Contact Details
- Phone
- +64 3 479 7471
- tania.slatter@otago.ac.nz
University Links
- Position
- Associate Professor and Academic Leader, Course Director Medical Laboratory Science, Histology, for Otago Micro and Nanoscale Imaging (OMNI)
- Department
- Department of Pathology (Dunedin)
- Qualifications
- BSc MSc(Dist) PhD
- Research summary
- Molecular and experimental pathology and translational medicine with a special interest in cancer, perinatal medicine, and autoimmune disease
- Memberships
- Manutū Hanora (Ministry of Health) Laboratory Sector Reference Group
- Associate Investigator, Maurice Wilkins Centre
- Clinical
- Brain cancer
- Breast cancer
- Laboratory medicine
- Chronic kidney disease
- Macular degeneration
- Perinatal disease
- Autoimmune disease
Research
Our goal is to improve outcomes for those with cancer and other chronic conditions by understanding how the mechanisms that regulate cellular damage and inflammation lead to molecular changes that predispose to life-long health effects.
For this research we use molecular and histo-pathological techniques in combination with collaborative clinical studies. The findings from the laboratory are then tested in clinical trials to see if they lead to improved patient outcomes.
Laboratory medicine is an integral part of medicine with 100% of cancer diagnoses requiring diagnostic laboratory tests. The Medical Laboratory Science programme at Otago works with diagnostic laboratories on collaborative projects aimed at developing new and improving existing tests.
Specific projects in the laboratory are outlined below:
- Understanding how a variant of the p53 tumour suppressor called Δ133p53 promotes cancer
- Investigating if new drug indications can better treat those with brain cancer, both tumours that develop and those that spread to the brain
- Investigating how chronic kidney disease and macular degeneration could be treated
- Developing new diagnostic tests for cancer patients
- Investigating DNA damage to the placenta and how this affects fetal and maternal health outcomes. This study is part of the Otago Placental Study in collaboration with the Department of Women's and Children's Health.
- Investigating DNA damage in autoimmune disease and how this leads to further health complications
Publications
Praditi, C., Beverley-Stone, E., Reid, M., Burgess, E. R., Crake, R. L., Vissers, M. C. M., Royds, J. A., Slatter, T. L., Dachs, G. U., & Phillips, E. (2025). Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic response in vitro. Frontiers in Oncology, 15, 1536549. doi: 10.3389/fonc.2025.1536549 Journal - Research Article
Bhandarkar, A. A., Sarkar, D., Jeffs, A., Kelly-Foleni, N. E., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Role of the TP53 splice mutations in cancer progression. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract
Shafaei Pishabad, Z., Sarkar, D., Jeffs, A., Samaratunga, H., Rhodes, J., Costello, R., Highton, A., Wright, D., Pattison, S., Kemp, R., Delahunt, B., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Development of a prognostic tool for identifying high-risk prostate cancer patients. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract
March de Ribot, F., Dolan, H., & Slatter, T. (2024). Amiloride in the retina: Fibrosis and inflammation modulation. Proceedings of the Royal Australian and New Zealand College of Ophthalmologists (RANZCO) New Zealand Branch Annual Scientific Meeting. Retrieved from https://web.cvent.com/event/90a69dc2-937d-4747-be96-7d01f4c2bc8c/summary Conference Contribution - Published proceedings: Abstract
Ray Das, S., Delahunt, B., Lasham, A., Li, K., Wright, D., Print, C., Slatter, T., Braithwaite, A., & Mehta, S. (2024). Combining TP53 mutation and isoform has the potential to improve clinical practice. Pathology. Advance online publication. doi: 10.1016/j.pathol.2024.02.003 Journal - Research Other
2025
Journal - Research Article
Praditi, C., Beverley-Stone, E., Reid, M., Burgess, E. R., Crake, R. L., Vissers, M. C. M., Royds, J. A., Slatter, T. L., Dachs, G. U., & Phillips, E. (2025). Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic response in vitro. Frontiers in Oncology, 15, 1536549. doi: 10.3389/fonc.2025.1536549
Conference Contribution - Published proceedings: Abstract
