Associate Professor Martin Fronius

2022

Journal - Research Article

Brown, E. F., Fronius, M., & Brown, C. H. (2022). Vasopressin regulation of maternal body fluid balance in pregnancy and lactation: A role for TRPV channels? Molecular & Cellular Endocrinology, 558, 111764. doi: 10.1016/j.mce.2022.111764

Paudel, P., van Hout, I., Bunton, R. W., Parry, D. J., Coffey, S., McDonald, F. J., & Fronius, M. (2022). Epithelial sodium channel δ subunit is expressed in human arteries and has potential association with hypertension. Hypertension, 79(7), 1385-1394. doi: 10.1161/hypertensionaha.122.18924

Journal - Research Other

Brown, E. F., Mitaera, T., & Fronius, M. (2022). COVID-19 and liquid homeostasis in the lung: A perspective through the epithelial sodium channel (ENaC) lens. Cells, 11, 1801. doi: 10.3390/cells11111801

Fronius, M. (2022). Epithelial Na⁺ channel and the glycocalyx: A sweet and salty relationship for arterial shear stress sensing. Current Opinion in Nephrology & Hypertension, 31(2), 142-150. doi: 10.1097/mnh.0000000000000779

Conference Contribution - Poster Presentation (not in published proceedings)

Chin, W. Q., Ware, A., McDonald, F., & Fronius, M. (2022, August-September). Epithelial-mesenchymal plasticity and breast cancer: A role for the epithelial sodium channel? Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Stewart, A. C., Brown, E. F., Brown, C. H., & Fronius, M. (2022, August-September). Effect of F-actin on the mechanical activation of putative ΔN-TRPV1 and TRPV4 heteromers. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fronius, M. (2022, November). N-glycans have different roles for mediating the shear force response of epithelial Na+ channel (ENaC). Verbal presentation at the 4th International Symposium on Mechanobiology (ISMB), Sydney, Australia.

Chang, H. H. G., Leask, M. P., Kallingappa, P. K., Merry, T. L., Hotu, C., de Zoysa, J., … Fronius, M., … Hay, D. L., Merriman, T. R., & Davidson, A. J. (2022, August). The CALCRL receptor: A potential new genetic determinant of diabetic kidney disease in NZ. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Brown, E. F., Mitaera, T., & Fronius, M. (2022, August-September). Investigation of SARS-CoV-2 spike glycoprotein expression and ENaC function in lung epithelia. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2021

Journal - Research Article

Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140

Barth, D., Knoepp, F., & Fronius, M. (2021). Enhanced shear force responsiveness of epithelial Na+ channel’s (ENaC) δ subunit following the insertion of N-glycosylation motifs relies on the extracellular matrix. International Journal of Molecular Sciences, 22(5), 2500. doi: 10.3390/ijms22052500

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Journal - Research Other

Paudel, P., McDonald, F. J., & Fronius, M. (2021). The δ subunit of epithelial sodium channel in humans: A potential player in vascular physiology. American Journal of Physiology: Heart & Circulatory Physiology, 320, H487-H493. doi: 10.1152/ajpheart.00800.2020

Conference Contribution - Published proceedings: Abstract

Paudel, P., McDonald, F., & Fronius, M. (2021). Vascular ENaC in human arteries and its role in hypertension. FASEB Journal, 35(Suppl. 1). doi: 10.1096/fasebj.2021.35.S1.02625

Shah, V. K., & Fronius, M. (2021). Increased expression of epithelial sodium channel affects mechanical properties of endothelial cells by reorganising the F-actin cytoskeleton. Journal of Hypertension, 39(e-Suppl. 12), (pp. e326). doi: 10.1097/01.hjh.0000748264.65818.f6

Shah, V. K., & Fronius, M. (2021). Evidence of how epithelial sodium channel promotes stiffness in human and mouse endothelial cells. Journal of Hypertension, 39(e Suppl. 1), (pp. e329-e392). doi: 10.1097/01.hjh.0000748308.30220.7e

