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Contact Details

Phone
64 3 479 5410
Email
shakila.rizwan@otago.ac.nz
Position
Senior Lecturer
Qualifications
BPharm PhD(Otago)
Research summary
Delivery of pharmceuticals to the brain

Research

My primary research interests are the development and evaluation (physicochemical and biological) of novel formulations for delivering pharmaceuticals to the brain. Specifically, I am interested in self-assembled liquid crystalline nanoparticles for targeted delivery of peptides/proteins to the brain.

  • Development and validation of healthy and diseased (epilepsy) blood-brain barrier (BBB) models in the zebrafish.
  • Understand factors affecting drug permeability/transport across the healthy and diseased (epilepsy) BBB.
  • Formulation and physicochemical characterisation of self-assembled liquid crystalline nanoparticles (cubosomes and hexosomes).
  • In vivo evaluation of formulations in rodent and zebrafish models.

Dr Rizwan on Scopus

Publications

Reynolds, J., Banstola, A., Gray, J., Murray, E., Mohammad, Y., Rizwan, S., … Tan, E. (2023). Non-invasive targeted drug delivery to the sheep brain using focused ultrasound [Invited]. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home Conference Contribution - Published proceedings: Abstract

Reynolds, J., Banstola, A., Gray, J., Murray, E., Younus, M., Rizwan, S., … Tan, E. (2023). Targeted brain delivery of therapeutics using focused ultrasound in a sheep model of Parkinson's disease. In K.-L. Horne (Ed.), Proceedings of the 39th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from https://www.awcbr.org Conference Contribution - Published proceedings: Abstract

Banstola, A., Vautrelle, N., Bergin, D., Gray, J., Murray, E., Mohammad, Y., Rizwan, S., … Tan, E., & Reynolds, J. (2023, June). Translational feasibility of a novel focused ultrasound approach for phasic dopamine receptor stimulation in a sheep model of Parkinson’s disease. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden. Conference Contribution - Poster Presentation (not in published proceedings)

Prentice, R. N., & Rizwan, S. B. (2023). Translational considerations in the development of intranasal treatments for epilepsy. Pharmaceutics, 15(1), 233. doi: 10.3390/pharmaceutics15010233 Journal - Research Article

Arora, S., Cooper, P., Friedlander, L., Rizwan, S., Seo, B., Rich, A., & Hussaini, H. (2022). Evaluation of IL-23 inhibitor as a pulp immunomodulating agent: An in vitro and in vivo study. New Zealand Dental Journal, 118(4), (pp. 167). [Abstract] Conference Contribution - Published proceedings: Abstract

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