Bhandarkar, A. A., Sarkar, D., Jeffs, A., Kelly-Foleni, N. E., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Role of the TP53 splice mutations in cancer progression. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Shafaei Pishabad, Z., Sarkar, D., Jeffs, A., Samaratunga, H., Rhodes, J., Costello, R., Highton, A., Wright, D., Pattison, S., Kemp, R., Delahunt, B., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Development of a prognostic tool for identifying high-risk prostate cancer patients. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
2024
Journal - Research Other
Ray Das, S., Delahunt, B., Lasham, A., Li, K., Wright, D., Print, C., Slatter, T., Braithwaite, A., & Mehta, S. (2024). Combining TP53 mutation and isoform has the potential to improve clinical practice. Pathology. Advance online publication. doi: 10.1016/j.pathol.2024.02.003
Conference Contribution - Published proceedings: Abstract
March de Ribot, F., Dolan, H., & Slatter, T. (2024). Amiloride in the retina: Fibrosis and inflammation modulation. Proceedings of the Royal Australian and New Zealand College of Ophthalmologists (RANZCO) New Zealand Branch Annual Scientific Meeting. Retrieved from https://web.cvent.com/event/90a69dc2-937d-4747-be96-7d01f4c2bc8c/summary
2023
Journal - Research Article
Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8
Evans, G. E., Mahajan, V., Wakeman, S., Slatter, T., Ponnampalam, A. P., Anderson, T. P., Sarwar, M., & Evans, J. J. (2023). A pilot study using unique targeted testing of the urogenital microbiome has potential as a predictive test during IVF for implantation outcome. Archives of Gynecology & Obstetrics, 307, 1957-1967. doi: 10.1007/s00404-023-06987-w
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267
Conference Contribution - Published proceedings: Abstract
McLean, K., Dolan, H., March de Ribot, F., & Slatter, T. (2023). Optimization of RNA scope for identification of TP53 isoform △133p53β in macular degeneration. New Zealand Journal of Medical Laboratory Science, 77(3), (pp. 142). [Abstract]
March de Ribot, F., Dolan, H., & Slatter, T. (2023). Amiloride fibrosis and survival in an AMD model. Ophthalmic Research, Advance online publication. doi: 10.1159/000531114
2022
Journal - Research Article
Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8
Mehta, P. M., Gimenez, G., Walker, R. J., & Slatter, T. L. (2022). Reduction of lithium induced interstitial fibrosis on co-administration with amiloride. Scientific Reports, 12(1), 14598. doi: 10.1038/s41598-022-18825-1
Burgess, E. R., Crake, R. L. I., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022). Increased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival. Frontiers in Oncology, 12, 829524. doi: 10.3389/fonc.2022.829524
Journal - Research Other
Barzegar-Fallah, A., Gandhi, K., Rizwan, S. B., Slatter, T. L., & Reynolds, J. N. J. (2022). Harnessing ultrasound for targeting drug delivery to the brain and breaching the blood–brain tumour barrier. Pharmaceutics, 14(10), 2231. doi: 10.3390/pharmaceutics14102231
Conference Contribution - Published proceedings: Abstract
Mehta, P., Gimenez, G., Slatter, T., & Walker, R. J. (2022). Reduction of lithium induced interstitial fibrosis on co-administration with amiloride. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Costello, R., Rhodes, J., Miller, M., Munro, F., Kemp, R., & Slatter, T. (2022). Association of cancer-associated fibroblast phenotype and frequency with two-point immunoscore in colorectal cancer patients. Proceedings of the New Zealand Branch of the Australian and New Zealand Society for Immunology (NZASI) Conference. (pp. 11). Retrieved from https://nzasi2022.com/programme
Conference Contribution - Verbal presentation and other Conference outputs
Polwatta, S. N., Boix De Jesús, A. N., Wang, D., Taha, A., Kazantseva, M., Zhou, J., Mehta, S., Saraiva, A. M., … Royds, J., … Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2022, August). The Δ 133p53 isoform enhances cell-surface trafficking to promote metastasis. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
McDonald, F. J., Harris, J. J., Slatter, T. L., Cunliffe, H. E., & Ware, A. W. (2022, August). Epithelial sodium channel regulates breast cancer cell proliferation. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Moloney-Geany, K., Slatter, T., Black, M., & Guilford, P. (2022, August). Characterisation of single cell transcriptomics in urinary cells for the detection of bladder cancer. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Meharry, S., Slatter, T., & Kendrick, C. (2022, August-September). Future of the BMLSc. Plenary presentation at the New Zealand Institute of Medical Laboratory Science (NZIMLS) Annual Scientific Meeting, Wellington, New Zealand.
