Professor Patrick Manning

2026

Journal - Research Article

Yue, Y., Katare, R., Deng, J., Alencar da Costa, D., & Manning, P. (2026). Circulating microRNA signatures reveal core and reversible dysregulation in obesity via machine learning. Journal of Physiology. Advance online publication. doi: 10.1113/jp290345

Yue, Y., Manning, P., De Ridder, D., Hall, M., Adhia, D. B., Ross, S., Alencar da Costa, D., & Deng, J. D. (2026). Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states. Communications Medicine, 6, 241. doi: 10.1038/s43856-026-01518-5

2025

Journal - Research Other

Green, L., Simpson, M., Bahri, A., Fong, A., & Manning, P. (2025). A pituitary macroadenoma cosecreting prolactin and growth hormone in a patient with multiple endocrine neoplasia type 4. JCEM Case Reports, 3, luaf124. doi: 10.1210/jcemcr/luaf124

Conference Contribution - Published proceedings: Full paper

Yue, Y., De Ridder, D., Manning, P., & Deng, J. D. (2025). Variational autoencoder learns better feature representations for EEG-based obesity classification. In A. Antonacopoulos, S. Chaudhuri, R. Chellappa, C.-L. Liu, S. Bhattacharya & U. Pal (Eds.), Pattern Recognition: Lecture notes in computer science (Vol. 15323). (pp. 179-191). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-78347-0_12

2024

Conference Contribution - Poster Presentation (not in published proceedings)

Herath, B., Roberts, L., Manning, P., & Katare, R. (2024, August-September). Salivary microRNAs as biomarkers for diabetes mellitus and related cardiovascular disease. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Other

Bellae Papannarao, J., Schwenke, D. O., Manning, P., & Katare, R. (2022). Upregulated miR-200c is associated with downregulation of the functional receptor for severe acute respiratory syndrome coronavirus 2 ACE2 in individuals with obesity [Brief communication]. International Journal of Obesity, 46, 238-241. doi: 10.1038/s41366-021-00984-2

2021

Journal - Research Article

Meredith-Jones, K., Taylor, R., Brown, R., Cooke, R., Vlietstra, L., Manning, P., Poulton, R., & Haszard, J. (2021). Age- and sex-specific visceral fat reference cutoffs and their association with cardio-metabolic risk. International Journal of Obesity, 45, 808-817. doi: 10.1038/s41366-021-00743-3

2020

Journal - Research Article

Chandrasekera, D. N. K., Neale, J. P. H., van Hout, I., Rawal, S., Coffey, S., Jones, G. T., … Manning, P., Williams, M. J. A., & Katare, R. (2020). Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. Apoptosis, 25(5-6), 388-399. doi: 10.1007/s10495-020-01609-1

Leong, S. L., Glue, P., Manning, P., Vanneste, S., Lim, L. J., Mohan, A., & De Ridder, D. (2020). Anterior cingulate cortex implants for alcohol addiction: A feasibility study. Neurotherapeutics, 17, 1287-1299. doi: 10.1007/s13311-020-00851-4

2019

Journal - Research Article

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2019). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism, 104(4), 1239-1248. doi: 10.1210/jc.2018-00684

2018

Journal - Research Article

Redondo, M. J., Geyer, S., Steck, A. K., Sharp, S., Wentworth, J. M., Weedon, M. N., … and Type 1 Diabetes TrialNet Study Group, including Scott, R., Heenan, H., Lunt, H., Willis, J., Darlow, B., Manning, P., Taylor, B., Jones, S., Wiltshire, E., & Krebs, J. (2018). A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk. Diabetes Care, 41(9), 1887-1894. doi: 10.2337/dc18-0087

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity, 42, 1871-1879. doi: 10.1038/s41366-018-0165-3

Leong, S. L., Vanneste, S., Lim, J., Smith, M., Manning, P., & De Ridder, D. (2018). A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction. Scientific Reports, 8, 11659. doi: 10.1038/s41598-018-30181-7

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

Ma, Z. F., Venn, B. J., Manning, P. J., Cameron, C. M., & Skeaff, S. A. (2018). The sensitivity and specificity of thyroglobulin concentration using repeated measures of urinary iodine excretion. European Journal of Nutrition, 57(4), 1313-1320. doi: 10.1007/s00394-017-1410-6

Journal - Research Other

Oliphant, J., Veale, J., Macdonald, J., Carroll, R., Johnson, R., Harte, M., … Cole, D., & Manning, P. (2018). Guidelines for gender affirming healthcare for gender diverse and transgender children, young people and adults in Aotearoa, New Zealand. New Zealand Medical Journal, 131(1487), 86-96. Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Leong, S. L., Vanneste, S., Lim, J., Smith, M., Manning, P., De Ridder, D., & Stoeckl-Drax, T. (2018). Effects and side effects of Infraslow Network Neurofeedback (ISF-NF): A randomised double blind placebo controlled trial. International Journal of Psychophysiology, 131(Suppl.), (pp. S151). doi: 10.1016/j.ijpsycho.2018.07.402

Other Research Output

Manning, P. (2018, October). The academic clinician: Oxymoron or reality?. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].

