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Barry HockScientific Officer
Honorary Research Fellow

BSc(Hons), PhD(Otago)

Email barry.hock@otago.ac.nz
Tel 64 3 364 0579

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Publications

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE, 16(10), e0258831. doi: 10.1371/journal.pone.0258831

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters, 239, 60-71. doi: 10.1016/j.imlet.2021.08.005

Buss, L. A., Dachs, G. U., Goddard, L., Ang, A. D., Robinson, B. A., Currie, M. J., & Hock, B. (2021). Is the immunogenicity of PD-1 blocking antibodies a confounding variable in murine studies? Immunology Letters, 234, 13-15. doi: 10.1016/j.imlet.2021.04.003

Hock, B. D., McKenzie, J. L., Strother, M., Goddard, L., Butt, L., & Currie, M. J. (2020). Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies. Cancer Immunology, Immunotherapy, 69(12), 2453-2464. doi: 10.1007/s00262-020-02636-2

Buss, L. A., Ang, A. D., Hock, B., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2020). Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice. PLoS ONE, 15(3), e0229290. doi: 10.1371/journal.pone.0229290

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE, 16(10), e0258831. doi: 10.1371/journal.pone.0258831

Journal - Research Article

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters, 239, 60-71. doi: 10.1016/j.imlet.2021.08.005

Journal - Research Article

Baxter-Parker, G., Prebble, H. M., Cross, S., Steyn, N., Shchepetkina, A., Hock, B. D., … Gieseg, S. P. (2020). Neopterin formation through radical scavenging of superoxide by the macrophage synthesised antioxidant 7,8-dihydroneopterin. Free Radical Biology & Medicine, 152, 142-151. doi: 10.1016/j.freeradbiomed.2020.03.002

Journal - Research Article

Buss, L. A., Ang, A. D., Hock, B., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2020). Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice. PLoS ONE, 15(3), e0229290. doi: 10.1371/journal.pone.0229290

Journal - Research Article

Hock, B. D., McKenzie, J. L., Strother, M., Goddard, L., Butt, L., & Currie, M. J. (2020). Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies. Cancer Immunology, Immunotherapy, 69(12), 2453-2464. doi: 10.1007/s00262-020-02636-2

Journal - Research Article

Barclay, M. L., Karim, S., Helms, E. T. J., Keating, P. E., Hock, B., Stamp, L. K., & Schultz, M. (2019). Infliximab and adalimumab concentrations and anti-drug antibodies in inflammatory bowel disease control using New Zealand assays. Internal Medicine Journal, 49, 513-518. doi: 10.1111/imj.14064

Journal - Research Article

Hock, B. D., Mulholland, K. S., Ganly, P., McKenzie, J. L., Pearson, J. F., & Macpherson, S. A. (2019). Impact of increased access to novel agents on the survival of multiple myeloma patients treated at a single New Zealand centre. Internal Medicine Journal, 49, 598-606. doi: 10.1111/imj.14155

Journal - Research Article

Hock, B. D., Smith, S. M., McEntyre, C. J., McKenzie, J. L., Sies, C., & Keating, P. E. (2019). Development of a competitive binding homogeneous mobility shift assay for the quantification of adalimumab levels in patient serum. Journal of Immunological Methods, 474, 112672. doi: 10.1016/j.jim.2019.112672

Journal - Research Article

Hock, B. D., McKenzie, J. L., Goddard, L., Smith, S. M., McEntyre, C. J., & Keating, P. E. (2018). Discrimination of anti-drug antibodies with neutralizing capacity in infliximab-and adalimumab-treated patients: Comparison of the homogeneous mobility shift assay and the affinity capture and elution assay. Therapeutic Drug Monitoring, 40(6), 705-715. doi: 10.1097/FTD.0000000000000553

Journal - Research Article

Prebble, H., Cross, S., Marks, E., Healy, J. L., Searle, E., Aamir, R., Butler, A., Roake, J., Hock, B., Anderson, N., & Gieseg, S. P. (2018). Induced macrophage activation in live excised atherosclerotic plaque. Immunobiology, 223(8-9), 526-535. doi: 10.1016/j.imbio.2018.03.002

