Time course of drug concentration (pharmacokinetics) and drug effect (pharmacodynamics) applied to pre-clinical and early clinical studies for drug development.
In this paper you will study the quantitative aspects of pharmacology.
Pharmacokinetics (PK) is the time-course of drug concentrations in the body when a medicine is administered and pharmacodynamics (PD) investigates the relationships between drug concentrations and therapeutic (beneficial) and toxic (harmful) effects.
When these two are put together (PKPD) you get an understanding the time-course of drug effects that occur after a medicine is administered.
Understanding PKPD is a critical step in the drug development pathway and after completion of this paper you will have developed skills in analysing PK and PD data and have a greater understanding of how this information is applied in the pharmaceutical industry to develop new medicines.
| Paper title | Pharmacokinetics and Pharmacodynamics |
|---|---|
| Paper code | PSCI304 |
| Subject | Pharmaceutical Science |
| EFTS | 0.1500 |
| Points | 18 points |
| Teaching period | Semester 2 (On campus) |
| Domestic Tuition Fees (NZD) | $1,141.35 |
| International Tuition Fees | Tuition Fees for international students are elsewhere on this website. |
- Prerequisite
- PSCI 201 or PHAL 211
- Contact
Professor Natalie Medlicott natalie.medlicott@otago.ac.nz
- More information link
- Teaching staff
Paper Co-ordinator: Professor Natalie Medlicott
Teaching staff: Associate Professor Hesham Al-Sallami
Professor Natalie Medlicott
Associate Professor Dan Wright
- Paper Structure
PSCI304 will be taught through lectures and workshops covering the following general topics,
- Mathematical concepts used in PKPD.
- Pharmacokinetic concepts.
- Pharmacodynamic concepts.
- PKPD for introduction to the pharmaceutical industry.
- Textbooks
Recommended Textbook - will be available through the University library.
Rosenbaum - Basic Pharmacokinetics and Pharmacodynamics: An integrated Textbook and computer simulations, 2nd edition.
- Graduate Attributes Emphasised
Global perspective, Interdisciplinary perspective, Lifelong learning, Scholarship, Communication, Critical thinking, Ethics, Environmental literacy, Information literacy, Research, Self-motivation, Teamwork
View more information about Otago's graduate attributes.- Learning Outcomes
By completion of this paper students will be able to,
- Define pharmacokinetics (PK) and pharmacodynamics (PD) and describe the role of PKPD in drug development.
- Calculate and interpret key PKPD parameters from data.
- Understand the relationships between drug exposure and therapeutic and toxicological effects of medicines.
- Interpret aspects of PKPD use in drug development documentation.
- Communicate effectively information on drug PKPD for drug development.
