Dr Erin Macaulay

2024

Journal - Research Article

Keighley, L. M., Lynch-Sutherland, C. F., McDougall, L., Almomani, S. N., Stockwell, P., & Macaulay, E. C. (2024). Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions. Placenta. Advance online publication. doi: 10.1016/j.placenta.2024.09.010

Journal - Research Other

Powell, R. M., Moravec, J. C., Jones, G. T., Bhat, B., Lin, S. M., Planer, J. D., … Pattison, S., Morison, I. M., … Eccles, M. R., & Macaulay, E. C. (2024). DNA methylation profiling of heterogeneous sporadic LAM and matched lung tissue. American Journal of Respiratory Cell & Molecular Biology, 70(1), 81-84. doi: 10.1165/rcmb.2023-0300LE

2023

Journal - Research Article

Lynch-Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., … Chatterjee, A., … Eccles, M. R., & Macaulay, E. C. (2023). The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours. Molecular Genetics & Genomics. Advance online publication. doi: 10.1007/s00438-023-02033-1

Keighley, L. M., Lynch-Sutherland, C. F., Almomani, S. N., Eccles, M. R., & Macaulay, E. C. (2023). Unveiling the hidden players: The crucial role of transposable elements in the placenta and their potential contribution to pre-eclampsia. Placenta. Advance online publication. doi: 10.1016/j.placenta.2023.05.017

Conference Contribution - Verbal presentation and other Conference outputs

Weeks, R., Almomani, S. N., Macaulay, E., Powell, R., Bhat, B., Zuk, M., … Eccles, M. R., & Ratajska, M. (2023, August). Early detection of lung cancer and identification of potential molecular targets for novel therapies via genetic and epigenetic screening. Verbal presentation at the Queenstown Molecular Biology (QMB) Genomics Satellite, Queenstown, New Zealand.

2022

Journal - Research Article

Powell, R. M., Pattison, S., Moravec, J. C., Bhat, B., Guirguis, N., Markie, D., Jones, G. T., … Print, C. G., Morison, I. M., Gavryushkin, A., … Eccles, M. R., & Macaulay, E. C. (2022). Tuberous sclerosis complex: A complex case. Molecular Case Studies, 8, a006182. doi: 10.1101/mcs.a006182

Conference Contribution - Published proceedings: Abstract

Keighley, L., Lynch-Sutherland, C., McDougall, L., Almomani, S., Weeks, R., Gamage, T., … Eccles, M., & Macaulay, E. (2022). Investigating transposable element derived genes in pre-eclampsia. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2021

Journal - Research Article

Stockwell, P. A., Lynch-Sutherland, C. F., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). RepExpress: A novel pipeline for the quantification and characterization of transposable element expression from RNA-seq data. Current Protocols, 1(8), e206. doi: 10.1002/cpz1.206

Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005

Motwani, J., Rodger, E. J., Stockwell, P. A., Baguley, B. C., Macaulay, E. C., & Eccles, M. R. (2021). Genome-wide DNA methylation and RNA expression differences correlate with invasiveness in melanoma cell lines. Epigenomics, 13(8), 577-598. doi: 10.2217/epi-2020-0440

McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320

Journal - Research Other

Hossain, S. M., Lynch-Sutherland, C., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). Can immune suppression and epigenome regulation in placenta offer novel insights into cancer immune evasion and immunotherapy resistance? Epigenomes, 5, 16. doi: 10.3390/epigenomes5030016

2020

Journal - Research Article

Lynch-Sutherland, C. F., Chatterjee, A., Stockwell, P. A., Eccles, M. R., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Frontiers in Oncology, 10, 468. doi: 10.3389/fonc.2020.00468

Reily-Bell, A. L., Fisher, A., Harrison, B., Bowie, S., Ray, S., Hawkes, M., … Fukuzawa, R., Macaulay, E. C., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2020). Human papillomavirus E6/E7 expression in preeclampsia-affected placentae. Pathogens, 9(3), 239. doi: 10.3390/pathogens9030239