Miller, D., Gray, A., & Manning, P. (2018, July). Cross-sectional study of the effect of the levonorgestrel-releasing intra-uterine system MIRENA® on bone mineral density: An update. Department of Women's & Children's Health, University of Otago, Dunedin, New Zealand. [Department Seminar].

2017

Journal - Research Article

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Journal - Research Other

Manning, P. (2017). Osteoporosis and osteonecrosis of the jaw. New Zealand Dental Journal, 113(2), 2-3. [Editorial].

De Ridder, D., Leong, S. L., Manning, P., Vanneste, S., & Glue, P. (2017). Anterior cingulate implant for obsessive-compulsive disorder. World Neurosurgery, 97, 754.e7-754.e16. doi: 10.1016/j.wneu.2016.10.046

Conference Contribution - Published proceedings: Abstract

Galt, T., de Ridder, D., Manning, P., & Cutfield, N. (2017). EEG biofeedback of the posterior cingulate cortex for memory. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 34). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Leong, S. L., de Ridder, D., Vanneste, S., Ross, S., Sutherland, W., & Manning, P. (2017). Effect of transcranial pink noise stimulation of anterior cingulate cortex on food craving. Brain Stimulation, 10(2), (pp. 351). doi: 10.1016/j.brs.2017.01.028

2016

Chapter in Book - Research

De Ridder, D., Manning, P., Cape, G., Vanneste, S., Langguth, B., & Glue, P. (2016). Pathophysiology-based neuromodulation for addictions: An overview. In V. R. Preedy (Ed.), Neuropathology of drug addictions and substance misuse (Vol. 1: Foundations of understanding, tobacco, alcohol, cannabinoids and opioids). (pp. 14-24). London: Elsevier. doi: 10.1016/B978-0-12-800213-1.00002-X

Journal - Research Article

De Ridder, D., Manning, P., Leong, S. L., Ross, S., & Vanneste, S. (2016). Allostasis in health and food addiction. Scientific Reports, 6, 37126. doi: 10.1038/srep37126

De Ridder, D., Manning, P., Leong, S. L., Ross, S., Sutherland, W., Horwath, C., & Vanneste, S. (2016). The brain, obesity and addiction: An EEG neuroimaging study. Scientific Reports, 6, 34122. doi: 10.1038/srep34122

Williams, K. H., Sullivan, D. R., Nicholson, G. C., George, J., Jenkins, A. J., Januszewski, A. S., … Manning, P., … Keech, A. C. (2016). Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes: Analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Metabolism, 65(5), 783-793. doi: 10.1016/j.metabol.2015.12.008

De Ridder, D., Vanneste, S., Gillett, G., Manning, P., Glue, P., & Langguth, B. (2016). Psychosurgery reduces uncertainty and increases free will? A review. Neuromodulation, 19, 239-248. doi: 10.1111/ner.12405

Ma, Z. F., Venn, B. J., Manning, P. J., Cameron, C. M., & Skeaff, S. A. (2016). Iodine supplementation of mildly iodine-deficient adults lowers thyroglobulin: A randomized controlled trial. Journal of Clinical Endocrinology & Metabolism, 101(4), 1737-1744. doi: 10.1210/jc.2015-3591

Journal - Research Other

De Ridder, D., Manning, P., Glue, P., Cape, G., Langguth, B., & Vanneste, S. (2016). Anterior cingulate implant for alcohol dependence. Neurosurgery, 78(6), E883-E893. doi: 10.1227/neu.0000000000001248

Conference Contribution - Published proceedings: Abstract

Ross, S., Manning, P., De Ridder, D., Sutherland, W., Leong, S., Ryalls, A., … Berry, E., Hendry, G., … Horwath, C. (2016). Post-weight loss changes in brain activity after a very low calorie diet. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 53). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Conference Contribution - Poster Presentation (not in published proceedings)

Rawal, S., Munasinghe, P. E., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2016, August). microRNA-126 and microRNA-132 are the early modulators of diabetic microangiopathy in heart. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Wilson, L. C., Wilkins, G. T., Cotter, J. D., Manning, P., & Walker, R. J. (2016, December). What aspects of altered cerebral vascular function can be implicated in the elevated risk of cerebrovascular disease in those with type 2 diabetes: Can six-months of high-intensity interval training improve cerebral vascular function? Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Manning, P. (2016, August). Development of a NZSE position on complementary medicine. Verbal presentation at the New Zealand Society of Endocrinology (NZSE) Conference, Nelson, New Zealand.

Manning, P. (2016, August). Diagnosis of Cushing's syndrome. Verbal presentation at the New Zealand Society of Endocrinology (NZSE) Conference, Nelson, New Zealand.

Sandlands, S., & Manning, P. (2016, March-April). Improving outcomes in diabetes care in rural New Zealand. Verbal presentation at the New Zealand Rural General Practice Network (NZRGPN) National Rural Health Conference, Dunedin, New Zealand.

Manning, P. (2016, March-April). Diabetes complications. Workshop presentation at the New Zealand Rural General Practice Network (NZRGPN) National Rural Health Conference, Dunedin, New Zealand.

Manning, P. (2016, March-April). Starting insulin in primary care. Workshop presentation at the New Zealand Rural General Practice Network (NZRGPN) National Rural Health Conference, Dunedin, New Zealand.

