Dr Trudy Milne

Contact Details
- Phone
- +64 3 479 7105
- trudy.milne@otago.ac.nz
University Links
- Position
- Senior Research Fellow
- Qualifications
- NZCS PhD
- Research summary
- Oral health
Research
Dr Milne's research continues in a number of oral health areas including endodontics, periodontology and orthodontics.
Investigation of periodontopathogens and their association with angiogenic and inflammatory gene expression in dental pulp continues with the hope of improved dental treatment outcomes for smokers and patients with Type 2 diabetes. A study of a grafting material in a bone-healing sheep model and the genes associated with osteogenesis aims to advance the development of implant options for dental patients.
Dr Milne is also investigating the role osteoblasts and periodontal ligament cells play in the immune response and bone remodelling during orthodontic tooth movement.
Publications
Ram, A., Duncan, W. J., Coates, D. E., Nobakht, S., Tkatchenko, T., & Milne, T. J. (2023). Bone remodelling marker expression in grafted and ungrafted sheep tooth extraction sockets: A comparative randomised study. Archives of Oral Biology, 153, 105738. doi: 10.1016/j.archoralbio.2023.105738
Nobakht, S., Milne, T. J., Duncan, W. J., Ram, A., Tkatchenko, T., Dong, Z., & Coates, D. E. (2023). Expression of the pleiotrophin–midkine axis in a sheep tooth socket model of bone healing. Journal of Periodontal Research, 58, 109-121. doi: 10.1111/jre.13073
AlSamahi, S., Milne, T. J., Hussaini, H., Rich, A. M., & Friedlander, L. T. (2022). Type 2 diabetes and the clinically normal pulp: An in-vitro study. International Endodontic Journal, 55, 660-671. doi: 10.1111/iej.13732
Itskovich, Y., Meikle, M. C., Cannon, R. D., Farella, M., Coates, D. E., & Milne, T. J. (2021). Differential behaviour and gene expression in 3D cultures of femoral- and calvarial-derived human osteoblasts under a cyclic compressive mechanical load. European Journal of Oral Sciences, 129, e12818. doi: 10.1111/eos.12818
Perry, S. E., Huckabee, M.-L., Tompkins, G., & Milne, T. (2020). The association between oral bacteria, the cough reflex and pneumonia in patients with acute stroke and suspected dysphagia. Journal of Oral Rehabilitation, 47, 386-394. doi: 10.1111/joor.12903
Ram, A., Duncan, W. J., Coates, D. E., Nobakht, S., Tkatchenko, T., & Milne, T. J. (2023). Bone remodelling marker expression in grafted and ungrafted sheep tooth extraction sockets: A comparative randomised study. Archives of Oral Biology, 153, 105738. doi: 10.1016/j.archoralbio.2023.105738
Journal - Research Article
Nobakht, S., Milne, T. J., Duncan, W. J., Ram, A., Tkatchenko, T., Dong, Z., & Coates, D. E. (2023). Expression of the pleiotrophin–midkine axis in a sheep tooth socket model of bone healing. Journal of Periodontal Research, 58, 109-121. doi: 10.1111/jre.13073
Journal - Research Article
AlSamahi, S., Milne, T. J., Hussaini, H., Rich, A. M., & Friedlander, L. T. (2022). Type 2 diabetes and the clinically normal pulp: An in-vitro study. International Endodontic Journal, 55, 660-671. doi: 10.1111/iej.13732
Journal - Research Article
Itskovich, Y., Meikle, M. C., Cannon, R. D., Farella, M., Coates, D. E., & Milne, T. J. (2021). Differential behaviour and gene expression in 3D cultures of femoral- and calvarial-derived human osteoblasts under a cyclic compressive mechanical load. European Journal of Oral Sciences, 129, e12818. doi: 10.1111/eos.12818
Journal - Research Article
Perry, S. E., Huckabee, M.-L., Tompkins, G., & Milne, T. (2020). The association between oral bacteria, the cough reflex and pneumonia in patients with acute stroke and suspected dysphagia. Journal of Oral Rehabilitation, 47, 386-394. doi: 10.1111/joor.12903
Journal - Research Article
