Professor Steve Chambers' research interests relate to diagnostics in respiratory infections, the treatment of infectious diseases and intermediary metabolism with particular emphasis on the relationship between bacterial and human metabolism.
He is interested in the effective delivery of treatment for infectious disease that minimises harm to the patient depends on rapid, accurate diagnosis of the infecting organism.
Clinical studies undertaken by Professor Chambers and his team have confirmed the limitations of current methods such as culture and PCR, particularly in children, which depend on the collection of sputum and other specimens. This lead the concept of diagnostic breath testing, which can be performed on readily available samples that can be easily repeated, to follow microbial metabolism. Markers of bacterial metabolisms are obvious diagnostic candidates particularly as they are specific to a particular respiratory pathogen.
In the media
Professors Steve Chambers and David Murdoch were interviewed for Radio New Zealand's Our Changing World series in March 2014.
Manandhar, S., Chambers, S., Miller, A., Ishii, I., & Bhatia, M. (2023). Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells. International Journal of Molecular Sciences, 24, 13650. doi: 10.3390/ijms241713650
Journal - Research Article
Carr, A. C., Vlasiuk, E., Zawari, M., Scott-Thomas, A., Storer, M., Maze, M., & Chambers, S. T. (2023). Low vitamin C concentrations in patients with community-acquired pneumonia resolved with pragmatic administration of intravenous and oral vitamin C. Antioxidants, 12, 1610. doi: 10.3390/antiox12081610
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Chambers, S. T., Scott-Thomas, A., Storer, M., Slow, S., Williman, J., Epton, M., Murdoch, D. R., Metcalf, S., Carr, A., Isenman, H., & Maze, M. (2023). Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: Feasibility of randomized controlled trial. Scientific Reports, 13, 11879. doi: 10.1038/s41598-023-37934-z
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Jun, H., Scott-Thomas, A., Slow, S., Williman, J., Murdoch, D. R., & Chambers, S. T. (2023). The inhibitory effect of copper, zinc, and manganese on Legionella longbeachae and other Legionella spp. in vitro. Letters in Applied Microbiology, 76, 1-9. doi: 10.1093/lambio/ovad074
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Coleman, M., Hill, J., Timeon, E., Rimon, E., Bauro, T., Ioteba, N., … Douglas, N. M., … Campbell, P. O., Williman, J., Priest, P., … Chambers, S. T. (2023). Effectiveness of population-wide screening and mass drug administration for leprosy control in Kiribati: The COMBINE protocol. BMJ Open, 13, e065369. doi: 10.1136/bmjopen-2022-065369
Journal - Research Other
Campbell, P. O., Chin, P. K. L., Dalton, S. C., Metcalf, S. C. L., Douglas, N. M., & Chambers, S. T. (2023). Frequency of pharmacological target attainment with flucloxacillin and cefazolin in invasive methicillin-susceptible Staphylococcus aureus infection: A prospective cohort study in hospitalized patients. International Journal of Antimicrobial Agents, 61, 106695. doi: 10.1016/j.ijantimicag.2022.106695
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Campbell, P. O., Gallagher, K., Dalton, S. C., Metcalf, S. C. L., Douglas, N. M., & Chambers, S. T. (2023). Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study. International Journal of Infectious Diseases. Advance online publication. doi: 10.1016/j.ijid.2023.06.008
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Cheung, J., Nordmeier, K., Kelland, S., Harrington, M., Williman, J., Storer, M., Beaglehole, B., Beckert, L., Chambers, S. T., Epton, M. J., Freeman, J., Murdoch, D. R., Werno, A. M., & Maze, M. J. (2023). Symptom persistence and recovery among COVID-19 survivors during a limited outbreak in Canterbury, New Zealand: A prospective cohort study. Internal Medicine Journal, 53, 37-45. doi: 10.1111/imj.15930
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Munk, P., Brinch, B., Møller, F. D., Petersen, T. N., Hendriksen, R. S., Seyfarth, A. M., … Global Sewage Surveillance Consortium, including Jeunen, G.-J., Gemmell, N., Chambers, S. T., … Aarestrup, F. M. (2023). Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. Nature Communications, 14(1), 7251. doi: 10.1038/s41467-022-34312-7
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Carr, A. C., Vlasiuk, E., Zawari, M., Meijer, N., Lauren, C., MacPherson, S., Williman, J., & Chambers, S. T. (2022). Supplementation with oral vitamin C prior to and during myeloablative chemotherapy and autologous haematopoietic stem cell transplantation: A pilot study. Antioxidants, 11(10), 1949. doi: 10.3390/antiox11101949