2021
Journal - Research Article
Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2
Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005
Ware, A. W., Harris, J. J., Slatter, T. L., Cunliffe, H. E., & McDonald, F. J. (2021). The epithelial sodium channel has a role in breast cancer cell proliferation. Breast Cancer Research & Treatment, 187, 31-43. doi: 10.1007/s10549-021-06133-7
Journal - Research Other
Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085
Conference Contribution - Published proceedings: Abstract
Mehta, P., Slatter, T. L., & Walker, R. J. (2021). Amiloride reduces lithium induced interstitial fibrosis and inflammation. Nephrology, 26(Suppl. 2), (pp. 18). doi: 10.1111/nep.13930
2020
Journal - Research Article
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3
Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472
Fabre, M.-S., Stanton, N. M., Slatter, T. L., Lee, S., Senanayake, D., Gordon, R. M. A., … Taha, A., Royds, J. A., Hung, N., … McConnell, M. J. (2020). The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy. PLoS ONE, 15(4), e0231470. doi: 10.1371/journal.pone.0231470
Reily-Bell, A. L., Fisher, A., Harrison, B., Bowie, S., Ray, S., Hawkes, M., … Fukuzawa, R., Macaulay, E. C., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2020). Human papillomavirus E6/E7 expression in preeclampsia-affected placentae. Pathogens, 9(3), 239. doi: 10.3390/pathogens9030239
Conference Contribution - Published proceedings: Abstract
Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Bessemer, B., Chatterjee, A., Alsaleh, A. A., Stockwell, P. A., Ludgate, J. L., Weeks, R. J., Jones, G. T., Day, R. C., Fukazawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2020). The potential power of placental epigenetics [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. W. (2020). Age-related changes in muscle morphology elucidatea role for myofibre fibrosis as an additional mechanism underpinning sarcopenia. Clinical Anatomy, 33(2), (pp. E38). doi: 10.1002/ca.23370
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. W. (2020). Age-related changes in muscle architecture differentially obscure accurate myofibre counts: Is age-related decline in myofibre number a technical artefact? Clinical Anatomy, 33(2), (pp. E37-E38). doi: 10.1002/ca.23370
Lal, N., Cornwall, J., Slatter, T., Kleffmann, T., & Sheard, P. (2020). Proteomic differences between young, elderly, and exercised-elderly murine soleus muscles and their correlations with deficits in force production. Australasian Journal on Ageing, 39(Suppl. 2), (pp. 18). doi: 10.1111/ajag.12808
2019
Journal - Research Article
Mehta-Mujoo, P. P., Cunliffe, H. E., Hung, N. A., & Slatter, T. L. (2019). Long non-coding RNA ANRIL in the nucleus associates with periostin expression in breast cancer. Frontiers in Oncology, 9, 885. doi: 10.3389/fonc.2019.00885
Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1
Conference Contribution - Published proceedings: Abstract
Li, K., Wilson, M., Parker, K., Wiles, A., Schultz, M., Slatter, T., Baird, M., & Braithwaite, A. (2019). An Δ133p53-like isoform drives exaggerated immune responses to promote chronic inflammation. European Journal of Immunology, 49(Suppl. 3), (pp. 782). doi: 10.1002/eji.201970400
Conference Contribution - Verbal presentation and other Conference outputs
Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Chatterjee, A. C., Stockwell, P. A., Alsaleh, A. A., Wilson, J. L., Weeks, R. J., Day, R. C., Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2019, August-September). The placental potential: Harnessing insights from placental epigenetics to predict disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3
Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111
Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0
Zhou, J., Reddy, M. V., Wilson, B. K. J., Blair, D. A., Taha, A., Frampton, C. M., Eiholzer, R. A., … Hung, N. A., Royds, J. A., & Slatter, T. L. (2018). MR imaging characteristics associate with tumor-associated macrophages in glioblastoma and provide an improved signature for survival prognostication. American Journal of Neuroradiology, 39(2), 252-259. doi: 10.3174/ajnr.A5441
Conference Contribution - Published proceedings: Abstract
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. (2018). Is myofiber death a major contributor to age-related skeletal muscle atrophy? Proceedings of the Australian & New Zealand Society for Sarcopenia & Frality Research (ANZSSFR) Annual Meeting. (pp. 22). Retrieved from https://anzssfr.org/past-meetings