2020

Journal - Research Article

Kumar, P., Scholze, P., Fronius, M., Krasteva-Christ, G., & Hollenhorst, M. I. (2020). Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors. British Journal of Pharmacology, 177, 5595-5608. doi: 10.1111/bph.15270

Baldin, J.-P., Barth, D., & Fronius, M. (2020). Epithelial Na⁺ channel (ENaC) formed by one or two subunits forms functional channels that respond to shear force. Frontiers in Physiology, 11, 141. doi: 10.3389/fphys.2020.00141

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na⁺ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Conference Contribution - Published proceedings: Abstract

Paudel, P., McDonald, F., & Fronius, M. (2020). Epithelial Na+ channel (ENaC) in human arteries: An emerging player in hypertension. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03713

Brown, E., Brown, C. H., & Fronius, M. (2020). Mechanosensitivity of TRPV channels: Implications for vasopressin neuron activity. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03561

SawKatare, E. E. L., Rawal, S., Pearson, J., Schwenke, D., Kakinuma, Y., Fronius, M., & Katare, R. (2020). Diabetes induced dysregulation of cardiac non-neuronal cholinergic system impairs heart metabolism. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 14). doi: 10.1016/j.yjmcc.2019.11.031

2019

Journal - Research Article

Barth, D., & Fronius, M. (2019). Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands. Scientific Reports, 9, 6781. doi: 10.1038/s41598-019-43097-7

Conference Contribution - Published proceedings: Abstract

Saw, E., Tsuchimochi, H., Pearson, J. T., Yoshihiko, K., Schwenke, D. O., Fronius, M., & Katare, R. (2019). Non-neuronal cholinergic system prevents coronary vascular dysfunction in diabetic heart. European Heart Journal, 40(Suppl. 1), (pp. 319). doi: 10.1093/eurheartj/ehz747.0317

Conference Contribution - Poster Presentation (not in published proceedings)

Shuang, G., & Fronius, M. (2019, September). Effects of shear stress and carbon monoxide on epithelial sodium channels. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Shah, V. K., & Fronius, M. (2019, September). Epithelial sodium channel (ENaC): Mediator of the aldosterone induced stiffness in endothelial cells. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Brown, E., Brown, C. H., & Fronius, M. (2019, August-September). Mechanosensitivity of TRPV channels: Implications for vasopressin neuron activity. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na⁺ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Journal - Research Other

Saw, E. L., Kakinuma, Y., Fronius, M., & Katare, R. (2018). The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of Molecular & Cellular Cardiology, 125, 129-139. doi: 10.1016/j.yjmcc.2018.10.013

Conference Contribution - Published proceedings: Abstract

Futi, T., Fronius, M., Bahn, A., & Ashley, Z. (2018). Soluble klotho decreases the shear stress response of epithelial sodium channels. In A. Finigan, R. Richards & P. Vakaoti (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices XV. (pp. 11). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. Retrieved from https://www.otago.ac.nz/pacific

Saw, E., Rawal, S., Bunton, R., Galvin, I., Davis, P., Fronius, M., & Katare, R. (2018). Non-neuronal cholinergic system in the diabetic heart. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S115). doi: 10.1016/j.hlc.2018.06.161

Knoepp, F., Ashley, Z., & Fronius, M. (2018). Arterial shear stress sensation and blood pressure regulation relies on glycosylated asparagines of the epithelial Na⁺ channel. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S64-S65). doi: 10.1016/j.hlc.2018.06.047

Ashley, Z., Barth, D., Baldin, J. P., & Fronius, M. (2018). N-Glycan and heparan sulphate components of the extracellular matrix are essential for laminar shear stress response of the epithelial sodium channel (ENaC). FASEB Journal, 32(1, Suppl.), (pp. 868.1). doi: 10.1096/fasebj.2018.32.1_supplement.868.1

Conference Contribution - Poster Presentation (not in published proceedings)

