Professor Madhav Bhatia's research focuses on inflammation, and he is the head of the Inflammation Research Group at the University of Otago, Christchurch.
Professor Bhatia leads an active research programme on the molecular pharmacology and molecular pathology of inflammatory conditions, such as acute pancreatitis, polymicrobial sepsis, burns, and arthritis.
His research has shown hydrogen sulfide and substance P as mediators of inflammation and potential therapeutic targets for inflammatory diseases. Professor Bhatia is interested in defining the mechanism by which hydrogen sulfide and substance P contribute to inflammation.
The Group's research has shown a key role of chemokines in inflammatory diseases, and of pancreatic acinar cell apoptosis in acute pancreatitis. The Group has also been working on novel markers for diagnosis and prognosis of inflammatory and infectious diseases
The long-term goal of this research is to translate this knowledge to the clinic, and early results in this direction have been promising.
Funding
The Inflammation Research Group is supported by:
Lottery Health
Canterbury Medical Research Foundation
Arthritis New Zealand
University of Otago Research Grant
Maurice & Phyllis Paykel Trust
Health Reseach Council of New Zealand Singapore Networking Grant
Royal Scoiety of New Zealand's Catalyst: Leaders New Zealand-China Scientist Exchange Programme
Prior to moving to Christchurch, Professor Bhatia's research was supported by research grants from Biomedical Research Council, Singapore, National Medical Research Council, Singapore, Academic Research Fund, National University of Singapore, Singapore, and Defence Science and Technology Agency-National University of Singapore Joint Applied R&D Co-operation Programme, Singapore.
Major review articles
Publications to peer reviewed literature: More than 190 papers and review articles, and more than 130 abstracts published in journals.
Citations: More than 14000 (One article cited more than 1000 times, and 39 articles cited more than 100 times).
“h” index: 60
Zhu Z, Chambers S, Zeng Y, and Bhatia M. Gases in sepsis: novel mediators and therapeutic targets. Int J Mol Sci. 2022; 23: 3669.
Lian X, Scott-Thomas A, Lewis JG, Bhatia M, MacPherson S, Zeng Y, and Chambers S. Monoclonal antibody and invasive aspergillosis: diagnostic and therapeutic perspectives. Int J Mol Sci. 2022; 23: 5563.
Kumar A, and Bhatia M. Role of hydrogen sulfide, substance P, and adhesion molecules in acute pancreatitis. Int J Mol Sci. 2021; 22: 12136.
Patel BK, Patel KH, Bhatia M, Iyer SG, Madhavan KK, and Moochhala SM. Gut microbiome in acute pancreatitis-A review based on current literature. World J Gastroenterol. 2021; 27: 5019-5036.
Bhatia M, and Gaddam R. Hydrogen sulfide in inflammation: a novel mediator and therapeutic target. Antioxid Redox Signal. 2021; 34: 1368-1377.
Dawoodbhoy FM, Patel BK, Patel K, Bhatia M, Lee CN, and Moochhala SM. Gut microbiota dysbiosis as a target for improved post-surgical outcomes and improved patient care. A review of current literature. Shock. 2021; 55: 441–454.
Bhatia M. Understanding hydrogen sulfide in inflammation: opportunities and challenges (Editorial). Mol Cell Ther. 2019; 7: 9-14.
Gaddam RR, Jha P, and Bhatia M. The infections and hydrogen sulfide. Frontiers in Anti-Infective Drug Discovery. (Eds. Rahman AU, and Choudhary MI). 2018; 7: 261-272.
Pan LL, Li J, Shamoon M, Bhatia M, and Sun J. Recent advances on nutrition in treatment of acute pancreatitis. Front Immunol. 2017; 8: 762.
Shamoon M, Chen Y, Bhatia M, and Sun J. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016; 20: 73-87.
Bhatia M. H2S and inflammation - an overview. Handb Exp Pharmacol. 2015; 230: 165-180.
Bhatia M. H2S and substance P in inflammation. Meth Enzymol. 2015; 555: 195-205.
Bhatia M, Zemans RL, and Jeyaseelan S. Role of chemokines in the pathogenesis of acute lung injury. Amer J Resp Cell Mol Biol. 2012; 46: 566-572.