Lal, N., Cornwall, J., Slatter, T., & Sheard, P. (2018). Identification of denervated fibers in elderly skeletal muscles. Proceedings of the Australian & New Zealand Society for Sarcopenia & Frality Research (ANZSSFR) Annual Meeting. (pp. 22). Retrieved from https://anzssfr.org/past-meetings
Conference Contribution - Poster Presentation (not in published proceedings)
Reily-Bell, A., Fisher, A., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2018, November). Human papillomavirus in the placenta and its relationship to birth complications. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Mehta-Mujoo, P., Landmann, M., Pilbrow, A. P., Currie, M. J., Morrin, H. R., Hung, N. A., & Slatter, T. L. (2018, August). Visualisation of long non-coding RNA ANRIL in breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Reily-Bell, A., Fisher, A., Devenish, C. J., Hung, N. A., Braithwaite, A. W., & Slatter, T. L. (2018, August). Investigating p53 isoforms in HPV positive cervical cancers and in the placenta. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Eiholzer, R. A., Kazantseva, M., Mehta, S., Roth, I., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018, August). The role of the p53 isoform Δ133TPP53 in treatment resistance. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Ray, S., McKinney, C., Roth, L., Heinzel, S., Hodgkin, P., Mehta, S., Slatter, T. L., & Braithwaite, A. W. (2018, August). p53 does not cause growth arrest or death in normal B cells but only affects division rate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Slatter, T. L., Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., … Royds, J. A., Zhou, J., Hung, N. A., & Braithwaite, A. W. (2018, August). The TP53 isoform Δ133p53β in glioblastoma development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Fabre, M. S., Jones, N. M., Slatter, T. L., Rowe, M. R., Gordon, R. A. M., Castro, M. L., Hung, N., … McConnell, M. J. (2018, August). BCL6: An essential role in glioblastoma therapy resistance and survival. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Other Research Output
Slatter, T. (2018, July). Improving outcomes from brain tumours: The Otago collaborative approach. Department of Public Health, University of Otago, Wellington, New Zealand. [Public Seminar].
2017
Journal - Research Article
Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6
Conference Contribution - Published proceedings: Abstract
Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio
Ray, S., Fisher, A., Bowie, S., Devenish, C., Slatter, T., & Hung, N. (2017). Human papilloma virus in the placenta: The role of p53. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 766. Retrieved from http://gen2017.w.events4you.currinda.com
Kazantseva, M., Mehta, S., Eiholzer, R. A., Roth, I., Bowie, S., Joruiz, S., Royds, J. A., Taha, A., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2017). Elevated Δ133p53β in prostate tumours correlates with an immune suppressive signature and poorer outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 29). Retrieved from http://www.uib.no/en/ccbio
Mehta, P., & Slatter, T. (2017). Germline variant in tumour supressor p16INK4A and long-coding RNA ANRIL in breast cancer. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 765. Retrieved from http://gen2017.w.events4you.currinda.com
Wiles, A., Kazantseva, M., Li, K., Williams, M., Bowie, S., Jo, S., Millier, M., Hessian, P., Stamp, L., Baird, M. A., Slatter, T., & Braithwaite, A. (2017). The presence of Δ133p53β in the autoimmune disease rheumatoid arthritis. Proceedings of the 3rd International p53 Isoform Conference. P10. Retrieved from http://www.uib.no/en/ccbio
Almomani, S., Morison, I., Hung, N., Slatter, T., & Macaulay, E. (2017). Predicting altered methylation patterns in early pre-eclampsia. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 778. Retrieved from http://gen2017.w.events4you.currinda.com
Harrison, B., Hung, N., Ussher, J., Slatter, T., & Devenish, C. (2017). A new peripheral blood test for HPV to predict perinatal disease. New Zealand Medical Journal, 130(1461), (pp. 88-89). Retrieved from http://www.nzma.org.nz/journal
Cornwall, J., Lal, N., Slatter, T., Rowlands, D., & Sheard, P. (2017). Autophagic dysfunction has a key role in age-related myofibre death. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395
Conference Contribution - Poster Presentation (not in published proceedings)
Momani, S., Morison, I. M., Hung, N. A., Slatter, T. L., & Macaulay, E. C. (2017, September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Slatter, T. (2017, June). Using genetic differences amongst brain tumours to predict tumour behaviour. Invited presentation at the Southern Health Symposium, Dunedin, New Zealand.