Journal - Research Article

Hock, B. D., Macpherson, S. A., & McKenzie, J. L. (2017). Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells. PLoS ONE, 12(3), e0172858. doi: 10.1371/journal.pone.0172858

Journal - Research Article

Shchepetkina, A. A., Hock, B. D., Miller, A., Kennedy, M. A., & Gieseg, S. P. (2017). Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. International Journal of Biochemistry & Cell Biology, 87, 27-33. doi: 10.1016/j.biocel.2017.03.017

Journal - Research Article

Hock, B. D., McIntosh, N. D., McKenzie, J. L., Pearson, J. F., Simcock, J. W., & Macpherson, S. A. (2016). Incidence of cutaneous squamous cell carcinoma in a New Zealand population of chronic lymphocytic leukaemia patients. Internal Medicine Journal, 46(12), 1414-1421. doi: 10.1111/imj.13261

Journal - Research Article

Hock, B. D., Stamp, L. K., Hayman, M. W., Keating, P. E., Helms, E. T. J., & Barclay, M. L. (2016). Development of an ELISA-based competitive binding assay for the analysis of drug concentration and anti-drug antibody levels in patients receiving adalimumab or infliximab. Therapeutic Drug Monitoring, 38(1), 32-41. doi: 10.1097/ftd.0000000000000229

Journal - Research Article

Seddon, A., Hock, B., Miller, A., Frei, L., Pearson, J., McKenzie, J., Simcock, J., & Currie, M. (2016). Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Journal of Dermatological Science, 83(2), 124-130. doi: 10.1016/j.jdermsci.2016.04.013

Journal - Research Article

Hock, B. D., McKenzie, J. L., Cross, N. B., & Currie, M. J. (2015). Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology, 32(3), 164-171. doi: 10.1016/j.trim.2015.05.001

Journal - Research Article

Hock, B. D., Macpherson, S. A., Fernyhough, L. J., & McKenzie, J. L. (2014). Chronic lymphocytic leukemia cells become both activated and immunosuppressive following interaction with CD3 and CD28 stimulated PBMC. Leukemia Research, 38(10), 1217-1223. doi: 10.1016/j.leukres.2014.06.004

Journal - Research Article

Fernyhough, L. J., Buchan, V. A., McArthur, L. T., & Hock, B. D. (2013). Relative recovery of haematopoietic stem cell products after cryogenic storage of up to 19 years. Bone Marrow Transplantation, 48(1), 32-35. doi: 10.1038/bmt.2012.97

Journal - Research Article

Fernyhough, L. J., Hock, B. D., Taylor, J., Pearson, J., & Ganly, P. (2013). Survival of myeloma patients following the introduction of thalidomide as a second-line therapy: A retrospective study at a single New Zealand centre. Internal Medicine Journal, 43(2), 130-137. doi: 10.1111/j.1445-5994.2012.02819.x

Journal - Research Article

Hock, B. D., Fernyhough, L. J., Gough, S. M., & McKenzie, J. L. (2013). Clinical significance of plasma levels of soluble CD40 in patients with chronic lymphocytic leukemia. Open Journal of Blood Diseases, 3(1), 1-5. doi: 10.4236/ojbd.2013.31001

Journal - Research Article

Hock, B. D., Mackenzie, K. A., Cross, N. B., Taylor, K. G., Currie, M. J., Robinson, B. A., Simcock, J. W., & McKenzie, J. L. (2012). Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells. Nephrology Dialysis Transplantation, 27(1), 402-410. doi: 10.1093/ndt/gfr264

Journal - Research Article

Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004

Journal - Research Article

Geertsema, L., Lucas, S. J. E., Cotter, J. D., Hock, B., McKenzie, J., & Fernyhough, L. J. (2011). The cardiovascular risk factor, soluble CD40 ligand (CD154), but not soluble CD40, is lowered by ultra-endurance exercise in athletes. British Journal of Sports Medicine, 45(1), 42-45. doi: 10.1136/bjsm.2008.051896

Journal - Research Article

MacKenzie, K. A., Miller, A. P., Hock, B. D., Gardner, J., Simcock, J. W., Roake, J. A., Dachs, G. U., Robinson, B. A., & Currie, M. J. (2011). Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients. Histopathology, 58(6), 875-885. doi: 10.1111/j.1365-2559.2011.03845.x