Rivers J, Badiei A, and Bhatia M. Hydrogen sulfide as a therapeutic target for inflammation. Expert Opin Ther Targets. 2012; 16: 439-449.
Bhatia M. Hydrogen sulfide and substance P in inflammation. Antioxid Redox Signal. 2010; 12: 1191-1202.
Watch Prof. Bhatia's IPL, Inflammation: A new frontier of medicine, Feb 2011. Part 1, Part 2, Part 3
Publications
Manandhar, S., Chambers, S., Miller, A., Ishii, I., & Bhatia, M. (2023). Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells. International Journal of Molecular Sciences, 24, 13650. doi: 10.3390/ijms241713650
Journal - Research Article
Pan, L.-L., Ren, Z.-N., Yang, J., Li, B.-B., Huang, Y.-W., Song, D.-X., … Bhatia, M., … Sun, J. (2023). Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria. Acta Pharmaceutica Sinica B. Advance online publication. doi: 10.1016/j.apsb.2023.08.002
Journal - Research Article
Zhu, Z., & Bhatia, M. (2023). Inflammation and organ injury the role of substance P and its receptors. International Journal of Molecular Sciences, 24, 6140. doi: 10.3390/ijms24076140
Journal - Research Other
Tian, H., Li, J., Chen, X., Ren, Z., Pan, X., Huang, W., Bhatia, M., … Sun, J. (2023). Oral delivery of mouse β-defensin 14 (mBD14)-producing Lactococcus lactis NZ9000 attenuates experimental colitis in mice. Journal of Agricultural & Food Chemistry. Advance online publication. doi: 10.1021/acs.jafc.2c07098
Journal - Research Article
Ishii, I., & Bhatia, M. (2023). Amino acids in health and disease: The good, the bad, and the ugly. International Journal of Molecular Sciences, 24, 4931. doi: 10.3390/ijms24054931
Journal - Research Other
Lian, X., Chambers, S., Lewis, J. G., Scott-Thomas, A., & Bhatia, M. (2022). Two monoclonal antibodies that specifically recognize aspergillus cell wall antigens and can detect circulating antigens in infected mice. International Journal of Molecular Sciences, 23, 252. doi: 10.3390/ijms23010252
Journal - Research Article
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2022). A novel monoclonal antibody 1D2 that broadly inhibits clinically important Aspergillus species. Journal of Fungi, 8, 960. doi: 10.3390/jof8090960
Journal - Research Article
Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639
Journal - Research Article
Manandhar, S., Sinha, P., Ejiwale, G., & Bhatia, M. (2021). Hydrogen sulfide and its interaction with other players in inflammation. In Y.-C. Zhu (Ed.), Advances in hydrogen sulfide biology: Advances in experimental medicine and biology (Vol. 1315). (pp. 129-159). Singapore: Springer. doi: 10.1007/978-981-16-0991-6_6
Chapter in Book - Research
Ellmers, L. J., Templeton, E. M., Pilbrow, A. P., Frampton, C., Ishii, I., Moore, P. K., Bhatia, M., Richards, A. M., & Cameron, V. A. (2020). Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice. International Journal of Molecular Sciences, 21(12), 4284. doi: 10.3390/ijms21124284
Journal - Research Article
Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191
Journal - Research Article
Pan, L.-L., Niu, W., Fang, X., Liang, W., Li, H., Chen, W., … Bhatia, M., & Sun, J. (2019). Clostridium butyricum strains suppress experimental acute pancreatitis by maintaining intestinal homeostasis. Molecular Nutrition & Food Research, 63, 1801419. doi: 10.1002/mnfr.201801419
Journal - Research Article
Pan, L.-L., Deng, Y.-Y., Wang, R., Wu, C., Li, J., Niu, W., … Bhatia, M., … Sun, J. (2018). Lactose induces phenotypic and functional changes of neutrophils and macrophages to alleviate acute pancreatitis in mice. Frontiers in Immunology, 9, 751. doi: 10.3389/fimmu.2018.00751
Journal - Research Article
Lv, J., Bhatia, M., & Wang, X. (2017). Roles of mitochondrial DNA in energy metabolism. In H. Sun & X. Wang (Eds.), Mitochondrial DNA and diseases: Advances in experimental medicine and biology (Vol. 1038). (pp. 71-83). Singapore: Springer Nature. doi: 10.1007/978-981-10-6674-0_6
Chapter in Book - Research
Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005
Journal - Research Article
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755
Journal - Research Article
Gillies, N. A., Pendharkar, S. A., Singh, R. G., Windsor, J. A., Bhatia, M., & Petrov, M. S. (2017). Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines. Archives of Physiology & Biochemistry, 123(4), 238-248. doi: 10.1080/13813455.2017.1308382
Journal - Research Article
Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472
Journal - Research Article
Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762
Journal - Research Article
Singh, P. M., Reid, K., Gaddam, R., Bhatia, M., Smith, S., Jacob, A., & Chambers, P. (2017). Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep. Veterinary Anaesthesia & Analgesia, 44(5), 1149-1155. doi: 10.1016/j.vaa.2017.01.002
Journal - Research Article
Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9
Journal - Research Article
Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z
Journal - Research Article
Deng, Y.-Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13(5), 3881-3885. doi: 10.3892/mmr.2016.5008
Journal - Research Article
Dong, Z., Shang, H., Chen, Y. Q., Pan, L.-L., Bhatia, M., & Sun, J. (2016). Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxidative Medicine & Cellular Longevity, 2016, 7864150. doi: 10.1155/2016/7864150
Journal - Research Article
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521
Journal - Research Article
Shamoon, M., Deng, Y., Chen, Y. Q., Bhatia, M., & Sun, J. (2016). Therapeutic implications of innate immune system in acute pancreatitis. Expert Opinion on Therapeutic Targets, 20(1), 73-87. doi: 10.1517/14728222.2015.1077227
Journal - Research Article
Bhatia, M. (2015). H2S and inflammation: An overview. In P. K. Moore & M. Whiteman (Eds.), Chemistry, biochemistry and pharmacology of hydrogen sulfide (Handbook of experimental pharmacology, Vol. 230). (pp. 165-180). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-18144-8_8
Chapter in Book - Research
Bhatia, M. (2015). H2S and substance P in Inflammation. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen sulfide in redox biology, Part B (Vol. 555). (pp. 195-205). Elsevier. doi: 10.1016/bs.mie.2014.11.024
Chapter in Book - Research
Badiei, A., Gieseg, S., Davies, S., Othman, M. I., & Bhatia, M. (2015). LPS up-regulates cystathionine γ-lyase gene expression in Primary human macrophages via NF-κB/ERK pathway. Inflammation & Allergy Drug Targets, 14(2), 99-104. doi: 10.2174/1871528114666151201201719
Journal - Research Article
Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007
Journal - Research Article
Ang, A. D., Rivers-Auty, J., Hegde, A., Ishii, I., & Bhatia, M. (2013). The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. American Journal of Physiology: Gastrointestinal & Liver Physiology, 305, G712-G721. doi: 10.1152/ajpgi.00044.2013
Journal - Research Article
Badiei, A., Rivers-Auty, J., Ang, A. D., & Bhatia, M. (2013). Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Applied Microbiology & Biotechnology, 97(17), 7845-7852. doi: 10.1007/s00253-013-5080-x
Journal - Research Article
Ang, A. D., Konigstorfer, A., Giles, G. I., & Bhatia, M. (2012). Measuring free tissue sulfide. Advances in Biological Chemistry, 2(4), 360-365. doi: 10.4236/abc.2012.24044
Journal - Research Article
Bhatia, M., Zemans, R. L., & Jeyaseelan, S. (2012). Role of chemokines in the pathogenesis of acute lung injury. American Journal of Respiratory Cell & Molecular Biology, 46(5), 566-572. doi: 10.1165/rcmb.2011-0392TR
Journal - Research Article
Koh, Y.-H., Moochhala, S., Bian, J.-S., & Bhatia, M. (2012). Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 16(7), 1582-1592. doi: 10.1111/j.1582-4934.2011.01475.x
Journal - Research Article
Rivers, J. R., Badiei, A., & Bhatia, M. (2012). Hydrogen sulfide as a therapeutic target for inflammation. Expert Opinion on Therapeutic Targets, 16(5), 439-449. doi: 10.1517/14728222.2012.673591
Journal - Research Article
Sidhapuriwala, J. N., Hegde, A., Ang, A. D., Zhu, Y. Z., & Bhatia, M. (2012). Effects of S-Propargyl-Cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS ONE, 7(3), e32574. doi: 10.1371/journal.pone.0032574
Journal - Research Article
Ang, S.-F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: Involvement of substance P and ERK-NF-κB signaling. PLoS ONE, 6(9), e24535. doi: 10.1371/journal.pone.0024535
Journal - Research Article
Ang, S.-F., Sio, S. W. S., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. Journal of Immunology, 187(9), 4778-4787. doi: 10.4049/jimmunol.1101559
Journal - Research Article
Hegde, A., & Bhatia, M. (2011). Hydrogen sulfide in inflammation: Friend or foe? Inflammation & Allergy Drug Targets, 10(2), 118-122.