Conference Contribution - Published proceedings: Abstract

Powell, R. M., Merrilees, M. J., Pattison, S., Gray, B., Jones, G. T., Eccles, M. R., & Macaulay, E. C. (2020). Epigenetic investigations in LAM: Using heritable biomarkers to trace cell lineage. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Lynch-Sutherland, C. F., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Bessemer, B., Chatterjee, A., Alsaleh, A. A., Stockwell, P. A., Ludgate, J. L., Weeks, R. J., Jones, G. T., Day, R. C., Fukazawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2020). The potential power of placental epigenetics [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

2019

Conference Contribution - Published proceedings: Abstract

Lynch-Sutherland, C., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2019). Good genes gone bad: Are placental genes hijacked by cancer cells to facilitate invasion? Proceedings of the 16th Asian Conference on Transcription. (pp. 77). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Conference Contribution - Verbal presentation and other Conference outputs

Lynch-Sutherland, C. F., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2019, August-September). Good genes gone bad: Are placental genes hijacked by cancer cells to facilitate invasion? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Chatterjee, A. C., Stockwell, P. A., Alsaleh, A. A., Wilson, J. L., Weeks, R. J., Day, R. C., Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2019, August-September). The placental potential: Harnessing insights from placental epigenetics to predict disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics, 13(12), 1154-1173. doi: 10.1080/15592294.2018.1549462

Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open, 7, bio034884. doi: 10.1242/bio.034884

Conference Contribution - Published proceedings: Abstract

Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Global DNA methylation levels are comparable between trophoblast populations and many somatic cells. Placenta, 69, (pp. E64). doi: 10.1016/j.placenta.2018.06.004

2017

Journal - Research Article

Macaulay, E. C., Chatterjee, A., Cheng, X., Baguley, B. C., Eccles, M. R., & Morison, I. M. (2017). The genes of life and death: A potential role for placental-specific genes in cancer: Active retrotransposons in the placenta encode unique functional genes that may also be used by cancer cells to promote malignancy. BioEssays, 39(11), 1700091. doi: 10.1002/bies.201700091

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Conference Contribution - Published proceedings: Abstract

Almomani, S., Morison, I., Hung, N., Slatter, T., & Macaulay, E. (2017). Predicting altered methylation patterns in early pre-eclampsia. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 778. Retrieved from http://gen2017.w.events4you.currinda.com

Gamage, T., Schierding, W., Tsai, P., Ludgate, J., Macaulay, E., Weeks, R., … James, J. (2017). Global methylation profiling reveals intragenic methylation as a novel regulator of human trophoblast differentiation. Placenta, 57, (pp. 261). doi: 10.1016/j.placenta.2017.07.128

Gamage, T., Schierding, W., Hurley, D., Tsai, P., Ludgate, J., Macaulay, E., Weeks, R., … James, J. (2017). Gene methylation regulates the acquisition of an invasive phenotype during extravillous trophoblast differentiation. Placenta, 57, (pp. 304). doi: 10.1016/j.placenta.2017.07.255

Conference Contribution - Poster Presentation (not in published proceedings)

Momani, S., Morison, I. M., Hung, N. A., Slatter, T. L., & Macaulay, E. C. (2017, September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Morison, I. M., Weeks, R. J., Macaulay, E. C., Alsaleh, A. A., Almomani, S. N., & Day, R. C. (2017, September). Tissue-specific epigenetic markers and disease discovery. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Macaulay, E. C., Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2017, September). Profiling the placental epigenome in pre-eclampsia to predict pregnancy outcomes. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Journal - Research Article

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379

Journal - Research Other

Macaulay, E. C., & Bloomfield, F. H. (2016). Unravelling the link between the placental epigenome and pregnancy outcomes. Biology of Reproduction, 94(4), 82. doi: 10.1095/biolreprod.116.139915

Conference Contribution - Poster Presentation (not in published proceedings)

Macaulay, E. C., Chatterjee, A., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., & Morison, I. M. (2016, March). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Poster session presented at the Keystone Symposia on Molecular and Cellular Biology: Chromatin and Epigenetics, Whistler, Canada.

Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2016, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Macaulay, E. (2016, February). Methylome meets maternity ward: Predicting pre-eclampsia in early pregnancy. Invited presentation at the Placenta: A Key Mediator of Fetal Development Workshop, Auckland, New Zealand.

2015

Conference Contribution - Published proceedings: Full paper

Macaulay, E. C., Roberts, H. E., Al-Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2015). Methylome meets maternity ward: Predicting pre-eclampsia in early pregnancy. Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics (BCB). (pp. 484-485). New York: ACM. doi: 10.1145/2808719.2811419

Conference Contribution - Poster Presentation (not in published proceedings)

Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2015, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Macaulay, E. (2015, October). How Gravida has supported/directed my career. Invited presentation at the Gravida Science Symposium, Auckland, New Zealand.

Morison, I. M., Macaulay, E. C., & Chatterjee, A. (2015, August-September). Patterns of placental methylation and implications for placental disease and cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840

Journal - Research Other

Macaulay, E. C., Donovan, E. L., Leask, M. P., Bloomfield, F. H., Vickers, M. H., Dearden, P. K., … and on behalf of the Gravida International College Summit Team. (2014). The importance of early life in childhood obesity and related diseases: A report from the 2014 Gravida Strategic Summit. Journal of Developmental Origins of Health & Disease, 5(6), 398-407. doi: 10.1017/S2040174414000488

Conference Contribution - Published proceedings: Abstract

Knarston, I., Macaulay, E., Roberts, H., Slatter, T., Hung, N., Devenish, C., & Morison, I. (2014). Validation of DNA methylation biomarkers for pre-eclampsia. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

2013

Conference Contribution - Published proceedings: Abstract

Macaulay, E. C., Roberts, H. E., Hung, N. A., & Morison, I. M. (2013). Epigenetic markers for pre-eclampsia. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/

Roberts, H., Macaulay, E., Hung, N., & Morison, I. (2013). Epigenetic profiling of pre-eclamptic placentas. Placenta, 34(9), (pp. A66). doi: 10.1016/j.placenta.2013.06.199

Conference Contribution - Poster Presentation (not in published proceedings)

Macaulay, E. C., Roberts, H. E., Hung, N. A., & Morison, I. M. (2013, July). Epigenetic markers for pre-eclampsia. Poster session presented at the EpiCongress, Boston, USA.

Roberts, H. E., Macaulay, E. C., Hung, N. A., & Morison, I. M. (2013, August). Epigenetic profiling of pre-eclamptic placentas. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Macaulay, E. (2013, February). Epigenetic profiling of the normal and pre-eclamptic human placenta. Invited presentation at the Placenta and Healthy Pregnancy Workshop, Auckland, New Zealand.

2012

Journal - Research Article

Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981

Conference Contribution - Verbal presentation and other Conference outputs

Roberts, H. E., Macaulay, E. C., & Morison, I. M. (2012, November). Epigenetic profiling of pre-eclamptic placentas. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand.

Roberts, H. E., Macaulay, E. C., Cheng, S., & Morison, I. M. (2012, August). Retrotransposon hypomethylation is linked to expression of a placenta-specific transcript in melanoma. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1

Journal - Research Other

Abad, C., Antczak, D. F., Carvalho, J., Chamley, L. W., Chen, Q., Daher, S., … Daly, E., … Lash, G. E. (2011). IFPA Meeting 2010 Workshop Report I: Immunology; ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics. Placenta, 32(Suppl. 2), S81-S89. doi: 10.1016/j.placenta.2010.12.019

Conference Contribution - Verbal presentation and other Conference outputs

Macaulay, E. C., & Morison, I. M. (2011, November). The intersect of placental epigenetics with placental function and dysfunction. Verbal presentation at the National Research Centre for Growth & Development Science Symposium, Dunedin, New Zealand.

