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Contact Details

Phone
+64 20 4133 5102
Email
michael.garelja@otago.ac.nz
Position
Postdoctoral Fellow
Department
Department of Pharmacology and Toxicology
Qualifications
PhD
Research summary
Molecular basis of migraine
Memberships
  • Health Science EMCR Committee
  • Otago Medical School Research Society

Research

I am a postdoctoral fellow working in the lab of Debbie Hay. My research is based on the CGRP family of hormones and receptors, with a current focus on understanding how this family is linked to migraine disease. I am currently funded by a New Zealand Neurological Foundation First Fellowship.

Publications

Rees, T. A., Tasma, Z., Garelja, M. L., O'Carroll, S. J., Walker, C. S., & Hay, D. L. (2024). Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia. Journal of Headache & Pain, 25, 36. doi: 10.1186/s10194-024-01744-z

Mazzini, G., Le Foll, C., Boyle, C. N., Garelja, M. L., Zhyvoloup, A., Miller, M. E. T., Hay, D. L., … Lutz, T. A. (2024). The processing intermediate of human amylin, pro-amylin(1–48) has in vivo and in vitro bioactivity. Biophysical Chemistry. Advance online publication. doi: 10.1016/j.bpc.2024.107201

Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S., & Hay, D. L. (2024). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology, 181, 142-161. doi: 10.1111/bph.16218

Garelja, M. L., Hay, D., Poyner, D. R., & Walker, C. S. (2023). Calcitonin receptors in GtoPdb v.2023.1 [Citation summary]. IUPHAR/BPS Guide to Pharmacology CITE, (1). doi: 10.2218/gtopdb/F11/2023.1

Hendrikse, E. R., Rees, T. A., Tasma, Z., Garelja, M. L., Siow, A., Harris, P. W. R., … Hay, D. L. (2022). Characterization of antibodies against receptor activity-modifying protein 1 (RAMP1): A cautionary tale. International Journal of Molecular Sciences, 23, 16035. doi: 10.3390/ijms232416035

Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S., & Hay, D. L. (2024). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology, 181, 142-161. doi: 10.1111/bph.16218

Journal - Research Article

Mazzini, G., Le Foll, C., Boyle, C. N., Garelja, M. L., Zhyvoloup, A., Miller, M. E. T., Hay, D. L., … Lutz, T. A. (2024). The processing intermediate of human amylin, pro-amylin(1–48) has in vivo and in vitro bioactivity. Biophysical Chemistry. Advance online publication. doi: 10.1016/j.bpc.2024.107201

Journal - Research Article

Rees, T. A., Tasma, Z., Garelja, M. L., O'Carroll, S. J., Walker, C. S., & Hay, D. L. (2024). Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia. Journal of Headache & Pain, 25, 36. doi: 10.1186/s10194-024-01744-z

Journal - Research Article

Garelja, M. L., & Hay, D. L. (2022). A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond. Headache, 62(9), 1093-1104. doi: 10.1111/head.14388

Journal - Research Article

Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., … Hay, D. L. (2022). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. British Journal of Pharmacology, 179, 416-434. doi: 10.1111/bph.15628

Journal - Research Article

Hendrikse, E. R., Rees, T. A., Tasma, Z., Garelja, M. L., Siow, A., Harris, P. W. R., … Hay, D. L. (2022). Characterization of antibodies against receptor activity-modifying protein 1 (RAMP1): A cautionary tale. International Journal of Molecular Sciences, 23, 16035. doi: 10.3390/ijms232416035

Journal - Research Article

Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., … Hay, D. L. (2020). Molecular mechanisms of class B GPCR activation: Insights from adrenomedullin receptors. ACS Pharmacology & Translational Science, 3(2), 246-262. doi: 10.1021/acsptsci.9b00083

Journal - Research Article

Musa, H., Hendrikse, E. R., Brimble, M. A., Garelja, M. L., Watkins, H. A., Harris, P. W. R., & Hay, D. L. (2019). Pharmacological characterization and investigation of N-terminal loop amino acids of adrenomedullin 2 that are important for receptor activation. Biochemistry, 58(32), 3468-3474. doi: 10.1021/acs.biochem.9b00571

Journal - Research Article

Yule, L. R., Garelja, M. L., Hendrikse, E. R., Gingell, J. J., Poyner, D. R., Harris, P. W. H., Brimble, M. A., & Hay, D. L. (2019). A potent fluorescent calcitonin gene-related peptide analogue enables visualization of receptor internalization. Peptide Science, 111(6), e2416. doi: 10.1002/pep2.24126

Journal - Research Article

Garelja, M. L., Walker, C. A., Siow, A., Yang, S. H., Harris, P. W. R., Brimble, M. A., … Hay, D. L. (2018). Receptor activity modifying proteins have limited effects on the class B G protein-coupled receptor calcitonin receptor-like receptor stalk. Biochemistry, 57(8), 1410-1422. doi: 10.1021/acs.biochem.7b01180

Journal - Research Article

Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., … Poyner, D. R. (2018). Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the CalcitoninRreceptor-Like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) complex. Biochemistry, 57(32), 4915-4922. doi: 10.1021/acs.biochem.8b00502

Journal - Research Article

Woolley, M. J., Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., … Hay, D. L. (2017). Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142, 96-110. doi: 10.1016/j.bcp.2017.07.005

Journal - Research Article

Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M. L., Pardamwar, M., … Hay, D. L. (2016). Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry, 291(22), 11657-11675. doi: 10.1074/jbc.M115.688218

Journal - Research Article

Garelja, M. L., Hay, D., Poyner, D. R., & Walker, C. S. (2023). Calcitonin receptors in GtoPdb v.2023.1 [Citation summary]. IUPHAR/BPS Guide to Pharmacology CITE, (1). doi: 10.2218/gtopdb/F11/2023.1

Journal - Research Other

Garelja, M. L., Walker, C. S., & Hay, D. L. (2021). CGRP receptor antagonists for migraine: Are they also AMY1 receptor antagonists? British Journal of Pharmacology, 179, 454-459. doi: 10.1111/bph.15585

Journal - Research Other

Hay, D. L., Garelja, M. L., Poyner, D. R., & Walker, C. S. (2018). Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. British Journal of Pharmacology, 175(1), 3-17. doi: 10.1111/bph.14075

Journal - Research Other

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