2024
Journal - Research Article
Keighley, L. M., Lynch-Sutherland, C. F., McDougall, L., Almomani, S. N., Stockwell, P., & Macaulay, E. C. (2024). Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions. Placenta. Advance online publication. doi: 10.1016/j.placenta.2024.09.010
Journal - Research Other
Powell, R. M., Moravec, J. C., Jones, G. T., Bhat, B., Lin, S. M., Planer, J. D., … Pattison, S., Morison, I. M., … Eccles, M. R., & Macaulay, E. C. (2024). DNA methylation profiling of heterogeneous sporadic LAM and matched lung tissue. American Journal of Respiratory Cell & Molecular Biology, 70(1), 81-84. doi: 10.1165/rcmb.2023-0300LE
2023
Journal - Research Article
Lynch-Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., … Chatterjee, A., … Eccles, M. R., & Macaulay, E. C. (2023). The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours. Molecular Genetics & Genomics. Advance online publication. doi: 10.1007/s00438-023-02033-1
Keighley, L. M., Lynch-Sutherland, C. F., Almomani, S. N., Eccles, M. R., & Macaulay, E. C. (2023). Unveiling the hidden players: The crucial role of transposable elements in the placenta and their potential contribution to pre-eclampsia. Placenta. Advance online publication. doi: 10.1016/j.placenta.2023.05.017
Conference Contribution - Verbal presentation and other Conference outputs
Weeks, R., Almomani, S. N., Macaulay, E., Powell, R., Bhat, B., Zuk, M., … Eccles, M. R., & Ratajska, M. (2023, August). Early detection of lung cancer and identification of potential molecular targets for novel therapies via genetic and epigenetic screening. Verbal presentation at the Queenstown Molecular Biology (QMB) Genomics Satellite, Queenstown, New Zealand.
2022
Journal - Research Article
Powell, R. M., Pattison, S., Moravec, J. C., Bhat, B., Guirguis, N., Markie, D., Jones, G. T., … Print, C. G., Morison, I. M., Gavryushkin, A., … Eccles, M. R., & Macaulay, E. C. (2022). Tuberous sclerosis complex: A complex case. Molecular Case Studies, 8, a006182. doi: 10.1101/mcs.a006182
Conference Contribution - Published proceedings: Abstract
Keighley, L., Lynch-Sutherland, C., McDougall, L., Almomani, S., Weeks, R., Gamage, T., … Eccles, M., & Macaulay, E. (2022). Investigating transposable element derived genes in pre-eclampsia. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
2021
Journal - Research Article
Stockwell, P. A., Lynch-Sutherland, C. F., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). RepExpress: A novel pipeline for the quantification and characterization of transposable element expression from RNA-seq data. Current Protocols, 1(8), e206. doi: 10.1002/cpz1.206
Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005
Motwani, J., Rodger, E. J., Stockwell, P. A., Baguley, B. C., Macaulay, E. C., & Eccles, M. R. (2021). Genome-wide DNA methylation and RNA expression differences correlate with invasiveness in melanoma cell lines. Epigenomics, 13(8), 577-598. doi: 10.2217/epi-2020-0440
McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320
Journal - Research Other
Hossain, S. M., Lynch-Sutherland, C., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). Can immune suppression and epigenome regulation in placenta offer novel insights into cancer immune evasion and immunotherapy resistance? Epigenomes, 5, 16. doi: 10.3390/epigenomes5030016
2020
Journal - Research Article
Lynch-Sutherland, C. F., Chatterjee, A., Stockwell, P. A., Eccles, M. R., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Frontiers in Oncology, 10, 468. doi: 10.3389/fonc.2020.00468
Reily-Bell, A. L., Fisher, A., Harrison, B., Bowie, S., Ray, S., Hawkes, M., … Fukuzawa, R., Macaulay, E. C., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2020). Human papillomavirus E6/E7 expression in preeclampsia-affected placentae. Pathogens, 9(3), 239. doi: 10.3390/pathogens9030239
Conference Contribution - Published proceedings: Abstract
Powell, R. M., Merrilees, M. J., Pattison, S., Gray, B., Jones, G. T., Eccles, M. R., & Macaulay, E. C. (2020). Epigenetic investigations in LAM: Using heritable biomarkers to trace cell lineage. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/
Lynch-Sutherland, C. F., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/
Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Bessemer, B., Chatterjee, A., Alsaleh, A. A., Stockwell, P. A., Ludgate, J. L., Weeks, R. J., Jones, G. T., Day, R. C., Fukazawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2020). The potential power of placental epigenetics [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/
2019
Conference Contribution - Published proceedings: Abstract
Lynch-Sutherland, C., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2019). Good genes gone bad: Are placental genes hijacked by cancer cells to facilitate invasion? Proceedings of the 16th Asian Conference on Transcription. (pp. 77). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02
Conference Contribution - Verbal presentation and other Conference outputs
Lynch-Sutherland, C. F., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2019, August-September). Good genes gone bad: Are placental genes hijacked by cancer cells to facilitate invasion? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Chatterjee, A. C., Stockwell, P. A., Alsaleh, A. A., Wilson, J. L., Weeks, R. J., Day, R. C., Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2019, August-September). The placental potential: Harnessing insights from placental epigenetics to predict disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Journal - Research Article
Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics, 13(12), 1154-1173. doi: 10.1080/15592294.2018.1549462
Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open, 7, bio034884. doi: 10.1242/bio.034884
Conference Contribution - Published proceedings: Abstract
Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Global DNA methylation levels are comparable between trophoblast populations and many somatic cells. Placenta, 69, (pp. E64). doi: 10.1016/j.placenta.2018.06.004
2017
Journal - Research Article
Macaulay, E. C., Chatterjee, A., Cheng, X., Baguley, B. C., Eccles, M. R., & Morison, I. M. (2017). The genes of life and death: A potential role for placental-specific genes in cancer: Active retrotransposons in the placenta encode unique functional genes that may also be used by cancer cells to promote malignancy. BioEssays, 39(11), 1700091. doi: 10.1002/bies.201700091
Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176
Conference Contribution - Published proceedings: Abstract
Almomani, S., Morison, I., Hung, N., Slatter, T., & Macaulay, E. (2017). Predicting altered methylation patterns in early pre-eclampsia. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 778. Retrieved from http://gen2017.w.events4you.currinda.com
Gamage, T., Schierding, W., Tsai, P., Ludgate, J., Macaulay, E., Weeks, R., … James, J. (2017). Global methylation profiling reveals intragenic methylation as a novel regulator of human trophoblast differentiation. Placenta, 57, (pp. 261). doi: 10.1016/j.placenta.2017.07.128
Gamage, T., Schierding, W., Hurley, D., Tsai, P., Ludgate, J., Macaulay, E., Weeks, R., … James, J. (2017). Gene methylation regulates the acquisition of an invasive phenotype during extravillous trophoblast differentiation. Placenta, 57, (pp. 304). doi: 10.1016/j.placenta.2017.07.255
Conference Contribution - Poster Presentation (not in published proceedings)
Momani, S., Morison, I. M., Hung, N. A., Slatter, T. L., & Macaulay, E. C. (2017, September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Morison, I. M., Weeks, R. J., Macaulay, E. C., Alsaleh, A. A., Almomani, S. N., & Day, R. C. (2017, September). Tissue-specific epigenetic markers and disease discovery. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Macaulay, E. C., Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2017, September). Profiling the placental epigenome in pre-eclampsia to predict pregnancy outcomes. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2016
Journal - Research Article
Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379
Journal - Research Other
Macaulay, E. C., & Bloomfield, F. H. (2016). Unravelling the link between the placental epigenome and pregnancy outcomes. Biology of Reproduction, 94(4), 82. doi: 10.1095/biolreprod.116.139915
Conference Contribution - Poster Presentation (not in published proceedings)
Macaulay, E. C., Chatterjee, A., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., & Morison, I. M. (2016, March). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Poster session presented at the Keystone Symposia on Molecular and Cellular Biology: Chromatin and Epigenetics, Whistler, Canada.
Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2016, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Macaulay, E. (2016, February). Methylome meets maternity ward: Predicting pre-eclampsia in early pregnancy. Invited presentation at the Placenta: A Key Mediator of Fetal Development Workshop, Auckland, New Zealand.
2015
Conference Contribution - Published proceedings: Full paper
Macaulay, E. C., Roberts, H. E., Al-Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2015). Methylome meets maternity ward: Predicting pre-eclampsia in early pregnancy. Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics (BCB). (pp. 484-485). New York: ACM. doi: 10.1145/2808719.2811419
Conference Contribution - Poster Presentation (not in published proceedings)
Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2015, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Macaulay, E. (2015, October). How Gravida has supported/directed my career. Invited presentation at the Gravida Science Symposium, Auckland, New Zealand.
Morison, I. M., Macaulay, E. C., & Chatterjee, A. (2015, August-September). Patterns of placental methylation and implications for placental disease and cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Journal - Research Article
Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840
Journal - Research Other
Macaulay, E. C., Donovan, E. L., Leask, M. P., Bloomfield, F. H., Vickers, M. H., Dearden, P. K., … and on behalf of the Gravida International College Summit Team. (2014). The importance of early life in childhood obesity and related diseases: A report from the 2014 Gravida Strategic Summit. Journal of Developmental Origins of Health & Disease, 5(6), 398-407. doi: 10.1017/S2040174414000488
Conference Contribution - Published proceedings: Abstract
Knarston, I., Macaulay, E., Roberts, H., Slatter, T., Hung, N., Devenish, C., & Morison, I. (2014). Validation of DNA methylation biomarkers for pre-eclampsia. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
2013
Conference Contribution - Published proceedings: Abstract
Macaulay, E. C., Roberts, H. E., Hung, N. A., & Morison, I. M. (2013). Epigenetic markers for pre-eclampsia. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/
Roberts, H., Macaulay, E., Hung, N., & Morison, I. (2013). Epigenetic profiling of pre-eclamptic placentas. Placenta, 34(9), (pp. A66). doi: 10.1016/j.placenta.2013.06.199
Conference Contribution - Poster Presentation (not in published proceedings)
Macaulay, E. C., Roberts, H. E., Hung, N. A., & Morison, I. M. (2013, July). Epigenetic markers for pre-eclampsia. Poster session presented at the EpiCongress, Boston, USA.
Roberts, H. E., Macaulay, E. C., Hung, N. A., & Morison, I. M. (2013, August). Epigenetic profiling of pre-eclamptic placentas. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Macaulay, E. (2013, February). Epigenetic profiling of the normal and pre-eclamptic human placenta. Invited presentation at the Placenta and Healthy Pregnancy Workshop, Auckland, New Zealand.
2012
Journal - Research Article
Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981
Conference Contribution - Verbal presentation and other Conference outputs
Roberts, H. E., Macaulay, E. C., & Morison, I. M. (2012, November). Epigenetic profiling of pre-eclamptic placentas. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand.
Roberts, H. E., Macaulay, E. C., Cheng, S., & Morison, I. M. (2012, August). Retrotransposon hypomethylation is linked to expression of a placenta-specific transcript in melanoma. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1
Journal - Research Other
Abad, C., Antczak, D. F., Carvalho, J., Chamley, L. W., Chen, Q., Daher, S., … Daly, E., … Lash, G. E. (2011). IFPA Meeting 2010 Workshop Report I: Immunology; ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics. Placenta, 32(Suppl. 2), S81-S89. doi: 10.1016/j.placenta.2010.12.019
Conference Contribution - Verbal presentation and other Conference outputs
Macaulay, E. C., & Morison, I. M. (2011, November). The intersect of placental epigenetics with placental function and dysfunction. Verbal presentation at the National Research Centre for Growth & Development Science Symposium, Dunedin, New Zealand.
