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Campbell Lab

Lab personnel

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Research interests

I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility. I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.

Keywords

GnRH neurons, dendrites, synchronization, PCOS

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Research topics

  • Exploring the neuroendocrine mechanism of polycystic ovary syndrome (PCOS)
  • Investigating the spatial distribution of synaptic inputs to GnRH dendrites
  • Mechanisms of pulse generation in the GnRH neuronal network

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Current funding

  • 2015–2018 Health Research Council (HRC) Grant, Probing novel pathways mediating PCOS. Principal Investigator (NZ$910,000).
  • 2015–2018 Royal Society Marsden Fund, Functional dissection of a novel GABAergic pathway in the brain circuitry controlling fertility. Principal Investigator (NZ$943,000).
  • 2012–2017 Health Research Council (HRC) Programme Grant, Neural control of fertility. Joint Principal Investigator (0.10FTE) (NZ$4,935,490). Director: Professor Allan Herbison.

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Previous funding

  • 2015 University of Otago Research Grant, Putting the pieces together: Getting the bigger picture on fertility regulation – Part II. Principal Investigator (NZ$30,000).
  • 2014 University of Otago Research Grant, Putting the pieces together: Getting the bigger picture on fertility regulation. Principal Investigator (NZ$42,085).
  • 2011–2014 Health Research Council (HRC) Grant, Investigating the Neuroendocrine Abnormalities of Polycystic Ovarian Syndrome. Principal Investigator (0.2FTE; NZ$650,735).
  • 2010–2013 Royal Society Marsden Fund, Primary cilia and the central regulation of fertility. Principal Investigator (0.25FTE; NZ$575,000).

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Previous lab personnel

  • Katrin Geist
  • Galina Gaidamaka

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Selected publications

Campbell, R. E. (2018). Morphology of the adult GnRH neuron. In A. E. Herbison & T. M. Plant (Eds.), The GnRHS neuron and its control. (pp. 121-142). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119233275

Moore, A. M., Abbott, G., Mair, J., Prescott, M., & Campbell, R. E. (2018). Mapping GABA and glutamate inputs to gonadotrophin-releasing hormone neurones in male and female mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12657

Moore, A. M., Prescott, M., Czieselsky, K., Desroziers, E., Yip, S. H., Campbell, R. E., & Herbison, A. E. (2018). Synaptic innervation of the GnRH neuron distal dendron in female mice. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00505

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neurohumoral regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology, 30(8), e12569. doi: 10.1111/jne.12569

Silva, M., Hessler, S., Prescott, M., Herbison, A. E., & Campbell, R. E. (2018). Selective activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion in mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 140). Retrieved from http://www.icn2018.org/

Desroziers, E., Coutinho, E., Prescott, M., Silva, M., Holland, S., & Campbell, R. E. (2018). The impact of chronic activation of arcuate GABA neurons on fertility. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 246). Retrieved from http://www.icn2018.org/

Desroziers, E., Prescott, M., & Campbell, R. E. (2018). Impaired sexual behaviour in a mouse model of PCOS. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 288-289). Retrieved from http://www.icn2018.org/

Coutinho, E., Prescott, M., Desroziers, E., Hessler, S., & Campbell, R. E. (2018). Activation of ARN AgRP/NPY neurons slows LH pulsality in control and PCOS mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 133). Retrieved from http://www.icn2018.org/

Campbell, R. E. (2018). Dissecting the neuroendocrine dysfunction of polycystic ovary syndrome. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 29). Retrieved from http://www.icn2018.org/

Jamieson, B., Bouwer, G., Campbell, R. E., & Piet, R. (2018). Suprachiasmatic vasopressin neurons project to preoptic kisspeptin neurons. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 244). Retrieved from http://www.icn2018.org/

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Kunovac-Kallak, T., Hellgren, C., Skalkidou, A., Sandelin-Francke, L., Ubhayasekhera, K., Bergquist, J., … Campbell, R. E., & Sundström Poromaa, I. (2017). Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain. European Journal of Endocrinology, 177, 379-388. doi: 10.1530/eje-17-0207

