Professor Wiltshire's primary areas of research involve investigation of the acute and chronic complications of diabetes, particularly their pathophysiology and early development, and also treatment. In this work Associate Professor Wiltshire has a major collaboration with Professor J Couper in South Australia. The aims of this research are to identify factors involved in the early pathogenesis of the vascular complications of diabetes, when interventions will have the greatest effect. In addition Associate Professor Wiltshire is a collaborator in the Australasian arm of “TrialNet”, a major international collaboration investigating treatments to prevent type 1 diabetes, and collaborates with Professor K Donaghue in Sydney, addressing aspects of autonomic dysfunction in children with diabetes. In addition, Professor Wiltshire has interests in other aspects of clinical paediatric endocrinology and metabolism, and has published scientific articles concerning clinical aspects of paediatric bone/calcium homeostasis, adrenal function and mitochondrial disease.
Peña, A. S., Wiltshire, E., MacKenzie, K., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2006). Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children.
Journal of Clinical Endocrinology & Metabolism,
91(11), 4467-4471.
Journal - Research Article
MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2006). Folate and vitamin B
6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
Pediatrics,
118, 242-253.
Journal - Research Article
Peña, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents.
Diabetes Care,
30(8), 2122-2127.
Journal - Research Article
Newton, K. H., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes.
Diabetes Care,
32(5), 813-815.
doi: 10.2337/dc08-1974
Journal - Research Article
Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., … Wiltshire, E., … Mootha, V. K. (2010). High-throughput, pooled sequencing identifies mutations in
NUBPL and
FOXRED1 in human complex I deficiency.
Nature Genetics,
42(10), 851-858.
doi: 10.1038/ng.659
Journal - Research Article
McTavish, L., & Wiltshire, E. (2011). Effective treatment of hypoglycemia in children with type 1 diabetes: A randomized controlled clinical trial.
Pediatric Diabetes,
12(4pt2), 381-387.
doi: 10.1111/j.1399-5448.2010.00725.x
Journal - Research Article
Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., … Wiltshire, E., … Mootha, V. K. (2010). High-throughput, pooled sequencing identifies mutations in
NUBPL and
FOXRED1 in human complex I deficiency.
Nature Genetics,
42(10), 851-858.
doi: 10.1038/ng.659
Journal - Research Article
Peña, A. S., Belobrajdic, D. P., Wiltshire, E., Gent, R., Hirte, C., & Couper, J. (2010). Adiponectin relates to smooth muscle function and folate in obese children.
International Journal of Pediatric Obesity,
5(2), 185-191.
doi: 10.3109/17477160903111748
Journal - Research Article
MacKenzie, K. E., Wiltshire, E. J., Peña, A. S., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2009). Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes.
Pediatric Diabetes,
10(1), 44-51.
doi: 10.1111/j.1399-5448.2008.00456.x
Journal - Research Article
Newton, K. H., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes.
Diabetes Care,
32(5), 813-815.
doi: 10.2337/dc08-1974
Journal - Research Article
Gleeson, H., Wiltshire, E., Briody, J., Hall, J., Chaitow, J., Sillence, D., … Munns, C. (2008). Childhood chronic recurrent multifocal osteomyelitis: Pamidronate therapy decreases pain and improves vertebral shape.
Journal of Rheumatology,
35(4), 707-712.
Journal - Research Article
Wiltshire, E. J., Mohsin, F., Chan, A., & Donaghue, K. C. (2008). Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes.
Pediatric Diabetes,
9(4, Part II), 348-353.
Journal - Research Article
Wiltshire, E., Davidzon, G., DiMauro, S., Akman, H. O., Sadleir, L., Haas, L., Zuccollo, J., McEwen, A., & Thorburn, D. R. (2008). Juvenile Alpers disease.
Archives of Neurology,
65(1), 121-124.
doi: 10.1001/archneurol.2007.14
Journal - Research Article
Fox, L., Sadowsky, J., Pringle, K. C., Kidd, A., Murdoch, J., Cole, D. E. C., & Wiltshire, E. (2007). Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant.
Pediatrics,
120(5), e1350-e1354.
Journal - Research Article
Peña, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents.
Diabetes Care,
30(8), 2122-2127.
Journal - Research Article
Wilson, C., Kerruish, N. J., Wilcken, B., Wiltshire, E., & Webster, D. (2007). The failure to diagnose inborn errors of metabolism in New Zealand: The case for expanded newborn screening.