Paudel, P., Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018, August). Epithelial sodium channel in human arteries: An emerging player for blood pressure regulation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Mamgain, A., Fronius, M., & Katare, R. (2018, August). Identifying the role of connexin-43 gap junctions as intracellular transporter of microRNAs. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Futi, T., Fronius, M., Bahn, A., & Ashley, Z. (2018, August). Soluble klotho changes epithelial sodium channel activity. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Brown, E., Brown, C. H., & Fronius, M. (2018, August). Mechanosensitivity of transient receptor potential vanilloid channels. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Twyman, C., Bahn, A., & Fronius, M. (2018, August). Uric acid as a modulator of endothelial sodium channels in the vasculature. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Ware, A. W., McQueen, S., Cunliffe, H., Fronius, M., & McDonald, F. J. (2018, August). Epithelial sodium channel, ENaC, as a potential therapeutic target for breast cancer. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2018, August). Characterising the role of vascular ENaC for blood pressure regulation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Lal, P., Ashley, Z., & Fronius, M. (2018, August). Elucidating the effect of shear stress on the expression of ENaC in endothelial cells. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Fronius, M., Ashley, Z., Baldin, J.-P., Barth, D., & Knöpp, F. (2018, December). The extracellular matrix facilitates mechanical activation of epithelial Na+ channel in response to shear force to regulate blood pressure. Verbal presentation at the 41st Scientific Meeting of the Matrix Biology Society of Australia and New Zealand (MBSANZ), Auckland, New Zealand.

2017

Journal - Research Article

Knoepp, F., Bettmer, J., & Fronius, M. (2017). Gadolinium released by the linear gadolinium-based contrast-agent Gd-DTPA decreases the activity of human epithelial Na⁺ channels (ENaCs). Biochimica et Biophysica Acta: Biomembranes, 1859(5), 1040-1048. doi: 10.1016/j.bbamem.2017.02.019

Conference Contribution - Published proceedings: Abstract

Richter, K., Mathes, V., Fronius, M., Althaus, M., Hecker, A., Krasteva-Christ, G., … Grau, V. (2017). Phosphocholine, a novel unconventional agonist of nicotinic receptors containing subunit α9. Journal of Neurochemistry, 142(Suppl. 2), (pp. 218). doi: 10.1111/jnc.13925

Barth, D., & Fronius, M. (2017). Glycosylated asparagines are important constituents for the shear force dependent activation of the epithelial sodium channel. New Zealand Medical Journal, 130(1460), (pp. 97). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Saw, E. E. L., Rawal, S., Davis, P., Bunton, D., Galvin, I. F., Fronius, M., & Katare, R. (2017, September). Downregulation of non-neuronal cholinergic system (NNCS) reduces glucose transporter in the diabetic heart. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Lal, P., Mugloo, S., Bahn, A., & Fronius, M. (2017, September). Investigating the role of epithelial sodium channel (ENaC) as a shear stress sensor in endothelial cells. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Bussey, C. T., Erickson, J. R., Fronius, M., & Ashley, Z. (2017, September). The role of vascular ENaC in impaired flow-mediated responses of carotid arteries in diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2017, September). Hypertension is associated with increased ENaC expression in the arteries of Cyp1a1-Ren2 rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Barth, D., & Fronius, M. (2017, September). Shear force sensation of the epithelial sodium channel is facilitated via a connection to the extracellular matrix. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Baldin, J.-P., & Fronius, M. (2017, September). The β- and γ-subunit of ENaC play a modulatory role in shear force sensation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Working Paper; Discussion Paper; Technical Report

Knoepp, F., Ashley, Z., Barth, D., Kazantseva, M., Szczesniak, P. P., Clauss, W. G., … Fronius, M. (2017). Mechanical activation of epithelial Na⁺ channel relies on an interdependent activity of the extracellular matrix and extracellular N-glycans of αENaC. bioRxiv. doi: 10.1101/102756

