Principal Investigator
Professor Colin Brown
Professor Colin Brown's biography
Email colin.brown@otago.ac.nz
Tel +64 3 479 7354
Fax +64 3 479 7323
Department of Physiology website
Research interests
Our research group principally uses electrophysiology and immunohistochemistry to determine how the brain controls birth, lactation, and cardiovascular function. Our main focus is on how oxytocin and vasopressin contribute to preterm labour, high blood pressure and heart problems.
Clinical conditions
- Preterm labour
- Preeclampsia
- Hypertension
- Myocardial infarction
Professor Brown's researcher profile
The Colin Brown Laboratory has a code of conduct.
List of publications for Colin Brown (Google Scholar)
Colin Brown Laboratory staff & students
Phoebe Adler, PhD student
Email adlph682@student.otago.ac.nz
Jonty Small, Honours student
Anna-Catharina Veer, Honours student
Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.
Research Funders
- Health Research Council of New Zealand
- Royal Society of New Zealand Marsden Fund
- Lottery Health Research
- University of Otago Research Grant
- Wellcome Trust
Publications
Kumar, S. S., Bouwer, G. T., Jackson, M. K., Perkinson, M. R., McDonald, F. J., Brown, C. H., & Augustine, R. A. (2023). Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse. Brain Structure & Function, 228, 1535-1548. doi: 10.1007/s00429-023-02670-7 Journal - Research Article
Cheong, I., Brown, C. H., Sethi, S., & Lamberts, R. R. (2022, August-September). Time course of central nervous activation in type 2 diabetic rats. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2022, August-September). In vivo monitoring of oxytocin neuron activity in freely-behaving, lactating mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Stewart, A. C., Brown, E. F., Brown, C. H., & Fronius, M. (2022, August-September). Effect of F-actin on the mechanical activation of putative ΔN-TRPV1 and TRPV4 heteromers. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Adler, P. K., Perkinson, M. R., & Brown, C. H. (2022, August-September). Epithelial sodium channel regulation of vasopressin neuron activity. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
2023
Journal - Research Article
Kumar, S. S., Bouwer, G. T., Jackson, M. K., Perkinson, M. R., McDonald, F. J., Brown, C. H., & Augustine, R. A. (2023). Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse. Brain Structure & Function, 228, 1535-1548. doi: 10.1007/s00429-023-02670-7
2022
Journal - Research Article
Brown, E. F., Fronius, M., & Brown, C. H. (2022). Vasopressin regulation of maternal body fluid balance in pregnancy and lactation: A role for TRPV channels? Molecular & Cellular Endocrinology, 558, 111764. doi: 10.1016/j.mce.2022.111764
Abbasi, M., Augustine, R. A., Iremonger, K. J., & Brown, C. H. (2022). Central kisspeptin does not affect ERK1/2 or p38 phosphorylation in oxytocin neurons of late-pregnant rats. International Journal of Molecular Sciences, 23(14), 7729. doi: 10.3390/ijms23147729
Perkinson, M. R., Kirchner, M. K., Zhang, M., Augustine, R. A., Stern, J. E., & Brown, C. H. (2022). α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation. Physiological Reports, 10, e15226. doi: 10.14814/phy2.15226
Abbasi, M., Perkinson, M. R., Seymour, A. J., Piet, R., Campbell, R. E., Iremonger, K. J., & Brown, C. H. (2022). Local kisspeptin excitation of rat oxytocin neurones in late pregnancy. Journal of Physiology, 600(7), 1753-1770. doi: 10.1113/jp282531
Conference Contribution - Poster Presentation (not in published proceedings)
Cheong, I., Brown, C. H., Sethi, S., & Lamberts, R. R. (2022, August-September). Time course of central nervous activation in type 2 diabetic rats. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2022, August-September). In vivo monitoring of oxytocin neuron activity in freely-behaving, lactating mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Stewart, A. C., Brown, E. F., Brown, C. H., & Fronius, M. (2022, August-September). Effect of F-actin on the mechanical activation of putative ΔN-TRPV1 and TRPV4 heteromers. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Adler, P. K., Perkinson, M. R., & Brown, C. H. (2022, August-September). Epithelial sodium channel regulation of vasopressin neuron activity. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Vijayasekaran, S., Bird, P., Brown, C., Garland, R., & Ten Cate, W. (2022, February). Paediatric otology management controversies. Panel discussion at the New Zealand Society of Otolaryngology, Head & Neck Surgery (NZSOHNS) 74th Annual General & Scientific Meeting (ORL 21), Taupō, New Zealand.
