Differential changes in hippocampal nitric oxide synthase activity and protein expression following unilateral labrynthectomy in rat. 31st Annual Meeting of the Society for Neuroscience. 27. San Diego, USA: Society for Neuroscience. [Abstract]

Zheng, Y., Horii, A., Appleton, I., Darlington, C. L., Kerr, D. S., & Smith, P. F. (2001). Differential changes in hippocampal nitric oxide synthase activity and protein expression following unilateral labyrinthectomy in rat. Society for Neuroscience Abstracts. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Russell, N. A., Liu, P., Darlington, C. L., Bilkey, D. K., Horii, A., & Smith, P. F. (2001). Hippocampal neuron firing rate correlations with angular velocity and angular acceleration in rats with vestibular lesions. Verbal presentation at the 19th International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.

Commissioned Report for External Body

Smith, P. F. (2001). How Safe is Cannabis? Commissioned by The Health Select Committee On Legal and Safety Issues Relating to Cannabis. Ministry of Health, Wellington. Wellington: New Zealand Government. 15p.

2000

Chapter in Book - Research

Smith, P. F., & Darlington, C. L. (2000). The contributions of excitatory and inhibitory amino acid neurotransmitters to vestibular plasticity. In A. J. Beitz & J. H. Anderson (Eds.), Neurochemistry of the Vestibular System. (pp. 381-401). New York: CRC Press.

Journal - Research Article

Alexander, H., Sansom, A. J., Kerr, D. R., Smith, P. F., Dragunow, M., & Darlington, C. L. (2000). An antisense oligonucleotide for c-fos does not delay vestibular compensation of the static symptoms following unilateral vestibular deafferention in guinea pig. Neuroscience Research Communications, 26(2), 123-128.

Sansom, A. J., Smith, P. F., Darlington, C. L., & Laverty, R. (2000). Vestibular nucleus N-methyl-D-aspartate receptors contribute to spontaneous nystagmus generation following unilateral labyrinthectomy in guinea pigs. Neuroscience Letters, 283(2), 117-120.

Peters, K., Darlington, C. L., & Smith, P. F. (2000). The effects of repeated optokinetic stimulation on human autonomic function. Journal of Vestibular Research, 10, 139-142.

Gowans, J., Matheson, A. J., Darlington, C. L., & Smith, P. F. (2000). The effects of scopolamine and cyclizine on visual-vestibular interaction in humans. Journal of Vestibular Research, 10, 87-92.

Darlington, C. L., Erasmus, J., Nicholson, M., King, J., & Smith, P. F. (2000). Comparison of visual-vestibular interaction in insulin-dependent and non-insulin-dependent diabetes mellitus. NeuroReport, 11(3), 487-490.

Smith, P. F. (2000). Cannabis on the brain: Is it neurotoxic or neuroprotective? New Zealand Journal of Psychology, 29(1), 36-39.

Maingay, M., Sansom, A. J., Kerr, D. R., Smith, P. F., & Darlington, C. L. (2000). The effects of intra-vestibular nucleus administration of brain-derived neurotrophic factor (BDNF) on recovery from peripheral vestibular damage in guinea pig. NeuroReport, 11(11), 2429-2432.

Smith, P. F. (2000). Are vestibular hair cells excited to death by aminoglycoside antibiotics? Journal of Vestibular Research, 10(1), 1-5.

Smith, P. F. (2000). Pharmacology of the vestibular system. Current Opinion in Neurology, 13, 31-37.

Smith, P. F. (2000). A neuroscientist looks at philosophy: Response to Beedle (1999). Journal of Neuroscience Research, 60, 281-283.

Kerr, D. R., Sansom, A. J., Smith, P. F., & Darlington, C. L. (2000). Comparison of protein kinase activity and protein phosphorylation in the medial vestibular nucleus and prepositus hypoglossi in labyrinthine-intact and labyrinthectomized guinea pigs. Journal of Vestibular Research, 10(2), 107-117.

Zheng, Y., Appleton, I., Smith, P. F., & Darlington, C. L. (2000). Subregional variation in the effects of unilateral vestibular deafferentation on nitric oxide synthase activity and nitrite formation in the guinea pig hippocampus. Neuroscience Research Communications, 27(2), 109-116.