Other Research Output

Jackson, C., Robertson, S., Richards, R., Manning, P., Young, S. & Wilkins, G. (2016, November). The future face of healthcare. Dunedin School of Medicine Lecture Series, Dunedin Public Art Gallery, New Zealand. Retrieved from http://www.otago.ac.nz/dsm/about/otago625813.html

2015

Journal - Research Article

Evans, M. C., Clark, V. W., Manning, P. J., De Ridder, D., & Reynolds, J. N. J. (2015). Optimizing deep brain stimulation of the nucleus accumbens in a reward preference rat model. Neuromodulation, 18(7), 531-541. doi: 10.1111/ner.12339

Holdaway, I. M., Hunt, P., Manning, P., Cutfield, W., Gamble, G., Ninow, N., … Metcalfe, S. (2015). Three-year experience with access to nationally funded growth hormone (GH) replacement for GH-deficient adults. Clinical Endocrinology, 83(1), 85-90. doi: 10.1111/cen.12691

Journal - Research Other

Manning, T. E., Manning, A. E., & Manning, P. J. (2015). Systemic capillary leak syndrome: A case-report. New Zealand Medical Journal, 128(1415). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Skeaff, S., Ma, Z. F., Venn, B., Manning, P., & Cameron, C. (2015). Effect of iodine supplementation on thyroglobulin concentration in adults: A randomised, double-blind, placebo-controlled intervention trial. Annals of Nutrition & Metabolism, 67(Suppl. 1), (pp. 175-176). doi: 10.1159/000440895

Rawal, S., Munasinghe, E., Manning, P., & Katare, R. (2015). Cardiovascular microRNAs in diagnosis and therapeutic intervention of diabetic heart disease. New Zealand Medical Journal, 128(1425). Retrieved from http://www.nzma.org.nz/journal

Rawal, S., Munasinghe, E., Shindikar, A., Manning, P., & Katare, R. (2015). Orchestrated role of cardiovascular microRNAs in diabetic cardiomyopathy. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S214). doi: 10.1016/j.hlc.2015.06.246

Conference Contribution - Poster Presentation (not in published proceedings)

Ma, Z. F., Venn, B., Manning, P., Cameron, C., & Skeaff, S. A. (2015, October). Effect of iodine supplementation on serum thyroglobulin concentration in mildly iodine deficient adults. Poster session presented at the Potsdam Summer School of International Nutrition: Future Food, Potsdam, Germany.

Conference Contribution - Verbal presentation and other Conference outputs

Rawal, S., Munasinghe, E., Manning, P., & Katare, R. (2015, August-September). Cardiovascular microRNAs in diagnosis and therapeutic intervention of diabetic heart disease. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2014

Journal - Research Article

Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014). ‘Exercise snacks’ before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia, 57(7), 1437-1445. doi: 10.1007/s00125-014-3244-6

Rawal, S., Manning, P., & Katare, R. (2014). Cardiovascular microRNAs: As modulators and diagnostic biomarkers of diabetic heart disease. Cardiovascular Diabetology, 13, 44. doi: 10.1186/1475-2840-13-44

Conference Contribution - Published proceedings: Abstract

Ma, Z. F., Venn, B., Manning, P., & Skeaff, S. A. (2014). A randomised controlled trial of thyroglobulin as a biomarker of iodine deficiency: Study update. Nutrients, 6(11), (pp. 4738-4739). doi: 10.3390/nu6114731

Rawal, S., Paulin, J., Munasinghe, E., Manning, P., & Katare, R. (2014). Circulating cardiovascular microRNAs as diagnostic biomarkers for early diagnosis of diabetic heart disease. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e38-e39). doi: 10.1016/j.hlc.2014.04.227

Conference Contribution - Verbal presentation and other Conference outputs

Ma, Z. F., Venn, B., Manning, P., & Skeaff, S. A. (2014, August). A randomised controlled trial of thyroglobulin as a biomarker of iodine deficiency: Study update. Verbal presentation at the Postgraduate & Early Career Nutrition Conference, Dunedin, New Zealand.

Manning, P. (2014, August). Obesity and the brain. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Manning, P. J., Ross, S., Vanneste, S., & De Ridder, D. (2014, May). The differences in brain activity in lean and obese individuals. Verbal presentation at the New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting, Queenstown, New Zealand.

2013

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., Williams, S. M., de Jong, S. A., & Hendry, G. P. (2013). Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals. PLoS ONE, 8(6), e66395. doi: 10.1371/journal.pone.0066395

Latta, L., Tordoff, D., Manning, P., & Dent, J. (2013). Enhancing clinical skill development through an Ambulatory Medicine Teaching Programme: An evaluation study. Medical Teacher, 35(8), 648-654. doi: 10.3109/0142159X.2013.801553

Manning, P. J., Sutherland, W. H. F., Williams, S. M., Walker, R. J., Berry, E. A., De Jong, S. A., & Ryalls, A. R. (2013). The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases, 23(6), 543-549. doi: 10.1016/j.numecd.2011.11.006

Journal - Research Other

Wheeler, B. J., Patterson, N., Love, D. R., Prosser, D., Tomlinson, P., Taylor, B. J., & Manning, P. (2013). Frequency and genetic spectrum of maturity-onset diabetes of the young (MODY) in southern New Zealand. Journal of Diabetes & Metabolic Disorders, 12, 46. doi: 10.1186/2251-6581-12-46