2021
Journal - Research Article
Roy, R. K., Althammer, F., Seymour, A. J., Du, W., Biancardi, V. C., Hamm, J. P., … Brown, C. H., & Stern, J. E. (2021). Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge. Cell Reports, 37(5), 109925. doi: 10.1016/j.celrep.2021.109925
Sethi, S., Augustine, R. A., Bouwer, G. T., Perkinson, M. R., Cheong, I., Bussey, C. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2021). Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats. Journal of Neuroendocrinology, 33, e13016. doi: 10.1111/jne.13016
Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140
Li, T., Jia, S.-W., Hou, D., Liu, X., Li, D., Liu, Y., … Brown, C. H., & Wang, Y.-F. (2021). Intranasal oxytocin restoration of maternal behavior and oxytocin neuronal activity in the supraoptic nucleus in rat dams with pre-labor cesarean delivery. Neuroscience, 468, 235-246. doi: 10.1016/j.neuroscience.2021.06.020
Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., Silva, M. S. B., Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology, 33, e12972. doi: 10.1111/jne.12972
Journal - Research Other
Perkinson, M. R., Kim, J. S., Iremonger, K. J., & Brown, C. H. (2021). Visualising oxytocin neurone activity in vivo: The key to unlocking central regulation of parturition and lactation [Invited review]. Journal of Neuroendocrinology, 33, e13012. doi: 10.1111/jne.13012
2020
Journal - Research Other
Brown, C. H., Ludwig, M., Tasker, J. G., & Stern, J. E. (2020). Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation. Journal of Neuroendocrinology, 32, e12856. doi: 10.1111/jne.12856
Conference Contribution - Published proceedings: Abstract
Sethi, S., Augustine, R. A., Bouwer, G. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2020). Type 2 diabetes is associated with increased activation of brain regions that regulate sympathetic drive to the heart. New Zealand Medical Journal, 133(1527), (pp. 126). Retrieved from https://www.nzma.org.nz/journal
Brown, C. H., Roy, R. K., Hamm, J. P., & Stern, J. E. (2020). Development of a novel approach for real-time two-photon imaging of the rat hypothalamus in vivo. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.04797
Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2020). Characterisation of an oxytocin-ires-cre mouse model for recording oxytocin neuron bursts in behaving mice. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03560
Brown, E., Brown, C. H., & Fronius, M. (2020). Mechanosensitivity of TRPV channels: Implications for vasopressin neuron activity. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03561
Abbasi, M., Perkinson, M., Brown, C., & Iremonger, K. (2020). Kisspeptin regulation of oxytocin neuron activity in late pregnancy. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.02418
2019
Journal - Research Article
Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2019). Acute myocardial infarction activates magnocellular vasopressin and oxytocin neurons. Journal of Neuroendocrinology, 31, e12808. doi: 10.1111/jne.12808
Journal - Research Other
Zhang, L., Vaudry, D., Brown, C. H., & Eiden, L. E. (2019). Regulatory peptides in neuroscience and endocrinology: A new era begins. Frontiers in Endocrinology, 10, 793. doi: 10.3389/fendo.2019.00793
Conference Contribution - Published proceedings: Abstract
Augustine, R., Barad, Z., Wallace, R., Erickson, J., & Brown, C. (2019). Mapping o-linked glycosylation in the brain during pregnancy. Brain & Neuroscience Advances, 3, PM102. doi: 10.1177/2398212819855490
Seymour, A., Bourque, C., & Brown, C. (2019). Effect of the TRPV1 channel blocker SB-366791 on isolated vasopressin neurons from non-pregnant and late-pregnant rats. Brain & Neuroscience Advances, 3, PM101. doi: 10.1177/2398212819855490
Roy, R., Augustine, R., Schwenke, D., & Brown, C. (2019). Acute myocardial infarction activates magnocellular vasopressin and oxytocin neurons. Brain & Neuroscience Advances, 3, PS099. doi: 10.1177/2398212819855490
Kumar, S., Augustine, R., & Brown, C. (2019). Prolactin receptor-mediated stimulation of kisspeptin expression in periventricular nucleus projections to the oxytocin system in virgin mice. Brain & Neuroscience Advances, 3, PS097. doi: 10.1177/2398212819855490
Conference Contribution - Poster Presentation (not in published proceedings)
Murrell, C. L., Brown, C. H., & Augustine, R. A. (2019, September). Distribution of O-GlcNAc in glucose sensing areas of the rat brain. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Sethi, S., Augustine, R. A., Bouwer, G. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2019, August-September). Central mechanisms underlying cardiac dysfunction in type 2 diabetes. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Augustine, R. A., Dell, C., Wallace, R. S., Erickson, J. R., & Brown, C. H. (2019, August-September). Do mice with gestational glucose intolerance have increased O-linked glycosylation in the brain? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Murrell, C. L., Brown, C. H., & Augustine, R. A. (2019, August-September). Distribution of O-GlcNa in glucose sensing areas of the rat brain. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Abbasi, M., Perkinson, M. R., Iremonger, K. J., & Brown, C. H. (2019, August-September). Local kisspeptin regulation of oxytocin neuron activity in late pregnancy. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Seymour, A. J., Perkinson, M. R., & Brown, C. H. (2019, August-September). TRPV channels reset the threshold for vasopressin neuron activation in pregnant rats. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Brown, E., Brown, C. H., & Fronius, M. (2019, August-September). Mechanosensitivity of TRPV channels: Implications for vasopressin neuron activity. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Sethi, S., Augustine, R. A., Bouwer, G. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2019, September). Central regulation of the diabetic heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2018
Journal - Research Article
Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2018). Activation of oxytocin neurons in the paraventricular nucleus drives cardiac sympathetic nerve activation following myocardial infarction in rats. Communications Biology, 1, 160. doi: 10.1038/s42003-018-0169-5
Korpal, A. K., Brown, C. H., & Schwenke, D. O. (2018). Assessing the role of hypothalamic microglia and blood vessel disruption in the development of angiotensin II-dependent hypertension in Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 470(6), 883-895. doi: 10.1007/s00424-018-2128-x
Korpal, A. K., Han, S. Y., Schwenke, D. O., & Brown, C. H. (2018). A switch from GABA inhibition to excitation of vasopressin neurones exacerbates the development angiotensin II-dependent hypertension. Journal of Neuroendocrinology, 30(8), e12564. doi: 10.1111/jne.12564
Journal - Research Other
Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neurohumoral regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology, 30(8), e12569. doi: 10.1111/jne.12569
Conference Contribution - Published proceedings: Abstract