Journal - Research Article
Koh, Y.-H., Moochhala, S., & Bhatia, M. (2011). The role of neutral endopeptidase in caerulein-induced acute pancreatitis. Journal of Immunology, 187, 5429-5439. doi: 10.4049/jimmunol.1102011
Journal - Research Article
Koh, Y.-H., Tamizhselvi, R., Moochhala, S., Bian, J.-S., & Bhatia, M. (2011). Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 15(10), 2139-2149. doi: 10.1111/j.1582-4934.2010.01205.x
Journal - Research Article
Ang, S.-F., Moochhala, S. M., & Bhatia, M. (2010). Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Critical Care Medicine, 38(2), 619-628. doi: 10.1097/CCM.0b013e3181c0df00
Journal - Research Article
Bhatia, M. (2010). Hydrogen sulfide and substance P in inflammation. Antioxidants & Redox Signaling, 12(10), 1191-1202. doi: 10.1089/ars.2009.2927
Journal - Research Article
Hegde, A., Tamizhselvi, R., Manikandan, J., Melendez, A. J., Moochhala, S. M., & Bhatia, M. (2010). Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Molecular Medicine, 16, 188-198. doi: 10.2119/molmed.2009.00166
Journal - Research Article
Hegde, A., Uttamchandani, M., Bhatia, M., & Moochhala, S. M. (2010). Plasma cytokine profiles in Preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Molecular Medicine, 16(1-2), 45-52. doi: 10.2119/molmed.2009.00112
Journal - Research Article
Koh, Y.-H., Tamizhselvi, R., & Bhatia, M. (2010). Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-κB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 332(3), 940-948. doi: 10.1124/jpet.109.160416
Journal - Research Article
Ramnath, R. D., Sun, J., & Bhatia, M. (2010). PKC δ mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. Journal of Molecular Medicine, 88, 1055-1063. doi: 10.1007/s00109-010-0647-9
Journal - Research Article
Shrivastava, P., & Bhatia, M. (2010). Essential role of monocytes and macrophages in the progression of acute pancreatitis. World Journal of Gastroenterology, 16(32), 3995-4002. doi: 10.3748/wjg.v16.i32.3995
Journal - Research Article
Sio, S. W. S., Ang, S. F., Lu, J., Moochhala, S., & Bhatia, M. (2010). Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-κB in a mouse model of burn-induced remote acute lung injury. Journal of Immunology, 185(10), 6265-6276. doi: 10.4049/jimmunol.1001739
Journal - Research Article
Sio, S. W. S., Moochhala, S., Lu, J., & Bhatia, M. (2010). Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. American Journal of Respiratory & Critical Care Medicine, 181(1), 36-46. doi: 10.1164/rccm.200907-1073OC
Journal - Research Article
Sowmya, S., Swathi, Y., Yeo, A. L., Shoon, M. L., Moore, P. K., & Bhatia, M. (2010). Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vascular Pharmacology, 53, 138-143. doi: 10.1016/j.vph.2010.05.004
Journal - Research Article
Tamizhselvi, R., Koh, Y.-H., Sun, J., Zhang, H., & Bhatia, M. (2010). Hydrogen sulfide-induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-κB and Src-family kinases pathway. Experimental Cell Research, 316, 1625-1636. doi: 10.1016/j.yexcr.2010.02.044
Journal - Research Article
Zhang, J., Sio, S. W. S., Moochhala, S., & Bhatia, M. (2010). Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Molecular Medicine, 16(9-10), 417-424. doi: 10.2119/molmed.2010.00027
Journal - Research Article
Ang, A. D., Adhikari, S., Ng, S. W., & Bhatia, M. (2009). Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury. Pancreatology, 9(1-2), 150-159. doi: 10.1159/000178886