New Zealand Medical Journal,
120(1262). Retrieved from
http://journal.nzma.org.nz/journal/120-1262/2727/content.pdf
Journal - Research Article
MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2006). Folate and vitamin B
6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
Pediatrics,
118, 242-253.
Journal - Research Article
Peña, A. S., Wiltshire, E., MacKenzie, K., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2006). Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children.
Journal of Clinical Endocrinology & Metabolism,
91(11), 4467-4471.
Journal - Research Article
Scott, A., Toomath, R., Bouchier, D., Bruce, R., Crook, N., Carroll, D., … Lunt, H., Wiltshire, E., & Wu, D. (2006). First national audit of the outcomes of care in young people with diabetes in New Zealand: High prevalence of nephropathy in Māori and Pacific Islanders.
New Zealand Medical Journal,
119(1235). Retrieved from
http://journal.nzma.org.nz/journal/119-1235/2015/content.pdf
Journal - Research Article
Wiltshire, E. J., Newton, K., & McTavish, L. (2006). Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the continuous glucose monitoring system: Prevalence and contributors.
Journal of Paediatrics & Child Health,
42, 758-763.
Journal - Research Article
Gibbs, S., Sadleir, L., Cole, D. E. C., Hendy, G. N., & Wiltshire, E. (2011). Does the calcium sensing receptor have a role in neuronal function and idiopathic epilepsy?
Proceedings of the 8th International Brain Research Organization (IBRO) World Congress. Retrieved from
http://www.abstractstosubmit.com/ibro2011/abstracts/
Conference Contribution - Published proceedings: Abstract
Tucker, E. J., Calvo, S. E., Compton, A. G., Goldberger, O. A., Wiltshire, E., Wilson, C. J., … Thorburn, D. R. (2010). High-throughput, pooled sequencing of a patient cohort identifies novel genes that cause human complex I deficiency.
Proceedings of the OzBio Combined Conference: The Molecules of Life: From Discovery to Biotechnology. (pp. 50). Retrieved from
http://www.asbmb.org.au/ozbio2010/abstracts.html
Conference Contribution - Published proceedings: Abstract
McTavish, L., & Wiltshire, E. (2009). Effective treatment of hypoglycaemia in children with type 1 diabetes: A randomised controlled clinical trial.
Hormone Research. 71(Suppl. 1), (pp. 148).
doi: 10.1159/000178060
Conference Contribution - Published proceedings: Abstract
McTavish, L., & Wiltshire, E. (2009). Effective treatment of hypoglycaemia in children with type 1 diabetes: A randomised controlled clinical trial.
Pediatric Diabetes,
10(Suppl. 11), (pp. 68). [Abstract]
Conference Contribution - Published proceedings: Abstract
Pena, A. S., Wiltshire, E. J., Harrington, J., MacKenzie, K., Gent, R., Piotto, L., … Couper, J. (2009). Deterioration in vascular function during puberty in adolescents with type 1 diabetes.
Hormone Research,
72(Suppl. 3), (pp. 57).
doi: 10.1159/000239668
Conference Contribution - Published proceedings: Abstract
Wiltshire, E. J., Pena, A. S., MacKenzie, K., Piotto, L., Gent, R., Bose, T., & Couper, J. J. (2009). Polymorphisms in endothelial nitric oxide synthase influence folate status and predict endothelial response to folate in children and adolescents with type 1 diabetes or obesity.
Hormone Research,
72(Suppl. 3), (pp. 58).
doi: 10.1159/000239668
Conference Contribution - Published proceedings: Abstract
Cowell, C. T., Gleeson, H. K., Wiltshire, E., Grimwood, K., Briody, J., Chaitow, J., … Munns, C. F. (2007). Chronic recurrent multifocal osteomyelitis: Effectiveness of cyclic intravenous pamidronate therapy in pain relief and spinal involvement.
Bone. 40(6, Suppl. 1), (pp. S34-S35). [Abstract]
Conference Contribution - Published proceedings: Abstract
Pena, A., Belobrajdic, D., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Adiponectin relates independently to vascular smooth muscle function to obese and non-obese children.
Hormone Research. 68(Suppl. 1), (pp. 129). [Abstract]
Conference Contribution - Published proceedings: Abstract
Peña, A., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese non diabetic children and adolescents.
Journal of Paediatrics and Child Health. 43, (pp. A1). [Abstract]
Conference Contribution - Published proceedings: Abstract