Brown, C. H., Jackson, M., & Augustine, R. (2018). Periventricular kisspeptin neurons project to the paraventricular nucleus in late-pregnant mice. Proceedings of the Society for Neuroscience 48th Annual Meeting. 774.04/YY20. SfN. Retrieved from https://www.sfn.org
Brown, C. H., Korpal, A. K., Han, S. Y., & Schwenke, D. O. (2018). Vasopressin exacerbates the development of hypertension. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 339). Retrieved from http://www.icn2018.org/
Kumar, S. S., Augustine, R. A., & Brown, C. H. (2018). Chronic prolactin administration does not affect kisspeptin or oxytocin expression in virgin mice. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 261). Retrieved from http://www.icn2018.org/
Augustine, R. A., Jackson, M., & Brown, C. H. (2018). Periventricular kisspeptin neurons send projections to the paraventricular nucleus in the mouse. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 246-247). Retrieved from http://www.icn2018.org/
Seymour, A. J., & Brown, C. H. (2018). TRPV regulation of vasopressin neuron firing rate in pregnant rats in vivo. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 140-141). Retrieved from http://www.icn2018.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Augustine, R. A., Kumar, S. S., & Brown, C. H. (2018, November). Plasticity in kisspeptin neuron projections to the oxytocin system in pregnancy. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Seymour, A. J., & Brown, C. H. (2018, November). TRPV regulation of vasopressin neuron firing rate in pregnant rats in vivo. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Sethi, S., Augustine, R. A., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2018, August). Central regulation of the diabetic heart. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Perkinson, M. R., Augustine, R. A., & Brown, C. H. (2018, August). Alpha-melanocyte-stimulating hormone switches from inhibition to excitation of oxytocin neurons in lactation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kumar, S. S., Augustine, R. A., & Brown, C. H. (2018, August). Chronic prolactin administration increases kisspeptin expression in virgin mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Brown, E., Brown, C. H., & Fronius, M. (2018, August). Mechanosensitivity of transient receptor potential vanilloid channels. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Barad, Z., Augustine, R. A., Wallace, R. S., Erickson, J. R., & Brown, C. H. (2018, August). Mapping O-linked glycosylation in the brain during pregnancy. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Augustine, R. A., Jackson, M., Bouwer, G. T., & Brown, C. H. (2018, August). Characterisation of periventricular nucleus kisspeptin neuron projections to oxytocin neurons in pregnancy and lactation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kumar, S. S., Augustine, R. A., & Brown, C. H. (2018, November). Towards safer births. Verbal presentation at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Schwenke, D. O., Ranjan, R., & Brown, C. H. (2018, August). Oxytocin is sympathetic to a broken heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Abbasi, M., Iremonger, K. J., & Brown, C. H. (2018, August). Kisspeptin regulation of oxytocin neuron activity in late pregnancy. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kumar, S. S., Augustine, R. A., & Brown, C. H. (2018, August). Chronic prolactin administration increases kisspeptin expression in virgin mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2017
Journal - Research Article
Augustine, R. A., Ladyman, S. R., Bouwer, G. T., Alyousif, Y., Sapsford, T. J., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2017). Prolactin regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Physiology, 595(11), 3591-3605. doi: 10.1113/jp273712
Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051
Conference Contribution - Published proceedings: Abstract
Brown, C. H., & Augustine, R. A. (2017). Alpha-melanocyte stimulating hormone regulation of oxytocin neuron activity in lactation. Proceedings of the Society for Neuroscience 47th Annual Meeting. 785.09/KK26. SfN. Retrieved from https://www.sfn.org/
Seymour, A. J., Augustine, R. A., & Brown, C. H. (2017). Regulation of supraoptic nucleus vasopressin neuron activity by TRPV in lactating rats. Proceedings of the Society for Neuroscience 47th Annual Meeting. 161.06/OO36. SfN. Retrieved from https://www.sfn.org/
Nair, B., Khant Aung, Z., Porteous, R., Prescott, M., Ng, J., Yip, S., Augustine, R., Glendining, K., Bouwer, G., Kim, J., Jenkins, D., Silva, M., Brown, C., Campbell, R., Jasoni, C., Bunn, S., Anderson, G., Grattan, D., Herbison, A., & Iremonger, K. (2017). Impact of chronic stress on the neuroendocrine axis in the mouse. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 49). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Seymour, A. J., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. New Zealand Medical Journal, 130(1460), (pp. 98). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Augustine, R. A., Kumar, S. S., & Brown, C. H. (2017, September). Paraventricular nucleus kisspeptin fibres originate from kisspeptin cell bodies located in the periventricular nucleus. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Brown, E., Seymour, A. J., & Brown, C. H. (2017, September). TRPV1 expression in the supraoptic nucleus of pregnant rats. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Kumar, S. S., Augustine, R. A., & Brown, C. H. (2017, September). Prolactin effects on kisspeptin fibre expression in the paraventricular and supraoptic nucleus of the mouse. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Augustine, R. A., Kumar, S. S., & Brown, C. H. (2017, September). Paraventricular nucleus kisspeptin fibres arise from kisspeptin cell bodies located in the periventricular nucleus in the mouse. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Seymour, A. J., Jaquiery, Z., Augustine, R. A., & Brown, C. H. (2017, September). TRPV regulation of magnocellular neurosecretory cell activity in lactation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Rance, N., Padilla, S., Szawka, R., Brown, C., & Oka, Y. (2017, March). How do kisspeptin neurons participate in regulation of body temperature, stress and other non-reproductive functions? Verbal presentation at the 3rd World Conference on Kisspeptin, Orlando, USA.
Brown, C. H. (2017, September). Stating the obvious? Vasopressin neurons contribute to increased blood pressure during the development of hypertension. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2016
Chapter in Book - Research
Brown, C. H. (2016). Magnocellular neurons and posterior pituitary function. In D. M. Pollock (Ed.), Comprehensive physiology (Vol. 6). (pp. 1701-1741). American Physiological Society. doi: 10.1002/cphy.c150053
Journal - Research Article
Kim, J. S., Brown, C. H., & Anderson, G. M. (2016). Anti-opioid effects of RFRP-3 on magnocellular neuron activity in morphine-naïve and morphine-treated female rats. Endocrinology, 157(10), 4003-4011. doi: 10.1210/en.2016-1374
