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Dr Thorsten Stanley, Department of Paediatrics and Child Health

photo-of-Tosh-Stanley

MB ChB DCH DObstRCOG FRCP
Senior Lecturer in the Department of Paediatrics

Email: thorsten.stanley@otago.ac.nz

Dr Thorsten Stanley completed his undergraduate studies at the University of Edinburgh, Scotland, and his paediatric specialty training in Yorkhill and Royal Maternity hospitals, Glasgow with a special interest in immunology, before coming to NZ initially as a Senior Lecturer in 1980.

Dr Stanley has clinical involvement in general paediatrics and neonatology and his outpatient clinics specialise in allergic disease.

He has been convenor of the Otago DCH diploma [CHHE702] course since 1997 and has also established and convened the Annual Regional Paediatric Update meetings for GPs since 2001. He also has extensive commitments in undergraduate teaching to both 5th and 6th year medical students. He continues to retain academic and clinical links with the University of Xiamen, China.

Research Interests

Dr Stanley's research interests have included immunology, paediatric infectious disease, neonatology, neurology and neonatal seizures but increasingly over the past decade have tended to focus on paediatric allergy and asthma.

Dr Stanley has been acting Head of the Academic Department from 1995-1997, 2007-2010, and March –July 2011.

Dr Stanley has developed expertise in medical misadventure and regularly advises both ACC and the Medical Council of New Zealand.

Dr Stanley's research has focused on the areas of allergy and infectious disease and he has increasingly been involved in collaborations with the Department of Medicine and in particular WARG (Wellington Asthma Research Group) and Public Health, and valuable collaborations with the Department of Paediatrics at Auckland Medical School, Massey University, and the University of Kuopio, Finland.

Recent research has looked at the role of probiotics in preventing and treating infant eczema and atopy, Vitamin D supplementation in bronchiolitis, dampness and fungal spores in childhood wheeze, the effectiveness of allergen desensitisation, the microbiome in asthma, effective asthma control by enhanced communication in pacific island asthmatic teenagers, the role of paracetamol in childhood asthma, the effect of plant species diversity in childhood asthma, probiotics for the treatment of food allergy and recently the use of faecal calprotectin in diagnosing non-IgE food allergy, and the use of probiotics in pregnancy to prevent gestational diabetes and to reduce postnatal anxiety and depression.

Ongoing research (HRC grants) include probiotic supplementation to prevent otitis media, endotoxin exposure to reduce childhood wheeze, mediators in asthma in adolescents and the use of faecal leucocyte esterase as an alternative to calprotectin in gut inflammation, and a new device for the treatment of allergic rhinitis.

Dr Stanley holds patents in the use of probiotics for the prevention of allergic disease, and for the prevention of postnatal anxiety and depression

Dr Stanley also collaborates with the Wellington Hospital CCDHB Clinical Research Unit [Director, Dr Marina Dzhelali] where he is a Principal Investigator, and has worked on vaccine development (e.g. RSV virus, influenza) and new treatments for infectious diseases, particularly bronchiolitis due to RSV, for over a decade.

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Publications

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Wickens, K., Black, P. N., Stanley, T. V., Mitchell, E., Fitzharris, P., Tannock, G. W., Purdie, G., Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., & Munro, K. (2008). A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial. Journal of Allergy & Clinical Immunology, 122(4), 788-794. doi: 10.1016/j.jaci.2008.07.011

Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., … Fitzharris, P., Siebers, R., … Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., Nicholson, A., & Purdie, G. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection. Clinical & Experimental Allergy, 38(10), 1606-1614. doi: 10.1111/j.1365-2222.2008.03061.x

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L. R. F., … Stanley, T., … de Jonghe, P. (2012). KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy. Annals of Neurology, 71(1), 15-25. doi: 10.1002/ana.22644

Journal - Research Article

Grinton, B. E., Heron, S. E., Pelekanos, J. T., Zuberi, S. M., Kivity, S., Afawi, Z., … Stanley, T., … Berkovic, S. F. (2015). Familial neonatal seizures in 36 families: Clinical and genetic features correlate with outcome. Epilepsia, 56(7), 1071-1080. doi: 10.1111/epi.13020

Marlow, G., Han, D. Y., Wickens, K., Stanley, T., Crane, J., Mitchell, E. A., … Barthow, C., … Morgan, A. R. (2015). Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatric Allergy & Immunology, 26(3), 262-271. doi: 10.1111/pai.12371

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Wickens, K., Black, P., Stanley, T. V., Mitchell, E., Barthow, C., Fitzharris, P., Purdie, G., & Crane, J. (2012). A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clinical & Experimental Allergy, 42(7), 1071-1079. doi: 10.1111/j.1365-2222.2012.03975.x

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L. R. F., … Stanley, T., … de Jonghe, P. (2012). KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy. Annals of Neurology, 71(1), 15-25. doi: 10.1002/ana.22644