Reid, P., Heng, N. C. K., Hale, J. D., Krishnan, D., Crane, J., Tagg, J. R., & Milne, T. J. (2020). A TaqMan™-based quantitative PCR screening assay for the probiotic Streptococcus salivarius K12 based on the specific detection of its megaplasmid-associated salivaricin B locus [Note]. Journal of Microbiological Methods, 170, 105837. doi: 10.1016/j.mimet.2020.105837
Journal - Research Other
Firth, F. A., Milne, T. J., Seo, B., & Farella, M. (2020). An in-vitro mechanical strain three-dimensional culture model: Periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response. European Journal of Oral Sciences, 128, 120-127. doi: 10.1111/eos.12681
Journal - Research Article
James, J. E., Lamping, E., Santhanam, J., Milne, T. J., Razak, M. F. A., Zakaria, L., & Cannon, R. D. (2020). A 23 bp cyp51A promoter deletion associated with voriconazole resistance in clinical and environmental isolates of Neocosmospora keratoplastica. Frontiers in Microbiology, 11, 272. doi: 10.3389/fmicb.2020.00272
Journal - Research Article
McLaughlin, K. I., Milne, T. J., Zafar, S., Zanicotti, D. G., Cullinan, M. P., Seymour, G. J., & Coates, D. E. (2020). The in vitro effect of VEGF receptor inhibition on primary alveolar osteoblast nodule formation. Australian Dental Journal, 65, 196-204. doi: 10.1111/adj.12752
Journal - Research Article
Al-Hassiny, A., Hussani, H., Milne, T., Seo, B., Rich, A. M., & Friedlander, L. T. (2019). Vascularity and angiogenic signaling in the dentine-pulp complex of immature and mature permanent teeth. European Endodontic Journal, 4(2), 80-85. doi: 10.14744/eej.2019.26349
Journal - Research Article
Hidayat, M. F. H., Milne, T., Cullinan, M. P., & Seymour, G. J. (2018). Feasibility of the salivary transcriptome as a novel biomarker in determining disease susceptibility. Journal of Periodontal Research, 53(3), 369-377. doi: 10.1111/jre.12522
Journal - Research Article
Parachuru, V. P. B., Coates, D. E., Milne, T. J., Rich, A. M., & Seymour, G. J. (2018). FoxP3+ regulatory T cells, interleukin 17 and mast cells in chronic inflammatory periodontal disease. Journal of Periodontal Research, 53(4), 622-635. doi: 10.1111/jre.12552
Journal - Research Article
Al-Dujaili, M., Milne, T. J., Cannon, R. D., & Farella, M. (2018). Postnatal expression of chondrogenic and osteogenic regulatory factor mRNA in the rat condylar cartilage. Archives of Oral Biology, 93, 126-132. doi: 10.1016/j.archoralbio.2018.05.019
Journal - Research Article
Hasmun, N. N. b., Drummond, B. K., Milne, T., Cullinan, M. P., Meldrum, A. M., & Coates, D. (2017). Effects of environmental tobacco smoke on the oral health of preschool children. European Archives of Paediatric Dentistry, 18(6), 393-398. doi: 10.1007/s40368-017-0308-6
Journal - Research Article
Avadhani, A. V., Parachuru, V. P. B., Milne, T., Seymour, G. J., & Rich, A. M. (2017). Multiple cells express interleukin 17 in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 46(1), 39-45. doi: 10.1111/jop.12465
Journal - Research Article
Balaji, K., Milne, T. J., Drummond, B. K., Cullinan, M. P., & Coates, D. E. (2016). A comparison of salivary IgA in children with Down syndrome and their family members. Archives of Oral Biology, 67, 39-45. doi: 10.1016/j.archoralbio.2016.03.005
Journal - Research Article
Siddiqi, A., Milne, T., Cullinan, M. P., & Seymour, G. J. (2016). Analysis of P. gingivalis, T. forsythia and S. aureus levels in edentulous mouths prior to and 6 months after placement of one-piece zirconia and titanium implants. Clinical Oral Implants Research, 27, 288-294. doi: 10.1111/clr.12536
Journal - Research Article
Milne, T. J., Coates, D. E., Leichter, J. W., Soo, L., Williams, S. M., Seymour, G. J., & Cullinan, M. P. (2016). Periodontopathogen levels following the use of an Er:YAG laser in the treatment of chronic periodontitis. Australian Dental Journal, 61, 35-44. doi: 10.1111/adj.12306
