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Christopher J. Charles

BSc(Cant) MSc(Cant) PhD(Otago)


Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand

Current roles

  • Research Professor Christchurch Heart Institute
  • Co-Director, Physiology Division, Christchurch Heart Institute
  • Named Investigator, HRC Programme Grant
  • Concurrent appointment with Cardiovascular Research Institute (CVRI), National University Singapore

Research interests

  • Integrative cardiovascular, endocrine and renal physiology of pressure / volume homeostasis
  • Bioactivity of vasoactive hormones including natriuretic peptides, adrenomedullins and urocortins
  • Pathophysiology of myocardial infarction, heart failure and sudden cardiac death

Professional memberships / roles

  • 2008-present, Executive Council and Treasurer, NZ Society Medical Sciences (MedSci)


Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2024). Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure. JACC: Heart Failure, 12(1), 100-113. doi: 10.1016/j.jchf.2023.08.028 Journal - Research Article

Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015 Journal - Research Article

Tian, X., Zeng, Q., Kurt, S. A., Li, R. R., Nguyen, D. T., Xiong, Z., … Charles, C. J., & Ho, J. S. (2023). Implant-to-implant wireless networking with metamaterial textiles. Nature Communications, 14, 4335. doi: 10.1038/s41467-023-39850-2 Journal - Research Article

Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290 Journal - Research Article

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure, 11(2), 227-239. doi: 10.1016/j.jchf.2022.11.006 Journal - Research Article

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