Journal - Research Article
Ramnath, R. D., Sun, J., & Bhatia, M. (2009). Involvement of Src family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. Journal of Pharmacology & Experimental Therapeutics, 329, 418-428. doi: 10.1124/jpet.108.148684
Journal - Research Article
Sidhapuriwala, J. N., Ng, S. W., & Bhatia, M. (2009). Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. Journal of Inflammation, 6, 35. doi: 10.1186/1476-9255-6-35
Journal - Research Article
Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2009). Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages. FASEB Journal, 23, 997-1010. doi: 10.1096/fj.08-121756
Journal - Research Article
Tamizhselvi, R., Sun, J., Koh, Y.-H., & Bhatia, M. (2009). Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 329, 1166-1178. doi: 10.1124/jpet.109.150532
Journal - Research Article
Ynsa, M. D., Ren, M. Q., Rajendran, R., Sidhapuriwala, J. N., van Kan, J. A., Bhatia, M., & Watt, F. (2009). Zinc mapping and density imaging of rabbit pancreas endocrine tissue sections using nuclear microscopy. Microscopy & Microanalysis, 15, 345-352. doi: 10.1017/S1431927609090795
Journal - Research Article
Zhang, H., & Bhatia, M. (2009). Role of hydrogen sulfide in acute lung injury and acute respiratory distress syndrome. Open Critical Care Medicine Journal, 2, 13-17. doi: 10.2174/1874828700902010013
Journal - Research Article
Adhikari, S., Ramnath, R. D., Wallig, M., & Bhatia, M. (2008). Role of mitogen-activated protein kinases in crambene-induced pancreatic acinar cell apoptosis. International Journal of Integrative Biology, 3(1), 25-35.
Journal - Research Article
Ang, A. D., Adhikari, S., Wei, N. S., & Bhatia, M. (2008). NFkappaB mediated expression of iNOS in pancreatic acinar cells contributes to the severity of acute pancreatitis and associated lung injury. International Journal of Integrative Biology, 2(2), 70-78.
Journal - Research Article
Bhatia, M., Landolfi, C., Basta, F., Bovi, G., Ramnath, R. D., Capezzone de Joannon, A., & Guglielmotti, A. (2008). Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis. Inflammation Research, 57(10), 464-471. doi: 10.1007/s00011-008-7210-y
Journal - Research Article
Ng, S. W., Zhang, H., Hegde, A., & Bhatia, M. (2008). Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia. Journal of Leukocyte Biology, 83, 288-295. doi: 10.1189/jlb.0807575
Journal - Research Article
Ramnath, R. D., Ng, S. W., Guglielmotti, A., & Bhatia, M. (2008). Role of MCP-1 in endotoxemia and sepsis. International Immunopharmacology, 8(6), 810-818. doi: 10.1016/j.intimp.2008.01.033
Journal - Research Article
Ramnath, R. D., Sun, J., & Bhatia, M. (2008). Role of calcium in substance P-induced chemokine synthesis in mouse pancreatic acinar cells. British Journal of Pharmacology, 154(6), 1339-1348. doi: 10.1038/bjp.2008.188
Journal - Research Article
Ramnath, R. D., Sun, J., Adhikari, S., Zhi, L., & Bhatia, M. (2008). Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells. American Journal of Physiology: Cell Physiology, 294, C683-C692. doi: 10.1152/ajpcell.00360.2007
Journal - Research Article
Sio, S. W. S., Puthia, M. K., Lu, J., Moochhala, S., & Bhatia, M. (2008). The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. Journal of Immunology, 180, 8333-8341.