Macaulay, E. (2011, September). The intersect of placental epigenetics with placental function and dysfunction. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Other Research Output

Daly, E. (2011, February). Epigenetics of the placenta: A SINE of the times. Microbiology & Immunology Department Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar].

Macaulay, E. (2011, June). An epigenetic analysis of the human placenta. Pathology Department Seminar, University of Otago, Dunedin, New Zealand. [Department Seminar].

Daly, E. (2011, April). Placental epigenetics. Centre for Reproduction and Genomics "Focus On" Seminar Series: Focus on Epigenetics, University of Otago, Dunedin, New Zealand. [Public Seminar].

Awarded Doctoral Degree

Macaulay, E. C. (2011). An epigenetic analysis of the human placenta (PhD). University of Otago, Dunedin, New Zealand. 269p.

2010

Conference Contribution - Published proceedings: Abstract

Daly, E. C., & Morison, I. M. (2010). Differential epigenetic modification of retrotransposon-derived genes in the human placenta. Proceedings of the Genetics Society of America Conference: Model Organisms to Human Biology. (pp. 72-73). Retrieved from http://www.genetics-gsa.org/pages/conferences.shtml

Conference Contribution - Poster Presentation (not in published proceedings)

Daly, E. C., & Morison, I. M. (2010, June). Differential epigenetic modification of retrotransposon-derived genes in the human placenta. Poster session presented at the Epigenetic Mechanisms in Health & Disease Conference, Brussels, Belgium.

Conference Contribution - Verbal presentation and other Conference outputs

Daly, E. C., & Morison, I. M. (2010, October). Epigenetics in the placenta: A SINE of the times. Verbal presentation at the International Federation of Placenta Associations (IFPA) Conference: Fetus and Placenta: A Perfect Harmony, Santiago, Chile.

Daly, E., & Morison, I. (2010, August). Dichotomous methylation of retrotransposon-derived genes reveals early human cell lineage commitment. Verbal presentation at the National Research Centre for Growth & Development Science Symposium, Auckland, New Zealand.

2009

Conference Contribution - Poster Presentation (not in published proceedings)

Daly, E. C., & Morison, I. (2009, September). Turning off tumours: The placental potential. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Daly, E. C., & Morison, I. M. (2009, September-October). An epigenetic analysis of first-trimester human placenta. Verbal presentation at the National Research Centre for Growth & Development Science Symposium, Hamilton, New Zealand.

Daly, E. (2009, September). An epigenetic analysis of first-trimester human placenta. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Daly, E. (2009, November). Epigenetics in the placenta: A SINE of the times. Verbal presentation at the Genetics Otago Postgraduate Symposium, Dunedin, New Zealand.

2008

Conference Contribution - Published proceedings: Abstract

Daly, E. C., & Morison, I. M. (2008). Epigenetics in the placenta: A genome-wide methylation analysis of first trimester trophoblasts. Proceedings of the 8th Annual Australasian Microarray and Associated Technologies (AMATA) Conference. Retrieved from http://www.amata.org.au/index.php/resources/2008-conference-abstracts

Conference Contribution - Verbal presentation and other Conference outputs

Daly, E. C., & Morison, I. M. (2008, November). An epigenetic analysis of first-trimester human placenta. Verbal presentation at the Post-Graduates of Genetics Otago Research Symposium, Dunedin, New Zealand.

2007

Journal - Research Article

Botta, P., Radcliffe, R. A., Carta, M., Mameli, M., Daly, E., Floyd, K. L., … Valenzuela, C. F. (2007). Modulation of GABA_A receptors in cerebellar granule neurons by ethanol: A review of genetic and electrophysiological studies. Alcohol, 41, 187-199. doi: 10.1016/j.alcohol.2007.04.004