Marshall, C. J., Desroziers, E., McLennan, T., & Campbell, R. E. (2017). Defining subpopulations of arcuate nucleus GABA neurons in male, female, and prenatally androgenized female mice. Neuroendocrinology, 105(2), 157-169. doi: 10.1159/000452105

Moore, A. M., & Campbell, R. E. (2017). Polycystic ovary syndrome: Understanding the role of the brain. Frontiers in Neuroendocrinology, 46, 1-14. doi: 10.1016/j.yfrne.2017.05.002

Nair, B., Khant Aung, Z., Porteous, R., Prescott, M., Ng, J., Yip, S., Augustine, R., Glendining, K., Bouwer, G., Kim, J., Jenkins, D., Silva, M., Brown, C., Campbell, R., Jasoni, C., Bunn, S., Anderson, G., Grattan, D., Herbison, A., & Iremonger, K. (2017). Impact of chronic stress on the neuroendocrine axis in the mouse. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 49). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Marshall, C. J., & Campbell, R. E. (2017). Interrogation of arcuate nucleus GABAergic NPY neural circuitry in prenatally androgenised female mice. New Zealand Medical Journal, 130(1460), (pp. 95). Retrieved from http://www.nzma.org.nz/journal

Seymour, A. J., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. New Zealand Medical Journal, 130(1460), (pp. 98). Retrieved from http://www.nzma.org.nz/journal

Desroziers, E., Coutinho, E., Prescott, M., Silva, S., Holland, S., & Campbell, R. E. (2017, September). Deciphering the role of arcuate GABA neurons in fertility regulation with chemogenetic tools in vivo. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Prescott, M., Czieselsky, K., Desroziers, E., Herbison, A. E., & Campbell, R. E. (2017, September). Finding CLARITY: Visualising the gonadotrophin-releasing hormone neuron. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2017, September). Optogenetic activation of arcuate nucleus GABA neurons in vivo elicits luteinizing hormone secretion in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017, September). Activation of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Holland, S. L., Desroziers, E., Silva, M., Prescott, M., & Campbell, R. E. (2017, September). Investigating the role of microglia in polycystic ovary syndrome (PCOS). Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017, September). Activations of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jamieson, B. B., Campbell, R. E., & Piet, R. (2017, September). Vasopressinergic control of RP3V kisspeptin neurons. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chapter in Book - Research

Campbell, R. E. (2018). Morphology of the adult GnRH neuron. In A. E. Herbison & T. M. Plant (Eds.), The GnRHS neuron and its control. (pp. 121-142). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119233275

Clarke, I. J., Campbell, R., Smith, J. T., Prevot, V., & Wray, S. (2012). Neuroendocrine control of reproduction. In G. Fink, D. W. Pfaff & J. Levine (Eds.), Handbook of Neuroendocrinology. (pp. 197-235). Elsevier. doi: 10.1016/b978-0-12-375097-6.10009-5

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Journal - Research Article

Moore, A. M., Abbott, G., Mair, J., Prescott, M., & Campbell, R. E. (2018). Mapping GABA and glutamate inputs to gonadotrophin-releasing hormone neurones in male and female mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12657

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Moore, A. M., Prescott, M., Czieselsky, K., Desroziers, E., Yip, S. H., Campbell, R. E., & Herbison, A. E. (2018). Synaptic innervation of the GnRH neuron distal dendron in female mice. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00505

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Moore, A. M., & Campbell, R. E. (2017). Polycystic ovary syndrome: Understanding the role of the brain. Frontiers in Neuroendocrinology, 46, 1-14. doi: 10.1016/j.yfrne.2017.05.002

Marshall, C. J., Desroziers, E., McLennan, T., & Campbell, R. E. (2017). Defining subpopulations of arcuate nucleus GABA neurons in male, female, and prenatally androgenized female mice. Neuroendocrinology, 105(2), 157-169. doi: 10.1159/000452105