Royo, J. M., Brown, C. H., Leng, G., & MacGregor, D. J. (2016). Oxytocin neurones: Intrinsic mechanisms governing the regularity of spiking activity. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12358
Augustine, R. A., Bouwer, G. T., Seymour, A. J., Grattan, D. R., & Brown, C. H. (2016). Reproductive regulation of gene expression in the hypothalamic supraoptic and paraventricular nuclei. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12350
Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605
Journal - Professional & Other Non-Research Articles
Brown, C. H., & Bosch, O. J. (2016). Vasopressin and oxytocin: Conductors of the symphony of physiology and behaviour. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12386
Conference Contribution - Published proceedings: Abstract
Roy, R. K., Brown, C. H., & Schwenke, D. O. (2016). Central modulation of cardiac sympathetic nerve activity following acute myocardial infarction. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Brown, C. H., & Augustine, R. A. (2016). Reproductive status does not affect phasic activity patterning in hypothalamic vasopressin neurons. Proceedings of the Society for Neuroscience 46th Annual Meeting. 817.04/TT9. SfN. Retrieved from https://www.sfn.org/
Korpal, A., Schwenke, D. O., & Brown, C. H. (2016). Vasopressin contributes to the development of angiotensin II-dependent hypertension. Proceedings of the Society for Neuroscience 46th Annual Meeting. 341.08/WW1. SfN. Retrieved from https://www.sfn.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Roy, R. K., Brown, C. H., & Schwenke, D. O. (2016, August-September). Magnocellular neuronal activation in response to acute myocardial infarction. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Augustine, R. A., Bouwer, G. T., Seymour, A. J., & Brown, C. H. (2016, August). Increase in kisspeptin fibre projection to the oxytocin system in late pregnancy in the mouse. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Schwenke, D. O., Roy, R., & Brown, C. H. (2016, August-September). Identifying the neural network that triggers sympathetic activation following acute myocardial infarction. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Brown, C. H., Korpal, A. K., Han, S. Y., & Schwenke, D. O. (2016, August-September). Contribution of vasopressin neurons to the development of angiotensin-dependent hypertension. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Roy, R. K., Brown, C. H., & Schwenke, D. O. (2016, August). Magnocellular neuronal activation in response to acute myocardial infarction. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Seymour, A. J., Piet, R., Campbell, R. E., & Brown, C. H. (2016, August). Regulation of oxytocin neurons by central kisspeptin in late-pregnant rats. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2016, August). Vasopressin secretion exacerbates the development of angiotensin II-dependent hypertension. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Chapter in Book - Research
Brown, C. H., Han, S. Y., Moaddab, M., Scott, V., & Schwenke, D. O. (2015). Peptidergic control of oxytocin and vasopressin neurons and its role in reproduction and hypertension-associated plasticity. In W. E. Armstrong & J. G. Tasker (Eds.), Neurophysiology of neuroendocrine neurons. (pp. 63-84). Chichester, UK: Wiley Blackwell. doi: 10.1002/9781118606803.ch3
Journal - Research Article
Han, S. Y., Bouwer, G. T., Seymour, A. J., Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat. European Journal of Neuroscience, 42(9), 2690-2698. doi: 10.1111/ejn.13062
Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular & Cellular Neuroscience, 68, 323-330. doi: 10.1016/j.mcn.2015.08.013
Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., … Brown, C. H., … Bourque, C. W. (2015). High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron, 85(3), 549-560. doi: 10.1016/j.neuron.2014.12.048
Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin enhances the expression of morphine-induced conditioned place preference in rats. Psychoneuroendocrinology, 53, 159-169. doi: 10.1016/j.psyneuen.2015.01.003
Conference Contribution - Published proceedings: Abstract
Seymour, A., Piet, R., Campbell, R. E., & Brown, C. H. (2015). Kisspeptin does not affect excitatory postsynaptic currents in supraoptic nucleus neurons from virgin or pregnant rats. Proceedings of the Society for Neuroscience 45th Annual Meeting. 613.23/S18. SfN. Retrieved from https://www.sfn.org
Kim, J., Brown, C. H., & Anderson, G. M. (2015). In vivo electrophysiological evidence demonstrating the anti-opioid effect of the neuropeptide FF system. Proceedings of the Society for Neuroscience 45th Annual Meeting. 73.20/Q19. SfN. Retrieved from https://www.sfn.org
Roy, R. K., Brown, C. H., & Schwenke, D. O. (2015). Myocardial infarction increases Fos protein expression in the paraventricular and supraoptic nuclei. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 62-63). Retrieved from http://wcnh.otago.ac.nz/index.html
Augustine, R. A., Bouwer, G. T., & Brown, C. H. (2015). Kisspeptin regulation of oxytocin neurons in pregnant mice. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 61-62). Retrieved from http://wcnh.otago.ac.nz/index.html
Bouwer, G. T., Jaquiery, Z., Augustine, R. A., & Brown, C. H. (2015). Osmotic responsiveness of supraoptic nucleus neurons in virgin and lactating rats. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 51). Retrieved from http://wcnh.otago.ac.nz/index.html
Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of angiotensin II-dependent hypertension does not activate microglia in the hypothalamic supraoptic and paraventricular nuclei. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 40). Retrieved from http://wcnh.otago.ac.nz/index.html
Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., … Brown, C. H., … Bourque, C. W. (2015). Salt loading increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreceptor inhibition of vasopressin neurons. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 35-36). Retrieved from http://wcnh.otago.ac.nz/index.html
Seymour, A. J., Piet, R., Campbell, R. E., & Brown, C. H. (2015). Emergence of a kisspeptin projection from the periventricular nucleus to the perinuclear zone of the supraoptic nucleus during pregnancy. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 31). Retrieved from http://wcnh.otago.ac.nz/index.html
Kim, J. S., Brown, C. H., & Anderson, G. M. (2015). Blockade of the anti-opioid effects of the neuropeptide FF system using a novel antagonist reverses morphine tolerance in vasopressin neurons. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 23). Retrieved from http://wcnh.otago.ac.nz/index.html
Conference Contribution - Poster Presentation (not in published proceedings)
Kim, J., Brown, C., & Anderson, G. (2015, September). Anti-opioid effects of RFamide related peptide-‐3 and reversal of morphine tolerance using a novel antagonist. Poster session presented at the 3rd Joint Meeting of the British and French Societies for Neuroendocrinology (BSN-SNE), Lille, France.
