Associate Professor Hesham Al-Sallami

Contact Details
- Phone
- +64 3 479 7295
- hesham.al-sallami@otago.ac.nz
University Links
- Position
- Associate Dean (Pharmacy Practice)
- Qualifications
- BPharm MClinPharm PhD
- Research summary
- Clinical practice, clinical pharmacology and pharmacometrics
- Teaching
- Clinical Pharmacy practice and clinical pharmacology (undergraduate and postgraduate)
- Memberships
- Registered Pharmacist, RegPharmNZ
- Chair of the Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT NZ)
- Executive committee member of the Population Approach Group in Australia and New Zealand (PAGANZ)
- Executive editor of the British Journal of Clinical Pharmacology
- Member of the Otago Medical Research Foundation Scientific Committee
- Board member of the British Pharmacological Society (BPS) International Advisory Board
- Clinical
- Locum pharmacist (community and hospital pharmacy)
Research
My area of research is Clinical Pharmacy Practice with a focus on the individualisation of pharmacotherapy in order to optimise patient clinical outcomes.
My research focus is drug dosing in relation to body composition in children and in obese individuals. The clinical application of my research has been in the areas of anticoagulation and in insulin dosing in diabetes.
My research interests also include clinical education and professional competency.
Additional details
Otago Pharmacometrics GroupPublications
O'Hanlon, C. J., Holford, N., Sumpter, A., & Al-Sallami, H. S. (2023). Consistent methods for fat free mass, creatinine clearance and glomerular filtration rate to describe renal function from neonates to adults. Clinical & Translational Science, 12, 12924, 401-412. doi: 10.1002/psp4.12924
Derbalah, A., Duffull, S., Sherwin, C. M., Job, K., & Al-Sallami, H. (2022). Optimal dosing of enoxaparin in overweight and obese children. British Journal of Clinical Pharmacology, 88, 5348-5358. doi: 10.1111/bcp.15459
Al-Sallami, H. S., Wright, D. F. B., & Duffull, S. B. (2022). The propagation of between-subject variability from dose to response. British Journal of Clinical Pharmacology, 88, 1414-1417. doi: 10.1111/bcp.14699
Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2022). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British Journal of Clinical Pharmacology, 88, 1430-1440. doi: 10.1111/bcp.14451
Santiago, M., Davis, E. A., Hinton, T., Angelo, T. A., Shield, A., Babey, A.-M., … Al-Sallami, H. S., … White, P. J. (2021). Defining and unpacking the core concepts of pharmacology education. Pharmacology Research & Perspectives, 9(6), e00894. doi: 10.1002/prp2.894
O'Hanlon, C. J., Holford, N., Sumpter, A., & Al-Sallami, H. S. (2023). Consistent methods for fat free mass, creatinine clearance and glomerular filtration rate to describe renal function from neonates to adults. Clinical & Translational Science, 12, 12924, 401-412. doi: 10.1002/psp4.12924
Journal - Research Article
Derbalah, A., Duffull, S., Sherwin, C. M., Job, K., & Al-Sallami, H. (2022). Optimal dosing of enoxaparin in overweight and obese children. British Journal of Clinical Pharmacology, 88, 5348-5358. doi: 10.1111/bcp.15459
Journal - Research Article
Bahnasawy, S., Al-Sallami, H., & Duffull, S. (2021). A minimal model to describe short-term haemodynamic changes of the cardiovascular system. British Journal of Clinical Pharmacology, 87, 1411-1421. doi: 10.1111/bcp.14541
Journal - Research Article
Derbalah, A., Al-Sallami, H. S., & Duffull, S. B. (2021). Reduction of quantitative systems pharmacology models using artificial neural networks. Journal of Pharmacokinetics & Pharmacodynamics, 48, 509-523. doi: 10.1007/s10928-021-09742-3
Journal - Research Article
Derbalah, A., Duffull, S., Moynihan, K., & Al-Sallami, H. (2021). The influence of haemostatic system maturation on the dose-response relationship of unfractionated heparin. Clinical Pharmacokinetics, 60, 491-499. doi: 10.1007/s40262-020-00949-0
Journal - Research Article
Majimbi, M., Brook, E., Galettis, P., Eden, E., Al-Salami, H., Mooranian, A., Al-Sallami, H., … Takechi, R. (2021). Sodium alginate microencapsulation improves the short-term oral bioavailability of cannabidiol when administered with deoxycholic acid. PLoS ONE, 16(6), e0243858. doi: 10.1371/journal.pone.0243858
Journal - Research Article
Santiago, M., Davis, E. A., Hinton, T., Angelo, T. A., Shield, A., Babey, A.-M., … Al-Sallami, H. S., … White, P. J. (2021). Defining and unpacking the core concepts of pharmacology education. Pharmacology Research & Perspectives, 9(6), e00894. doi: 10.1002/prp2.894