Kunovac-Kallak, T., Hellgren, C., Skalkidou, A., Sandelin-Francke, L., Ubhayasekhera, K., Bergquist, J., … Campbell, R. E., & Sundström Poromaa, I. (2017). Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain. European Journal of Endocrinology, 177, 379-388. doi: 10.1530/eje-17-0207

Cimino, I., Casoni, F., Liu, X., Messina, A., Parkash, J., Jamin, S. P., … Prescott, M., Campbell, R., Herbison, A. E., … Giacobini, P. (2016). Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nature Communications, 7, 10055. doi: 10.1038/ncomms10055

Moore, A. M., & Campbell, R. E. (2016). The neuroendocrine genesis of polycystic ovary syndrome: A role for arcuate nucleus GABA neurons. Journal of Steroid Biochemistry & Molecular Biology, 160, 106-117. doi: 10.1016/j.jsbmb.2015.10.002

Czieselsky, K., Prescott, M., Porteous, R., Campos, P., Clarkson, J., Steyn, F. J., Campbell, R. E., & Herbison, A. E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157(12), 4794-4802. doi: 10.1210/en.2016-1351

Moore, A. M., Prescott, M., Marshall, C. J., Yip, S. H., & Campbell, R. E. (2015). Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. PNAS, 112(2), 596-601. doi: 10.1073/pnas.1415038112

Yip, S. H., Boehm, U., Herbison, A. E., & Campbell, R. E. (2015). Conditional viral tract tracing delineates the projections of the distinct kisspeptin neuron populations to gonadotropin-releasing hormone (GnRH) neurons in the mouse. Endocrinology, 156(7), 2582-2594. doi: 10.1210/en.2015-1131

Campbell, R. E., & Herbison, A. E. (2014). Gonadal steroid neuromodulation of developing and mature hypothalamic neuronal networks. Current Opinion in Neurobiology, 29, 96-102. doi: 10.1016/j.conb.2014.06.003

Shin, J., Prescott, M., Mair, J., & Campbell, R. E. (2014). Roles for primary cilia in gonadotropin-releasing hormone neurons in the mouse. Journal of Neuroendocrinology, 26(1), 18-25. doi: 10.1111/jne.12122

Moore, A. M., Prescott, M., & Campbell, R. E. (2013). Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology, 154(2), 796-806. doi: 10.1210/en.2012-1954

Norberg, R., Campbell, R., & Suter, K. J. (2013). Ion channels and information processing in GnRH neuron dendrites. Channels, 7(3), 135-145. doi: 10.4161/chan.24228

Campbell, R. E., Ducret, E., Porteous, R., Liu, X., Herde, M. K., Wellerhaus, K., … Herbison, A. E. (2011). Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology, 152(6), 2290-2301. doi: 10.1210/en.2010-1311

Herde, M. K., Geist, K., Campbell, R. E., & Herbison, A. E. (2011). Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology, 152(10), 3832-3841. doi: 10.1210/en.2011-1228

Chan, H., Prescott, M., Ong, Z. Y., Herde, M. K., Herbison, A. E., & Campbell, R. E. (2011). Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology, 152(12), 4906-4914. doi: 10.1210/en.2011-1522

Lee, K., Porteous, R., Campbell, R. E., Lüscher, B., & Herbison, A. E. (2010). Knockdown of GABAA receptor signaling in GnRH neurons has minimal effects upon fertility. Endocrinology, 151(9), 4428-4436. doi: 10.1210/en.2010-0314

Campbell, R. E., & Suter, K. J. (2010). Redefining the gonadotrophin-releasing hormone neurone dendrite. Journal of Neuroendocrinology, 22, 650-658. doi: 10.1111/j.1365-2826.2010.02032.x

Campbell, R. E., Gaidamaka, G., Han, S.-K., & Herbison, A. E. (2009). Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. PNAS, 106(26), 10835-10840. doi: 10.1073/pnas.0903463106

Roberts, C. B., Campbell, R. E., Herbison, A. E., & Suter, K. J. (2008). Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons. Endocrinology, 149(7), 3355-3360.