Roy, R. K., Brown, C. H., & Schwenke, D. O. (2015, August-September). Central modulation of cardiac sympathetic nerve activity following acute myocardial infarction. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015, August-September). BDNF and TrkB expression are not changed in the hypothalamic supraoptic and paraventricular nuclei during the development of angiotensin II-dependent hypertension. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kim, J. S., Brown, C. H., & Anderson, G. M. (2015, August-September). Reversal of morphine tolerance by modulating the neuropeptide FF receptor system. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Seymour, A. J., Piet, R., Campbell, R. E., & Brown, C. H. (2015, August-September). Kisspeptin does not affect excitatory or inhibitory synaptic transmission in magnocellular neurosecretory cells from virgin or late-pregnant rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2014
Journal - Research Article
Joe, N., Scott, V., & Brown, C. H. (2014). Glial regulation of extrasynaptic NMDA receptor-mediated excitation of supraoptic nucleus neurons during dehydration. Journal of Neuroendocrinology, 26(1), 35-42. doi: 10.1111/jne.12121
Han, S. Y., Gray, E., Hughes, G., Brown, C. H., & Schwenke, D. O. (2014). Increased sympathetic drive during the onset of hypertension in conscious Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 466(3), 459-466. doi: 10.1007/s00424-013-1338-5
Conference Contribution - Published proceedings: Abstract
Roy, R. K., Brown, C. H., & Schwenke, D. O. (2014). Central modulation of cardiac sympathetic nerve activity following acute myocardial infarction. Proceedings of the Medical Sciences Congress (MedSci). (pp. 32). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Korpal, A. K., Brown, C. H., & Schwenke, D. O. (2014). Neuroinflammation in the development of hypertension. Proceedings of the Medical Sciences Congress (MedSci). (pp. 31). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Seymour, A. J., Campbell, R. E., & Brown, C. H. (2014). Kisspeptin fibres in the perinuclear zone of the supraoptic nucleus originate from the periventricular nucleus. Proceedings of the Medical Sciences Congress (MedSci). (pp. 16). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Seymour, A., Campbell, R., & Brown, C. (2014). Periventricular nucleus kisspeptin neurons project to the perinuclear zone of the supraoptic nucleus. New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal
Choe, K., Han, S., Gaub, P., Shell, B., Knapp, B., Barker, P., Brown, C., … Bourque, C. (2014). Brain-derived neurotrophic factor causes chloride gradient collapse in supraoptic neurons inducing vasopressin-mediated blood pressure increase. FASEB Journal, 28(1, Suppl.), LB847. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Moaddab, M., Hyland, B., & Brown, C. (2014, September). Prior morphine exposure decreases oxytocin excitation of nucleus accumbens shell neurons. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
2013
Journal - Research Article
Brown, C. H., Bains, J. S., Ludwig, M., & Stern, J. E. (2013). Physiological regulation of magnocellular neurosecretory cell activity: Integration of intrinsic, local and afferent mechanisms. Journal of Neuroendocrinology, 25(8), 678-710. doi: 10.1111/jne.12051
Scott, V., & Brown, C. H. (2013). Beyond the GnRH axis: Kisspeptin regulation of the oxytocin system in pregnancy and lactation. Advances in Experimental Medicine & Biology, 784, 201-218. doi: 10.1007/978-1-4614-6199-9_10
Conference Contribution - Published proceedings: Abstract
Moaddab, M., Hyland, B., & Brown, C. (2013). Prior morphine exposure blocks oxytocin excitation of nucleus accumbens shell neurons. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions
Conference Contribution - Poster Presentation (not in published proceedings)
Seymour, A. J., Scott, V., Campbell, R. E., & Brown, C. H. (2013, August). Hypothalamic kisspeptin and neurokinin B immunoreactivity is increased in late pregnant rats. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Augustine, R. A., & Brown, C. H. (2013, August). JAK/STAT signalling in oxytocin neurons of the supraoptic and paraventricular nuclei during pregnancy and lactation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Jaquiery, Z., Brown, C., Scott, V., & Augustine, R. (2013, August). Trpv1 channel regulation of supraoptic nucleus magnocellular neuron activity in vivo. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Han, S. Y., Schwenke, D. O., & Brown, C. H. (2013, August). Hypertension-induced plasticity in vasopressin neuron activity in Cyplal-Ren2 (inducible hypertensive) rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Moaddab, M., Hyland, B. I., & Brown, C. H. (2013, August). Intracerebroventricular administration of oxytocin enhances nucleus accumbens shell neuronal activity in morphine-naive but not morphine-treated rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2012
Journal - Research Article
Tasker, J. G., Oliet, S. H. R., Bains, J. S., Brown, C. H., & Stern, J. E. (2012). Glial regulation of neuronal function: From synapse to systems physiology. Journal of Neuroendocrinology, 24(4), 566-576. doi: 10.1111/j.1365-2826.2011.02259.x
Journal - Professional & Other Non-Research Articles
de Vries, G. J., Veenema, A. H., & Brown, C. H. (2012). Vasopressin and oxytocin: Keys to understanding the neural control of physiology and behaviour. Journal of Neuroendocrinology, 24(4), 527. doi: 10.1111/j.1365-2826.2012.02305.x
Conference Contribution - Published proceedings: Abstract
Joe, N., Scott, V., & Brown, C. H. (2012). Glial GABA transporters modulate supraoptic nucleus neuron excitation by dehydration. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Han, S., Schwenke, D. O., & Brown, C. H. (2012). Induction of hypertension increases supraoptic nucleus vasopressin neuron activity in Cyp1a1-Ren2 rats. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Scott, V., Seymour, A. J., Campbell, R. E., & Brown, C. H. (2012). Kisspeptin regulation of the oxytocin system in pregnancy and lactation. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Choe, K. Y., Han, S., Gaub, P., Little, J. T., Shell, B., Barker, P. A., Brown, C., … Bourque, C. W. (2012). Chronic salt-loading depolarizes chloride reversal potential through TrkB-mediated downregulation of KCC2 and abolishes baroreceptor inhibition in rat vasopressin neurons. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Moaddab, M., Hyland, B. I., & Brown, C. H. (2012). Central oxytocin enhances morphine-induced conditioned place preference in the rat. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Han, S., Schwenke, D., & Brown, C. (2012). Induction of hypertension blunts baroreflex inhibition of vasopressin neuron activity in Cyp1a1-Ren2 (inducible hypertensive) rats. New Zealand Medical Journal, 125(1364). Retrieved from http://www.nzma.org.nz/journal
