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Contact Details

Phone
64 3 479 7293
Email
joel.tyndall@otago.ac.nz
Position
Professor and Associate Dean (Internationalisation)
Qualifications
BSc(Hons)(Monash) PhD(Qld)
Research summary
Drug design and discovery
Teaching
Medicinal Chemistry

Research

Drug design and discovery using computational techniques. Drug discovery in the areas of inflammatory disorders, cancer, antifungals, bacterial infections (chlamydia, tuberculosis), and viral infections targeting both enzymes and GPCRs. Techniques include virtual screening, structural biology, enzymatic, and cellular assays.

Professor Tyndall on PubMed

Publications

Payne, C. M., Baltos, J.-A., Langiu, M., Lu, C. S., Tyndall, J. D. A., Gregory, K. J., … Vernall, A. J. (2024). Development of putative bivalent dicovalent ligands for the adenosine A1 receptor. ChemBioChem. Advance online publication. doi: 10.1002/cbic.202400242 Journal - Research Article

Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., … Tyndall, J. D. A., … Cook, G. M. (2023). A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology. Advance online publication. doi: 10.1016/j.chembiol.2023.12.002 Journal - Research Article

Payne, C., Awalt, J. K., May, L. T., Tyndall, J. D. A., Jörg, M., & Vernall, A. J. (2023). Bifunctional tools to study adenosine receptors. In V. Colotta & C. T. Supuran (Eds.), Purinergic receptors and their modulators. (pp. 179-221). Cham, Switzerland: Springer. doi: 10.1007/7355_2022_154 Chapter in Book - Research

Tyndall, J. (2023, September). Targeting HtrA protease: Systematic modification to potential new antibacterial leads. Department of Microbiology and Immunology Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar]. Other Research Output

Tyndall, J. (2023, July). Looking at molecules and what they do in disease. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture]. Other Research Output

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