Alexander, H., Sansom, A. J., Kerr, D. R., Smith, P. F., Dragunow, M., & Darlington, C. L. (2000). Effects of c-fos antisense and mis-sense oligonucleotides on Fos expression in the vestibular nucleus and vestibular compensation following unilateral labyrinthectomy. Neuroscience Research Communications, 26(2), 123-128.

Sansom, A. J., Smith, P. F., Darlington, C. L., & Laverty, R. (2000). The effects of protein kinase C and calmodulin kinase II inhibitors on vestibular compensation in the guinea pig. Brain Research, 882(1-2), 45-54.

Paterson, S., Zheng, Y., Smith, P. F., & Darlington, C. L. (2000). The effects of L-NAME on vestibular compensation and NOS activity in the vestibular nucleus, cerebellum and cortex of the guinea pig. Brain Research, 879, 148-155.

Gliddon, C. M., Sansom, A. J., Smith, P. F., & Darlington, C. L. (2000). Effects of intra-vestibular nucleus injection of the Group I metabotropic glutamate receptor antagonist AIDA on vestibular compensation in guinea pigs. Experimental Brain Research, 134(1), 74-80. doi: 10.1007/s002210000437

Journal - Research Other

Darlington, C. L., & Smith, P. F. (2000). Molecular mechanisms of recovery from vestibular damage in mammals: Recent advances. Progress in Neurobiology, 62, 313-325. doi: 10.1016/S0301-0082(00)00002-2

Smith, P. F., & Darlington, C. L. (2000). The development of drugs targeting the HIV cognitive-motor complex. Current Opinion in Anti-inflammatory & Immunomodulatory Investigational Drugs. [Review].

Conference Contribution - Published proceedings: Abstract

Russell, N. A., Horii, A., Liu, P., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2000). Hippocampal place fields have decreased stability in rats with bilateral vestibular labyrinthectomies. Proceedings of the Society for Neuroscience. 26, (pp. 471). [Abstract]

Zheng, Y., Appleton, I., Smith, P. F., & Darlington, C. L. (2000). Subregional variation in the effects of unilateral deafferentation on nitric oxide synthase activity and nitrite formation in the guinea pig hippocampus. European Journal of Neuroscience. 12(Suppl 11), (pp. 34). [Abstract]

Zheng, Y., Horii, A., Smith, P. F., & Darlington, C. L. (2000). Time course changes of hippocampal nitric oxide synthase following unilateral vestibular deafferentation in rats. 18th International Australasian Winter Conference on Brain Research. Queenstown, New Zealand. [Abstract]

Smith, P. F., Pateson, S., Zheng, Y., & Darlington, C. L. (2000). The effects of the NOS inhibitor, L-Name, on vestibular compensation in Guinea Pig. 18th International Australasian Winter Conference on Brain Research. Queenstown, New Zealand. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Russell, N., Horii, A., Liu, P., Smith, P., Darlington, C., & Bilkey, D. K. (2000). Hippocampal theta rhythm has decreased power in rats with bilateral vestibular labyrinthectomies. Verbal presentation at the Eighteenth International Australasian Winter Conference on Brain Research, Queenstown.

1999

Chapter in Book - Research

Darlington, C. L., Smith, P. F., & Maclennan, K. M. (1999). The neuroprotective properties of ginkgo extracts. In T. A. Van Beek (Ed.), Medicinal and Aromatic Plants - Industrial Profiles: Ginkgo Biloba. (pp. 331-344). Amsterdam: Harwood Academic Publishers.

Journal - Research Article

Kerr, D. R., Sansom, A. J., Smith, P. F., & Darlington, C. L. (1999). Comparison of protein kinase activity and protein phosphorylation in the medical vastibular nucleus and prepositus hypoglossi in labyrinthine-intact and labyrinthectomized guinea pigs. Journal of Vestibular Research, 1, 1-11.

Matheson, A. J., Darlington, C. L., & Smith, P. F. (1999). Incidence of dizziness in the elderly: Correlation with ocular motor, optokinetic and postural function. New Zealand Journal of Psychology, 17-22.

Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Subregional analysis of amino acid levels in the guinea pig hippocampus following unilateral vestibular deafferentation. Journal of Vestibular Research, 9, 335-345.

Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Noradrenaline and serotonin levels in the guinea pig hippocampus following unilateral vestibular deafferentation. Brain Research, 836, 199-202.