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Lian, X., Chambers, S., Lewis, J. G., Scott-Thomas, A., & Bhatia, M. (2022). Two monoclonal antibodies that specifically recognize aspergillus cell wall antigens and can detect circulating antigens in infected mice. International Journal of Molecular Sciences, 23, 252. doi: 10.3390/ijms23010252
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Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2022). A novel monoclonal antibody 1D2 that broadly inhibits clinically important Aspergillus species. Journal of Fungi, 8, 960. doi: 10.3390/jof8090960
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Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639
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Palmer, D., Soule, S., Gaddam, R. R., Elder, P., Chambers, S., & Doogue, M. (2022). Unbound vitamin D concentrations are not decreased in critically ill patients. Internal Medicine Journal, 52, 89-94. doi: 10.1111/imj.15096
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Téllez, A., Ambrosioni, J., Hernández-Meneses, M., Llopis, J., Ripa, M., Chambers, S. T., … Raymond, N., … the International Collaboration on Endocarditis (ICE) Investigators, including Murdoch, D. R. (2022). Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci. Journal of Infection, 85, 137-146. doi: 10.1016/j.jinf.2022.05.023
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Chambers, S. T., Withers, A., Dawson, K., Anderson, T., Williman, J., Murdoch, D., Scott-Thomas, A., & Slow, S. (2021). How safe are gloves and masks used for protection against Legionella longbeachae infection when gardening? Letters in Applied Microbiology, 73, 616-622. doi: 10.1111/lam.13546
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Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887
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Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037
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Mohammadi, A., Chambers, S. T., Slow, S., Anderson, T., Williman, J., Scott, P., Murdoch, D., & Scott-Thomas, A. (2021). Presence of Legionella Longbeachae in pine but not composted green waste used in manufacture of potting soils in New Zealand. Journal of Applied & Environmental Microbiology, 9(1), 1-4. doi: 10.12691/jaem-9-1-1
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Scott, P., Zhang, J., Anderson, T., Priest, P. C., Chambers, S., Smith, H., Murdoch, D. R., French, N., & Biggs, P. J. (2021). Whole-genome sequencing and ad hoc shared genome analysis of Staphylococcus aureus isolates from a New Zealand primary school. Scientific Reports, 11(1), 20328. doi: 10.1038/s41598-021-99080-8
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Baxter-Parker, G., Gaddam, R. R., Moltchanova, E., Carr, A. C., Shaw, G., Chambers, S., & Gieseg, S. P. (2020). Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis. Pteridines, 31(1), 68-82. doi: 10.1515/pteridines-2020-0015
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Carr, A. C., Spencer, E., Das, A., Meijer, N., Lauren, C., MacPherson, S., & Chambers, S. T. (2020). Patients undergoing myeloablative chemotherapy and hematopoietic stem cell transplantation exhibit depleted vitamin C status in association with febrile neutropenia. Nutrients, 12(6), 1879. doi: 10.3390/nu12061879
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Chambers, S. T., Ioteba, N., Timeon, E., Rimon, E., Murdoch, H., Green, J., … Williman, J., & Priest, P. (2020). Surveillance of leprosy in Kiribati, 1935-2017. Emerging Infectious Diseases, 26(5), 833-840. doi: 10.3201/eid2605.181746
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Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972
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Everts, R. J., Begg, R., Gardiner, S. J., Zhang, M., Turnidge, J., Chambers, S. T., & Begg, E. J. (2020). Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 80, 42-53. doi: 10.1016/j.jinf.2019.09.004
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Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal
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Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal
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Green, J., Howard, J., Shankar, A., Clinghan, R., Luff, T., Birch, M., Pithie, A., … Metcalf, S., & Chambers, S. (2020). Assessing the impact of a ‘bundle of care’ approach to Staphylococcus aureus bacteraemia in a tertiary hospital. Infection Prevention in Practice, 2, 100096. doi: 10.1016/j.infpip.2020.100096