Baldi, J. C., Manning, P. J., Hofman, P. L., & Walker, R. J. (2013). Comment on: TODAY Study Group. Effects of Metformin, Metformin plus Rosiglitazone, and Metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY. Diabetes Care 2013;36:1749-1757 [Comment]. Diabetes Care, 36, e223. doi: 10.2337/dc13-1426

Conference Contribution - Published proceedings: Abstract

Miller, D. L., Gray, A., & Manning, P. (2013). A cross-sectional study of hip and spine bone mineral density in users of the levonorgestrel-releasing intrauterine system. Fertility & Sterility, 100(3, Suppl.), (pp. S313-S314). doi: 10.1016/j.fertnstert.2013.07.964

Conference Contribution - Poster Presentation (not in published proceedings)

Rawal, S., Manning, P., Munasinghe, P., & Katare, R. (2013, August). Circulating cardiac-specific microRNAs as diagnostic biomarkers for early diagnosis of diabetic heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2012

Journal - Research Article

Silverman, S. L., Chines, A. A., Kendler, D. L., Kung, A. W. C., Teglbjærg, C. S., Felsenberg, D., … for the Bazedoxifene Study Group, including Manning, P. (2012). Sustained efficacy and safety of bazedoxifene in preventing fractures in postmenopausal women with osteoporosis: Results of a 5-year, randomized, placebo-controlled study. Osteoporosis International, 23(1), 351-363. doi: 10.1007/s00198-011-1691-1

Manning, P. J., De Jong, S. A., Ryalls, A. R., & Sutherland, W. H. F. (2012). Paraoxonase 1 activity in chylomicrons and VLDL: The effect of type 2 diabetes and meals rich in saturated fat and oleic acid. Lipids, 47(3), 259-267. doi: 10.1007/s11745-011-3640-3

Vos, F. E., Schollum, J. B., Coulter, C. V., Manning, P. J., Duffull, S. B., & Walker, R. J. (2012). Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring. Nephrology, 17(2), 182-188. doi: 10.1111/j.1440-1797.2011.01517.x

2011

Journal - Research Article

Sullivan, D., Forder, P., Simes, J., Whiting, M., Kritharides, L., Merrifield, A., … for the FIELD Study Investigators, including Manning, P. (2011). Associations between the use of metformin, sulphonylureas, or diet alone and cardiovascular outcomes in 6005 people with type 2 diabetes in the FIELD study. Diabetes Research & Clinical Practice, 94(2), 284-290. doi: 10.1016/j.diabres.2011.07.028

Sosenko, J. M., Mahon, J., Rafkin, L., Lachin, J. M., Krause-Steinrauf, H., Krischer, J. P., … and the Diabetes Prevention Trial-Type 1 and TrialNet Study Groups, including Manning, P. (2011). A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History study participants. Pediatric Diabetes, 12(2), 85-90. doi: 10.1111/j.1399-5448.2010.00662.x

Vehik, K., Cuthbertson, D., Ruhlig, H., Schatz, D. A., Peakman, M., Krischer, J. P., for the DPT-1 and TrialNet Study Groups, including Manning, P. (2011). Long-term outcome of individuals treated with oral insulin: Diabetes Prevention Trial-Type 1 (DPT-1) oral insulin trial. Diabetes Care, 34(7), 1585-1590. doi: 10.2337/dc11-0523

Sosenko, J. M., Skyler, J. S., Mahon, J., Krischer, J. P., Beam, C. A., Boulware, D. C., … the Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups, including Manning, P. (2011). Validation of the Diabetes Prevention Trial-Type 1 risk score in the TrialNet Natural History study. Diabetes Care, 34(8), 1785-1787. doi: 10.2337/dc11-0641

Vehik, K., Beam, C. A., Mahon, J. L., Schatz, D. A., Haller, M. J., Sosenko, J. M., … for the TrialNet Natural History Study Group, including Manning, P. (2011). Development of autoantibodies in the TrialNet Natural History study. Diabetes Care, 34(9), 1897-1901. doi: 10.2337/dc11-0560

Sosenko, J. M., Skyler, J. S., Palmer, J. P., Krischer, J. P., Cuthbertson, D., Yu, L., … Diabetes Prevention Trial-Type 1, and Type 1 Diabetes TrialNet Study Groups, including Manning, P. (2011). A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants. Diabetes Care, 34(11), 2435-2437. doi: 10.2337/dc11-0981

Scott, R., Donoghoe, M., Watts, G. F., O'Brien, R., Pardy, C., Taskinen, M.-R., … Manning, P., … Keech, A. C. (2011). Impact of metabolic syndrome and its components on cardiovascular disease event rates in 4900 patients with type 2 diabetes assigned to placebo in the FIELD randomised trial. Cardiovascular Diabetology, 10, 102. doi: 10.1186/1475-2840-10-102

Davis, T. M. E., Ting, R. D., Best, J. D., Donoghoe, M. W., Drury, P. L., Sullivan, D. R., … on behalf of the FIELD Study Investigators, including Manning, P. (2011). Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: The fenofibrate intervention and event lowering in diabetes (FIELD) study. Diabetologia, 54(2), 280-290. doi: 10.1007/s00125-010-1951-1