McDermott, K. H., Matheson, A. J., Titov, N., Darlington, C. L. M., & Smith, P. F. (1999). Does habitual, vigorous optokinetic stimulation alter optokinetic nystagmus and sensitivity to circularvection? Journal of Vestibular Research, 9, 59-61.

Bolger, C., Sansom, A. J., Smith, P. F., & Darlington, C. L. (1999). An antisense oligonucleotide to brain-derived neurotrophic factor delays postural compensation following unilateral labyrinthectomy in guinea pig. NeuroReport, 10(7), 1485-1488.

Darlington, C. L., Matheson, A. J., Menenti, E. C., & Smith, P. F. (1999). Vestibular dysfunction in multiple sclerosis. Australian Journal of Otolaryngology, 3, 257-258.

Smith, P. F., & Maclennan, K. M. (1999). The neuroprotective effects of platelet activating factor (PAF) receptor antagonists in CNS disorders. Current Opinion in Anti-inflammatory & Immunomodulatory Investigational Drugs, 1, 205-218.

Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Temporal bone surgery causes reduced nitric oxide synthase activity in the ipsilateral guinea pig hippocampus. Neuroscience Letters, 259, 130-132.

Schlatter, M., Kerr, D. R., Darlington, C. L., & Smith, P. F. (1999). Evidence that the Ginkgo biloba extract, EGb 761, neither accelerates nor enhances rapid compensation of the static symptoms of unilateral vestibular deafferentation in guinea pig. Journal of Vestibular Research, 9, 111-118.

Matheson, A. J., Darlington, C. L., & Smith, P. F. (1999). Further evidence for age-related deficits in human postural control. Journal of Vestibular Research, 9, 261-264.

Journal - Research Other

Smith, P. F., & Darlington, C. L. (1999). Recent developments in drug therapy for multiple sclerosis. Multiple Sclerosis, 5, 110-120. doi: 10.1177/135245859900500208

Matheson, A. J., Darlington, C. L., & Smith, P. F. (1999). Dizziness in the elderly and age-related degeneration in the vestibular system. New Zealand Journal of Psychology, 28(1), 10-16. [Review].

Conference Contribution - Published proceedings: Abstract

Kerr, D. R., Sansom, A. J., Darlington, C. L., Smith, P. F., & Watson, J. A. (1999). Protein Phosphorylation in vitro in the guinea pig medial vestibular nucleus (MVN) compared to prepositus hypoglossi (PH) following unilateral vestibular deafferentiation. Society for Neuroscience 29th Annual Meeting. Abstract 7. [Abstract]

Kerr, D. R., Sansom, A. J., Darlington, C. L., & Smith, P. F. (1999). Calmodulin Kinase (CaMK) activity and Protein Kinase C (PKC) activity in guinea pig medial vestibular nucleus (MVN) and prepositus hypoglossi (PH). Australasian Winter Conference on Brain Research 1999. [Abstract]

Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Effects of peripheral vestibular damage on monoamine and amino acid levels in the guinea pig hippocampus. Proc. Univ. Otago Medical School. 77(17). [Abstract]

1998

Chapter in Book - Research

Smith, P. F., & Darlington, C. L. (1998). Neural mechanisms of psychiatric disturbances in patients with epilepsy. In H. McDonnell & P. Snyder (Eds.), Psychiatric co-morbidity in epilepsy: Basic mechanisms, diagnosis and treatment. (pp. 15-35). Washington DC: American Psychiatric Press.

Journal - Research Article

Paul, C. A., Sansom, A. J., Maclennan, K., Darlington, C. L., & Smith, P. F. (1998). The effects of steroids on vestibular compensation and vestibular nucleus neuronal activity in guinea pig. Journal of Vestibular Research, 8(3), 201-207.

Darlington, C. L., & Smith, P. F. (1998). Further evidence for gender differences in circularvection. Journal of Vestibular Research, 8(2), 151-153.

Darlington, C. L., & Smith, P. F. (1998). Drug treatment for vertigo and dizziness. New Zealand Medical Journal, Sept 11, 332-334.

Matheson, A. J., Darlington, C. L., & Smith, P. F. (1998). Age-related changes in human optokinetic sensitivity. NeuroReport, 9, 2175-2177.