Journal - Research Article
Sinon, S. H., Rich, A. M., Parachuru, V. P. B., Firth, F. A., Milne, T., & Seymour, G. J. (2016). Downregulation of toll-like receptor-mediated signalling pathways in oral lichen planus. Journal of Oral Pathology & Medicine, 45, 28-34. doi: 10.1111/jop.12319
Journal - Research Article
Zafar, S., Coates, D. E., Cullinan, M. P., Drummond, B. K., Milne, T., & Seymour, G. J. (2016). Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts. Clinical Oral Investigations, 20(8), 2023-2035. doi: 10.1007/s00784-015-1706-y
Journal - Research Article
Javvadi, L. R., Parachuru, V. P. B., Milne, T. J., Seymour, G. J., & Rich, A. M. (2016). Regulatory T-cells and IL17A+ cells infiltrate oral lichen planus lesions. Pathology, 48(6), 564-573. doi: 10.1016/j.pathol.2016.06.002
Journal - Research Article
Ohlrich, E. J., Coates, D. E., Cullinan, M. P., Milne, T. J., Zafar, S., Zhao, Y., Duncan, W. J., & Seymour, G. J. (2016). The bisphosphonate zoledronic acid regulates key angiogenesis-related genes in primary human gingival fibroblasts. Archives of Oral Biology, 63, 7-14. doi: 10.1016/j.archoralbio.2015.11.013
Journal - Research Article
Bisanz, J. E., Suppiah, P., Thomson, W. M., Milne, T., Yeoh, N., Nolan, A., … Cullinan, M. P., & Stebbings, S. M. (2016). The oral microbiome of patients with axial spondyloarthritis compared to healthy individuals. PeerJ, 4, e2095. doi: 10.7717/peerj.2095
Journal - Research Article
Parachuru, V. P. B., Coates, D. E., Milne, T. J., Hussaini, H. M., Rich, A. M., & Seymour, G. J. (2014). Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease. Journal of Periodontal Research, 49(6), 817-826. doi: 10.1111/jre.12169
Journal - Research Article
Zafar, S., Coates, D. E., Cullinan, M. P., Drummond, B. K., Milne, T., & Seymour, G. J. (2014). Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts. Journal of Oral Pathology & Medicine, 43, 711-721. doi: 10.1111/jop.12181
Journal - Research Article
Saminathan, A., Vinoth, K. J., Wescott, D. C., Pinkerton, M. N., Milne, T. J., Cao, T., & Meikle, M. C. (2012). The effect of cyclic mechanical strain on the expression of adhesion-related genes by periodontal ligament cells in two-dimensional culture. Journal of Periodontal Research, 47(2), 212-221. doi: 10.1111/j.1600-0765.2011.01423.x
Journal - Research Article
Milne, T. J., Ichim, I., Patel, B., McNaughton, A., & Meikle, M. C. (2009). Induction of osteopenia during experimental tooth movement in the rat: Alveolar bone remodelling and the mechanostat theory. European Journal of Orthodontics, 31(3), 221-231. doi: 10.1093/ejo/cjp032
Journal - Research Article
Pinkerton, M. N., Wescott, D. C., Gaffey, B. J., Beggs, K. T., Milne, T. J., & Meikle, M. C. (2008). Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation. Journal of Periodontal Research, 43(3), 343-351. doi: 10.1111/j.1600-0765.2007.01040.x
Journal - Research Article
Wescott, D. C., Pinkerton, M. N., Gaffey, B. J., Beggs, K. T., Milne, T. J., & Meikle, M. C. (2007). Osteogenic gene expression by human periodontal ligament cells under cyclic tension. Journal of Dental Research, 86(12), 1212-1216.
Journal - Research Article
Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J., & Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278(33), 31105-31110.
Journal - Research Article
Abbenante, G., Leung, D., Bond, T., & Fairlie, D. P. (2001). An efficient Fmoc strategy for the rapid synthesis of peptide para-nitroanilides. Letters in Peptide Science, 7, 347-351.
Journal - Research Article
Lewis, R. J., Nielsen, K. J., Craik, D. J., Loughnan, M. L., Adams, D. A., Sharpe, I. A., … Bond, T., … Alewood, P. F. (2000). Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. Journal of Biological Chemistry, 275(45), 35335-35344.
Journal - Research Article