Campbell, R. E., & Herbison, A. E. (2007). Definition of brainstem afferents to gonadotropin-releasing hormone neurons in the mouse using conditional viral tract tracing. Endocrinology, 148(12), 5884-5890.

Campbell, R. E. (2007). Defining the gonadotrophin-releasing hormone neuronal network: Transgenic approaches to understanding neurocircuitry. Journal of Neuroendocrinology, 19(7), 561-573. doi: 10.1111/j.1365-2826.2007.01568.x

Wintermantel, T. M., Campbell, R. E., Porteous, R., Bock, D., Gröne, H.-J., Todman, M. G., … Herbison, A. E. (2006). Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron, 52, 271-280.

Cottrell, E. C., Campbell, R. E., Han, S.-K., & Herbison, A. E. (2006). Postnatal remodeling of dendritic structure and spine density in gonadotropin-releasing hormone neurons. Endocrinology, 147(8), 3652-3661.

Campbell, R. E., Han, S.-K., & Herbison, A. E. (2005). Biocytin filling of adult gonadotropin-releasing hormone neurons in situ reveals extensive, spiny, dendritic processes. Endocrinology, 146(3), 1163-1169.

Campbell, R. E., Grove, K. L., & Smith, S. (2003). Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers. Endocrinology, 144(4), 1542-1548.

Campbell, R. E., Grove, K. L., & Smith, S. (2003). Distribution of corticotropin releasing hormone receptor immunoreactivity in the rat hypothalamus: Coexpression in neuropeptide Y and dopamine neurons in the arcuate nucleus. Brain Research, 973, 223-232.

Campbell, R. E., Smith, S., Allen, S. E., Grayson, B. E., ffrench-Mullen, J. M. H., & Grove, K. L. (2003). Orexin neurons express a functional pancreatic polypeptide Y4 receptor. Journal of Neuroscience, 23(4), 1487-1497.

Campbell, R. E., ffrench-Mullen, J. M. H., Cowley, M. A., Smith, M. S., & Grove, K. L. (2001). Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype. Neuroendocrinology, 73, 106-119.

Grove, K. L., Campbell, R. E., French-Mullen, J. M. H., Cowley, M. A., & Smith, M. S. (2000). Neuropeptide Y Y5 receptor expression in the cortical/limbic system and brainstem of the rat: Expression on γ-Aminobutyric acid and corticotropin-releasing hormone neurons. Neuroscience, 100(4), 731-740.

Lu, N. Z., Shales, T. A., Dziennis, S. E., Campbell, R. E., & Bethea, C. L. (1999). Ovarian steroid action on tryptophan hydroxylase protein and serotonin compared to localization of ovarian steroid receptors in midbrain of guinea pigs. Endocrine, 11(3), 257-267.

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Journal - Research Other

Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neurohumoral regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology, 30(8), e12569. doi: 10.1111/jne.12569

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Conference Contribution - Published proceedings: Abstract

Silva, M., Hessler, S., Prescott, M., Herbison, A. E., & Campbell, R. E. (2018). Selective activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion in mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 140). Retrieved from http://www.icn2018.org/

Jamieson, B., Bouwer, G., Campbell, R. E., & Piet, R. (2018). Suprachiasmatic vasopressin neurons project to preoptic kisspeptin neurons. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 244). Retrieved from http://www.icn2018.org/

Campbell, R. E. (2018). Dissecting the neuroendocrine dysfunction of polycystic ovary syndrome. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 29). Retrieved from http://www.icn2018.org/

Coutinho, E., Prescott, M., Desroziers, E., Hessler, S., & Campbell, R. E. (2018). Activation of ARN AgRP/NPY neurons slows LH pulsality in control and PCOS mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 133). Retrieved from http://www.icn2018.org/

Desroziers, E., Prescott, M., & Campbell, R. E. (2018). Impaired sexual behaviour in a mouse model of PCOS. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 288-289). Retrieved from http://www.icn2018.org/

