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Contact Details

Phone
+64 3 479 7436
Email
julia.horsfield@otago.ac.nz
Position
Professor and Head of the Department of Pathology (Dunedin)
Department
Department of Pathology (Dunedin)
Qualifications
BSc(Hons) PhD DipAppSci
Research summary
Developmental biology, genetics and epigenetics

Research

Julia Horsfield is the Principal Investigator of the Chromosome Structure and Development Group, and the Director of the Otago Zebrafish Facility.

Research Detail
  • Understanding the roles of sister chromatid cohesin proteins in animal development.
  • Exploring a link between cohesin subunit RAD21 and cancer.
  • Investigating oxidative stress and ageing using the zebrafish model.

We are interested in how proteins necessary for normal chromosome architecture during the cell cycle can also contribute to gene expression, animal development and cancer. The main focus of our research is exploring alternative roles for proteins needed for sister chromatid cohesion during mitosis. To do most of our research, we are using the genetically amenable vertebrate animal model, the zebrafish.

Publications

Schenk, S., Horsfield, J. A., Dwoskin, L., & Johnson, S. L. (2024). Methamphetamine effects in zebrafish (Danio rerio) depend on behavioral endpoint, dose and test session duration. Pharmacology Biochemistry & Behavior, 240, 173777. doi: 10.1016/j.pbb.2024.173777 Journal - Research Article

Sethi, A., Darroch, H., Horsfield, J., Morris, V., & Göbl, C. (2023). Unravelling the functional impact of the p16INK4a transition into amyloid fibrils using zebrafish recombinant protein. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Lynch, D. M., Meier, M., Labudina, A., Antony, J., & Horsfield, J. A. (2023). How STAG proteins influence cohesins role in cell fate determination. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract

Labudina, A. A., Gimenez, G., Meier, M., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2023). Using a zebrafish stem cell model to understand the molecular basis of cohesinopathies. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract

Labudina, A. A., Gimenez, G., Meier, M., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2023). Using a zebrafish stem cell model to understand the molecular basis of cohesinopathies. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839 Conference Contribution - Published proceedings: Abstract

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