Smith, C., Stanley, T., Crane, J., & Siebers, R. (2011). Do other components of bedding dust affect sensitisation to house dust mites? ISRN Allergy, 2011, 426941. doi: 10.5402/2011/426941

Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j.idairyj.2008.10.004

Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., … Fitzharris, P., Siebers, R., … Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., Nicholson, A., & Purdie, G. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection. Clinical & Experimental Allergy, 38(10), 1606-1614. doi: 10.1111/j.1365-2222.2008.03061.x

Wickens, K., Black, P. N., Stanley, T. V., Mitchell, E., Fitzharris, P., Tannock, G. W., Purdie, G., Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., & Munro, K. (2008). A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial. Journal of Allergy & Clinical Immunology, 122(4), 788-794. doi: 10.1016/j.jaci.2008.07.011

Harkin, L. A., McMahon, J. M., Iona, X., Dibbens, L., Pelekanos, J. T., Zuberi, S. M., Sadleir, L. G., … Stanley, T., … The Early Infantile Epileptic Encephalopathy Referral Consortium, … Scheffer, I. E. (2007). The spectrum of SCNIA-related infantile epileptic encephalopathies. Brain, 130, 843-852.

Sistek, D., Kelly, R., Wickens, K., Stanley, T., Fitzharris, P., & Crane, J. (2006). Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical & Experimental Allergy, 36, 629-633.

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Conference Contribution - Published proceedings: Abstract

Stanley, T., Rickard, D., Dellabarca, K., & Causer, S. (2011). Can preschool children with atopic eczema tolerate superfine merino wool cloth next to their skin? A pilot study. Allergy, 66(Suppl. 94), (pp. 105-106). doi: 10.1111/j.1398-9995.2011.02605.x

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L., … Stanley, T., … de Jonghe, P. (2011). KCNQ2 mutations are a cause of neonatal epileptic encephalopathies with a recognizable clinical and radiological phenotype. Epilepsia, 52(Suppl. 6), (pp. 17). [Abstract]

Ong, S. H., & Stanley, T. V. (2011). Predicting successful subcutaneous immunotherapy in children: Serial exhaled nitric oxide or combined serial aeroallergen skin prick test responses? Internal Medicine Journal, 41(Suppl. 4), P64, (pp. 19). doi: 10.1111/j.1445-5994.2011.02570.x

Wickens, K., Fitzharris, P., Stanley, T., Mitchell, E., & Crane, J. (2011). Does delaying the introduction of food in infancy increase the risk of atopic sensitisation? Allergy, 66(Suppl. 94), (pp. 47-48). doi: 10.1111/j.1398-9995.2011.02604.x

Barber, R., & Stanley, T. (2011). Management of acute and chronic food allergies in childhood: How do pediatricians, emergency physicians, general practitioners and junior hospital doctors differ in their approach and what is their level of understanding? A New Zealand nationwide email survey. Allergy, 66(Suppl. 94), (pp. 216). doi: 10.1111/j.1398-9995.2011.02606.x

Ong, S., & Stanley, T. (2011). Predicting successful subcutaneous immunotherapy in children: Do serial exhaled nitric oxide measurements assist? Allergy, 66(Suppl. 94), (pp. 211). doi: 10.1111/j.1398-9995.2011.02606.x

Crane, J., Wickens, K., Stanley, T., Mitchell, E., Barthow, C., Fitzharris, P., & Black, P. (2010). Staphylococcal colonisation and atopy. Internal Medicine Journal. 40(Suppl. 4), (pp. 6). doi: 10.1111/j.1445-5994.2010.02322.x

Stanley, T., Rickard, D., Wickens, K., & Villas-Boas, S. (2008). Gut permeability in infantile eczema: Relationship to severity, patch test responses and clinical history. Allergy. 63(Suppl. 88), (pp. 321-322). doi: 10.1111/j.1398-9995.2008.01760.x

Grinton, B., Heron, S., Pelekanos, J., Zuberi, S., Stanley, T., Kivity, S., … Berkovic, S. (2007). Benign familial neonatal seizures: Molecular basis and evidence for a third locus. Epilepsia, 48(Suppl. 7), (pp. 55-56). doi: 10.1111/j.1528-1167.2006.01370_7.x

Jones, B., Wickens, K., Nicholson, A., Malloy, S., Lampshire, P., Stanley, T., … Fitzharris, P., & Crane, J. (2006). Probiotics and the prevention of allergic disease: Treatment compliance at three months. Internal Medicine Journal. 36(Suppl. 6), (pp. A204). [Abstract]

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Conference Contribution - Verbal presentation and other Conference outputs

Jones, B., Wickens, K., Nicholson, A., Malloy, S., Lampshire, P., Stanley, T., Ingham, T. R., … Crane, J. (2006, September). Probiotics and the prevention of allergic disease: Treatment compliance at twelve months. Verbal presentation at the 17th Annual Scientific Meeting of the Australasian Society of Clinical Immunology & Allergy (ASCIA), Sydney, Australia.

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