Desroziers, E., Coutinho, E., Prescott, M., Silva, M., Holland, S., & Campbell, R. E. (2018). The impact of chronic activation of arcuate GABA neurons on fertility. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 246). Retrieved from http://www.icn2018.org/

Nair, B., Khant Aung, Z., Porteous, R., Prescott, M., Ng, J., Yip, S., Augustine, R., Glendining, K., Bouwer, G., Kim, J., Jenkins, D., Silva, M., Brown, C., Campbell, R., Jasoni, C., Bunn, S., Anderson, G., Grattan, D., Herbison, A., & Iremonger, K. (2017). Impact of chronic stress on the neuroendocrine axis in the mouse. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 49). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Seymour, A. J., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. New Zealand Medical Journal, 130(1460), (pp. 98). Retrieved from http://www.nzma.org.nz/journal

Marshall, C. J., & Campbell, R. E. (2017). Interrogation of arcuate nucleus GABAergic NPY neural circuitry in prenatally androgenised female mice. New Zealand Medical Journal, 130(1460), (pp. 95). Retrieved from http://www.nzma.org.nz/journal

Silva, M. S., Prescott, M., & Campbell, R. (2016). Development of gabaergic altered brain wiring and plasticity in a mouse model of polycystic ovary syndrome (PCOS). Proceedings of the Society for Neuroscience 46th Annual Meeting. 60.19/KK14. SfN. Retrieved from https://www.sfn.org/

Marshall, C. J., Desroziers, E., & Campbell, R. E. (2016). Defining subpopulations of arcuate nucleus GABA neurons in male, female and prenatally androgenized female mice: A role for GABAergic NPY neurons in regulating fertility? Proceedings of the Society for Neuroscience 46th Annual Meeting. 339.02/TT8. SfN. Retrieved from https://www.sfn.org/

Seymour, A., Piet, R., Campbell, R. E., & Brown, C. H. (2015). Kisspeptin does not affect excitatory postsynaptic currents in supraoptic nucleus neurons from virgin or pregnant rats. Proceedings of the Society for Neuroscience 45th Annual Meeting. 613.23/S18. SfN. Retrieved from https://www.sfn.org

Seymour, A. J., Piet, R., Campbell, R. E., & Brown, C. H. (2015). Emergence of a kisspeptin projection from the periventricular nucleus to the perinuclear zone of the supraoptic nucleus during pregnancy. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 31). Retrieved from http://wcnh.otago.ac.nz/index.html

Seymour, A. J., Campbell, R. E., & Brown, C. H. (2014). Kisspeptin fibres in the perinuclear zone of the supraoptic nucleus originate from the periventricular nucleus. Proceedings of the Medical Sciences Congress (MedSci). (pp. 16). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Seymour, A., Campbell, R., & Brown, C. (2014). Periventricular nucleus kisspeptin neurons project to the perinuclear zone of the supraoptic nucleus. New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal

Marshall, C. J., Prescott, M., & Campbell, R. E. (2014). Pulsatile luteinizing hormone secretion is increased in a prenatal androgen (PNA) treated model of polycystic ovarian syndrome (PCOS). Proceedings of the Medical Sciences Congress (MedSci). (pp. 35). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Campbell, R. E., Prescott, M., Marshall, C., & Moore, A. (2014). Prenatal androgen exposure re-wires the gonadotropin-releasing hormone (GnRH) neuronal network. Proceedings of the Medical Sciences Congress (MedSci). (pp. 9). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Prescott, M., Marshall, C. J., & Campbell, R. E. (2014). Increased luteinising hormone pulse frequency in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Yip, S., & Campbell, R. (2014). Revealing synaptic inputs along the full extent of gonadotropin-releasing hormone (GnRH) neuron processes using an in vivo viral-mediated cell filling technique. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Moore, A., Prescott, M., & Campbell, R. (2014). Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal

Moore, A. M., Prescott, M., & Campbell, R. E. (2014). Defining the neuronal network mediating impaired progesterone negative feedback in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Moore, A. M., Prescott, M., & Campbell, R. E. (2014). Investigating changes in the gonadotropin-releasing hormone neuronal network in a model of polycystic ovarian syndrome. Proceedings of the Medical Sciences Congress (MedSci). (pp. 23). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Marshall, C., Prescott, M., & Campbell, R. (2014). Measuring pulsatile luteinizing hormone secretion in a prenatal androgen treated model of polycystic ovarian syndrome. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

Moore, A. M., & Campbell, R. E. (2013). Investigating the synaptic regulation of gonadotropin-releasing hormone neurons in a mouse model of polycystic ovarian syndrome. Endocrine Reviews, 34(3, Suppl.), SAT-145. Retrieved from http://press.endocrine.org/series/endo-meetings

Campbell, R. E., Prescott, M., Constantin, S. S., & Moore, A. M. (2012). Altered hypothalamic gonadal steroid hormone receptor expression in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Campbell, R. E., Prescott, M., & Moore, A. M. (2012). Understanding the neuroendocrine abnormalities of polycystic ovarian syndrome in a mouse model. Proceedings of the Medical Sciences Congress (MedSci). (pp. 12). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Scott, V., Seymour, A. J., Campbell, R. E., & Brown, C. H. (2012). Regulation of the oxytocin system by kisspeptin. Proceedings of the Medical Sciences Congress (MedSci). (pp. 36-37). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Moore, A. M., Prescott, M., & Campbell, R. E. (2012). Investigating gonadal steroid hormone feedback in a mouse model of polycystic ovarian syndrome. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Moore, A. M., Prescott, M., & Campbell, R. E. (2012). Investigating changes in the gonadotropin-releasing hormone neuronal network in a mouse model of polycystic ovarian syndrome. Proceedings of the Medical Sciences Congress (MedSci). (pp. 58). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Scott, V., Seymour, A. J., Campbell, R. E., & Brown, C. H. (2012). Kisspeptin regulation of the oxytocin system in pregnancy and lactation. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Shin, J., Prescott, M., & Campbell, R. E. (2011). Is there a role for primary cilia in gonadotropin-releasing hormone (GnRH) neurons? In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.19. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Moore, A. M., Prescott, M., & Campbell, R. E. (2011). Investigating steroid hormone feedback in a mouse model of polycystic ovarian syndrome. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.10. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Chan, H., & Campbell, R. (2010). Plasticity in a subpopulation of gonadotropin-releasing hormone neurons at the time of the pre-ovulatory surge. New Zealand Medical Journal, 123(1314). Retrieved from http://journal.nzma.org.nz/journal/123-1314/4120/content.pdf

Campbell, R. E., & Chan, H. (2010). Dendritic plasticity in activated gonadotropin-releasing hormone (GnRH) neurons at the time of the pre-ovulatory surge. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx

Herbison, A. E., Gaidamaka, G., Han, S.-K., & Campbell, R. (2009). Dendro-dendritic bundling and shared synapses between GnRH neurons. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Campbell, R. E., Gaidamaka, G., Han, S.-K., & Herbison, A. E. (2009). Dendro-dendritic bundling and shared synapses between GnRH neurons. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Herbison, A. E., Clarkson, J., & Campbell, R. (2006). Kiss and tell in the brain: Kisspeptins and the neural control of fertility. Proceedings of the Australian Society for Biochemistry and Molecular Biology (ComBio). Retrieved from http://www.asbmb.org.au/combio2006/abstracts/edited/HERBISON.rtf

Campbell, R. E., & Herbison, A. E. (2006). Defining estrogen-sensitive inputs to GnRH neurons. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Herbison, A. E., Porteous, R., Clarkson, J., & Campbell, R. E. (2006). Understanding estrogen feedback actions on the brain using transgenic mouse models. Proceedings of the Australian Society for Biochemistry and Molecular Biology (ComBio). Retrieved from http://www.asbmb.org.au/combio2006/abstracts/edited/HERBISON-20060627124545.rtf

Campbell, R. E., & Herbison, A. E. (2005). Defining the GnRH neuronal network with GnRH neuron-specific retrograde labeling in the mouse. Proceedings of the Society for Neuroscience 35th Annual Meeting. Washington, DC: SfN. [Abstract]

