Red X iconGreen tick iconYellow tick icon
Skip to main content

Dr Indranil Basak

Contact Details

Phone
+64 3 479 3570
Email
indranil.basak@otago.ac.nz

University Links

Position
Research Fellow
Department
Department of Biochemistry
Research summary
Batten Disease; Neurodegeneration

Research

Indranil is a research fellow in the Department of Biochemistry. He joined the University of Otago in June 2018 to work with Prof. Stephanie Hughes. Indranil's research aims to understand the underlying mechanisms involved in neurodegeneration in Batten and Parkinson’s disease. Indranil obtained a Ph.D. in Biological Sciences from St. John's University, New York, focusing on Parkinson's disease.

While studying neurodegeneration in Batten disease, Indranil has established in vitro induced pluripotent stem cell-derived human neuronal, astrocyte, and organoid models. Using these models, CRISPR technology, multi-omics, and the expertise gained from his Ph.D., Indranil started studying the genetic forms of Parkinson's disease. Indranil is currently investigating lysosomal function and metal homeostasis in Parkinson’s disease with the help of independent funding from the Neurological Foundation of New Zealand.

Using his non-coding RNA expertise gained in his Ph.D. and first postdoctoral training at the University of Utah, Indranil is also keen to understand how non-coding RNAs regulate neuronal health. Funding from the Royal Society Marsden Fund and the University of Otago Research Grants is helping Indranil to investigate non-coding RNAs in neuronal lysosomes and Parkinson’s disease.

Besides research, Indranil has supervised honours, Master’s, and Ph.D. students, and lectured at undergraduate (Gene360) and postgraduate levels (Gene412). Indranil is involved in several service roles with the Brain Health Research Centre, Aotearoa Brain Project, and Otago CRISPR-Hub. Indranil has led several workshops/symposia on career development for early career researchers and is passionate about helping prospective students in their research and career progression.

Publications

Stoller, M. L., Basak, I., Denorme, F., Rowley, J. W., Alsobrooks, J., Parsawar, K., … Campbell, R. A. (2022). Neutrophil cathepsin G proteolysis of protease activated receptor 4 generates a novel, functional tethered ligand. Blood Advances, 6(7), 2303-2308. doi: 10.1182/bloodadvances.2021006133

Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences, 78, 4735-4763. doi: 10.1007/s00018-021-03813-x

Basak, I., Hansen, R. A., Ward, M. E., & Hughes, S. M. (2021). Deficiency of the lysosomal protein CLN5 alters lysosomal function and movement. Biomolecules, 11, 1412. doi: 10.3390/biom11101412

Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., … Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood, 136(15), 1760-1772. doi: 10.1182/blood.2020005230

Basak, I., Bhatlekar, S., Manne, B. K., Stoller, M., Hugo, S., Kong, X., … Bray, P. F. (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of Thrombosis & Haemostasis, 17(3), 511-524. doi: 10.1111/jth.14382

Stoller, M. L., Basak, I., Denorme, F., Rowley, J. W., Alsobrooks, J., Parsawar, K., … Campbell, R. A. (2022). Neutrophil cathepsin G proteolysis of protease activated receptor 4 generates a novel, functional tethered ligand. Blood Advances, 6(7), 2303-2308. doi: 10.1182/bloodadvances.2021006133

Journal - Research Article

Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences, 78, 4735-4763. doi: 10.1007/s00018-021-03813-x

Journal - Research Other

Basak, I., Hansen, R. A., Ward, M. E., & Hughes, S. M. (2021). Deficiency of the lysosomal protein CLN5 alters lysosomal function and movement. Biomolecules, 11, 1412. doi: 10.3390/biom11101412

Journal - Research Article

Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., … Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood, 136(15), 1760-1772. doi: 10.1182/blood.2020005230

Journal - Research Article

Basak, I., Bhatlekar, S., Manne, B. K., Stoller, M., Hugo, S., Kong, X., … Bray, P. F. (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of Thrombosis & Haemostasis, 17(3), 511-524. doi: 10.1111/jth.14382

Journal - Research Article

Bhatlekar, S., Basak, I., Edelstein, L. C., Campbell, R. A., Lindsey, C. R., Italiano, Jr, J. E., … Bray, P. F. (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083. doi: 10.3324/haematol.2018.204685

Journal - Research Article

Patil, K. S., Basak, I., Dalen, I., Hoedt, E., Lange, J., Lunde, K. A., … Møller, S. G. (2019). Combinatory microRNA serum signatures as classifiers of Parkinson's disease. Parkinsonism & Related Disorders, 64, 202-210. doi: 10.1016/j.parkreldis.2019.04.010

Journal - Research Article

Abdullah, R., Patil, K. S., Rosen, B., Pal, R., Prabhudesai, S., Lee, S., Basak, I., … Møller, S. G. (2017). Subcellular Parkinson’s disease-specific alpha-synuclein species show altered behavior in neurodegeneration. Molecular Neurobiology, 54(10), 7639-7655. doi: 10.1007/s12035-016-0266-8

Journal - Research Article

Prabhudesai, S., Bensabeur, F. Z., Abdullah, R., Basak, I., Baez, S., Alves, G., … Møller, S. G. (2016). LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Journal of Neuroscience Research, 94(8), 717-735. doi: 10.1002/jnr.23754

Journal - Research Article

Basak, I., Patil, K. S., Alves, G., Larsen, J. P., & Møller, S. G. (2016). MicroRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases. Cellular & Molecular Life Sciences, 73(4), 811-827. doi: 10.1007/s00018-015-2093-x

Journal - Research Article

Patil, K. S., Basak, I., Pal, R., Ho, H.-P., Alves, G., Chang, E. J., … Møller, S. G. (2015). A proteomics approach to investigate miR-153-3p and miR-205-5p targets in neuroblastoma cells. PLoS ONE, 10(12), e0143969. doi: 10.1371/journal.pone.0143969

Journal - Research Article

Basak, I., Pal, R., Patil, K. S., Dunne, A., Ho, H.-P., Lee, S., … Møller, S. G. (2014). Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins. Journal of Biological Chemistry, 289(21), 14458-14469. doi: 10.1074/jbc.M114.548156

Journal - Research Article

Patil, K. S., Basak, I., Lee, S., Abdullah, R., Larsen, J. P., & Møller, S. G. (2014). PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons. Journal of Neuroscience Research, 92(9), 1167-1177. doi: 10.1002/jnr.23396

Journal - Research Article

Back to top