Dr Jenny Clarkson

Contact Details
- Phone
- +64 3 479 8207
- jenny.clarkson@otago.ac.nz
University Links
- Position
- Research Fellow
- Department
- Department of Physiology
- Qualifications
- BPhEd MPhEd PhD
- Research summary
- Investigating the neural control of hot flushes in menopause
Research
I am a Research Fellow leading a research project that is investigating the neural mechanism that drives hot flushes in menopause.
Publications
McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z
Clarkson, J., Han, S. Y., Piet, R., McLennan, T., Kane, G. M., Ng, J., Porteous, R. W., Kim, J. S., … Iremonger, K. J., & Herbison, A. E. (2017). Definition of the hypothalamic GnRH pulse generator in mice. PNAS, 114(47), E10216-E10223. doi: 10.1073/pnas.1713897114
Han, S. Y., Clarkson, J., Piet, R., & Herbison, A. E. (2018). Optical approaches for interrogating neural circuits controlling hormone secretion [Mini-review]. Endocrinology, 159(11), 3822-3833. doi: 10.1210/en.2018-00594
Clarkson, J., Busby, E. R., Kirilov, M., Schütz, G., Sherwood, N. M., & Herbison, A. E. (2014). Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. Journal of Neuroscience, 34(46), 15297-15305. doi: 10.1523/JNEUROSCI.3061-14.2014
Kirilov, M., Clarkson, J., Liu, X., Roa, J., Campos, P., Porteous, R., … Herbison, A. E. (2013). Dependence of fertility on kisspeptin—Gpr54 signalling at the GnRH neuron. Nature Communications, 4, 2492. doi: 10.1038/ncomms3492
McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z
Journal - Research Article
Clarkson, J., Han, S. Y., Piet, R., McLennan, T., Kane, G. M., Ng, J., Porteous, R. W., Kim, J. S., … Iremonger, K. J., & Herbison, A. E. (2017). Definition of the hypothalamic GnRH pulse generator in mice. PNAS, 114(47), E10216-E10223. doi: 10.1073/pnas.1713897114
Journal - Research Article
Han, S. Y., Clarkson, J., Piet, R., & Herbison, A. E. (2018). Optical approaches for interrogating neural circuits controlling hormone secretion [Mini-review]. Endocrinology, 159(11), 3822-3833. doi: 10.1210/en.2018-00594
Journal - Research Other
Clarkson, J., Busby, E. R., Kirilov, M., Schütz, G., Sherwood, N. M., & Herbison, A. E. (2014). Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. Journal of Neuroscience, 34(46), 15297-15305. doi: 10.1523/JNEUROSCI.3061-14.2014
Journal - Research Article
Kirilov, M., Clarkson, J., Liu, X., Roa, J., Campos, P., Porteous, R., … Herbison, A. E. (2013). Dependence of fertility on kisspeptin—Gpr54 signalling at the GnRH neuron. Nature Communications, 4, 2492. doi: 10.1038/ncomms3492
Journal - Research Article
Clarkson, J. (2013). Effects of estradiol on kisspeptin neurons during puberty. Frontiers in Neuroendocrinology, 34, 120-131. doi: 10.1016/j.yfrne.2013.02.002
Journal - Research Article
Clarkson, J., d'Anglemont de Tassigny, X., Santos Moreno, A., Colledge, W. H., & Herbison, A. E. (2008). Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. Journal of Neuroscience, 28(35), 8691-8697. doi: 10.1523/JNEUROSCI.1775-08.2008
Journal - Research Article
Clarkson, J., & Herbison, A. E. (2006). Postnatal development of kisspeptin neurons in mouse hypothalamus: Sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology, 147(12), 5817-5825.
Journal - Research Article
Steyn, F. J., Wan, Y., Clarkson, J., Veldhuis, J. D., Herbison, A. E., & Chen, C. (2013). Development of methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice. Endocrinology, 154(12), 4939-4945. doi: 10.1210/en.2013-1502
Journal - Research Article
Clarkson, J., & Herbison, A. E. (2011). Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones. Journal of Neuroendocrinology, 23(4), 293-301. doi: 10.1111/j.1365-2826.2011.02107.x
Journal - Research Article
Clarkson, J., d'Anglemont de Tassigny, X., Colledge, W. H., Caraty, A., & Herbison, A. E. (2009). Distribution of kisspeptin neurones in the adult female mouse brain. Journal of Neuroendocrinology, 21(8), 673-682. doi: 10.1111/j.1365-2826.2009.01892.x
Journal - Research Article
Clarkson, J., & Herbison, A. E. (2016). Hypothalamic control of the male neonatal testosterone surge. Philosophical Transactions of the Royal Society B, 371(1688), 20150115. doi: 10.1098/rstb.2015.0115
Journal - Research Article
Czieselsky, K., Prescott, M., Porteous, R., Campos, P., Clarkson, J., Steyn, F. J., Campbell, R. E., & Herbison, A. E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157(12), 4794-4802. doi: 10.1210/en.2016-1351
Journal - Research Article
Clarkson, J., Shamas, S., Mallinson, S., & Herbison, A. E. (2012). Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse. Journal of Neuroendocrinology, 24(6), 907-915. doi: 10.1111/j.1365-2826.2012.02294.x
Journal - Research Article
Clarkson, J., Boon, W. C., Simpson, E. R., & Herbison, A. E. (2009). Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology, 150(7), 3214-3220. doi: 10.1210/en.2008-1733
Journal - Research Article
Yeo, S.-H., Clarkson, J., & Herbison, A. E. (2014). Kisspeptin-Gpr54 signaling at the GnRH neuron is necessary for negative feedback regulation of luteinizing hormone secretion in female mice. Neuroendocrinology, 100, 191-197. doi: 10.1159/000368608
Journal - Research Article
Clarkson, J., Han, S.-K., Liu, X., Lee, K., & Herbison, A. E. (2010). Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty. Molecular & Cellular Endocrinology, 324, 45-50. doi: 10.1016/j.mce.2010.01.026
Journal - Research Article
Constantin, S., Piet, R., Iremonger, K., Yeo, S. H., Clarkson, J., Porteous, R., & Herbison, A. E. (2012). GnRH neuron firing and response to GABA in vitro depend on acute brain slice thickness and orientation. Endocrinology, 153(8), 3758-3769. doi: 10.1210/en.2012-1126
Journal - Research Article
Clarkson, J., & Herbison, A. E. (2009). Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge. Journal of Neuroendocrinology, 21(4), 305-311. doi: 10.1111/j.1365-2826.2009.01835.x
Journal - Research Article
Kuo, J., Hamid, N., Bondar, G., Dewing, P., Clarkson, J., & Micevych, P. (2010). Sex differences in hypothalamic astrocyte response to estradiol stimulation. Biology of Sex Differences, 1, 7. doi: 10.1186/2042-6410-1-7
Journal - Research Article
Clarkson, J., & Herbison, A. E. (2006). Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty. Molecular & Cellular Endocrinology, 254-255, 32-38.
Journal - Research Article