Campbell, R. E., Han, S.-K., & Herbison, A. E. (2004). Synchronization of GnRH neurons: Potential dendro - dendritic mechanism? Proceedings of the 34th Annual Meeting of the Society for Neuroscience. (885.7). Retrieved from http://apu.sfn.org/AM2004

Campbell, R. E., Han, S.-K., & Herbison, A. E. (2004). Revealing GnRH neuronal morphology using transgenic mice: Have we underestimated their connectivity? Proceedings of the Australasian Winter Conference on Brain Research. 22, (pp. 38). Retrieved from http://psy.otago.ac.nz/awcbr/abstracts 2004/

Grove, K. L., Campbell, R. E., ffrench-Mullen, J. M. H., & Smith, M. S. (2001). Postnatal ontogeny of neuropeptide Y (NPY) Y4 receptor immunoreactivity (-IR) in the rat brain: Relationship with the orexin system. Proceedings of the Society for Neuroscience's 31st Annual Meeting. Washington DC: SfN. Retrieved from http://sfn.scholarone.com/itin2001/main.html

Campbell, R. E., Smith, M. S., ffrench-Mullen, J. M. H., & Grove, K. L. (2001). Distribution of neuropeptide Y (NPY) Y4 receptor immunoreactivity in the hypothalamus of the rat: Exclusive colocalization with orexin in the lateral hypothalamic area (LHA). Proceedings of the Society for Neuroscience's 31st Annual Meeting. Washington DC: SfN. Retrieved from http://sfn.scholarone.com/itin2001/main.html

Grove, K. L., Campbell, R. E., ffrench-Mullen, J. M. H., & Smith, M. S. (2000). Cellular localization of the neuropeptide Y (NPY) Y5 receptor protein in the cortical/limbic system of the rat: Coexpression in CRH and GABAergic neurons. Proceedings of the Society for Neuroscience's 30th Annual Meeting. Washington DC: SfN. Retrieved from http://sfn.scholarone.com/itin2000/main.html

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Conference Contribution - Poster Presentation (not in published proceedings)

Desroziers, E., Coutinho, E., Prescott, M., Silva, S., Holland, S., & Campbell, R. E. (2017, September). Deciphering the role of arcuate GABA neurons in fertility regulation with chemogenetic tools in vivo. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017, September). Activations of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Holland, S. L., Desroziers, E., Silva, M., Prescott, M., & Campbell, R. E. (2017, September). Investigating the role of microglia in polycystic ovary syndrome (PCOS). Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coutinho, E. A., Desroziers, E., Prescott, M., & Campbell, R. E. (2017, September). Activation of arcuate neuropeptide Y neurons alters luteinising hormone secretion in mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2017, September). Optogenetic activation of arcuate nucleus GABA neurons in vivo elicits luteinizing hormone secretion in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Prescott, M., Czieselsky, K., Desroziers, E., Herbison, A. E., & Campbell, R. E. (2017, September). Finding CLARITY: Visualising the gonadotrophin-releasing hormone neuron. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Desroziers, E., Marshall, C. J., Prescott, M., & Campbell, R. E. (2016, August). Sexually differentiated co-expression of neuronal nitric oxide synthase (nNOS) in arcuate nucleus GABA neurons. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Marshall, C. J., & Campbell, R. E. (2015, August-September). Defining the neuropeptide expression of GABA neurons in the arcuate nucleus of the mouse. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Yip, S. H., & Campbell, R. E. (2013, August). Revealing the extent of gonadotropin-releasing hormone neurons in vivo using a viral-mediated cell filling technique. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Seymour, A. J., Scott, V., Campbell, R. E., & Brown, C. H. (2013, August). Hypothalamic kisspeptin and neurokinin B immunoreactivity is increased in late pregnant rats. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Gaidamaka, G., Campbell, R. E., & Herbison, A. E. (2008, November). Revealing the ultrastructure of gonadotropin-releasing hormone (GnRH) neuron dendrites. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

Campbell, R. E., & Herbison, A. E. (2006, October). Defining estrogen-sensitive inputs to GnRH neurons. Poster session presented at the Neuroscience Society's 36th Annual Meeting, Atlanta, GA.