2016

Journal - Research Article

Richter, K., Mathes, V., Fronius, M., Althaus, M., Hecker, A., Krasteva-Christ, G., … Grau, V. (2016). Phosphocholine: An agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Scientific Reports, 6, 28660. doi: 10.1038/srep28660

Conference Contribution - Published proceedings: Abstract

Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016). The flow detection role of the vascular epithelial sodium channel (ENaC) in an experimental model of hypertension: The novel target for spironolactone therapy? Journal of Hypertension, 34(Suppl. 2), (pp. e103). [Abstract]

Ashley, Z., & Fronius, M. (2016). Epithelial Na⁺ channel (ENAC) differentially contributes to shear stress-mediated regulation of the vascular tone in murine carotid and mesenteric arteries. Acta Physiologica, 217(Suppl. 708), (pp. 46). doi: 10.1111/apha.12712

Knoepp, F., Ashley, Z., Barth, D., & Fronius, M. (2016). Shear force sensing of the epithelial Na⁺ channel (ENaC) involves glycosylated asparagines and the extracellular matrix. FEBS Journal, 283(Suppl.1 ), (pp. 50). doi: 10.1111/febs.13805

Barth, D., Knoepp, F., & Fronius, M. (2016). Glycosylated asparagines are important constituents for the shear force dependent activation of the epithelial sodium channel (ENaC). FASEB Journal, 30(Suppl. 1), 1223.7. doi: 10.1096/fj.1530-6860

Conference Contribution - Poster Presentation (not in published proceedings)

Bussey, C., Mugloo, S., Erickson, J., Fronius, M., & Ashley, Z. (2016, December). β-blockers rescue flow-mediated responses of carotid arteries in diabetes through a reduction in vascular ENaC activity? Poster session presented at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Mugloo, S., Leader, C., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2016, August). Characterising ENaC expression in vasculature. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Baldin, J.-P., & Fronius, M. (2016, August). Shear force activation of the epithelial sodium channel (ENaC): Role of the β and γ subunits. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Knöpp, F., Ashley, Z., Barth, D., Baldin, J.-P., & Fronius, M. (2016, December). Epithelial Na⁺ channel and the extracellular matrix: An intimate relationship that facilitates shear force responsiveness. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I., Walker, R., McDonald, F., & Fronius, M. (2016, December). Epithelial Sodium Channel (ENaC): An emerging regulator of vascular physiology. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016, December). Role of ENaC in the dysfunction of resistance arteries in hypertension with/without the confounding factor of myocardial infarction. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Barth, D., & Fronius, M. (2016, December). The epithelial sodium channel is activated by shear force via glycosylated asparagines and the extracellular matrix. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Jennings, M., Ashley, Z., Leader, C., McDonald, F., Sammut, I., Walker, R., & Fronius, M. (2016, December). The ultrastructure of mesenteric arteries in a hypertensive rat model. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Baldin, J.-P., & Fronius, M. (2016, December). Role of the β and γ subunit of the epithelial sodium channel (ENaC) in shear force sensation. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Ashley, Z. A., Knöpp, F., Barth, D., & Fronius, M. (2016, August-September). Epithelial Na⁺ channel and the endothelial glycocalyx mediate shear stress responsiveness in arteries. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Vitzthum, C., Clauss, W. G., & Fronius, M. (2015). Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress. Biochimica et Biophysica Acta: Biomembranes, 1848(11), 2942-2951. doi: 10.1016/j.bbamem.2015.09.009

Dittrich, N. P., Kummer, W., Clauss, W. G., & Fronius, M. (2015). Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs. International Immunopharmacology, 29(1), 166-172. doi: 10.1016/j.intimp.2015.08.010

Hecker, A., Küllmar, M., Wilker, S., Richter, K., Zakrzewicz, A., Atanasova, S., … Fronius, M., … Grau, V. (2015). Phosphocholine-modified macromolecules and canonical nicotinic agonists inhibit ATP-induced IL-1β release. Journal of Immunology, 195, 2325-2334. doi: 10.4049/jimmunol.1400974

