Red X iconGreen tick iconYellow tick icon

Contact Details

+64 3 470 3455
Senior Lecturer
Department of Pathology (Dunedin)
BSc(Hons) PhD
Research summary
Epigenetic regulation of early human development and later-life disease
  • GENE313 Medical Genetics
  • GENE412 Current Topics in Genetics
  • MICN201 Medicine 2nd year, Pathology
  • PSCI202 Medicines and Diseases
  • PATH302 Cancer Biology, guest lecturer
  • Convenor of PSCI202 Medicines and Diseases, Pathology
  • Editorial Board, Frontiers in Cell and Developmental Biology and Frontiers in Genetics
  • Review Editor, Frontiers in Epigenomics and Epigenetics
  • Genetics Otago Advisory Board
  • Australian & NZ Placental Research Association
  • Genetics Otago (University of Otago)
  • Early Career Researcher Advancement Group (University of Otago)
  • The Phi Beta Kappa Society (USA)


I investigate the epigenetic mechanisms that regulate early human and placental development, pregnancy-related pathologies and later-life diseases including cancer.

I have a particular interest in the activity of transposable elements in the genome, since some transposable elements create new genes that are critical for normal human development yet also feature in adult malignancies.

I also investigate the genetics and epigenetics of female-specific cancers, including a rare form of hormone-dependent lung tumours, known as Lymphangioleiomyomatosis (LAM).

My passion is to harness the insights gained from early human development to advance our evolving paradigms of human health and disease.


Powell, R. M., Moravec, J. C., Jones, G. T., Bhat, B., Lin, S. M., Planer, J. D., … Pattison, S., Morison, I. M., … Eccles, M. R., & Macaulay, E. C. (2024). DNA methylation profiling of heterogeneous sporadic LAM and matched lung tissue. American Journal of Respiratory Cell & Molecular Biology, 70(1), 81-84. doi: 10.1165/rcmb.2023-0300LE Journal - Research Other

Weeks, R., Almomani, S. N., Macaulay, E., Powell, R., Bhat, B., Zuk, M., … Eccles, M. R., & Ratajska, M. (2023, August). Early detection of lung cancer and identification of potential molecular targets for novel therapies via genetic and epigenetic screening. Verbal presentation at the Queenstown Molecular Biology (QMB) Genomics Satellite, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Lynch-Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., … Chatterjee, A., … Eccles, M. R., & Macaulay, E. C. (2023). The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours. Molecular Genetics & Genomics. Advance online publication. doi: 10.1007/s00438-023-02033-1 Journal - Research Article

Keighley, L. M., Lynch-Sutherland, C. F., Almomani, S. N., Eccles, M. R., & Macaulay, E. C. (2023). Unveiling the hidden players: The crucial role of transposable elements in the placenta and their potential contribution to pre-eclampsia. Placenta. Advance online publication. doi: 10.1016/j.placenta.2023.05.017 Journal - Research Article

Keighley, L., Lynch-Sutherland, C., McDougall, L., Almomani, S., Weeks, R., Gamage, T., … Eccles, M., & Macaulay, E. (2022). Investigating transposable element derived genes in pre-eclampsia. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from Conference Contribution - Published proceedings: Abstract

Back to top