Slade, H., Williams, S. M., Manning, P. J., & Walker, R. J. (2011). High-risk diabetic nephropathy patients: The outcome of evidence-based clinical practice in an outpatient clinic. Diabetes Research & Clinical Practice, 92(3), 356-360. doi: 10.1016/j.diabres.2011.02.022

Vos, F. E., Manning, P. J., Sutherland, W. H. F., Schollum, J. B., & Walker, R. J. (2011). Anti-inflammatory effect of an insulin infusion in patients on maintenance haemodialysis: A randomized controlled pilot study. Nephrology, 16(1), 68-75. doi: 10.1111/j.1440-1797.2010.01329.x

Conference Contribution - Published proceedings: Abstract

Latt, L., Manning, P., Tordoff, D., & Dent, J. (2011). Teaching and learning in an integrated ambulatory medicine programme for undergraduate medical students in Dunedin, New Zealand. Proceedings of the International Association for Medical Education in Europe (AMEE) Conference. (pp. 81-82). Retrieved from http://www.amee.org/index.asp

Vos, F. E., Schollum, J. B., Coulter, C. V., Manning, P. J., Duffull, S. B., & Walker, R. J. (2011). Assessment of glycaemic control in chronic kidney disease. Nephrology, 16(Suppl. 1), (pp. 38). doi: 10.1111/j.1440-1797.2011.01493_7.x

Conference Contribution - Verbal presentation and other Conference outputs

Manning, P. (2011, November). Treatment of metabolic syndrome/NASH. Verbal presentation at the New Zealand Society of Gastroenterology & NZNO Gastroenterology Nurses Section Annual Scientific Meeting, Dunedin, New Zealand.

2010

Journal - Research Article

Taskinen, M.-R., Barter, P. J., Ehnholm, C., Sullivan, D. R., Mann, K., Simes, J., … on behalf of the FIELD Study Investigators, including Manning, P. (2010). Ability of traditional lipid ratios and apolipoprotein ratios to predict cardiovascular risk in people with type 2 diabetes. Diabetologia, 53(9), 1846-1855. doi: 10.1007/s00125-010-1806-9

Simes, J., Voysey, M., O'Connell, R., Glasziou, P., Best, J. D., Scott, R., … for the FIELD Study Investigators, including Manning, P. (2010). A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials. PLoS ONE, 5(1), e8580. doi: 10.1371/journal.pone.0008580

Taylor, R. W., Brooking, L., Williams, S. M., Manning, P. J., Sutherland, W. H., Coppell, K. J., Tipene-Leach, D., Dale, K. S., McAuley, K. A., & Mann, J. I. (2010). Body mass index and waist circumference cutoffs to define obesity in indigenous New Zealanders. American Journal of Clinical Nutrition, 92, 390-397. doi: 10.3945/ajcn.2010.29317

Conference Contribution - Published proceedings: Abstract

Rajamani, K., Donoghoe, M., Li, L., Ting, R.-D., Colman, P., Scott, R., … FIELD Study Investigators, including Manning, P. (2010). Fenofibrate reduces peripheral neuropathy in type 2 diabetes: The fenofibrate intervention and event lowering in diabetes (FIELD) study. Atherosclerosis Supplements, 11(2), (pp. 219-220). [Abstract]

2009

Journal - Research Article

Herold, K. C., Brooks-Worrell, B., Palmer, J., Dosch, H. M., Peakman, M., Gottlieb, P., … and the Type 1 Diabetes TrialNet Research Group, including Manning, P. (2009). Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes, 58(11), 2588-2595. doi: 10.2337/db09-0249

Mahon, J. L., Sosenko, J. M., Rafkin-Mervis, L., Krause-Steinrauf, H., Lachin, J. M., Thompson, C., … for the TrialNet Natural History Committee, and Type 1 Diabetes TrialNet Study Group, including Manning, P. (2009). The TrialNet Natural History study of the development of type 1 diabetes: Objectives, design, and initial results. Pediatric Diabetes, 10(2), 97-104. doi: 10.1111/j.1399-5448.2008.00464.x

Taskinen, M.-R., Sullivan, D. R., Ehnholm, C., Whiting, M., Zannino, D., Simes, R. J., … for the FIELD Study Investigators, including Manning, P. (2009). Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate. Arteriosclerosis, Thrombosis, & Vascular Biology, 29, 950-955. doi: 10.1161/ATVBAHA.108.178228

Rajamani, K., Colman, P. G., Li, L. P., Best, J. D., Voysey, M., D'Emden, M. C., … on behalf of the FIELD Study Investigators, including Manning, P. (2009). Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): A prespecified analysis of a randomised controlled trial. Lancet, 373(9677), 1780-1788. doi: 10.1016/S0140-6736(09)60698-X

Scott, R., O'Brien, R., Fulcher, G., Pardy, C., D'Emden, M., Tse, D., … on behalf of the Fenofibrate Intervention and Event Lowering in Diabete (FIELD) Study Investigators, including Manning, P. (2009). Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome. Diabetes Care, 32(3), 493-498. doi: 10.2337/dc08-1543

