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Contact Details

+64 3 479 5298
Professor and Head of Department
Department of Pharmacology and Toxicology
BSc(Hons) PhD
Research summary
Pharmacological Targets in Cardiovascular and Renal Disease


Contact details

Departmental contact email:
Research or teaching contact email:

Research focus

Interests: cardiomyopathies, ischaemic heart disease, heart failure, ischaemic neurodegeneration, mitochondrial dysfunction and heme oxygenase

Main areas of Research:

  • Cardiac and Renal failure following MI.
  • Apoptosis and Mitochondrial Dysfunction Consequent to Ischaemia-Reperfusion Injury in Organ Grafts/Vascular Ligation Models.
  • Protection Of Myocardial Function and Mitochondrial Energetics from Ischaemia-Reperfusion Injury.
  • Mitochondrial Pathophysiology in Neurodegeneration and Stroke Injury
  • Neuroprotective Effects of Pharmacological Agents following Hypoxia-Ischaemia-induced Brain Damage.
  • Cardiovascular Effects following Hypoxia-Ischaemia-Induced Brain Damage.
  • Vascular Pathophysiology


Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f Journal - Research Article

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132 Journal - Research Article

Read, M. I., McCann, D. M., Millen, R. N., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus. American Journal of Physiology: Heart & Circulatory Physiology, 309(9), H1554-H1564. doi: 10.1152/ajpheart.00256.2015 Journal - Research Article

Yao, Y., Fomison-Nurse, I. C., Harrison, J. C., Walker, R. J., Davis, G., & Sammut, I. A. (2014). Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy. American Journal of Physiology: Renal Physiology, 307, F251-F262. doi: 10.1152/ajprenal.00578.2013 Journal - Research Article

Yao, Y., Davis, G., Harrison, J. C., Walker, R. J., & Sammut, I. A. (2017). Renal functional responses in diabetic nephropathy following chronic bilateral renal denervation. Autonomic Neuroscience, 204, 98-104. doi: 10.1016/j.autneu.2016.09.019 Journal - Research Article

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