Journal - Research Article

Hock, B. D., McKenzie, J. L., McArthur, L., Tansley, S., Taylor, K. G., & Fernyhough, L. J. (2010). CD38 as a prognostic marker in chronic lymphocytic leukaemia at a single New Zealand centre: Patient survival in comparison to age and sex matched population data. Internal Medicine Journal, 40(12), 842-849. doi: 10.1111/j.1445-5994.2009.02135.x

Journal - Research Article

Hock, B. D., Fernyhough, L. J., Gough, S. M., Steinkasserer, A., Cox, A. G., & McKenzie, J. L. (2009). Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia. Leukemia Research, 33(8), 1089-1095. doi: 10.1016/j.leukres.2009.01.001

Journal - Research Article

Saunderson, S. C., Schuberth, P. C., Dunn, A. C., Miller, L., Hock, B. D., MacKay, P. A., … Jack, R. W., & McLellan, A. D. (2008). Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. Journal of Immunology, 180(12), 8146-8152.

Journal - Research Article

Hock, B. D., Drayson, M., Patton, W. N., Taylor, K., Kerr, L., McKenzie, J. L., & on behalf of the Working Party on Leukaemia in Adults. (2006). Circulating levels and clinical significance of soluble CD86 in myeloma patients. British Journal of Haematology, 133, 165-172.

Journal - Research Article

Hock, B. D., McKenzie, J. L., Patton, N. W., Drayson, M., Taylor, K., Wakeman, C., … Albitar, M. (2006). Circulating levels and clinical significance of soluble CD40 in patients with hematologic malignancies. Cancer, 106(10), 2148-2157.

Journal - Research Article

Hock, B. D., O'Donnell, J. L., Taylor, K., Steinkasserer, A., McKenzie, J. L., Rothwell, A. G., & Summers, K. L. (2006). Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients. Tissue Antigens, 67(1), 57-60. doi: 10.1111/j.1399-0039.2005.00524.x

Journal - Research Article

Zinser, E., Lechmann, M., Golka, A., Hock, B., & Steinkasserer, A. (2006). Determination of the inhibitory activity and biological half-live of soluble CD83: Comparison of wild type and mutant isoforms. Immunobiology, 211, 449-453.

Journal - Research Article

Hock, B. D., Roberts, G., McKenzie, J. L., Gokhale, P., Salm, N., McLellan, A. D., Patton, N. W., & Roake, J. A. (2005). Exposure to the electrofusion process can increase the immunogenicity of human cells. Cancer Immunology, Immunotherapy, 54, 880-890.

Journal - Research Article

Hock, B. D., Haring, L. F., Steinkasserer, A., Taylor, K. G., Patton, W. N., & McKenzie, J. L. (2004). The soluble form of CD83 is present at elevated levels in a number of hematological malignancies. Leukemia Research, 28, 237-241.

Journal - Research Article

Hock, B. D., Starling, G. C., Patton, W. N., Salm, N., Bond, K., McArthur, L. T., & McKenzie, J. L. (2004). Identification of a circulating soluble form of CD80: Levels in patients with hematological malignancies. Leukemia & Lymphoma, 45(10), 2111-2118. doi: 10.1080/10428190410001712199

Journal - Research Article

Hock, B. D., McKenzie, J., Patton, W. N., Haring, L., Yang, Y., Shen, Y., … Albitar, M. (2003). The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome. Cancer, 98, 1681-1688.

Journal - Research Article

Hock, B. D., Kato, M., McKenzie, J., & Hart, D. N. J. (2001). A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. International Immunology, 13(7), 959-967.

Journal - Research Article

Summers, K. L., Hock, B. D., McKenzie, J. L., & Hart, D. N. J. (2001). Phenotypic characterization of five dendritic cell subsets in human tonsils. American Journal of Pathology, 159, 285-295.