Journal - Research Other

Choi, A.-R. A., & Manning, P. (2009). Overshooting the mark: Subclinical hyperthyroidism secondary to excess thyroid hormone treatment may be more prevalent than we realise [Letter]. New Zealand Medical Journal, 122(1289). Retrieved from http://journal.nzma.org.nz/journal/122-1289/3473/content.pdf

Conference Contribution - Published proceedings: Abstract

Vos, F. E., Manning, P. J., Sutherland, W. H. F., Schollum, J., & Walker, R. J. (2009). Does insulin have an anti-inflammatory effect in patients with end-stage renal disease on haemodialysis? Nephrology. 14(Suppl. 1), (pp. A4). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Vos, F. E., Manning, P. J., Sutherland, W. H. F., Schollum, J., & Walker, R. J. (2009, September). Does insulin have an anti-inflammatory effect on haemodialysis in patients with end-stage renal disease? Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

2008

Journal - Research Article

Greenbaum, C., Mandrup-Poulsen, T., McGee, P. F., Battelino, T., Haastert, B., Ludvigsson, J., … the Type 1 Diabetes TrialNet Research Group, and the European C-Peptide Trial Study Group, including Manning, P. (2008). Mixed-meal tolerance test versus glucagon stimulation test for the assessment of β-cell function in therapeutic trials in type 1 diabetes. Diabetes Care, 31(10), 1966-1971. doi: 10.2337/dc07-2451

Manning, P. J., Sutherland, W. H. F., McGrath, M. M., de Jong, S. A., Walker, R. J., & Williams, M. J. A. (2008). Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity, 16(9), 2046-2052. doi: 10.1038/oby.2008.334

Manning, P. J., Sutherland, W. H. F., Walker, R. J., Williams, S. M., de Jong, S. A., & Berry, E. A. (2008). The effect of rosiglitazone on oxidative stress and insulin resistance in overweight individuals. Diabetes Research & Clinical Practice, 81, 209-215.

Manning, P. J., Sutherland, W. H. F., Walker, R. J., de Jong, S. A., & Berry, E. A. (2008). The effect of glucose ingestion on inflammation and oxidative stress in obese individuals. Metabolism, 57, 1345-1349.

Conference Contribution - Published proceedings: Abstract

Stott, V., Manning, P., Astwood, D., & Farrand, S. (2008). Are insulin-like growth factor-1 levels affected by the presence of Type 2 diabetes mellitus? Diabetes Research and Clinical Practice. 79(Suppl. 1), (pp. S62). [Abstract]

Manning, P. J., Sutherland, W. H. F., McGrath, M., de Jong, S. A., Walker, R. J., & Williams, M. J. A. (2008). The effect of meals rich in different types of fat and carbohydrate on plasma inflammatory cytokine concentrations in obese and lean women. Diabetes Research and Clinical Practice. 79(Suppl. 1), (pp. S16). [Abstract]

Manning, P. J., Sutherland, W. H. F., Walker, R. J., de Jong, S. A., & Berry, E. A. (2008). The effect of glucose ingestion on inflammation and oxidative stress in obesity. Diabetes Research and Clinical Practice. 79(Suppl. 1), (pp. S26). [Abstract]

2007

Journal - Research Article

Keech, A. C., Mitchell, P., Summanen, P. A., O'Day, J., Davis, T. M. E., Moffitt, M. S., … for the FIELD Study Investigators, including Manning, P. (2007). Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial. Lancet, 370(9600), 1687-1697. doi: 10.1016/S0140-6736(07)61607-9

Sutherland, W. H. F., Manning, P. J., Walker, R. J., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2007). Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity, 15(2), 386-391. doi: 10.1038/oby.2007.546

Helge, J. W., Rehrer, N. J., Pilegaard, H., Manning, P., Lucas, S. J. E., Gerrard, D. F., & Cotter, J. D. (2007). Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise. Acta Physiologica, 191, 77-86.

2006

Journal - Research Article

Florkowski, C. M., Brownlie, B. E. W., Croxson, M. S., Manning, P., Farrand, S., Smith, G., … George, P. M. (2006). Thyroid hormone resistance: The role of mutational analysis. Internal Medicine Journal, 36, 738-741.

Coppell, K. J., Anderson, K., Williams, S., Manning, P., & Mann, J. (2006). Evaluation of diabetes care in the Otago region using a diabetes register, 1998-2003. Diabetes Research & Clinical Practice, 71, 345-352.

Journal - Research Other

Astwood, D., Yoon, H.-S., & Manning, P. J. (2006). Hyperandrogenism in a patient with previous colorectal cancer [Letter to the editor]. Internal Medicine Journal, 36(11), 751-752.

2005

Journal - Research Article

Markou, A., Manning, P., Kaya, B., Datta, S. N., Bomanji, J. B., & Conway, G. S. (2005). [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing's syndrome. European Journal of Endocrinology, 152(4), 521-525.

Adams, D. D., Knight, J. G., Manning, P., & Smith, G. (2005). An informative case of Graves' disease with implications for schizophrenia. Journal of Clinical & Laboratory Immunology, 53, 13-25.