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Mohammadi, A., Chambers, S. T., Scott-Thomas, A., Lewis, J. G., Anderson, T., Podmore, R., Williman, J., Murdoch, D., & Slow, S. (2020). Enhancement of culture of Legionella longbeachae from respiratory samples using immunomagnetic separation and antimicrobial decontamination. Journal of Clinical Microbiology, 58(11), e01218-20. doi: 10.1128/jcm.01218-20
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Thompson, L., Ioteba, N., & Chambers, S. (2020). Leprosy in kiribati: The lived experience. Leprosy Review, 91, 353-366. doi: 10.47276/lr.91.4.353
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Chambers, S. T., Basevi, A., Gallagher, K., Carswell-Moyna, A., Isenman, H., Pithie, A., Dalton, S., & Metcalf, S. C. L. (2019). Outpatient parenteral antimicrobial therapy (OPAT) in Christchurch: 18 years on. New Zealand Medical Journal, 132(1501), 21-32. Retrieved from https://www.nzma.org.nz/journal
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Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191
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Gilkison, C., Chambers, S., Blok, D. J., Richardus, J. H., Timeon, E., Rimon, E., & Priest, P. (2019). Predicting the impact of household contact and mass chemoprophylaxis on future new leprosy cases in South Tarawa, Kiribati: A modelling study. PLoS Neglected Tropical Diseases, 13(9), e0007646. doi: 10.1371/journal.pntd.0007646
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Mutreja, I., Warring, S. L., Lim, K. S., Swadi, T., Clinch, K., Mason, J. M., … Chambers, S. T., … Gerth, M. L., … Woodfield, T. B. F. (2019). Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. ACS Biomaterials Science & Engineering, 5(2), 748-758. doi: 10.1021/acsbiomaterials.8b01141
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Panta, G., Richardson, A. K., Shaw, I. C., Chambers, S., & Coope, P. A. (2019). Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study. PLoS ONE, 14(11), e0225595. doi: 10.1371/journal.pone.0225595
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Priest, P. C., Slow, S., Chambers, S. T., Cameron, C. M., Balm, M. N., Beale, M. W., Blackmore, T. K., … Ussher, J. E., van der Linden, A. J., … Murdoch, D. R. (2019). The burden of Legionnaires' disease in New Zealand (LegiNZ): A national surveillance study. Lancet Infectious Diseases, 19, 770-777. doi: 10.1016/S1473-3099(19)30113-6
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Shahid, K., Alamri, Y., Scowcroft, H., Dixon, L., Creighton, J., Isenman, H., Metcalf, S., & Chambers, S. (2019). Urinalysis orders and yield among General Medicine patients: A single-centre's experience in New Zealand. New Zealand Medical Journal, 132(1488), 21-27. Retrieved from https://www.nzma.org.nz/journal
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Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673
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Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370
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Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal
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Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal
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Scott, P., Priest, P. C., Chambers, S. T., Heijne, J. C. M., & Murdoch, D. R. (2018). Staphylococcus aureus carriage in a New Zealand primary school: A cohort study. Pediatric Infectious Disease Journal, 37(6), e172-e175. doi: 10.1097/inf.0000000000001796
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Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2
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Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017). Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Critical Care, 21, 300. doi: 10.1186/s13054-017-1891-y
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Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005
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Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755
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Lever, M., McEntyre, C. J., George, P. M., & Chambers, S. T. (2017). Is N,N-dimethylglycine N-oxide a choline and betaine metabolite? Biological Chemistry, 398(7), 775-784. doi: 10.1515/hsz-2016-0261
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Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9
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Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z
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Faatoese, A., Sikaleti, S., Priest, P., & Chambers, S. (2016). Knowledge and attitudes to leprosy of pacific people living in New Zealand. Leprosy Review, 87(3), 368-377.
