Group Leader, Inflammation Research Group
Co-ordinator, BBiomedSc(Hons) Programme
Professor Madhav Bhatia's research focuses on inflammation, and he is the head of the Inflammation Research Group at the University of Otago, Christchurch.
Professor Bhatia leads an active research programme on the molecular pharmacology and molecular pathology of inflammatory conditions, such as acute pancreatitis, polymicrobial sepsis, burns, and arthritis.
His research has shown hydrogen sulfide and substance P as mediators of inflammation and potential therapeutic targets for inflammatory diseases. Professor Bhatia is interested in defining the mechanism by which hydrogen sulfide and substance P contribute to inflammation.
The Group's research has shown a key role of chemokines in inflammatory diseases, and of pancreatic acinar cell apoptosis in acute pancreatitis. The Group has also been working on novel markers for diagnosis and prognosis of inflammatory and infectious diseases
The long-term goal of this research is to translate this knowledge to the clinic, and early results in this direction have been promising.
The Inflammation Research Group is supported by:
- Lottery Health
- Canterbury Medical Research Foundation
- Arthritis New Zealand
- University of Otago Research Grant
- Maurice & Phyllis Paykel Trust
- Health Reseach Council of New Zealand Singapore Networking Grant
- Royal Scoiety of New Zealand's Catalyst: Leaders New Zealand-China Scientist Exchange Programme
Prior to moving to Christchurch, Professor Bhatia's research was supported by research grants from Biomedical Research Council, Singapore, National Medical Research Council, Singapore, Academic Research Fund, National University of Singapore, Singapore, and Defence Science and Technology Agency-National University of Singapore Joint Applied R&D Co-operation Programme, Singapore.
Major review articles
Publications to peer reviewed literature: More than 190 papers and review articles, and more than 130 abstracts published in journals.
Citations: More than 14000 (One article cited more than 1000 times, and 39 articles cited more than 100 times).
“h” index: 60
- Zhu Z, Chambers S, Zeng Y, and Bhatia M. Gases in sepsis: novel mediators and therapeutic targets. Int J Mol Sci. 2022; 23: 3669.
- Lian X, Scott-Thomas A, Lewis JG, Bhatia M, MacPherson S, Zeng Y, and Chambers S. Monoclonal antibody and invasive aspergillosis: diagnostic and therapeutic perspectives. Int J Mol Sci. 2022; 23: 5563.
- Kumar A, and Bhatia M. Role of hydrogen sulfide, substance P, and adhesion molecules in acute pancreatitis. Int J Mol Sci. 2021; 22: 12136.
- Patel BK, Patel KH, Bhatia M, Iyer SG, Madhavan KK, and Moochhala SM. Gut microbiome in acute pancreatitis-A review based on current literature. World J Gastroenterol. 2021; 27: 5019-5036.
- Bhatia M, and Gaddam R. Hydrogen sulfide in inflammation: a novel mediator and therapeutic target. Antioxid Redox Signal. 2021; 34: 1368-1377.
- Dawoodbhoy FM, Patel BK, Patel K, Bhatia M, Lee CN, and Moochhala SM. Gut microbiota dysbiosis as a target for improved post-surgical outcomes and improved patient care. A review of current literature. Shock. 2021; 55: 441–454.
- Bhatia M. Understanding hydrogen sulfide in inflammation: opportunities and challenges (Editorial). Mol Cell Ther. 2019; 7: 9-14.
- Gaddam RR, Jha P, and Bhatia M. The infections and hydrogen sulfide. Frontiers in Anti-Infective Drug Discovery. (Eds. Rahman AU, and Choudhary MI). 2018; 7: 261-272.
- Pan LL, Li J, Shamoon M, Bhatia M, and Sun J. Recent advances on nutrition in treatment of acute pancreatitis. Front Immunol. 2017; 8: 762.
- Shamoon M, Chen Y, Bhatia M, and Sun J. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016; 20: 73-87.
- Bhatia M. H2S and inflammation - an overview. Handb Exp Pharmacol. 2015; 230: 165-180.
- Bhatia M. H2S and substance P in inflammation. Meth Enzymol. 2015; 555: 195-205.
- Bhatia M, Zemans RL, and Jeyaseelan S. Role of chemokines in the pathogenesis of acute lung injury. Amer J Resp Cell Mol Biol. 2012; 46: 566-572.
- Rivers J, Badiei A, and Bhatia M. Hydrogen sulfide as a therapeutic target for inflammation. Expert Opin Ther Targets. 2012; 16: 439-449.
- Bhatia M. Hydrogen sulfide and substance P in inflammation. Antioxid Redox Signal. 2010; 12: 1191-1202.
Manandhar, S., Chambers, S., Miller, A., Ishii, I., & Bhatia, M. (2023). Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells. International Journal of Molecular Sciences, 24, 13650. doi: 10.3390/ijms241713650
Pan, L.-L., Ren, Z.-N., Yang, J., Li, B.-B., Huang, Y.-W., Song, D.-X., … Bhatia, M., … Sun, J. (2023). Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria. Acta Pharmaceutica Sinica B. Advance online publication. doi: 10.1016/j.apsb.2023.08.002
Zhu, Z., & Bhatia, M. (2023). Inflammation and organ injury the role of substance P and its receptors. International Journal of Molecular Sciences, 24, 6140. doi: 10.3390/ijms24076140
Tian, H., Li, J., Chen, X., Ren, Z., Pan, X., Huang, W., Bhatia, M., … Sun, J. (2023). Oral delivery of mouse β-defensin 14 (mBD14)-producing Lactococcus lactis NZ9000 attenuates experimental colitis in mice. Journal of Agricultural & Food Chemistry. Advance online publication. doi: 10.1021/acs.jafc.2c07098
Ishii, I., & Bhatia, M. (2023). Amino acids in health and disease: The good, the bad, and the ugly. International Journal of Molecular Sciences, 24, 4931. doi: 10.3390/ijms24054931