O'Connell, R., Parkin, L., Manning, P., Bell, D., Herbison, P., & Holmes, J. (2005). A cluster of thyrotoxicosis associated with consumption of a soy milk product. Australian & New Zealand Journal of Public Health, 29(6), 511-512. doi: 10.1111/j.1467-842X.2005.tb00240.x

Goulding, A., Jones, I. E., Williams, S. M., Grant, A. M., Taylor, R. W., Manning, P. J., & Langley, J. (2005). First fracture is associated with increased risk of new fractures during growth. Journal of Pediatrics, 146, 286-288.

Journal - Research Other

Manning, P. J., Sutherland, W. H. F., & Walker, R. J. (2005). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects [Response to Vale]. Diabetes Care, 28(1), 230-231.

Stott, V., Manning, P., & Hung, N. (2005). Idiopathic granulomatous hypophysitis [Case report]. New Zealand Medical Journal, 118(1211). Retrieved from http://journal.nzma.org.nz/journal/118-1211/1355/content.pdf

Conference Contribution - Published proceedings: Abstract

Cotter, J. D., Rehrer, N. J., Manning, P., Lucas, S. J. E., Gerrard, D. F., & Helge, J. W. (2005). The metabolism of adventure racing. In I. Holmér, K. Kuklane & C. Gao (Eds.), Proceedings of the 11th International Conference on Environmental Ergonomics. (pp. 29). Retrieved from http://www.environmental-ergonomics.org/

Coppell, K., Anderson, K., Williams, S., Manning, P., & Mann, J. (2005). Changes in diabetes care over a 6-year period in the Otago region, New Zealand. Proceedings of the New Zealand Society for the Study of Diabetes 29th Annual Meeting. (pp. 19). Rotorua, New Zealand: NZSSD. [Abstract]

2004

Journal - Research Article

Manning, P. J., Sutherland, W. H., Hendry, G., de Jong, S. A., McGrath, M., & Williams, S. M. (2004). Changes in circulating postprandial proinflammatory cytokine concentrations in diet-controlled type 2 diabetes and the effect of ingested fat. Diabetes Care, 27(10), 2509-2511.

Manning, P. J., Sutherland, W. H., Walker, R. J., Williams, S. M., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2004). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. Diabetes Care, 27(9), 2166-2171.

2003

Journal - Research Article

Hall, R. J., Merriman, M. E., Green, R. A., Markham, V. H., Smyth, D. J., Heward, J. M., … Braithwaite, A., … Darlow, B. A., … Harrison, A. A., Highton, J., Hunt, P. J., Manning, P. J., … Scott, R. S., Taylor, B. J., Willis, J., … Merriman, T. R. (2003). The Deleted in Colorectal Carcinoma (DCC) gene 201 R → G polymorphism: No evidence for genetic association with autoimmune disease. European Journal of Human Genetics, 11, 840-844.

Manning, P. J., Espiner, E. A., Yoon, K., Drury, P. L., Holdaway, I. M., & Bowers, A. J. (2003). An unusual cause of hyperinsulinaemic hypoglycaemia syndrome. Diabetic Medicine, 20, 772-776.

Manning, P. J., Sutherland, W. H. F., Allum, A. R., de Jong, S. A., & Jones, S. (2003). HRT does not improve urinary albumen excretion in postmenopausal diabetic women. Diabetes Research & Clinical Practice, 60(1), 33-39.

Conference Contribution - Published proceedings: Abstract

Coppell, K., Manning, P., Medlicott, T., McBride, K., Gillies, J., Mann, J., & for the Otago Diabetes Team. (2003). The Otago Diabetes Project: Improvement in diabetes care after 4 years. Proceedings of the 9th Meeting of the International Diabetes Epidemiology Group and the 38th Annual Meeting of the European Diabetes Epidemiology Group. (OC20). [Abstract]

2002

Journal - Research Article

Coppell, K., & Manning, P. J. (2002). Establishing a regional diabetes register and a description of the registered population after one year. New Zealand Medical Journal, 115(1160), U146. Retrieved from http://www.nzma.org.nz/journal/

Jones, I. E., Taylor, R. W., Williams, S. M., Manning, P. J., & Goulding, A. (2002). Four-year gain in bone mineral in girls with and without past forearm fractures: A DXA study. Journal of Bone & Mineral Research, 17(6), 1065-1072.

Manning, P. J., Sutherland, W. H. F., Allum, A. R., de Jong, S. A., & Jones, S. D. (2002). The effect of hormone replacement therapy on inflammation-sensitive proteins in post-menopausal women with Type 2 diabetes. Diabetic Medicine, 19(10), 847-852. doi: 10.1046/j.1464-5491.2002.00808.x

Goulding, A., Taylor, R. W., Jones, I. E., Manning, P. J., & Williams, S. M. (2002). Spinal overload: A concern for obese children and adolescents? Osteoporosis International, 13, 835-840.

2001

Journal - Research Article

Manning, P. J., Allum, A., Jones, S., Sutherland, W. H. F., & Williams, S. M. (2001). The effect of hormone replacement therapy on cardiovascular risk factors in type 2 diabetes: A randomised controlled trial. Archives of Internal Medicine, 161, 1772-1776.

Goulding, A., Jones, I. E., Taylor, R. W., Williams, S. M., & Manning, P. J. (2001). Bone mineral density and body composition in boys with distal forearm fractures: A dual-energy x-ray absorptiometry study. Journal of Pediatrics, 139(4), 509-515.

