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Our tissue engineering and regenerative medicine research

Our tissue engineering and regenerative medicine strategies involve combining a patient's own cells with 3D printed biodegradable scaffolds and growth factors. With the right conditions and helpful scaffold constituents and geometries we can achieve automated construction of living tissue.

The therapies that can develop from these technologies may offer considerable advantages over current surgical interventions used to repair or regenerate damaged or lost tissue.

Close up of cell feeding media being pipetted

Current projects

Developing novel photo-polymerisable hydrogels for 3D bioprinting of functional tissues

Dr Khoon Lim is our biomedical engineer specialising in polymer chemistry. He leads a number of projects using a class of polymers know as hydrogels as tissue engineering matrices.

His research involves developing novel photo-polymerisable hydrogel bioinks or bioresins for the 3D bioprinting of functional tissues. The biodegradable matrices formed from hydrogels are also used for the delivery of bioactive molecules to promote tissue regeneration.

Key research applications include cartilage repair, bone vascularisation, 3D cancer models for high-throughput drug screening and smart delivery of growth factors for stroke recovery.

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Improving bone vascularisation using highly tailorable hydrogels and 3D co-cultures of living cells

Improving bone vascularisation is the research goal of Pau Atienza Roca.

He uses highly tailorable hydrogels as a mechanism for delivering vasculogenic and osteogenic growth factors in a fashion that is coordinated to the changing needs of the developing bone tissues.

The biofabrication of tissues with complex vascular networks are also explored using 3D co-cultures of endothelial and stromal cells.

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Cardiac tissue regeneration and the treatment of myocardial infarction

The use of 3D printing technologies to fabricate functional three-dimensional cardiac tissue is one of Dr Steven Cui’s research directions.

He aims to develop a minimally invasive surgical system for delivering cardiac stem cells to the site of damage, encouraging tissue regeneration as a treatment for myocardial infarction.

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Quantification of cartilage and bone quality using Spectral CT

Kenzie Baer works with MARS Spectral CT imaging to determine the quality of cartilage and bone tissue based on quantifiable factors of the tissue.

Her research investigates the ability to image multiple tissues in a single scan and determine health of both tissues and to create a quantitative scale for bone and cartilage health. A single scan with quantitative analysis of multiple tissue health will allow for easier detection of disease as well as aid in the understanding of multiple tissue connections through disease progression.

Her research also looks at the ability to image regenerative tissue engineering technologies currently being developed with Spectral CT as an additional spatial analysis tool.

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