Journal - Research Article
Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2008). Neurokinin A engages neurokinin-1 receptor to induce NF-κB-dependent gene expression in murine macrophages: Implications of ERK1/2 and PI 3-kinase/Akt pathways. American Journal of Physiology: Cell Physiology, 295, C679-C691. doi: 10.1152/ajpcell.00042.2008
Journal - Research Article
Sun, J., Ramnath, R. D., Zhi, L., Tamizhselvi, R., & Bhatia, M. (2008). Substance P enhances NF-κB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. American Journal of Physiology: Cell Physiology, 294, C1586-C1596. doi: 10.1152/ajpcell.00129.2008
Journal - Research Article
Webb, G. D., Lim, L. H., Oh, V. M. S., Yeo, S. B., Cheong, Y. P., Ali, M. Y., … Bhatia, M., … Moore, P. K. (2008). Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. Journal of Pharmacology & Experimental Therapeutics, 324, 876-882. doi: 10.1124/jpet.107.133538
Journal - Research Article
Zhang, H., & Bhatia, M. (2008). Hydrogen sulfide: A novel mediator of leukocyte activation. Immunopharmacology & Immunotoxicology, 30, 631-645. doi: 10.1080/08923970802278045
Journal - Research Article
Zhang, H., Moochhala, S. M., & Bhatia, M. (2008). Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. Journal of Immunology, 181, 4320-4331.
Journal - Research Article
Bhatia, M., & Hegde, A. (2007). Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regulatory Peptides, 138(1), 40-48. doi: 10.1016/j.regpep.2006.08.006
Journal - Research Article
Cao, Y., Adhikari, S., Clément, M. V., Wallig, M., & Bhatia, M. (2007). Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology, 170(5), 1521-1534. doi: 10.2353/ajpath.2007.061149
Journal - Research Article
He, M., Horuk, R., Moochhala, S. M., & Bhatia, M. (2007). Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1173-G1180. doi: 10.1152/ajpgi.00420.2006
Journal - Research Article
He, M., Lau, H. Y., Ng, S. W., & Bhatia, M. (2007). Chemokines in acute inflammation: Regulation, function and therapeutic strategies. International Journal of Integrative Biology, 1(1), 18-27.
Journal - Research Article
Hegde, A., Zhang, H., Moochhala, S., & Bhatia, M. (2007). Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. Journal of Leukocyte Biology, 82, 678-685. doi: 10.1189/jlb.0407217
Journal - Research Article
Lau, H. Y., & Bhatia, M. (2007). Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1283-G1292. doi: 10.1152/ajpgi.00429.2006
Journal - Research Article
Liew, H. C., Khoo, H. E., Moore, P. K., Bhatia, M., Lu, J., & Moochhala, S. M. (2007). Synergism between hydrogen sulfide (H2S) and nitric oxide (NO) in vasorelaxation induced by stonustoxin (SNTX), a lethal and hypotensive protein factor isolated from stonefish Synanceja horrida venom. Life Sciences, 80(18), 1664-1668. doi: 10.1016/j.lfs.2007.01.058
Journal - Research Article
Sidhapuriwala, J., Li, L., Sparatore, A., Bhatia, M., & Moore, P. K. (2007). Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. European Journal of Pharmacology, 569, 149-154. doi: 10.1016/j.ejphar.2007.05.003
Journal - Research Article
Sun, J., & Bhatia, M. (2007). Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G143-G153. doi: 10.1152/ajpgi.00271.2006
Journal - Research Article
Sun, J., Ramnath, R. D., & Bhatia, M. (2007). Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. American Journal of Physiology: Cell Physiology, 293, C696-C704. doi: 10.1152/ajpcell.00060.2007
Journal - Research Article
Zhang, H., Hegde, A., Ng, S. W., Adhikari, S., Moochhala, S. M., & Bhatia, M. (2007). Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury. Journal of Immunology, 179, 4153-4160.
