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Contact Details

Email
anurag.singh@otago.ac.nz
Position
Research Fellow
Department
Department of Pharmacology and Toxicology
Qualifications
MSc PhD
Research summary
Auditory-limbic interaction in tinnitus generation and perception
Memberships
  • Vice President, Emerging Neuroscientists Group, University of Otago
  • Research Fellow Representative, Brain Health Research Centre Management Committee

Research

Tinnitus, a complex disorder, results from sentient cognisance of a sound without an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to hissing and ringing in the ear.

Human imaging study shows that tinnitus affects both auditory and limbic regions, and the interplay between the auditory-limbic system may be central to understanding and perhaps therapeutics for persistent tinnitus.

Using electrophysiological, imaging and behavioural approaches in rodents, my research brings attention to the role of synaptic plasticity in the limbic system such as the hippocampus, amygdala and others (and its interaction with the auditory system) in tinnitus development.

Publications

Wright, A. L., Konen, L. M., Mockett, B. G., Morris, G. P., Singh, A., Burbano, L. E., … Abraham, W. C., & Vissel, B. (2023). The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease. Molecular Neurodegeneration, 18(1), 65. doi: 10.1186/s13024-023-00632-5

Singh, A., Smith, P. F., & Zheng, Y. (2023). Targeting the limbic system: Insights into its involvement in tinnitus. International Journal of Molecular Sciences, 24, 9889. doi: 10.3390/ijms24129889

Singh, A., Sateesh, S., Jones, O. D., & Abraham, W. C. (2022). Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1. Scientific Reports, 12, 1746. doi: 10.1038/s41598-022-05844-1

Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca2+-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208

Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019

Wright, A. L., Konen, L. M., Mockett, B. G., Morris, G. P., Singh, A., Burbano, L. E., … Abraham, W. C., & Vissel, B. (2023). The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease. Molecular Neurodegeneration, 18(1), 65. doi: 10.1186/s13024-023-00632-5

Journal - Research Article

Singh, A., Sateesh, S., Jones, O. D., & Abraham, W. C. (2022). Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1. Scientific Reports, 12, 1746. doi: 10.1038/s41598-022-05844-1

Journal - Research Article

Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca2+-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208

Journal - Research Article

Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019

Journal - Research Article

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Journal - Research Article

Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019

Journal - Research Article

Singh, A., & Abraham, W. C. (2017). Astrocytes and synaptic plasticity in health and disease. Experimental Brain Research, 235(6), 1645-1655. doi: 10.1007/s00221-017-4928-1

Journal - Research Article

Gautam, M., Prasoon, P., Kumar, R., Singh, A., Shrimal, P., & Ray, S. B. (2016). Direct intrawound administration of dimethylsulphoxide relieves acute pain in rats. International Wound Journal, 13, 252-256. doi: 10.1111/iwj.12280

Journal - Research Article

George, J., Pulickal, S. J., Singh, A., Gautam, M., Prasoon, P., Kumar, R., & Ray, S. B. (2014). Locally mediated analgesic effect of bradykinin type 2 receptor antagonist HOE 140 during acute inflammatory pain in rats. Journal of Burn Care & Research, 35, e391-e398. doi: 10.1097/BCR.0000000000000042

Journal - Research Article

Singh, A., Smith, P. F., & Zheng, Y. (2023). Targeting the limbic system: Insights into its involvement in tinnitus. International Journal of Molecular Sciences, 24, 9889. doi: 10.3390/ijms24129889

Journal - Research Other

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