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Contact Details

Phone
+64 3 479 7191
Email
mhairi.nimick@otago.ac.nz
Position
Assistant Research Fellow
Department
Department of Pharmacology and Toxicology
Research summary
Cancer drug development

Research

Mhairi works with Associate Professor Rhonda Rosengren.

Publications

Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S., & Hay, D. L. (2024). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology, 181, 142-161. doi: 10.1111/bph.16218

Chand, R. R., Nimick, M., Cridge, B., & Rosengren, R. J. (2023). Investigating the contribution of major drug-metabolising enzymes to possum-specific fertility control. International Journal of Molecular Sciences, 24, 9424. doi: 10.3390/ ijms24119424

Finlay, D. B., Mackie, W., Webb, H. D. J., Thomsen, L. R., Nimick, M., Rosengren, R. J., … Glass, M., & Wiley, J. L. (2023). The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus, signalling effects, or metabolism. Pharmacology Biochemistry & Behavior. Advance online publication. doi: 10.1016/j.pbb.2023.173530

Palmer, H., Nimick, M., Mazumder, A., Taurin, S., Rana, Z., & Rosengren, R. J. (2022). Raloxifene suppresses tumor growth and metastasis in an orthotopic model of castration-resistant prostate cancer. Biomedicines, 10, 853. doi: 10.3390/biomedicines10040853

Chand, R. R., Nimick, M., Cridge, B., & Rosengren, R. J. (2021). In vitro hepatic assessment of cineole and Its derivatives in common brushtail possums (Trichosurus vulpecula) and rodents. Biology, 10, 1326. doi: 10.3390/biology10121326

Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S., & Hay, D. L. (2024). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology, 181, 142-161. doi: 10.1111/bph.16218

Journal - Research Article

Chand, R. R., Nimick, M., Cridge, B., & Rosengren, R. J. (2023). Investigating the contribution of major drug-metabolising enzymes to possum-specific fertility control. International Journal of Molecular Sciences, 24, 9424. doi: 10.3390/ ijms24119424

Journal - Research Article

Finlay, D. B., Mackie, W., Webb, H. D. J., Thomsen, L. R., Nimick, M., Rosengren, R. J., … Glass, M., & Wiley, J. L. (2023). The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus, signalling effects, or metabolism. Pharmacology Biochemistry & Behavior. Advance online publication. doi: 10.1016/j.pbb.2023.173530

Journal - Research Article

Palmer, H., Nimick, M., Mazumder, A., Taurin, S., Rana, Z., & Rosengren, R. J. (2022). Raloxifene suppresses tumor growth and metastasis in an orthotopic model of castration-resistant prostate cancer. Biomedicines, 10, 853. doi: 10.3390/biomedicines10040853

Journal - Research Article

Chand, R. R., Nimick, M., Cridge, B., & Rosengren, R. J. (2021). In vitro hepatic assessment of cineole and Its derivatives in common brushtail possums (Trichosurus vulpecula) and rodents. Biology, 10, 1326. doi: 10.3390/biology10121326

Journal - Research Article

Finlay, D. B., Sircombe, K. J., Nimick, M., Jones, C., & Glass, M. (2020). Terpenoids from cannabis do not mediate an entourage effect by acting at cannabinoid receptors. Frontiers in Pharmacology, 11, 359. doi: 10.3389/fphar.2020.00359

Journal - Research Article

Bland, A. R., Bower, R. L., Nimick, M., Hawkins, B. C., Rosengren, R. J., & Ashton, J. C. (2019). Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer. European Journal of Pharmacology, 865, 172749. doi: 10.1016/j.ejphar.2019.172749

Journal - Research Article

Shrestha, N., Lateef, Z., Martey, O., Bland, A. R., Nimick, M., Rosengren, R., & Ashton, J. C. (2019). Does the mouse tail vein injection method provide a good model of lung cancer? F1000Research, 8, 190. doi: 10.12688/f1000research.17964.1

Journal - Research Article

Shrestha, N., Nimick, M., Dass, P., Rosengren, R. J., & Ashton, J. C. (2019). Mechanisms of suppression of cell growth by dual inhibition of ALK and MEK in ALK-positive non-small cell lung cancer. Scientific Reports, 9, 18842. doi: 10.1038/s41598-019-55376-4

Journal - Research Article

Chen, S., Nimick, M., Cridge, A. G., Hawkins, B. C., & Rosengren, R. J. (2018). Anticancer potential of novel curcumin analogs towards castrate-resistant prostate cancer. International Journal of Oncology, 52(2), 579-588. doi: 10.3892/ijo.2017.4207

Journal - Research Article

Martey, O., Nimick, M., Taurin, S., Sundararajan, V., Greish, K., & Rosengren, R. J. (2017). Styrene maleic acid-encapsulated RL71 micelles suppress tumor growth in a murine xenograft model of triple negative breast cancer. International Journal of Nanomedicine, 12, 7225-7237. doi: 10.2147/ijn.s148908

Journal - Research Article

Wilson, C., Nimick, M., Nehoff, H., & Ashton, J. C. (2017). ALK and IGF-1R as independent targets in crizotinib resistant lung cancer. Scientific Reports, 7, 13955. doi: 10.1038/s41598-017-14289-w

Journal - Research Article

Taurin, S., Nimick, M., Larsen, L., & Rosengren, R. J. (2016). A novel curcumin derivative increases the cytotoxicity of raloxifene in estrogen receptor-negative breast cancer cell lines. International Journal of Oncology, 48, 385-398. doi: 10.3892/ijo.2015.3252

Journal - Research Article

De Wever, V., Nasa, I., Chamousset, D., Lloyd, D., Nimick, M., Trinkle-Mulcahy, L., … Moorhead, G. B. G. (2014). The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif. Biochemical & Biophysical Research Communications, 453(3), 432-437. doi: 10.1016/j.bbrc.2014.09.105

Journal - Research Article

Skene-Arnold, T. D., Luu, H. A., Uhrig, R. G., De Wever, V., Nimick, M., Maynes, J., … Holmes, C. F. B. (2013). Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins. Biochemical Journal, 449(3), 649-659. doi: 10.1042/BJ20120506

Journal - Research Article

Araújo, W. L., Tohge, T., Nunes-Nesi, A., Daloso, D. M., Nimick, M., Krahnert, I., … Fernie, A. R. (2012). Phosphonate analogs of 2-oxoglutarate perturb metabolism and gene expression in illuminated Arabidopsis leaves. Frontiers in Plant Science, 3, 114. doi: 10.3389/fpls.2012.00114

Journal - Research Article

De Wever, V., Lloyd, D. C., Nasa, I., Nimick, M., Trinkle-Mulcahy, L., Gourlay, R., … Moorhead, G. B. G. (2012). Isolation of human mitotic protein phosphatase complexes: Identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21. PLoS ONE, 7(6), e39510. doi: 10.1371/journal.pone.0039510

Journal - Research Article

Tran, H. T., Nimick, M., Uhrig, R. G., Templeton, G., Morrice, N., Gourlay, R., … Moorhead, G. B. G. (2012). Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Plant Journal, 71(2), 263-272. doi: 10.1111/j.1365-313X.2012.04984.x

Journal - Research Article

Tran, H. T., Uhrig, R. G., Nimick, M., & Moorhead, G. B. (2012). Interfacing protein lysine acetylation and protein phosphorylation: Ancient modifications meet on ancient proteins [Short communication]. Plant Signaling & Behavior, (7), 8, 901-903. doi: 10.4161/psb.20704

Journal - Research Other

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