Augustine, R., Bouwer, G., Scott, V., Seymour, A., Grattan, D. R., & Brown, C. H. (2012). Increased expression of suppressors of cytokine signalling in the supraoptic and paraventricular nuclei of pregnant and lactating rats. Proceedings of the Medical Sciences Congress (MedSci). (pp. 62). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Moaddab, M., Hyland, B. I., & Brown, C. H. (2012). Intra-nucleus accumbens oxytocin administration enhances morphine-induced conditioned place preference in the rat. Proceedings of the Medical Sciences Congress (MedSci). (pp. 57). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Scott, V., Seymour, A. J., Campbell, R. E., & Brown, C. H. (2012). Regulation of the oxytocin system by kisspeptin. Proceedings of the Medical Sciences Congress (MedSci). (pp. 36-37). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Joe, N., Scott, V., & Brown, C. H. (2012). Extrasynaptic NMDA receptors modulate the activity of supraoptic nucleus neurons during dehydration. Proceedings of the Medical Sciences Congress (MedSci). (pp. 36). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Seymour, A., Augustine, R., Scott, V., & Brown, C. (2012). Changes in rat supraoptic nucleus gene expression in pregnancy and lactation. New Zealand Medical Journal, 125(1355). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Moaddab, M., Hyland, B. I., & Brown, C. H. (2012, September). Intra-nucleus accumbens oxytocin administration enhances morphone-induced conditioned place preference in the rat. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
2011
Journal - Research Article
Fleming, T. M., Scott, V., Naskar, K., Joe, N., Brown, C. H., & Stern, J. E. (2011). State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signalling in neurosecretory neurons. Journal of Physiology, 589(16), 3929-3941. doi: 10.1113/jphysiol.2011.207340
Scott, V., & Brown, C. H. (2011). Kisspeptin activation of supraoptic nucleus neurons in Vivo. Endocrinology, 152(10), 3862-3870. doi: 10.1210/en.2011-1181
Bull, P. M., Russell, J. A., Scott, V., & Brown, C. H. (2011). Apamin increases post-spike excitability of supraoptic nucleus neurons in anaesthetized morphine-naïve rats and morphine-dependent rats: Consequences for morphine withdrawal excitation. Experimental Brain Research, 212(4), 517-528. doi: 10.1007/s00221-011-2759-z
Ruan, M., Russell, J. A., & Brown, C. H. (2011). Acute morphine administration and withdrawal from chronic morphine increase afterdepolarization amplitude in rat supraoptic nucleus neurons in hypothalamic explants. Neuropharmacology, 61, 789-797. doi: 10.1016/j.neuropharm.2011.05.025
Conference Contribution - Published proceedings: Abstract
Augustine, R. A., Bouwer, G. T., Scott, V., Grattan, D. R., & Brown, C. H. (2011). Effects of prolactin on signal transduction pathways in the supraoptic and paraventricular nuclei of diestrous and lactating rats. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.15. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Scott, V., & Brown, C. H. (2011). A hormonal action of kisspeptin activates supraoptic nucleus neurons in vivo. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 4.2. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Brown, C. H., Ruan, M., Bull, P. M., & Russell, J. A. (2011). Contribution of post-spike after-potentials to morphine withdrawal excitation of supraoptic nucleus neurons. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 3.5. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Han, S., Schwenke, D., & Brown, C. (2011). Induction of hypertension increases vasopressin neuron activity in Cyp1a1-Ren2 rats. New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf
Scott, V., & Brown, C. (2011). Hormonal activation of oxytocin and vasopressin neurons by peripheral kisspeptin. New Zealand Medical Journal, 124(1342). Retrieved from http://journal.nzma.org.nz/journal/124-1342/4875/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Han, S. Y., Schwenke, D. O., & Brown, C. H. (2011, August). Induction of hypertension increases vasopressin neuron activity in Cyp1a1-Ren2 (inducible hypertensive) rats. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Scott, V., & Brown, C. H. (2011, July). Hormonal activation of oxytocin and vasopressin neurons by peripheral kisspeptin. Verbal presentation at the 9th World Congress on Neurohypophysial Hormones (WCNH), Boston, MA.
2010
Journal - Research Article
Scott, V., & Brown, C. H. (2010). State-dependent plasticity in vasopressin neurones: Dehydration-induced changes inactivity patterning. Journal of Neuroendocrinology, 22(5), 343-354. doi: 10.1111/j.1365-2826.2010.01961.x
Journal - Professional & Other Non-Research Articles
Brown, C. H., Oiso, Y., & Ueta, Y. (2010). Vasopressin and oxytocin: Focus in the post-genomic era [Editorial]. Journal of Neuroendocrinology, 22, 317. doi: 10.1111/j.1365-2826.2010.01985.x
Conference Contribution - Published proceedings: Abstract
Joe, N., Scott, V., & Brown, C. (2010). Modulation of supraoptic nuclei neuronal activity by a glial γ-amino butyric acid transporter. New Zealand Medical Journal, 123(1327). Retrieved from http://journal.nzma.org.nz/journal/123-1327/4493/content.pdf
Joe, N., Scott, V., & Brown, C. (2010). The role of glia in supraoptic nuclei neuron responses to dehydration. New Zealand Medical Journal, 123(1314). Retrieved from http://journal.nzma.org.nz/journal/123-1314/4120/content.pdf
Brown, C. (2010). Hormonal regulation of energy balance in pregnancy. Proceedings of the Centre for Reproduction and Genomics Second Annual Research Colloquium. (pp. 10). Retrieved from http://www.crg.org.nz/colloquium/colloquium.aspx
Conference Contribution - Poster Presentation (not in published proceedings)
Joe, N., Scott, V., Fleming, T. M., Stern, J. E., & Brown, C. H. (2010, November-December). Modulation of dehydration-induced increases in magnocellular neurosecretory cell activity by glial neurotransmitter transporters. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
Han, S. Y., Schwenke, D. O., & Brown, C. H. (2010, November-December). Telemetric monitoring of blood pressure during induction of hypertension in Cyp1a1-Ren2 rats. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
Abdul, N., Brown, C. H., & Scott, V. (2010, November-December). The effects of kisspeptin on supraoptic nucleus oxytocin neurons. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Scott, V., & Brown, C. H. (2010, November-December). A role for kisspeptin during pregnancy? Activation of oxytocin neurons in vivo. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2009
Journal - Research Article
Scott, V., Bishop, V. R., Leng, G., & Brown, C. H. (2009). Dehydration-induced modulation of κ-opioid inhibition of vasopressin neurone activity. Journal of Physiology, 587(23), 5679-5689. doi: 10.1113/jphysiol.2009.180232
Ruan, M., & Brown, C. H. (2009). Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization. Journal of Physiology, 587(Pt 5), 1043-1056. doi: 10.1113/jphysiol.2008.167239
Conference Contribution - Published proceedings: Abstract
Fleming, T. M., Scott, V., Brown, C. H., & Stern, J. E. (2009). Ambient glutamate levels under astrocytic control enhance excitability of supraoptic nucleus (SON) neurons. An in vitro and in vivo study. FASEB Journal, 23(Meeting Asbstracts), 792.16. [Abstract]
Alyousif, Y., Scott, V., Kokay, I., Grattan, D., & Brown, C. (2009). Cellular mechanisms of prolactin regulation of oxytocin neurons in reproduction. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf
Scott, V., & Brown, C. H. (2009). Kisspeptin activation of oxytocin neurons in vivo. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Brown, C. H., Ruan, M., & Scott, V. (2009). The role of intrinsic membrane properties in pattern generation in the brain. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Alyousif, Y., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2009). Cellular mechanisms of prolactin regulation of oxytocin neurons in reproduction. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
2008
Journal - Research Article
Brown, C. H., Ruan, M., Scott, V., Tobin, V. A., & Ludwig, M. (2008). Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons. Progress in Brain Research, 170, 219-228.
Brown, C. H., Brunton, P. J., & Russell, J. A. (2008). Rapid estradiol-17β modulation of opioid actions on the electrical and secretory activity of rat oxytocin neurons in vivo. Neurochemical Research, 33(4), 614-623.