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Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521
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Isenman, H. L., Chambers, S. T., Pithie, A. D., MacDonald, S. L. S., Hegarty, J. M., Fenwick, J. L., Maze, M. J., Metcalf, S. C. L., & Murdoch, D. R. (2016). Legionnaires' disease caused by Legionella longbeachae: Clinical features and outcomes of 107 cases from an endemic area. Respirology, 21(7), 1292-1299. doi: 10.1111/resp.12808
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Arnold, C. J., Johnson, M., Bayer, A. S., Bradley, S., Giannitsioti, E., Miró, J. M., … for the ICE Investigators, including Chambers, S., Raymond, N., & Murdoch, D. R. (2015). Candida infective endocarditis: An observational cohort study with a focus on therapy. Antimicrobial Agents & Chemotherapy, 59(4), 2365-2373. doi: 10.1128/AAC.04867-14
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Dobinson, H. C., Anderson, T. P., Chambers, S. T., Doogue, M. P., Seaward, L., & Werno, A. M. (2015). Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. Journal of Clinical Microbiology, 53(9), 2895-2899. doi: 10.1128/jcm.00760-15
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Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007
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Kennedy, N., Chambers, S. T., Nolan, I., Gallagher, K., Werno, A., Browne, M., & Stamp, L. K. (2015). Native joint septic arthritis: Epidemiology, clinical features, and microbiological causes in a New Zealand population. Journal of Rheumatology, 42(12), 2392-2397. doi: 10.3899/jrheum.150434
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McEntyre, C. J., Lever, M., Chambers, S. T., George, P. M., Slow, S., Elmslie, J. L., Florkowski, C. M., Lunt, H., & Krebs, J. D. (2015). Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine, and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. Annals of Clinical Biochemistry, 52(3), 352-360. doi: 10.1177/0004563214545346
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Blyth, C. C., Gilroy, N. M., Guy, S. D., Chambers, S. T., Cheong, E. Y., Gottlieb, T., … Thursky, K. A. (2014). Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014. Internal Medicine Journal, 44(12b), 1333-1349. doi: 10.1111/imj.12598
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Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., … Elmslie, J. L., … Troughton, R. W., Frampton, C. M., Richards, A. M., & Chambers, S. T. (2014). Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: An observational study. PLoS ONE, 9(12), e114969. doi: 10.1371/journal.pone.0114969
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Lever, M., McEntyre, C. J., George, P. M., Slow, S., Chambers, S. T., & Foucher, C. (2014). Fenofibrate causes elevation of betaine excretion but not excretion of other osmolytes by healthy adults. Journal of Clinical Lipidology, 8(4), 433-440. doi: 10.1016/j.jacl.2014.04.001
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Lever, M., McEntyre, C. J., George, P. M., Slow, S., Elmslie, J. L., Lunt, H., Chambers, S. T., Parry-Strong, A., & Krebs, J. D. (2014). Extreme urinary betaine losses in type 2 diabetes combined with bezafibrate treatment are associated with losses of dimethylglycine and choline but not with increased losses of other osmolytes. Cardiovascular Drugs & Therapy, 28, 459-468. doi: 10.1007/s10557-014-6542-9
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Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029
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Scragg, R., Slow, S., Stewart, A. W., Jennings, L. C., Chambers, S. T., Priest, P. C., Florkowski, C. M., … Murdoch, D. R. (2014). Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults: A randomized controlled trial. Hypertension, 64, 725-730. doi: 10.1161/hypertensionaha.114.03466
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Slow, S., Florkowski, C. M., Chambers, S. T., Priest, P. C., Stewart, A. W., Jennings, L. C., … Murdoch, D. R. (2014). Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: Randomised controlled trial. BMJ, 349, g7260. doi: 10.1136/bmj.g7260
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Slow, S., Priest, P. C., Chambers, S. T., Stewart, A. W., Jennings, L. C., Florkowski, C. M., … Murdoch, D. R. (2014). Effect of vitamin D3 supplementation on Staphylococcus aureus nasal carriage: A randomized, double-blind, placebo-controlled trial in healthy adults. Clinical Microbiology & Infection, 20(5), 453-458. doi: 10.1111/1469-0691.12350