Journal - Research Article
White, P. J., Davis, E. A., Santiago, M., Angelo, T., Shield, A., Babey, A.-M., … Al-Sallami, H. S., … Hinton, T. (2021). Identifying the core concepts of pharmacology education. Pharmacology Research & Perspectives, 9(4), e00836. doi: 10.1002/prp2.836
Journal - Research Article
Mooranian, A., Wagle, S. R., Kovacevic, B., Takechi, R., Mamo, J., Lam, V., … Al-Sallami, H., & Al-Salami, H. (2020). Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study. Scientific Reports, 10, 106. doi: 10.1038/s41598-019-53999-1
Journal - Research Article
Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2020). An extension of Janmahasatian’s Fat-Free Mass model for universal application across populations of different ethnicities. Clinical Pharmacokinetics, 59, 1161-1170. doi: 10.1007/s40262-020-00883-1
Journal - Research Article
Sinha, J., Duffull, S. B., Green, B., & Al-Sallami, H. S. (2020). Evaluating the relationship between lean liver volume and fat-free mass. Clinical Pharmacokinetics, 59, 475-483. doi: 10.1007/s40262-019-00824-7
Journal - Research Article
Abdul Aziz, Y. H., Al-Sallami, H. S., Wiltshire, E., Rayns, J., Willis, J., McClintock, J., Medlicott, N., Wheeler, B. J., the Paediatric Society of New Zealand Diabetes Clinical Network. (2019). Insulin pump initiation and education for children and adolescents: A qualitative study of current practice in New Zealand. Journal of Diabetes & Metabolic Disorders, 18, 59-64. doi: 10.1007/s40200-019-00390-6
Journal - Research Article
Dowd, L. A., Wheeler, B. J., Al-Sallami, H. S., Broadbent, R. S., Edmonds, L. K., & Medlicott, N. J. (2019). Paracetamol treatment for patent ductus arteriosus: Practice and attitudes in Australia and New Zealand. Journal of Maternal-Fetal & Neonatal Medicine, 32(18), 3039-3044. doi: 10.1080/14767058.2018.1456520
Journal - Research Article
Majid, A., Blackwell, M., Broadbent, R. S., Barker, D. P., Al-Sallami, H. S., Edmonds, L., Kerruish, N., & Wheeler, B. J. (2019). Newborn vitamin K prophylaxis: A historical perspective to understand modern barriers to uptake. Hospital Pediatrics, 9(1), 55-60. doi: 10.1542/hpeds.2018-0104
Journal - Research Article
Mooranian, A., Zamani, N., Luna, G., Al-Sallami, H., Mikov, M., Goločorbin-Kon, S., … Al-Salami, H. (2019). Bile acid-polymer-probucol microparticles: Protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine mode. Pharmaceutical Development & Technology, 24(10), 1272-1277. doi: 10.1080/10837450.2019.1665069
Journal - Research Article
Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2019). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics, 28(1), 89-100. doi: 10.1007/s40262-018-0667-0
Journal - Research Article
Al-Sallami, H., & Loke, S.-K. (2018). Learning a complex dose–response relationship with the computer simulation CoaguSim. Currents in Pharmacy Teaching & Learning, 10, 1406-1413. doi: 10.1016/j.cptl.2018.07.009
Journal - Research Article
Mooranian, A., Negrulj, R., Takechi, R., Mamo, J., Al-Sallami, H., & Al-Salami, H. (2018). The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: Potential hypoglycaemic and anti-inflammatory effects. Drug Delivery & Translational Research, 8(3), 543-551. doi: 10.1007/s13346-017-0473-5
Journal - Research Article
Mooranian, A., Zamani, N., Takechi, R., Al-Sallami, H., Mikov, M., Goločorbin-Kon, S., … Al-Salami, H. (2018). Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes. Artificial Cells, Nanomedicine & Biotechnology, 46(Suppl. 3), S748-S754. doi: 10.1080/21691401.2018.1511572
Journal - Research Article
Muller, M., Wheeler, B. J., Blackwell, M., Colas, M., Reith, D. M., Medlicott, N. J., & Al-Sallami, H. S. (2018). The influence of patient variables on insulin total daily dose in paediatric inpatients with new onset type 1 diabetes mellitus. Journal of Diabetes & Metabolic Disorders, 17, 159-163. doi: 10.1007/s40200-018-0355-5
Journal - Research Article
Gogoi-Tiwari, J., Williams, V., Waryah, C. B., Costantino, P., Al-Salami, H., Mathavan, S., … Al-Sallami, H., & Mukkur, T. (2017). Mammary gland pathology subsequent to acute infection with strong versus weak biofilm forming Staphylococcus aureus bovine mastitis isolates: A pilot study using non-invasive mouse mastitis model. PLoS ONE, 12(1), e0170668. doi: 10.1371/journal.pone.0170668
Journal - Research Article