Macaulay, E. (2011, September). The intersect of placental epigenetics with placental function and dysfunction. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Other Research Output
Daly, E. (2011, February). Epigenetics of the placenta: A SINE of the times. Microbiology & Immunology Department Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar].
Macaulay, E. (2011, June). An epigenetic analysis of the human placenta. Pathology Department Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar].
Daly, E. (2011, April). Placental epigenetics. Centre for Reproduction and Genomics "Focus On" Seminar Series: Focus on Epigenetics, University of Otago, Dunedin, New Zealand. [Public Seminar].
Awarded Doctoral Degree
Macaulay, E. C. (2011). An epigenetic analysis of the human placenta (PhD). University of Otago, Dunedin, New Zealand. 269p.
2010
Conference Contribution - Published proceedings: Abstract
Daly, E. C., & Morison, I. M. (2010). Differential epigenetic modification of retrotransposon-derived genes in the human placenta. Proceedings of the Genetics Society of America Conference: Model Organisms to Human Biology. (pp. 72-73). Retrieved from http://www.genetics-gsa.org/pages/conferences.shtml
Conference Contribution - Poster Presentation (not in published proceedings)
Daly, E. C., & Morison, I. M. (2010, June). Differential epigenetic modification of retrotransposon-derived genes in the human placenta. Poster session presented at the Epigenetic Mechanisms in Health & Disease Conference, Brussels, Belgium.
Conference Contribution - Verbal presentation and other Conference outputs
Daly, E. C., & Morison, I. M. (2010, October). Epigenetics in the placenta: A SINE of the times. Verbal presentation at the International Federation of Placenta Associations (IFPA) Conference: Fetus and Placenta: A Perfect Harmony, Santiago, Chile.
Daly, E., & Morison, I. (2010, August). Dichotomous methylation of retrotransposon-derived genes reveals early human cell lineage commitment. Verbal presentation at the National Research Centre for Growth & Development Science Symposium, Auckland, New Zealand.
2009
Conference Contribution - Poster Presentation (not in published proceedings)
Daly, E. C., & Morison, I. (2009, September). Turning off tumours: The placental potential. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Daly, E. C., & Morison, I. M. (2009, September-October). An epigenetic analysis of first-trimester human placenta. Verbal presentation at the National Research Centre for Growth & Development Science Symposium, Hamilton, New Zealand.
Daly, E. (2009, September). An epigenetic analysis of first-trimester human placenta. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Daly, E. (2009, November). Epigenetics in the placenta: A SINE of the times. Verbal presentation at the Genetics Otago Postgraduate Symposium, Dunedin, New Zealand.
2008
Conference Contribution - Published proceedings: Abstract
Daly, E. C., & Morison, I. M. (2008). Epigenetics in the placenta: A genome-wide methylation analysis of first trimester trophoblasts. Proceedings of the 8th Annual Australasian Microarray and Associated Technologies (AMATA) Conference. Retrieved from http://www.amata.org.au/index.php/resources/2008-conference-abstracts
Conference Contribution - Verbal presentation and other Conference outputs
Daly, E. C., & Morison, I. M. (2008, November). An epigenetic analysis of first-trimester human placenta. Verbal presentation at the Post-Graduates of Genetics Otago Research Symposium, Dunedin, New Zealand.
2007
Journal - Research Article
Botta, P., Radcliffe, R. A., Carta, M., Mameli, M., Daly, E., Floyd, K. L., … Valenzuela, C. F. (2007). Modulation of GABAA receptors in cerebellar granule neurons by ethanol: A review of genetic and electrophysiological studies. Alcohol, 41, 187-199. doi: 10.1016/j.alcohol.2007.04.004