Journal - Research Article

El Sherbini, H., Hock, B., Fearnley, D., McLellan, A., Vuckovic, S., & Hart, D. N. J. (2000). Lectin ligands on human dendritic cells and identification of a peanut agglutinin positive subset in blood. Cellular Immunology, 200, 36-44. doi: 10.1006/cimm.1999.1612

Journal - Research Article

Hock, B. D., Fearnley, D. B., Boyce, A., McLellan, A. D., Sorg, R. V., Summers, K., & Hart, D. N. J. (1999). Human dendritic cells express a 95 kDa activation/differentiation antigen defined by CMRF-56. Tissue Antigens, 53(4), 320-334. doi: 10.1034/j.1399-0039.1999.530402.x

Journal - Research Article

Sorg, R. V., McLellan, A. D., Hock, B. D., Fearnley, D. B., & Hart, D. N. J. (1998). Human dendritic cells express functional interleukin-7. Immunobiology, 198(5), 514-526. doi: 10.1016/S0171-2985(98)80075-2

Journal - Research Article

Fearnley, D. B., McLellan, A. D., Mannering, S. I., Hock, B. D., & Hart, D. N. J. (1997). Isolation of human blood dendritic cells using the CMRF-44 monoclonal antibody: implications for studies on antigen-presenting cell function and immunotherapy. Blood, 89(10), 3708-3726.

Journal - Research Article

Sorg, U. R., Morse, T. M., Patton, W. N., Hock, B. D., Angus, H. B., Robinson, B. A., Colls, B. M., & Hart, D. N. J. (1997). Hodgkin's cells express CD83, a dendritic cell lineage associated antigen. Pathology, 29(3), 294-299. doi: 10.1080/00313029700169125

Journal - Research Article

Williams, L. A., Hock, B. D., & Hart, D. N. J. (1996). Human T lymphocytes and hematopoietic cell lines expression CD24-associated carbohydrate epitopes in the absence of CD24 mRNA or protein. Blood, 88(8), 3048-3055.

Journal - Research Article

Buss, L. A., Dachs, G. U., Goddard, L., Ang, A. D., Robinson, B. A., Currie, M. J., & Hock, B. (2021). Is the immunogenicity of PD-1 blocking antibodies a confounding variable in murine studies? Immunology Letters, 234, 13-15. doi: 10.1016/j.imlet.2021.04.003

Journal - Research Other

Keating, P. E., Duncan, R., Spellerberg, M., O'Donnell, J., & Hock, B. D. (2020). Measurement of anti-natalizumab antibodies by homogeneous mobility shift assay. Pathology, 52(3), 373-374. doi: 10.1016/j.pathol.2020.01.682

Journal - Research Other

Purcell, R. V., Hock, B. D., Gardner, J., Goddard, L., MacPherson, S. A., & McKenzie, J. L. (2019). Analysis of human papillomavirus infection and leukaemic infiltrate in cutaneous squamous cell carcinoma from patients with chronic lymphocytic leukaemia. British Journal of Haematology, 186(4), e67-e71. doi: 10.1111/bjh.15907

Journal - Research Other

Hock, B. D., McKenzie, J. L., & Keenan, J. I. (2017). Helicobacter pylori outer membrane vesicles inhibit human T cell responses via induction of monocyte COX-2 expression [Short communication]. Pathogens & Disease, 75(4), ftx034. doi: 10.1093/femspd/ftx034

Journal - Research Other

Hock, B. D., & McKenzie, J. L. (2013). Suppression of CD3/CD28 antibody stimulated responses by human granulocytic myeloid-derived suppressor cells: Fact or artefact? Immunology Letters, 152(2), 151-152. doi: 10.1016/j.imlet.2013.05.009

Journal - Research Other

Hart, D. N., Clark, G., Dekker, J. W., Fearnley, D. B., Kato, M., Hock, B. D., McLellan, A. D., Neil, T. K., Sorg, R. V., Sorg, U. R., Summers, K., & Vuckovic, S. (1997). Dendritic cell surface molecules. A proliferating field. Advances in Experimental and Medical Biology. 417, (pp. 439-442). [Full Paper]

Conference Contribution - Published proceedings: Full paper

McLellan, A. D., Sorg, R. V., Fearnley, D. B., Hock, B. D., Tiedemann, R. J., Fraser, J. R., & Hart, D. N. J. (1997). T lymphocyte mediated regulation of costimulator molecule expression of human dendritic cells. Advances in Experimental and Medical Biology. 417, (pp. 203-206). [Full Paper]

Conference Contribution - Published proceedings: Full paper

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