Leng, G., Brown, C., Sabatier, N., & Scott, V. (2008). Population dynamics in vasopressin cells. Neuroendocrinology, 88(3), 160-172.
Conference Contribution - Published proceedings: Abstract
Brown, C. H., & Ruan, M. (2008). Endogenous adenosine inhibits spike discharge by enhancement of the medium afterhyperpolarization. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
Conference Contribution - Verbal presentation and other Conference outputs
Brown, C. H., & Ruan, M. (2008, November). Endogenous adenosine increases medium afterhyperpolarization amplitude to generate phasic activity in vassopressin neurons. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Scott, V., & Brown, C. H. (2008, November). Continued kappa-opioid restraint of vasopressin neuron activity in dehydration. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Brown, C. (2008, June). Pattern generation by single neurons. Verbal presentation at the Brain Health and Repair Research Centre 2nd Annual Conference, Dunedin, New Zealand.
2007
Journal - Research Article
Brown, C. H., Scott, V., Ludwig, M., Leng, G., & Bourque, C. W. (2007). Somatodendritic dynorphin release: Orchestrating activity patterns of vasopressin neurons. Biochemical Society Transactions, 35(5), 1236-1242.
Brown, C. H., & Grattan, D. R. (2007). Does maternal oxytocin protect the fetal brain? Trends in Endocrinology & Metabolism, 18(6), 225-226.
Conference Contribution - Published proceedings: Abstract
Brown, C. H., & Scott, V. (2007). Cutting out the middle-man: Autocrine inhibition of vasopressin secretion by central neuropeptide release. Endocrine Journal, 54(Suppl), (pp. 90). [Abstract]
Brown, C. H., Bull, P. M., & Russell, J. A. (2007). Apamine increases the firing rate of phasic, but not continuously -active, vasopressin neurons in vivo. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp
Brown, C. H., Bull, P. M., & Russell, J. A. (2007). The medium after-hyperpolarization contributes to morphine withdrawal excitation of rat oxytocin neurons in vivo. Endocrine Journal. 54(Suppl.), (pp. 184). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Scott, V., & Brown, C. H. (2007, November). Vasopressin neuron activity during dehydration. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Brown, C. H., Bull, P. M., & Russell, J. A. (2007, November). Inhibition of the medium afterhyperpolarization increases the firing rate of phasic vasopressin neurons in vivo. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
2006
Journal - Research Article
Bull, P. M., Brown, C. H., Russell, J. A., & Ludwig, M. (2006). Activity-dependent feedback modulation of spike patterning of supraoptic nucleus neurons by endogenous adenosine. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 291, R83-R90. doi: 10.1152/ajpregu.00744.2005
Brown, C. H., Leng, G., Ludwig, M., & Bourque, C. W. (2006). Endogenous activation of supraoptic nucleus κ-opioid receptors terminates spontaneous phasic bursts in rat magnocellular neurosecretory cells. Journal of Neurophysiology, 95, 3235-3244.
Brown, C. H., & Bourque, C. W. (2006). Mechanisms of rhythmogenesis: Insights from hypothalamic vasopressin neurons. Trends in Neurosciences, 29(2), 108-115.
Conference Contribution - Published proceedings: Abstract
Brown, C. H., Bull, P. M., & Russell, J. A. (2006). Functional contribution of the medium after-hyperpolarization to morphine withdrawal excitation of rat supraoptic nucleus cells in vivo. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
Conference Contribution - Poster Presentation (not in published proceedings)
Brown, C. H., Bull, P. M., & Russell, J. A. (2006, October). Functional contribution of the medium after-hyperpolarization to morphine withdrawal excitation of rat supraoptic nucleus cells in vivo. Poster session presented at the Neuroscience Meeting, Atlanta, GA.
Conference Contribution - Verbal presentation and other Conference outputs
Brown, C. H., Bull, P. M., & Russell, J. A. (2006, November-December). The medium after-hyperpolarization conributes to morphine withdrawal excitation of rat oxytocin neurons in vivo. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.
2005
Chapter in Book - Research
Roper, P., Brown, C. H., Bourque, C. W., & Armstrong, W. E. (2005). Autoregulation of bursting of AVP neurons of the rat hypothalamus. In S. Coombes & P. C. Bressloff (Eds.), Bursting: The genesis of rhythm in the nervous system. (pp. 49-88). Singapore: World Scientific.
Brown, C. H. (2005). Autocrine modulation of excitability by dendritic peptide release from magnocellular neurosecretory cells. In M. Ludwig (Ed.), Dendritic neurotransmitter release. (pp. 223-237). New York: Kluwer Academic.
Journal - Research Article
Brown, C. H., Stern, J. E., Jackson, K. L. M., Bull, P. M., Leng, G., & Russell, J. A. (2005). Morphine withdrawal increases intrinsic excitability of oxytocin neurons in morphine-dependent rats. European Journal of Neuroscience, 21, 501-512.
Conference Contribution - Published proceedings: Abstract
Ludwig, M., Brown, C. H., & Bull, P. M. (2005). Differential effects of endogenous adenosine on continuous and phasic activity in rat supraoptic nucleus neurones in vivo. The Physiologist. 48(3), (pp. 151). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Brown, C. H., Leng, G., & Bourque, C. W. (2005, December). Autocrine generation of rhythmic activity in vasopressin neurons. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Brown, C. H., & Bourque, C. W. (2005, December). Activity dependent kappa-opioid inhibition of intrinsic membrane properties in vasopressin neurons. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
2004
Journal - Research Article
Johnstone, L. E., Leng, G., & Brown, C. (2004). Effects of neurotensin on the organization of activity in supraoptic nucleus cells in virgin and lactating rats. Journal of Neuroendocrinology, 16, 605-611.
Brown, C., & Bourque, C. W. (2004). Autocrine feedback inhibition of plateau potentials terminates phasic bursts in magnocellular neurosecretory cells of the rat supraoptic nucleus. Journal of Physiology, 557(3), 949-960.
Engelmann, M., Bull, P. M., Brown, C., Landgraf, R., Horn, T. F. W., Singewald, N., … Wotjak, C. T. (2004). GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus. European Journal of Neuroscience, 19, 601-608.
Brown, C., Ludwig, M., & Leng, G. (2004). Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in vasopressin cells. Neuroscience, 124, 105-111.
