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Christopher J. Charles

BSc(Cant) MSc(Cant) PhD(Otago)


Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand

Current roles

  • Research Professor Christchurch Heart Institute
  • Co-Director, Physiology Division, Christchurch Heart Institute
  • Named Investigator, HRC Programme Grant
  • Concurrent appointment with Cardiovascular Research Institute (CVRI), National University Singapore

Research interests

  • Integrative cardiovascular, endocrine and renal physiology of pressure / volume homeostasis
  • Bioactivity of vasoactive hormones including natriuretic peptides, adrenomedullins and urocortins
  • Pathophysiology of myocardial infarction, heart failure and sudden cardiac death

Professional memberships / roles

  • 2008-present, Executive Council and Treasurer, NZ Society Medical Sciences (MedSci)


Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015

Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2023). Combined inhibition of phosphodiesterases 5 and 9 in experimental heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2023.08.028

Tian, X., Zeng, Q., Kurt, S. A., Li, R. R., Nguyen, D. T., Xiong, Z., … Charles, C. J., & Ho, J. S. (2023). Implant-to-implant wireless networking with metamaterial textiles. Nature Communications, 14, 4335. doi: 10.1038/s41467-023-39850-2

Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2022.11.006

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