Anderson, T. V., Moulton, A., Sansom, A. J., Kerr, D. R., Laverty, R., Darlington, C. L., & Smith, P. F. (1998). Evidence for reduced nitric oxide synthase (NOS) activity in the ipsilateral medial vestibular nucleus and bilateral prepositus hypoglossi following unilateral vestibular deafferentation in the guinea pig. Brain Research, 787(2), 311-314.

Newsham-West, D., Darlington, C. L., & Smith, P. F. (1998). Potent effects of a selective cannabinoid receptor agonist on some guinea pig medial vestibular nucleus neurons. European Journal of Pharmacology, 348(May 1), R1-R2.

Smith, P. F., Darlington, C. L., Yan, Y., & Dragunow, M. (1998). Unilateral vestibular deafferentation induces brain-derived neurotrophic factor (BDNF) protein expression in the guinea pig lateral, but not medial, vestibular nuclei. Journal of Vestibular Research, 8, 443-447.

Journal - Research Other

Maclennan, K., Smith, P. F., & Darlington, C. L. (1998). Adrenalectomy-induced neuronal degeneration. Progress in Neurobiology, 54, 481-498. doi: 10.1016/S0301-0082(97)00076-2

Conference Contribution - Published proceedings: Abstract

Zheng, Y., Smith, P. F., & Darlington, C. L. (1998). Temporal bone trauma causes reduced nitric oxide synthase (NOS) activity in the ipsilateral guinea pig hippocampus. Proceedings of the University of Otago Medical School. 76(35). Dunedin: University of Otago. [Abstract]

1997

Chapter in Book - Research

Darlington, C. L., Smith, P. F., & Maclennan, K. M. (1997). Effects of Ginkgo biloba extract (EGb 761) on recovery from peripheral vestibular deafferentation (vestibular compensation). In V. Papadopoulos, K. Drieu & Y. Christen (Eds.), Advances in Ginkgo biloba Research, Vol. 6. (pp. 47-58). Paris: Elsevier.

Journal - Research Article

Smith, P. F. (1997). Vestibular-hippocampal interactions. Hippocampus, 7(5), 465-471.

Sansom, A. J., Brent, V. A., Jarvie, P. E., Darlington, C. L., Smith, P. F., Laverty, R., & Rostas, J. A. P. (1997). In vitro phosphorylation of medial vestibular nucleus and prepositus hypoglossi proteins during behavioural recovery from unilateral vestibular deafferentation in guinea pig. Brain Research, 778(1), 166-177.

Smith, P. F., & Darlington, C. L. (1997). The contribution of N-methyl-D-aspartate receptors to lesion-induced plasticity in the vestibular nucleus. Progress in Neurobiology, 53(5), 517-531.

1996

Authored Book - Research

Smith, P. F., & Darlington, C. L. (1996). Clinical Psychopharmacology: A Primer. New York: Lawrence Erlbaum Associates, 143p.

Chapter in Book - Research

Darlington, C., & Smith, P. (1996). What neurotransmitters are important in the vestibular system? In R. Baloh & G. M. Halmagyi (Eds.), Disorders of the Vestibular System. (pp. 140-144). New York: Oxford University Press.

Journal - Research Article

Sansom, A. J. J., Smith, P. F., & Darlington, C. L. (1996). Fentazin anesthesia for labyrinthine surgery in guinea pigs. Journal of Vestibular Research, 6, 49-52.

Dutia, M. B., Gilchrist, D. P. D., Sansom, A. J. J., Smith, P. F., & Darlington, C. L. M. (1996). The opioid receptor antagonist, naloxone, enhances ocular motor compensation following peripheral vestibular deafferentation in guinea pig. Experimental Neurology, 141, 141-144.

Darlington, C. L. M., & Smith, P. F. (1996). Recovery of static vestibular function following peripheral vestibular lesions (vestibular compensation) in mammals: the intrinsic mechanism hypothesis. Journal of Vestibular Research, 6, 185-201.

Darlington, C. L. M., Lawlor, P., Smith, P. F., & Dragunow, M. (1996). Temporal relationship between the expression of Fos, Jun and Krox-24 in the guinea pig vestibular nuclei during the development of vestibular compensation for unilateral vestibular deafferentation. Brain Research, 735, 173-176.

Darlington, C. L., Gilchrist, D. P. D., & Smith, P. F. (1996). Melanocortins and lesion-induced plasticity in the CNS: a review. Brain Research Reviews, 22(3), 245-257.