Selvakumar, D., Al-Sallami, H. S., de Bock, M., Ambler, G. R., Benitez-Aguirre, P., Wiltshire, E., … Willis, J., Wheeler, B. J., on behalf of the Paediatric Society of New Zealand Diabetes Clinical Network. (2017). Insulin regimens for newly diagnosed children with type 1 diabetes mellitus in Australia and New Zealand: A survey of current practice. Journal of Paediatrics & Child Health, 53(12), 1208-1214. doi: 10.1111/jpc.13631
Journal - Research Article
Al-Sallami, H., Newall, F., Monagle, P., Ignjatovic, V., Cranswick, N., & Duffull, S. (2016). Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients. British Journal of Clinical Pharmacology, 82(1), 178-184. doi: 10.1111/bcp.12930
Journal - Research Article
Negrulj, R., Mooranian, A., Chen-Tan, N., Al-Sallami, H. S., Mikov, M., Golocorbin-Kon, S., … Al-Salami, H. (2016). Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes. Artificial Cells, Nanomedicine & Biotechnology, 44(5), 1290-1297. doi: 10.3109/21691401.2015.1024845
Journal - Research Article
Tordoff, J. M., Ailabouni, N. J., Browne, D. P., Al-Sallami, H. S., & Gray, A. R. (2016). Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand. International Journal of Clinical Pharmacy, 38(4), 941-949. doi: 10.1007/s11096-016-0318-1
Journal - Research Article
Al-Sallami, H. S., & Medlicott, N. J. (2015). Investigation of an anti-activated factor X (anti-Xa) assay for the quantification of enoxaparin in human plasma. Journal of Pharmacy & Pharmacology, 67(2), 209-214. doi: 10.1111/jphp.12333
Journal - Research Article
Al-Sallami, H. S., Goulding, A., Grant, A., Taylor, R., Holford, N., & Duffull, S. B. (2015). Prediction of fat-free mass in children. Clinical Pharmacokinetics, 54(11), 1169-1178. doi: 10.1007/s40262-015-0277-z
Journal - Research Article
Mooranian, A., Negrulj, R., Al-Sallami, H. S., Fang, Z., Mikov, M., Golocorbin-Kon, S., … Al-Salami, H. (2015). Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment. Journal of Microencapsulation, 32(2), 151-156. doi: 10.3109/02652048.2014.958204
Journal - Research Article
Mooranian, A., Negrulj, R., Al-Sallami, H. S., Fang, Z., Mikov, M., Golocorbin-Kon, S., … Al-Salami, H. (2015). Probucol release from novel multicompartmental microcapsules for the oral targeted delivery in type 2 diabetes. AAPS PharmSciTech, 16(1), 45-52. doi: 10.1208/s12249-014-0205-9
Journal - Research Article
Mooranian, A., Negrulj, R., Chen-Tan, N., Al-Sallami, H. S., Fang, Z., Mukkur, T. K., Mikov, M., … Al-Salami, H. (2014). Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol. Drug Design, Development & Therapy, 8, 1221-1230. doi: 10.2147/dddt.s67349
Journal - Research Article
Mooranian, A., Negrulj, R., Chen-Tan, N., Al-Sallami, H. S., Fang, Z., Mukkur, T., Mikov, M., … Al-Salami, H. (2014). Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: A characterization study. Drug Design, Development & Therapy, 8, 1003-1012. doi: 10.2147/dddt.s65396
Journal - Research Article
Loke, S.-K., Al-Sallami, H. S., Wright, D. F. B., McDonald, J., Jadhav, S., & Duffull, S. B. (2012). Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology, 28(4), 671-683. doi: 10.14742/ajet.834
Journal - Research Article
Wright, D. F. B., Pavan Kumar, V. V., Al-Sallami, H. S., & Duffull, S. B. (2011). The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: Simulations from a pharmacokinetic—pharmacodynamic model. Basic & Clinical Pharmacology & Toxicology, 109(6), 494-498. doi: 10.1111/j.1742-7843.2011.00757.x
Journal - Research Article
Al-Sallami, H. S., Barras, M. A., Green, B., & Duffull, S. B. (2010). Routine plasma anti-Xa monitoring is required for low-molecular-weight heparins. Clinical Pharmacokinetics, 49(9), 567-571. doi: 10.2165/11532960-000000000-00000
Journal - Research Article
Wright, D. F. B., Al-Sallami, H. S., Jackson, P. M., & Reith, D. M. (2010). Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772. doi: 10.1111/j.1365-2125.2010.03749.x
Journal - Research Article
Al-Sallami, H. S., Kumar, V. V. P., Landersdorfer, C. B., Bulitta, J. B., & Duffull, S. B. (2009). The time course of drug effects. Pharmaceutical Statistics, 8, 176-185. doi: 10.1002/pst.393
Journal - Research Article
Al-Sallami, H., Ferguson, R., Wilkins, G., Gray, A., & Medlicott, N. J. (2008). Bleeding events in patients receiving enoxaparin for the management of non-ST-elevation acute coronary syndrome (NSTEACS) at Dunedin Public Hospital, New Zealand. New Zealand Medical Journal, 121(1285). Retrieved from http://journal.nzma.org.nz/journal/121-1285/3342/content.pdf
Journal - Research Article
Al-Sallami, H., Ball, P. A., & Davey, A. (2001). Metered-dose inhaler with spacer versus nebuliser for acute exacerbation of asthma - a literature review. Australian Journal of Hospital Pharmacy, 31(3), 189-192.