Slatter, T. (2017, October). Elevation of the p53 isoform, delta133p53β, in glioblastoma with an immune suppressive signature and poorer prognosis. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.
Macaulay, E. C., Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2017, September). Profiling the placental epigenome in pre-eclampsia to predict pregnancy outcomes. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2016
Journal - Research Article
Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379
Slatter, T. L., Wilson, M., Tang, C., Campbell, H. G., Ward, V. K., Young, V. L., … Fleming, N. I., Braithwaite, A. W., & Baird, M. A. (2016). Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. OncoImmunology, 5(3), e1112941. doi: 10.1080/2162402X.2015.1112941
Hung, N. A., Eiholzer, R. A., Kirs, S., Zhou, J., Ward-Hartstonge, K., Wiles, A. K., Frampton, C. M., Taha, A., Royds, J. A., & Slatter, T. L. (2016). Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma. Modern Pathology, 29, 212-226. doi: 10.1038/modpathol.2015.156
Royds, J. A., Pilbrow, A. P., Morrin, H. R., Frampton, C., Russell, I. A., Moravec, C. S., … Currie, M. J., Hung, N. A., & Slatter, T. L. (2016). The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4a expression. Frontiers in Oncology, 5, 306. doi: 10.3389/fonc.2015.00306
Conference Contribution - Published proceedings: Abstract
Braithwaite, A., Slatter, T., Wilson, M., & Baird, M. (2016). D133p53 isoform: A novel adjuvant for tumour vaccination. European Journal of Immunology, 46(Suppl. 1), (pp. 1007). doi: 10.1002/eji.201670200
Conference Contribution - Poster Presentation (not in published proceedings)
Macaulay, E. C., Chatterjee, A., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., & Morison, I. M. (2016, March). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Poster session presented at the Keystone Symposia on Molecular and Cellular Biology: Chromatin and Epigenetics, Whistler, Canada.
Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2016, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Slatter, T. (2016, June). Improving the prognosis from high-grade brain tumours: Implications for molecular differences. Verbal presentation at the 10th Annual Brain Health Research Centre Conference: The Developing Brain, Dunedin, New Zealand.
Kazantseva, M., Hung, N., Mehta, S., Roth, I., Baird, M., Braithwaite, A., & Slatter, T. (2016, October). Mutant p53 promotes incorrect B cell differentiation and adverse outcome in DLBCL. Verbal presentation at the 7th International Mutant p53 Workshop, Melbourne, Australia.
Kazantseva, M., Hung, N., Mehta, S., Baird, M., Slatter, T., & Braithwaite, A. (2016, August-September). Investigating the association of Δ133p53 isoform expression and the inflammatory microenvironment in prostate tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Eiholzer, R., Zhou, J., Taha, A., Kirs, S., Wang, D., Ziad, F., … Wilson, B., … Fulton, J., … Ward-Hartstonge, K., Wiles, A., Frampton, C., Hung, N., & Slatter, T. (2016, August-September). Surgical success and response to adjuvant therapy in glioblastoma depends on telomere maintenance associated markers. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Slatter, T. L., Hung, N. G. L. Y., Clow, W. M., Royds, J. A., Devenish, C. J., & Hung, N. A. (2015). A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications. Modern Pathology, 28, 1369-1382. doi: 10.1038/modpathol.2015.88
Slatter, T. L., Hung, N., Bowie, S., Campbell, H., Rubio, C., Speidel, D., Wilson, M., Baird, M., Royds, J. A., & Braithwaite, A. W. (2015). Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease, 6, e1783. doi: 10.1038/cddis.2015.149
Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015). Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE, 10(2), e0116270. doi: 10.1371/journal.pone.0116270
Slatter, T. L., Hsia, H., Samaranayaka, A., Sykes, P., Clow, W., Devenish, C. J., … Royds, J. A., … Hung, N. A. (2015). Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. Journal of Pathology: Clinical Research, 1(2), 95-105. doi: 10.1002/cjp2.11
Conference Contribution - Published proceedings: Full paper
Macaulay, E. C., Roberts, H. E., Al-Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2015). Methylome meets maternity ward: Predicting pre-eclampsia in early pregnancy. Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics (BCB). (pp. 484-485). New York: ACM. doi: 10.1145/2808719.2811419
Conference Contribution - Published proceedings: Abstract
Kirs, S., Taha, A., Royds, J., Slatter, T., & Hung, N. (2015). The repair protein MGMT and scavenger receptor CD163 are independent prognostic factors for metastatic brain tumours. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2015, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kazantseva, M., Slatter, T., Hung, N., & Braithwaite, A. (2015, September). Altered regulation of Δ133p53 isoforms expression in prostate tumours. Verbal presentation at the 2nd International p53 Isoform Workshop, Aix-en-Provence, France.