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Walls, G., McBride, S., Raymond, N., Read, K., Coomarasamy, C., Morris, A. J., Chambers, S., … Murdoch, D. R. (2014). Infective endocarditis in New Zealand: Data from the International Collaboration on Endocarditis Prospective Cohort Study. New Zealand Medical Journal, 127(1391). Retrieved from http://www.nzma.org.nz/journal
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Yew, H. S., Chambers, S. T., Roberts, S. A., Holland, D. J., Julian, K. A., Raymond, N. J., … Murdoch, D. R. (2014). Association between HACEK bacteraemia and endocarditis. Journal of Medical Microbiology, 63(Part 6), 892-895. doi: 10.1099/jmm.0.070060-0
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Chambers, S. T., Murdoch, D., Morris, A., Holland, D., Pappas, P., Almela, M., … Raymond, N., … and the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2013). HACEK infective endocarditis: Characteristics and outcomes from a large, multi-national cohort. PLoS ONE, 8(5), e63181. doi: 10.1371/journal.pone.0063181
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Chang, C. L., Mills, G. D., Karalus, N. C., Jennings, L. C., Laing, R., Murdoch, D. R., Chambers, S. T., … Hancox, R. J. (2013). Biomarkers of cardiac dysfunction and mortality from community-acquired pneumonia in adults. PLoS ONE, 8(5), e62612. doi: 10.1371/journal.pone.0062612
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Chirouze, C., Athan, E., Alla, F., Chu, V. H., Corey, G. R., Selton-Suty, C., … on behalf of the International Collaboration on Endocarditis Study Group, including Chambers, S., & Murdoch, D. R. (2013). Enterococcal endocarditis in the beginning of the 21st century: Analysis from the International Collaboration on Endocarditis-Prospective Cohort Study. Clinical Microbiology & Infection, 19(12), 1140-1147. doi: 10.1111/1469-0691.12166
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Dummer, J., Storer, M., Sturney, S., Scott-Thomas, A., Chambers, S., Swanney, M., & Epton, M. (2013). Quantification of hydrogen cyanide (HCN) in breath using selected ion flow tube mass spectrometry: HCN is not a biomarker of Pseudomonas in chronic suppurative lung disease. Journal of Breath Research, 7(1), 017105. doi: 10.1088/1752-7155/7/1/017105
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Maze, M. J., Laws, P., Buckenham, T., Pithie, A., Gallagher, K., Metcalf, S., Roake, J., & Chambers, S. T. (2013). Outcomes of infected abdominal aortic grafts managed with antimicrobial therapy and graft retention in an unselected cohort. European Journal of Vascular & Endovascular Surgery, 45(4), 373-380. doi: 10.1016/j.ejvs.2013.01.019
Journal - Research Article
Maze, M. J., Skea, S., Pithie, A., Metcalf, S., Pearson, J. F., & Chambers, S. T. (2013). Prevalence of concurrent deep vein thrombosis in patients with lower limb cellulitis: A prospective cohort study. BMC Infectious Diseases, 13, 141. doi: 10.1186/1471-2334-13-141
Journal - Research Article
Murdoch, D. R., Podmore, R. G., Anderson, T. P., Barratt, K., Maze, M. J., French, K. E., … Chambers, S. T., & Werno, A. M. (2013). Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: A pre-post comparison study. Clinical Infectious Diseases, 57(9), 1275-1281. doi: 10.1093/cid/cit504
Journal - Research Article
Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Scott-Thomas, A., Epton, M., & Chambers, S. (2013). Validating a breath collection and analysis system for the new tuberculosis breath test. Journal of Breath Research, 7(3), 037108. doi: 10.1088/1752-7155/7/3/037108
Journal - Research Article
Scott-Thomas, A., Syhre, M., Epton, M., Murdoch, D. R., & Chambers, S. T. (2013). Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test. Tuberculosis, 93(3), 312-317. doi: 10.1016/j.tube.2013.01.005
Journal - Research Article
Chambers, S. T., Scott-Thomas, A., & Epton, M. (2012). Developments in novel breath tests for bacterial and fungal pulmonary infection. Current Opinion in Pulmonary Medicine, 18(3), 228-232. doi: 10.1097/MCP.0b013e328351f98b
Journal - Research Article
Cornelius, A. J., Chambers, S. T., Aitken, J., Brandt, S. M., Horn, B., & On, S. L. W. (2012). Epsilonproteobacteria in humans: New Zealand. Emerging Infectious Diseases, 18(3), 510-512. doi: 10.3201/eid1803.110875
Journal - Research Article
Lever, M., George, P. M., Atkinson, W., Elmslie, J. L., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS ONE, 7(3), e32460. doi: 10.1371/journal.pone.0032460
Journal - Research Article
Lever, M., George, P. M., Elmslie, J. L., Atkinson, W., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). Betaine and secondary events in an acute coronary syndrome cohort. PLoS ONE, 7(5), e37883. doi: 10.1371/journal.pone.0037883
Journal - Research Article