Darlington, C. L., & Smith, P. F. (1996). Oscillopsia and dizziness resulting from gentamicin antibiotic treatment: a clinical note on the beneficial effects of vestibular rehabilitation therapy. New Zealand Journal of Psychology, 25(2), 24-28.

Darlington, C. L., & Smith, P. F. (1996). Circularvection: visually-induced illusion of self-rotation. New Zealand Journal of Psychology, 25(2), 20-23.

Smith, P. F., & Darlington, C. L. (1996). Cannabis: uses and abuses. New Ethicals, 33, 79-83.

Smith, P. F., McLennan, K., & Darlington, C. L. (1996). The neuroprotective properties of the Ginkgo Biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). Journal of Ethnopharmacology, 50, 131-139.

Smith, P. F., & Darlington, C. L. (1996). The development of psychosis in epilepsy: a re-examination of the Kindling hypothesis. Behavioural Brain Research, 75, 59-66.

Smith, P. F., & Darlington, C. L. (1996). Epistemological realism in psychology: Kant or won't? New Zealand Journal of Psychology, 25, 13-20.

Martin, J., Gilchrist, D. P. D., Smith, P. F., & Darlington, C. L. (1996). Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous hystagmus in guinea pig. Journal of Vestibular Research, 6, 135-139.

Jerram, A., Smith, P. F., & Darlington, C. L. (1996). A dose-response analysis of the behavioral effects of (+)MK-801 in guinea pig: comparison with CPP. Pharmacology Biochemistry & Behavior, 53, 799-807.

Hutchinson, M., Smith, P. F., & Darlington, C. L. (1996). Tolerance to the ataxic effects of diazepam in guinea pig is not associated with a reduced sensitivity of GABAa receptors in the vestibular nucleus. European Journal of Pharmacology, 301, 83-90.

Hutchinson, M., Smith, P. F., & Darlington, C. L. (1996). The behavioral and neuronal effects of the chronic administration of benzodiazepine anxiolytic and hypnotic drugs. Progress in Neurobiology, 49, 73-97.

Gilchrist, D. P. D., Darlington, C. L., & Smith, P. F. (1996). Evidence that short ACTH fragments enhance vestibular compensation via direct action on the ipsilateral vestibular nucleus. NeuroReport, 7, 1489-1492.

Gilchrist, D. P. D., Darlington, C. L., & Smith, P. F. (1996). An in vitro investigation of the effects of the ACTH/MSH-(4-9) analogue, Org 2766, on guinea pig medial vestibular nucleus neurons. Peptides, 17, 681-688.

Jerram, A., Smith, P. F., & Darlington, C. L. (1996). Comparison of the effects of SKF 10047 and ketamine hydrochloride on stereotyped behavior, locomotor activity and ataxia in guinea pig. European Journal of Pharmacology, 307, 269-272.

Maclennan, K. M., Smith, P. F., & Darlington, C. L. (1996). Platelet-activating factor in the CNS. Progress in Neurobiology, 50(5-6), 585-596.

Smith, P. F., & Darlington, C. L. (1996). Recent advances in the pharmacology of the vestibulo-ocular reflex system. Trends in Pharmacological Sciences, 17(11), 421-427.

Hutchinson, M. A., Smith, P. F., & Darlington, C. L. M. (1996). The behavioural and neuronal effects of the chronic administration of benzodiazepine anxiolytic and hypnotic drugs. Progress in Neurobiology, 49(1), 73-97.

Maclennan, K., Smith, P. F., & Darlington, C. L. M. (1996). The effects of ginkgolide B (BN52021) on guinea pig vestibular nucleus neurons in vitro: importance of controlling for effects of dimethylsulphoxide (DMSO) vehicles. Neuroscience Research, 26(4), 395-399.

Conference Contribution - Published proceedings: Full paper

Darlington, C. L., Lawlor, P., Smith, P. F., & Dragunow, M. (1996). Expression of immediate early gene proteins in the brainstem vestibular nucleus following unilateral vestibular deafferentation. Proceedings of the University of Otago Medical School. 74, (pp. 3-4). [Full Paper]

1995

Journal - Research Article

Smith, P. F., Darlington, C. L., & Maclennan, K. (1995). Ginko Biloba: An ancient Chinese tree with neuroprotective properties. Asia Pacific Journal of Pharmacology, 10, 3-4.