Journal - Research Article
Zhang, H., Zhi, L., Moochhala, S. M., Moore, P. K., & Bhatia, M. (2007). Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. Journal of Leukocyte Biology, 82, 894-905. doi: 10.1189/jlb.0407237
Journal - Research Article
Zhang, H., Zhi, L., Moochhala, S., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-κB. American Journal of Physiology: Lung Cellular & Molecular Physiology, 292, L960-L971. doi: 10.1152/ajplung.00388.2006
Journal - Research Article
Zhi, L., Ang, A. D., Zhang, H., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-κB pathway. Journal of Leukocyte Biology, 81, 1322-1332. doi: 10.1189/jlb.1006599
Journal - Research Article
Ali, M. Y., Ping, C. Y., Mok, Y.-Y., Ling, L., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Regulation of vascular nitric oxide in vitro and in vivo: A new role for endogenous hydrogen sulphide? British Journal of Pharmacology, 149(6), 625-634. doi: 10.1038/sj.bjp.0706906
Journal - Research Article
Anuar, F., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflammation Research, 55(11), 498-503. doi: 10.1007/s00011-006-5150-y
Journal - Research Article
Anuar, F., Whiteman, M., Siau, J. L., Kwong, S. E., Bhatia, M., & Moore, P. K. (2006). Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. British Journal of Pharmacology, 147(8), 966-974. doi: 10.1038/sj.bjp.0706696
Journal - Research Article
Bhatia, M., Li, L., & Moore, P. K. (2006). The role of hydrogen sulfide in lung inflammation. Drug Discovery Today: Disease Mechanisms, 3(1), 71-75. doi: 10.1016/j.ddmec.2006.02.010
Journal - Research Article
Bhatia, M., Zhi, L., Zhang, H., Ng, S.-W., & Moore, P. (2006). Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. American Journal of Physiology: Lung Cellular & Molecular Physiology, 291, L896-L904. doi: 10.1152/ajplung.00053.2006
Journal - Research Article
Cao, Y., Adhikari, S., Ang, A. D., Clément, M. V., Wallig, M., & Bhatia, M. (2006). Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G95-G101. doi: 10.1152/ajpgi.00520.2005
Journal - Research Article
Cao, Y., Adhikari, S., Ang, A. D., Moore, P. K., & Bhatia, M. (2006). Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. American Journal of Physiology: Cell Physiology, 291, 503-510. doi: 10.1152/ajpcell.00547.2005
Journal - Research Article
Lau, H. Y., & Bhatia, M. (2006). The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Journal of Pathology, 208, 364-371. doi: 10.1002/path.1899
Journal - Research Article
Li, L., Bhatia, M., & Moore, P. K. (2006). Hydrogen sulphide: A novel mediator of inflammation? Current Opinion in Pharmacology, 6(2), 125-129. doi: 10.1016/j.coph.2005.10.007
Journal - Research Article
Pawlak, J., Mackessy, S. P., Fry, B. G., Bhatia, M., Mourier, G., Fruchart-Gaillard, C., & et al (2006). Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (mangrove catsnake) with bird-specific activity. Journal of Biological Chemistry, 281(39), 29030-29041. doi: 10.1074/jbcM605850200
Journal - Research Article
Puneet, P., Hegde, A., Ng, S. W., Lau, H. Y., Lu, J., Moochhala, S. M., & Bhatia, M. (2006). Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. Journal of Immunology, 176, 3813-3820.
Journal - Research Article
Ramnath, R. D., & Bhatia, M. (2006). Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-κB. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G1113-G1119. doi: 10.1152/ajpgi.00177.2006
Journal - Research Article
Ramnath, R. D., Weing, S., He, M., Sun, J., Zhang, H., Bawa, M. S., & Bhatia, M. (2006). Inflammatory mediators in sepsis: Cytokines, chemokines, adhesion molecules and gases. Journal of Organ Dysfunction, 2(2), 80-92. doi: 10.1080/17471060500435662
Journal - Research Article
Whiteman, M., Li, L., Kostetski, I., Chu, S. H., Siau, J. L., Bhatia, M., & Moore, P. K. (2006). Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochemical & Biophysical Research Communications, 343(1), 303-310. doi: 10.1016/j.bbrc.2006.02.154
Journal - Research Article
Group Leader, Inflammation Research Group