Devenish, C. J., Hung, N., & Slatter, T. (2015, July). What is the evidence that HPV effects pregnancy outcomes? Verbal presentation at the Perinatal Society of New Zealand (PSNZ) 35th Annual Scientific Meeting, Dunedin, New Zealand.
2014
Journal - Research Article
Berney-Meyer, L., Hung, N., Slatter, T., Schollum, J. B. W., Kitching, A. R., & Walker, R. J. (2014). Omeprazole-induced acute interstitial nephritis: A possible Th1–Th17-mediated injury? Nephrology, 19(6), 359-365. doi: 10.1111/nep.12226
Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159
Slatter, T. L., Park, L., Anderson, K., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J. A., Devenish, C., & Hung, N. A. (2014). Smoking during pregnancy causes double-strand DNA break damage to the placenta. Human Pathology, 45(1), 17-26. doi: 10.1016/j.humpath.2013.07.024
Journal - Research Other
Cornwall, J., Slatter, T., Guilford, P., Print, C. G., Henaghan, M., & Wee, R. (2014). Culture, law, ethics, and social implications: Is society ready for advanced genomic medicine? Australasian Medical Journal, 7(4), 200-202. doi: 10.4066/amj.2014.2069
Conference Contribution - Published proceedings: Abstract
Ward-Hartstonge, K., Taha, A., Hung, N., Kemp, R., & Slatter, T. (2014). Increased CD163 expression defines a subgroup of glioblastoma multiforme. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
Knarston, I., Macaulay, E., Roberts, H., Slatter, T., Hung, N., Devenish, C., & Morison, I. (2014). Validation of DNA methylation biomarkers for pre-eclampsia. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Poster Presentation (not in published proceedings)
Ward Hartstonge, K., Taylor, E., Slatter, T., McCulloch, T., Cretney, E., & Kemp, R. (2014, November). The characterisation and role of effector regulatory T cells in colorectal cancer. Poster session presented at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.
2013
Chapter in Book - Research
Hung, N., & Slatter, T. (2013). Histopathology in biomolecular research. In A. Divan & J. Royds (Eds.), Tools and techniques in biomolecular science. (pp. 418-437). Oxford, UK: Oxford University Press.
Slatter, T., & Fitches, A. (2013). DNA sequencing. In A. Divan & J. Royds (Eds.), Tools and techniques in biomolecular science. (pp. 66-87). Oxford University Press.