Conference Contribution - Published proceedings: Abstract

Knoepp, F., Szczesniak, P., Althaus, M., & Fronius, M. (2015). Glycosylated extracellular asparagines of the α-subunit provide a connection to the extracellular matrix and facilitate the shear force-dependent activation of the human epithelial Na⁺-channel (ENaC). FASEB Journal, 29(1, Suppl.), 845.1. Retrieved from http://www.fasebj.org/content/29/1_Supplement/845.1.abstract

Conference Contribution - Poster Presentation (not in published proceedings)

Ashley, Z., & Fronius, M. (2015, August-September). The vascular responses to modulation of flow, but not pressure, are dependent on vascular ENaC function in carotid, femoral and mesenteric arteries from mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Barth, D., Knoepp, F., & Fronius, M. (2015, August-September). Mechanotransduction of ENaC and the extracellular matrix. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2014

Journal - Research Article

Ashry, O., Schnecko, A., Clauss, W. G., & Fronius, M. (2014). Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respiratory Physiology & Neurobiology, 195(1), 37-40. doi: 10.1016/j.resp.2014.02.001

Schönberger, M., Althaus, M., Fronius, M., Clauss, W., & Trauner, D. (2014). Controlling epithelial sodium channels with light using photoswitchable amilorides. Nature Chemistry, 6(8), 712-719. doi: 10.1038/nchem.2004

Deckmann, K., Filipski, K., Krasteva-Christ, G., Fronius, M., Althaus, M., Rafiq, A., … Kummer, W. (2014). Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. PNAS, 111(22), 8287-8292. doi: 10.1073/pnas.1402436111

Richter, K., Kiefer, K. P., Grzesik, B. A., Clauss, W. G., & Fronius, M. (2014). Hydrostatic pressure activates ATP-sensitive K⁺ channels in lung epithelium by ATP release through pannexin and connexin hemichannels. FASEB Journal, 28(1), 45-55. doi: 10.1096/fj.13-229252

Conference Contribution - Published proceedings: Abstract

Knoepp, F., Clauss, W., & Fronius, M. (2014). Gd³⁺ and Gd³⁺-containing contrast agents affect human ENaC activity in Xenopus ocytes. FASEB Journal, 28(1, Suppl.), 1181.14. [Abstract]

2013

Journal - Research Other

Fronius, M. (2013). Treatment of pulmonary edema by ENaC activators/stimulators. Current Molecular Pharmacology, 6(1), 13-27. doi: 10.2174/1874467211306010003

Conference Contribution - Poster Presentation (not in published proceedings)

Fronius, M., Knoepp, F., Bednarz, M., & Althaus, M. (2013, August). The δ1 and δ2 ENaC subunits form mechanosensitive channels when coexpressed with β and γ subunits. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Chapter in Book - Research

Fronius, M. (2012). Mechanical forces impair alveolar ion transport processes: A putative mechanism contributing to the formation of pulmonary edema. In E. M. Irusen (Ed.), Lung diseases: Selected state of the art reviews. (pp. 561-578). Rijeka, Croatia: InTech.

Journal - Research Article

Hollenhorst, M. I., Lips, K. S., Wolff, M., Wess, J., Gerbig, S., Takats, Z., … Fronius, M. (2012). Luminal cholinergic signalling in airway lining fluid: A novel mechanism for activating chloride secretion via Ca ²⁺-dependent Cl^- and K⁺ channels. British Journal of Pharmacology, 166(4), 1388-1402. doi: 10.1111/j.1476-5381.2012.01883.x

Hollenhorst, M. I., Lips, K. S., Weitz, A., Krasteva, G., Kummer, W., & Fronius, M. (2012). Evidence for functional atypical nicotinic receptors that activate K⁺-dependent Cl^- secretion in mouse tracheal epithelium. American Journal of Respiratory Cell & Molecular Biology, 46(1), 106-114. doi: 10.1165/rcmb.2011-0171OC