Brown, C., & Russell, J. A. (2004). Cellular mechanisms underlying neuronal excitability during morphine withdrawal in physical dependence: Lessons from the magnocellular oxytocin system. Stress, 7(2), 97-107.
Brown, C. (2004). Rhythmogenesis in vasopressin cells. Journal of Neuroendocrinology, 16, 727-739.
Sabatier, N., Brown, C., Ludwig, M., & Leng, G. (2004). Phasic spike patterning in rat supraoptic neurones in vivo and in vitro. Journal of Physiology, 558(1), 161-180.
Brown, C., Bull, P. M., & Bourque, C. W. (2004). Phasic bursts in rat magnocellular neurosecretory cells are not intrinsically regenerative in vivo. European Journal of Neuroscience, 19, 2977-2983.
Conference Contribution - Published proceedings: Abstract
Russell, J. A., Stern, J. E., Jackson, K. L., Bull, P. M., Leng, G., & Brown, C. (2004). Morphine withdrawal increases intrinsic excitability in oxytocin neurones. Proceedings of the Society for Neuroscience 34th Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2004/main.html
Brown, C., & Bourque, C. W. (2004). Effects of kappa-opioid receptor antagonism on spontaneous phasic activity in magnocellular neurosecretory cells in vitro. Proceedings of the Society for Neuroscience 34th Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.schlarone.com/itin2004/main.html
Conference Contribution - Verbal presentation and other Conference outputs
Brown, C. (2004, September). Intrinsic control of excitability in magnocellular neurosecretory cells. Verbal presentation at the Japan Partnering Workshop
2003
Journal - Research Article
Bull, P. M., Ludwig, M., Blackburn-Munro, G. J., Delgado-Cohen, H., Brown, C., & Russell, J. A. (2003). The role of nitric oxide in morphine dependence and withdrawal excitation of rat oxytocin neurons. European Journal of Neuroscience, 18, 2545-2551.
Conference Contribution - Published proceedings: Abstract
Brown, C., Ludwig, M., & Leng, G. (2003). Time course of the autocrine feedback effects of co-released peptides on the firing rate of vasopressin cells in vivo. Proceedings of the Society for Neuroscience Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2003
Conference Contribution - Verbal presentation and other Conference outputs
Brown, C., & Bourque, C. W. (2003, August). Autocrine modulation of rhythmogenesis in vasopressin cells. Verbal presentation at the World Congress on Neurohypophysical Hormones, Kyoto, Japan.
Brown, C., Ludwig, M., Leng, G., & Bourque, C. W. (2003, November). Feedback effects of dynorphin on vasopressin cell activity. Verbal presentation at the Autoregulation of Magnocellular Neurosecretory Neurons Workshop, New Orleans, LA, USA.
Brown, C. (2003, August). Signal processing by vasopressin neurones. Verbal presentation at the Computation and Control in Spiking Neuronal Networks Conference, Edinburgh, UK.
2002
Conference Contribution - Published proceedings: Abstract
Brown, C., & Bourque, C. W. (2002). Involvement of vesicular release in activity-dependent inhibition of plateau potentials in supraoptic nucleus neurons. Proceedings of the Society for Neuroscience Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2002/main.html?
2001
Journal - Research Article
Doi, N., Brown, C., Delgado Cohen, H., Leng, G., & Russell, J. A. (2001). Effects of the endogenous opioid peptide, endomorphin 1, on supraoptic nucleus oxytocin and vasopressin neurones in vivo and in vitro. British Journal of Pharmacology, 132, 1136-1144.
Leng, G., Brown, C., & et al (2001). Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: An experimental and theoretical analysis. Journal of Neuroscience, 21(17), 6967-6977.
Conference Contribution - Published proceedings: Abstract
Brown, C., & Bourque, C. W. (2001). Endogeneous opioid inhibition of depolarising after-potentials in supraoptic nucleus cells. Proceedings of the Society for Neuroscience Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2001/main.html?
Russell, J. A., Blackburn-Munro, G. J., Delgado-Cohen, H., Brown, C., Bull, P. M., Leng, G., & Ludwig, M. (2001). The role of nitric oxide in morphine withdrawal excitation of oxytocin neurones in rats. Proceedings of the Society for Neuroscience Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2001/main.html?
Conference Contribution - Verbal presentation and other Conference outputs
Brown, C., & Bourque, C. (2001, September). Activity-dependent endogenous opioid inhibition of post-spike depolarising after-potentials (DAPs) in magnocellular neurosecretory cells (MNCs). Verbal presentation at the World Congress on Neurohypophysial Hormones, Bordeaux, France.
2000
Journal - Research Article
Russell, J. A., Brown, C., & Leng, G. (2000). Opioid modulation of magnocellular neurosecretory cell activity. Neuroscience Research, 36, 97-120.
Brown, C., & Leng, G. (2000). In vivo modulation of post-spike excitability in vasopressin cells by κ-opioid receptor activation. Journal of Neuroendocrinology, 12, 711-714.
Blackburn-Munro, G., Brown, C., Neumann, I. D., Landgraf, R., & Russell, J. A. (2000). Verapamil prevents withdrawal excitation of oxytocin neurones in morphine-dependent rats. Neuropharmacology, 39, 1596-1607.
Johnstone, L. E., Brown, C., & et al (2000). Local morphine withdrawal increases c-fos gene, Fos protein, and oxytocin gene expression in hypothalamic magnocellular neurosecretory cells. Journal of Neuroscience, 20(3), 1272-1280.
Brown, C., Johnstone, L. E., Murphy, N. P., Leng, G., & Russell, J. A. (2000). Local injection of pertussis toxin attenuates morphine withdrawal excitation of rat supraoptic nucleus neurones. Brain Research Bulletin, 52(2), 115-121.
Conference Contribution - Published proceedings: Abstract
Johnstone, L. E., Brown, C., & Leng, G. (2000). Neurotensin administration increases vasopressin cell but not oxytocin cell firing rate in anesthetised virgin rats. Proceedings of the Society for Neuroscience Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2000/main.html?
Meddle, S. L., Deviche, P., Maclean, J. R., Brown, C., & Wingfield, J. C. (2000). Immunocytochemical localization of GNRH I and its precursor in the hypothalamus of photorefractory male dark-eyed juncos (Junco hyemalis) of different year classes. Proceedings of the Society for Neuroscience Annual Meeting. Washington, DC: SfN. Retrieved from http://sfn.scholarone.com/itin2000/main.html?