Campbell, R. E., & Herbison, A. E. (2006, November-December). Defining estrogen-sensitive inputs to GNRH neurons. Poster session presented at the Medical Sciences Congress, Rotorua, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Jamieson, B. B., Campbell, R. E., & Piet, R. (2017, September). Vasopressinergic control of RP3V kisspeptin neurons. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Campbell, R. E. (2017, September). Polycystic ovary syndrome (PCOS): Is it all in our heads? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2017, September). Dissecting the functional relevance and ontogeny of altered GABAergic circuitry in polycystic ovary syndrome (PCOS). Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Seymour, A. J., Piet, R., Campbell, R. E., & Brown, C. H. (2016, August). Regulation of oxytocin neurons by central kisspeptin in late-pregnant rats. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2016, August). Development of GABAergic altered wiring and plasticity in a mouse model of Polycystic Ovary Syndrome (PCOS). Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Marshall, C. J., & Campbell, R. E. (2016, August). Interrogation of arcuate nucleus GABAergic NPY neural circuitry in prenatally androgenized female mice. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

da Silva, M. S. B., & Campbell, R. E. (2015, August-September). Role of arcuate nucleus GABA neurons in female fertility and the pathophysiology of polycystic ovary syndrome. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Abbott, G. I. A., Moore, A. M., & Campbell, R. E. (2015, August-September). Investigating GABAergic input to GnRH neurons at the time of the preovulatory surge. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Seymour, A. J., Piet, R., Campbell, R. E., & Brown, C. H. (2015, August-September). Kisspeptin does not affect excitatory or inhibitory synaptic transmission in magnocellular neurosecretory cells from virgin or late-pregnant rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Campbell, R. E., Prescott, M., Yip, S.-H., Marshall, C. J., McLennan, T., & Moore, A. M. (2015, August-September). Arcuate nucleus GABA neurons and the regulation of fertility. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Moore, A. M., & Campbell, R. E. (2013, August). Investigating the synaptic regulation of gonadotropin-releasing hormone neurons in a mouse model of polycystic ovarian syndrome. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Neill, A., Yip, S. H., & Campbell, R. (2013, August). Establishing the whole morphology of gonadotropin-releasing hormone neurons with optical clearing. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Herde, M. K., Geist, K., Hyland, B. I., Campbell, R. E., & Herbison, A. E. (2010, November-December). GnRH neurons project dendrites into the OVLT. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Campbell, R. E. (2010, July). The new morphology of GnRH neurons: Discovering the dendrite. Verbal presentation at the 7th International Congress of Neuroendocrinology (ICN), Rouen, France.

Campbell, R. E., Suter, K., & Herbison, A. E. (2008, November). Changing our view of GnRH neurons and their regulation of fertility. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Campbell, R. (2008, June). Investigating the functional neuroanatomy of the GnRH neuronal network. Verbal presentation at the Brain Health and Repair Research Centre 2nd Annual Conference, Dunedin, New Zealand.

Herbison, A. E., Campbell, R., Clarkson, J., Jasoni, C., Porteous, R., & Wintermantle, T. (2006, June). New horizons in the biology of the GnRH neuron. Verbal presentation at the 6th International Congress of Neuroendocrinology, Pittsburgh, Pennsylvania.

Herbison, A. E., Clarkson, J., & Campbell, R. E. (2006, August). Kisspeptin activation of GnRH neurons to initiate puberty and ovulation. Verbal presentation at the Annual Conference of the Endocrine Society of Australia and Society for Reproductive Biology, Queensland, Australia.

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Awarded Doctoral Degree

Campbell, R. E. (2002). The role of neuropeptide Y in the hypothalamic integrationof signals mediating energy balance and reproductive function Oregon Health and Science University, Portland, OR, USA. 241p.

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