Journal - Research Article
Hung, N. A., Royds, J. A., & Slatter, T. L. (2013). Molecular markers of glioblastoma and the potential for integration with imaging: The future for assigning prognosis and best treatment strategy. Current Molecular Imaging, 2(2), 107-116. doi: 10.2174/2211555211302020001
Ferrandon, S., Saultier, P., Carras, J., Battiston-Montagne, P., Alphonse, G., Beuve, M., … Slatter, T., Hung, N., Royds, J., … Poncet, D. (2013). Telomere profiling: Toward glioblastoma personalized medicine. Molecular Neurobiology, 47(1), 64-76. doi: 10.1007/s12035-012-8363-9
Hung, N. A., Hsia, H., Royds, J. A., & Slatter, T. L. (2013). Telomere maintenance mechanisms: Prognostic and therapeutic implications for the pathologist and oncologist. Open Journal of Pathology, 3(1), 10-20. doi: 10.4236/ojpathology.2013.31003
Campbell, H. G., Mehta, R., Neumann, A. A., Rubio, C., Baird, M., Slatter, T. L., & Braithwaite, A. W. (2013). Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene, 32(7), 827-836. doi: 10.1038/onc.2012.102
Conference Contribution - Published proceedings: Abstract
Ward-Hartstonge, K., Taylor, E., Cretney, E., Slatter, T., & Kemp, R. (2013). Effector regulatory T cells in colorectal cancer. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 142). Retrieved from http://www.asi2013.org/
Slatter, T., Park, L., Anderson, K., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J., Devenish, C., & Hung, N. (2013). Smoking during pregnancy causes double strand DNA break damage to the placenta. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/
2012
Journal - Research Article
Campbell, H. G., Slatter, T. L., Jeffs, A., Mehta, R., Rubio, C., Baird, M., & Braithwaite, A. W. (2012). Does Δ133p53 isoform trigger inflammation and autoimmunity? Cell Cycle, 11(3), 446-450. doi: 10.4161/cc.11.3.19054
Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981
Conference Contribution - Poster Presentation (not in published proceedings)
Anderson, K., Slatter, T., Park, L., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J., Devenish, C., & Hung, N. (2012, September). The smoking gun: Cigarette smoking in pregnancy. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Campbell, H. G., Rubio, C., Slatter, T. L., Jeffs, A. R., Baird, M., & Braithwaite, A. W. (2012, August). The p53 isoform, Δ133p53 binds to and inhibits the p53 family members, p63 and p73. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Braithwaite, A. W., Baird, M. A., Campbell, H. G., Hung, N. A., Jeffs, A. R., Print, C. G., & Slatter, T. L. (2012, August). Isoforms of the p53 tumour suppressor, inflammation, and cancer. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737
Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851
Conference Contribution - Published proceedings: Abstract
Royds, J. A., Al Nadaf, S., Ahn, A., Chen, Y.-J., Wiles, A., Jellinek, D., Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). Older patients with glioma have a high frequency of a rare CDKN2A P14/16 allele. Neuro-Oncology, 13(Suppl. 2), 50, (pp. ii10). doi: 10.1093/neuonc/nor144
2010
Journal - Research Article
Slatter, T., Gifford-Garner, J., Wiles, A., Tan, X., Chen, Y.-J., MacFarlane, M., Sullivan, M., Royds, J., & Hung, N. (2010). Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. American Journal of Pathology, 177(6), 2694-2700. doi: 10.2353/ajpath.2010.100468
Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death & Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136
2009
Conference Contribution - Published proceedings: Abstract
Tang, C., Slatter, T., Wilson, M., Braithwaite, A., & Baird, M. (2009). Dendritic cells from mice lacking p53, in contrast to those from mutant p53 and wild type mice, fail to induce Th1 immune responses and do not suppress tumour growth. Proceedings of the Australasian Society for Immunology 39th Annual Scientific Meeting. ASI. Retrieved from http://www.asi2009.org/
Conference Contribution - Verbal presentation and other Conference outputs
Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Tang, C. W., Baird, M. A., & Braithwaite, A. W. (2009, June). New roles for p53-mediated apoptosis in B cell development and in dendritic cell function. Verbal presentation at the New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand.
2008
Journal - Research Article
Slatter, T. L., Jones, G. T., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2008). Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics, 73, 179-184. doi: 10.1111/j.1399-0004.2007.00940.x
2006
Journal - Research Article
Slatter, T. L., Williams, M. J. A., Frikke-Schmidt, R., Tybjærg-Hansen, A., Morison, I. M., & McCormick, S. P. A. (2006). Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. Atherosclerosis, 187, 393-400.
2004
Conference Contribution - Poster Presentation (not in published proceedings)
Slatter, T. L., Williams, M. J., Frikke-Schmidt, R., Tybjærg-Hansen, A., Morison, I., & McCormick, S. P. A. (2004, December). ABCA1 promoter haplotypes influence HDL levels in a novel case of Tangier disease. Poster session presented at the 14th Annual Queenstown Molecular Biology Meeting in conjunction with the New Zealand Society for Biochemical and Molecular Biology Conference, Queenstown, New Zealand.
2000
Conference Contribution - Poster Presentation (not in published proceedings)
Slatter, T. L., Logan, J., & McCormick, S. P. A. (2000, December). Analysing the origin of a cholesterol-lowering mutation in two New Zealand kindred's. Poster session presented at the Combined Meeting of the ASBMB, ASPS, NZSBMB, & NZSPP, Wellington, New Zealand.