Lever, M., Slow, S., George, P. M., & Chambers, S. T. (2012). Betaine excretion correlates with plasma homocysteine when plasma lipids are elevated. Clinical Biochemistry, 45(1-2), 154-156. doi: 10.1016/j.clinbiochem.2011.10.021
Journal - Research Article
Lever, M., Slow, S., McGregor, D. O., Dellow, W. J., George, P. M., & Chambers, S. T. (2012). Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses. Cardiovascular Diabetology, 11, 34. doi: 10.1186/1475-2840-11-34
Journal - Research Article
Lever, M., Storer, M. K., Lewis, J. G., George, P. M., & Chambers, S. T. (2012). Plasma betaine concentrations correlate with plasma cortisol but not with C-reactive protein in an elderly population. Clinical Chemistry & Laboratory Medicine, 50(9), 1635-1640. doi: 10.1515/cclm-2011-0844
Journal - Research Article
Mangin, D., Murdoch, D., Wells, J. E., Coughlan, E., Bagshaw, S., Corwin, P., Chambers, S., & Toop, L. (2012). Chlamydia trachomatis testing sensitivity in midstream compared with first-void urine specimens. Annals of Family Medicine, 10(1), 50-53. doi: 10.1370/afm.1323
Journal - Research Article
Murdoch, D. R., Slow, S., Chambers, S. T., Jennings, L. C., Stewart, A. W., Priest, P. C., Florkowski, C. M., … Scragg, R. (2012). Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: The vidaris randomized controlled trial. JAMA, 308(13), 1333-1339. doi: 10.1001/jama.2012.12505
Journal - Research Article
Bhandari, S., Chambers, S., Pearson, J., Syhre, M., Epton, M., & Scott-Thomas, A. (2011). Determining the limits and confounders for the 2-pentyl furan breath test by gas chromatography/mass spectrometry. Journal of Chromatography B, 879(26), 2815-2820. doi: 10.1016/j.jchromb.2011.08.010
Journal - Research Article
Chambers, S. T., Bhandari, S., Scott-Thomas, A., & Syhre, M. (2011). Novel diagnostics: Progress toward a breath test for invasive Aspergillus fumigatus. Medical Mycology, 49(Suppl. 1), S54-S61. doi: 10.3109/13693786.2010.508187
Journal - Research Article
Dummer, J., Storer, M., Swanney, M., McEwan, M., Scott-Thomas, A., Bhandari, S., Chambers, S., … Epton, M. (2011). Analysis of biogenic volatile organic compounds in human health and disease. Trends in Analytical Chemistry, 30(7), 960-967. doi: 10.1016/j.trac.2011.03.011
Journal - Research Article
Lever, M., George, P. M., Atkinson, W., Molyneux, S. L., Elmslie, J. L., Slow, S., Richards, A. M., & Chambers, S. T. (2011). Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS ONE, 6(7), e21666. doi: 10.1371/journal.pone.0021666
Journal - Research Article
Love, R. L., Allison, R., & Chambers, S. T. (2011). Peritonsillar infection in Christchurch 2006-2008: Epidemiology and microbiology. New Zealand Medical Journal, 124(1337). Retrieved from http://journal.nzma.org.nz/journal/124-1337/4732/content.pdf
Journal - Research Article
Maze, M. J., Pithie, A., Dawes, T., & Chambers, S. T. (2011). An audit of venous duplex ultrasonography in patients with lower limb cellulitis. New Zealand Medical Journal, 124(1329). Retrieved from http://journal.nzma.org.nz/journal/124-1329/4538/content.pdf
Journal - Research Article
Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Cameron, C., Jeffery, M., … Pithie, A., … Sainsbury, R. (2007). Management guidelines for common medical conditions (12th ed.). Christchurch, New Zealand: Canterbury District Health Board, 288p.
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Doogue, M., Jeffery, M., … Pithie, A., … Sainsbury, R. (2005). Management guidelines for common medical conditions (11th ed.). Christchurch, NZ: Canterbury District Health Board, 271p.
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Begg, E. J., Chambers, S., Colls, B. M., Jeffery, G. M., … Pithie, A., … Sainsbury, R., & Young, C. (2003). Management guidelines for common medical conditions (10th ed.). Christchurch, NZ: Canterbury District Health Board, 299p.
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Begg, E. J., Chambers, S., Jeffery, G. M., King, S., Pithie, A., … Sainsbury, R., & Young, C. (2001). Management Guidelines for Common Medical Conditions (9th ed.). Christchurch: Canterbury District Health Board.
Authored Book - Other
Beard, M. E. J., Town, G. I., Ardagh, M. W., Begg, E. J., Chambers, S., Jeffery, G. M., & Laing, R. T. R. (2000). Management Guidelines for Common Medical Conditions (8th ed.). Christchurch, New Zealand: Internal Medicine Services, Canterbury Health, 284p.
Authored Book - Other
Beard, M. E. J., Begg, E. J., Ardagh, M. W., Chambers, S. T., Fink, J. N., Lim, V., & Town, G. I. (1996). Management Guidelines for Common Medical Conditions. (6th ed.). Christchurch: Internal Medicine Services, Canterbury Health Ltd.
Authored Book - Other