Althaus, M., Urness, K. D., Clauss, W. G., Baines, D. L., & Fronius, M. (2012). The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells. British Journal of Pharmacology, 166(6), 1946-1963. doi: 10.1111/j.1476-5381.2012.01909.x

Wesch, D., Althaus, M., Miranda, P., Cruz-Muros, I., Fronius, M., González-Hernández, T., … Giraldez, T. (2012). Differential N termini in epithelial Na⁺ channel δ-subunit isoforms modulate channel trafficking to the membrane. American Journal of Physiology: Cell Physiology, 302(6), C868-879. doi: 10.1152/ajpcell.00255.2011

Krumm, P., Giraldez, T., Alvarez de la Rosa, D., Clauss, W. G., Fronius, M., & Althaus, M. (2012). Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & Medicinal Chemistry, 20(13), 3979-3984. doi: 10.1016/j.bmc.2012.05.021

Journal - Research Other

Hollenhorst, M. I., Clauss, W., & Fronius, M. (2012). Acetylcholin als non-neuronales Signalmolekül [The non-neuronal cholinergic system]. Biologie in unserer Zeit, 42(6), 390-395. doi: 10.1002/biuz.201210495

Fronius, M., Clauss, W. G., & Althaus, M. (2012). Why do we have to move fluid to be able to breathe? Frontiers in Physiology, 3, 146. doi: 10.3389/fphys.2012.00146

Conference Contribution - Published proceedings: Full paper

Hollenhorst, M. I., Lips, K. S., Kummer, W., & Fronius, M. (2012). Nicotine-induced activation of soluble adenylyl cyclase participates in ion transport regulation in mouse tracheal epithelium. Life Sciences, 91(21-22), (pp. 1009-1012). doi: 10.1016/j.lfs.2012.06.027

2011

Journal - Research Article

Kessler, S., Clauss, W. G., Günther, A., Kummer, W., & Fronius, M. (2011). Expression and functional characterization of P2X receptors in mouse alveolar macrophages. Pflügers Archiv: European Journal of Physiology, 462(3), 419-430. doi: 10.1007/s00424-011-0980-z

Kessler, S., Clauss, W. G., & Fronius, M. (2011). Laminar shear stress modulates the activity of heterologously expressed P2X4 receptors. Biochimica et Biophysica Acta: Biomembranes, 1808(10), 2488-2495. doi: 10.1016/j.bbamem.2011.07.010

Hollenhorst, M. I., Richter, K., & Fronius, M. (2011). Ion transport by pulmonary epithelia. Journal of Biomedicine & Biotechnology, 2011, 174306. doi: 10.1155/2011/174306

Berger, J., Richter, K., Clauss, W. G., & Fronius, M. (2011). Evidence for basolateral Cl^- channels as modulators of apical Cl^- secretion in pulmonary epithelia of Xenopus laevis. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 300(3), R616-R623. doi: 10.1152/ajpregu.00464.2010

Althaus, M., Pichl, A., Clauss, W. G., Seeger, W., Fronius, M., & Morty, R. E. (2011). Nitric oxide inhibits highly selective sodium channels and the Na⁺/K⁺-ATPase in H441 cells. American Journal of Respiratory Cell & Molecular Biology, 44(1), 53-65. doi: 10.1165/2009-0335OC

Althaus, M., Clauss, W. G., & Fronius, M. (2011). Amiloride-sensitive sodium channels and pulmonary edema. Pulmonary Medicine, 2011, 830320. doi: 10.1155/2011/830320

2010

Journal - Research Article

Mikulski, Z., Hartmann, P., Jositsch, G., Zasłona, Z., Lips, K. S., Pfeil, U., … Fronius, M., & Kummer, W. (2010). Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration. Respiratory Research, 11, 133. doi: 10.1186/1465-9921-11-133

Fronius, M., Bogdan, R., Althaus, M., Morty, R. E., & Clauss, W. G. (2010). Epithelial Na⁺ channels derived from human lung are activated by shear force. Respiratory Physiology & Neurobiology, 170(1), 113-119. doi: 10.1016/j.resp.2009.11.004