Journal - Research Article
Al-Sallami, H. S., Wright, D. F. B., & Duffull, S. B. (2022). The propagation of between-subject variability from dose to response. British Journal of Clinical Pharmacology, 88, 1414-1417. doi: 10.1111/bcp.14699
Journal - Research Other
Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2022). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British Journal of Clinical Pharmacology, 88, 1430-1440. doi: 10.1111/bcp.14451
Journal - Research Other
Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2020). Authors' reply to Friesen: "An extension of Janmahasatian's Fat-Free Mass Model for universal application across populations of different ethnicities". Clinical Pharmacokinetics, 59, 1315. doi: 10.1007/s40262-020-00906-x
Journal - Research Other
Sinha, J., Duffull, S. B., Green, B., & Al-Sallami, H. S. (2020). Evaluating lean liver volume as a potential scaler for in vitro-in vivo extrapolation of drug clearance in obesity using the model drug antipyrine. Current Drug Metabolism, 21(10), 746-750. doi: 10.2174/1389200221666200515105800
Journal - Research Other
Derbalah, A., Duffull, S., Newall, F., Moynihan, K., & Al-Sallami, H. (2019). Revisiting the pharmacology of unfractionated heparin. Clinical Pharmacokinetics, 58(8), 1015-1028. doi: 10.1007/s40262-019-00751-7
Journal - Research Other
Hennig, S., Hannam, J. A., Kirkpatrick, C. M. J., Staatz, C. E., Holford, S., Duffull, S. B., Al-Sallami, H. S., … Foster, D. J. R. (2019). Pharmacometrics in Australasia: Twenty years of Population Approach Group of Australia and New Zealand. CPT: Pharmacometrics & Systems Pharmacology, 8(10), 701-704. doi: 10.1002/psp4.12460
Journal - Research Other
Mooranian, A., Zamani, N., Takechi, R., Al-Sallami, H., Mikov, M., Goločorbin-Kon, S., … Al-Salami, H. (2019). Probucol-poly(meth)acrylate-bile acid nanoparticles increase IL-10, and primary bile acids in prediabetic mice. Therapeutic Delivery, 10(9), 563-571. doi: 10.4155/tde-2019-0052
Journal - Research Other
Reith, D. M., & Al-Sallami, H. S. (2018). Comment on van Rongen et al., "Higher midazolam clearance in obese adolescents compared with morbidly obese adults". Clinical Pharmacokinetics, 57, 1355. doi: 10.1007/s40262-018-0691-0
Journal - Research Other
Sinha, J., Duffull, S. B., & Al-Sallami, H. S. (2018). A review of the methods and associated mathematical models used in the measurement of fat-free mass. Clinical Pharmacokinetics, 57(7), 781-795. doi: 10.1007/s40262-017-0622-5
Journal - Research Other
Al-Sallami, H. S., Cheah, S. L., Han, S. Y., Liew, J., Lim, J., Ng, M. A., Solanki, H., Soo, R. J., Tan, V., & Duffull, S. B. (2014). Between-subject variability: Should high be the new normal? European Journal of Clinical Pharmacology, 70(11), 1403-1404. doi: 10.1007/s00228-014-1740-8
Journal - Research Other
Wright, D. F. B., Al-Sallami, H. S., & Duffull, S. B. (2013). Is the dose of dabigatran really more predictable than warfarin? British Journal of Clinical Pharmacology, 76(6), 997-998. doi: 10.1111/bcp.12144
Journal - Research Other
Duffull, S. B., Wright, D. F. B., Al-Sallami, H. S., Zufferey, P. J., & Faed, J. M. (2012). Dabigatran: Rational dose individualisation and monitoring guidance is needed. New Zealand Medical Journal, 125(1357). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Al-Sallami, H., Jordan, S., Ferguson, R., Medlicott, N. J., Schollum, J., & Duffull, S. B. (2010). Current enoxaparin dosing guidelines have dubious credibility [Viewpoint]. New Zealand Medical Journal, 123(1313). Retrieved from http://journal.nzma.org.nz/journal/123-1313/4076/content.pdf
Journal - Research Other