Hip Intervention Program Study, & Manning, P. J. (2001). Effect of risedronate on the risk of hip fracture in elderly women. New England Journal of Medicine, 344(5), 333-340.

Sutherland, W. H., Manning, P. J., de Jong, S. A., Allum, A. R., Jones, S. D., & Williams, S. M. (2001). Hormone replacement therapy increases serum paraoxonase arylesterase activity in diabetic postmenopausal women. Metabolism, 50, 319-324.

Conference Contribution - Published proceedings: Abstract

Merriman, T., Hall, R., Merriman, M., Cundy, T., Darlow, B., Highton, J., … Mann, J., Manning, P., … Markham, V., Rossaak, J., Scott, R., Taylor, B., & Willis, J. (2001). Deleted in colorectal carcinoma (DCC): A candidate autoimmune susceptibility gene on chromosome 18. Internal Medicine Journal, 31(4), (pp. A5). doi: 10.1046/j.1445-5994.2001.0060a.x

2000

Journal - Research Article

Rodby, R. A., Rohde, R. D., Clarke, W. R., Hunsicker, L. G., Anzalone, D. A., Atkins, R. C., … Manning, P. J. (2000). The Ibesarten type 2 diabetic nephropathy trial: Study design and baseline characteristics. Nephrology Dialysis Transplantation, 15(4), 487-497.

McBain, L., McLeod, D., Coppell, K., & Manning, P. (2000). The provision of care for patients with diabetes in general practice. New Zealand Family Physician, 27(26), 49-55.

Goulding, A., Jones, I. E., Taylor, R. W., Manning, P. J., & Williams, S. M. (2000). More broken bones: A 4-year double cohort study of young girls with and without distal forearm fractures. Journal of Bone & Mineral Research, 15(10), 2011-2018.

McBain, L., McLeod, D., Coppell, K., & Manning, P. J. (2000). Diabetes care in general practice. New Zealand Family Physician, 27(6), 49-60.

Goulding, A., Taylor, R. W., Jones, I. E., McAuley, K. A., Manning, P. J., & Williams, S. M. (2000). Overweight and obese children have low bone mass and area for their weight. International Journal of Obesity, 24, 627-632.

McAuley, K., Cambridge, L., Galloway, S. M., Sullivan, J. A., & Manning, P. J. (2000). De nono deletion of xq associated with premature ovarian failure. Australian & New Zealand Journal of Medicine, 30, 89-90.

1999

Journal - Professional & Other Non-Research Articles

Manning, P. J. (1999). Hypoglycaemia in type 1 diabetes. New Zealand Medical Journal, 112(1090), 219-221.

Walker, R. J., & Manning, P. J. (1999). Diabetic nephropathy: Assessment and management. New Ethicals, 2(7), 49-55.

Conference Contribution - Published proceedings: Abstract

Clow, O. L., Manning, P. J., & Fleming, J. S. (1999). Expression of activin subunits and activin receptors in human pituitary adenomas. Proceedings of the New Zealand Society of Endocrinology. 42, (pp. NZ14, 243). Melbourne, Australia: The Endocrine Society of Australia. [Abstract]

Bolter, C. J., Manning, P. J., & Fleming, J. S. (1999). Expression of growth hormone receptor messenger RNA in human pituitary adenomas. Proceedings of the NZ Society of Endocrinology 1999. 42, (pp. NZ21, 225-NZ21,225). Melbourne: The Endocrine Society of Australia. [Abstract]

1998

Journal - Research Article

Schwartz, M. M., Lewis, E. J., Leonard-Martin, T., Lewis, J. B., Batlle, D., & Manning, P. J. (1998). Renal pathology patterns in type 2 diabetes mellitis: Relationship with retinopathy: The collaborative study group. Nephrology Dialysis Transplantation, 13(10), 2547-2552.

Conference Contribution - Published proceedings: Abstract

Goulding, A., Taylor, R. W., Jones, I. E., McAuley, K., & Manning, P. J. (1998). Fractures: are overweight children at increased risk? In J. Jensen (Ed.), Proceedings of New Zealand Dietetic Association. 3, (pp. 68-70). Christchurch: New Zealand Dietetic Association. [Abstract]

1997

Journal - Research Article

Manning, P. J., Sutherland, W. H. F., & Mann, J. (1997). Late diagnosis of diabetic ketoacidosis and underlying disease influence response to treatment. British Medical Journal, 314, 63.

Manning, P. J., Sutherland, W. H. F., & Mann, J. (1997). Hyperchylomicronaemia might have resolved anyway. British Medical Journal, 314, 65.

McAuley, K. A., Jones, S., Lewis-Barned, N. J., Manning, P. J., & Goulding, A. (1997). Low vitamin D status is common among elderly Dunedin women. New Zealand Medical Journal, 110(1048), 275-277.

Taylor, R. W., Gold, E. J., Manning, P. J., & Goulding, A. (1997). Gender differences in body fat content are present well before puberty. International Journal of Obesity, 21(11), 1082-1084.

1996

Journal - Research Article

Florkowski, C. M., Holdaway, I. M., Manning, P. J., & Donald, R. A. (1996). The case for growth hormone replacement in adult hypopituitarism. New Zealand Medical Journal, 109, 349-351.