Berger, J., Hardt, M., Clauss, W. G., & Fronius, M. (2010). Basolateral Cl^- uptake mechanisms in Xenopus laevis lung epithelium. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 299(1), R92-R100. doi: 10.1152/ajpregu.00749.2009

2009

Journal - Research Article

Althaus, M., Fronius, M., Buchäckert, Y., Vadász, I., Clauss, W. G., Seeger, W., … Morty, R. E. (2009). Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. American Journal of Respiratory Cell & Molecular Biology, 41(6), 639-650. doi: 10.1165/rcmb.2008-0458OC

2008

Journal - Research Article

Fronius, M., & Clauss, W. G. (2008). Mechano-sensitivity of ENaC: May the (shear) force be with you. Pflügers Archiv: European Journal of Physiology, 455(5), 775-785. doi: 10.1007/s00424-007-0332-1

Bogdan, R., Veith, C., Clauss, W., & Fronius, M. (2008). Impact of mechanical stress on ion transport in native lung epithelium (Xenopus laevis): Short-term activation of Na⁺, Cl^- and K⁺ channels. Pflügers Archiv: European Journal of Physiology, 456(6), 1109-1120. doi: 10.1007/s00424-008-0486-5

2007

Journal - Research Article

Sommer, D., Bogdan, R., Berger, J., Peters, D. M., Morty, R. E., Clauss, W. G., & Fronius, M. (2007). CFTR-dependent Cl^- secretion in Xenopus laevis lung epithelium. Respiratory Physiology & Neurobiology, 158(1), 97-106. doi: 10.1016/j.resp.2007.03.016

Schnizler, M. K., Bogdan, R., Bennert, A., Bury, N. R., Fronius, M., & Clauss, W. (2007). Short-term exposure to waterborne free silver has acute effects on membrane current of Xenopus oocytes. Biochimica et Biophysica Acta: Biomembranes, 1768(2), 317-323. doi: 10.1016/j.bbamem.2006.09.007

Althaus, M., Bogdan, R., Clauss, W. G., & Fronius, M. (2007). Mechano-sensitivity of epithelial sodium channels (ENaCs): Laminar shear stress increases ion channel open probability. FASEB Journal, 21(10), 2389-2399. doi: 10.1096/fj.06-7694com

2005

Journal - Research Article

Krumm, S., Goebel-Lauth, S. G., Fronius, M., & Clauss, W. (2005). Transport of sodium and chloride across earthworm skin in vitro. Journal of Comparative Physiology B, 175, 601-608. doi: 10.1007/s00360-005-0023-1

2004

Journal - Research Article

Berk, A., Fronius, M., Clauss, W., & Schnizler, M. (2004). Prostaglandin E2 induces upregulation of Na+ transport across Xenopus lung epithelium. Journal of Comparative Physiology B, 174, 83-89. doi: 10.1007/s00360-003-0391-3

Fronius, M., Berk, A., Clauss, W., & Schnizler, M. (2004). Ion transport across Xenopus alveolar epithelium is regulated by extracellular ATP, UTP and adenosine. Respiratory Physiology & Neurobiology, 139, 133-144. doi: 10.1016/j.resp.2003.09.007

2003

Journal - Research Article

Fronius, M., Clauss, W., & Schnizler, M. (2003). Stimulation of transepithelial Na⁺ current by extracellular Gd³⁺ in Xenopus laevis alveolar epithelium. Journal of Membrane Biology, 195(1), 43-51. doi: 10.1007/s00232-003-2043-7

2001

Journal - Research Article

Fronius, M., Rehn, M., Eckstein-Ludwig, U., & Clauss, W. (2001). Inhibitory non-genomic effects of progesterone on Na⁺ absorption in epithelial cells from Xenopus kidney (A6). Journal of Comparative Physiology B, 171, 377-386. doi: 10.1007/s003600100186