2024
Journal - Research Article
Rizwan, M. Z., Kamstra, K., Pretz, D., Shepherd, P. R., Tups, A., & Grattan, D. R. (2024). Conditional deletion of β-catenin in the mediobasal hypothalamus impairs adaptive energy expenditure in response to high fat diet and exacerbates diet-induced obesity. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.1666-23.2024
2023
Journal - Research Article
Rizwan, M. Z., Kerbus, R., Kamstra, K., Keerthisinghe, P., & Tups, A. (2023). Dietary wheat gluten induces astro- and microgliosis in the hypothalamus of male mice. Journal of Neuroendocrinology, e13326. Advance online publication. doi: 10.1111/jne.13326
Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Keerthisinghe, P., Perry, N. B., & Tups, A. (2023). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Life Metabolism, 2(4), load026. doi: 10.1093/lifemeta/load026
2022
Journal - Research Article
Kamstra, K., Rizwan, M. Z., Grattan, D. R., Horsfield, J. A., & Tups, A. (2022). Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB Journal, 36, e22207. doi: 10.1096/fj.202101764R
2021
Journal - Research Article
Mamgain, A., Sawyer, I. L., Timajo, D. A. M., Rizwan, M. Z., Evans, M. C., Ancel, C. M., Inglis, M. A., & Anderson, G. M. (2021). RFamide-related peptide neurons modulate reproductive function and stress responses. Journal of Neuroscience, 41(3), 474-488. doi: 10.1523/JNEUROSCI.1062-20.2020
Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A. (2021). Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal, 35, e21216. doi: 10.1096/fj.202001147R
Loehfelm, A., Rizwan, M. Z., & Tups, A. (2021). A New Zealand green-lipped mussel oil-enriched high-fat diet exhibits beneficial effects on body weight and metabolism in mice. British Journal of Nutrition, 125(9), 972-982. doi: 10.1017/s0007114520002342
2019
Journal - Research Article
Boucsein, A., Rizwan, M. Z., & Tups, A. (2019). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB Journal, 33, 12175-12187. doi: 10.1096/fj.201901004R
Skinner, N. J., Rizwan, M. Z., Grattan, D. R., & Tups, A. (2019). Chronic light cycle disruption alters central insulin and leptin signaling as well as metabolic markers in male mice. Endocrinology, 160(10), 2257-2270. doi: 10.1210/en.2018-00935
Benzler, M., Benzler, J., Stoehr, S., Hempp, C., Rizwan, M. Z., Heyward, P., & Tups, A. (2019). "Insulin-like" effects of palmitate compromise insulin signalling in hypothalamic neurons. Journal of Comparative Physiology B, 189(3-4), 413-424. doi: 10.1007/s00360-019-01220-0
Conference Contribution - Published proceedings: Abstract
Rizwan, M., Shepherd, P., Tups, A., & Grattan, D. (2019). Region specific deletion of beta-catenin leads to impaired glucose tolerance and increased body weight. Brain & Neuroscience Advances, 3, PS108. doi: 10.1177/2398212819855490
Conference Contribution - Poster Presentation (not in published proceedings)
Rizwan, M. Z., Shepherd, P. R., Tups, A., & Grattan, D. R. (2019, August-September). Region-specific deletion of β-catenin leads to impaired glucose tolerance and increased bodyweight. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Boucsein, A., Rizwan, M. Z., & Tups, A. (2019, July). Time of day-dependent action of hypothalamic leptin signalling. Poster session presented at the Society for the Study of Ingestive Behavior (SSIB) 27th Annual Meeting, Utrecht, The Netherlands.
Conference Contribution - Verbal presentation and other Conference outputs
Boucsein, A., Rizwan, M. Z., & Tups, A. (2019, August-September). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Conference Contribution - Published proceedings: Abstract
Rizwan, M. Z., Shepherd, P., Tups, A., & Grattan, D. (2018). Stabilization of beta-catenin in mouse hypothalamic cell lines. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 348-349). Retrieved from http://www.icn2018.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Kerbus, R., Rizwan, M., & Tups, A. (2018, August). Dose dependent central insulin resistance in response to high fat diet. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Boucsein, A., Rizwan, M., & Tups, A. (2018, February). Circadian regulation of leptin action. Verbal presentation at the 9th Swiss Winter Conference on Ingestive Behavior, St. Moritz, Switzerland.
Other Research Output
Rizwan, M. (2018, January). Metabolic diseases. Journal of Neuroendocrinology (JNE) Podcasts. Retrieved from https://www.youtube.com/watch?v=oYVfCMVjWkU&feature=youtu.be
2017
Journal - Research Article
Rizwan, M. Z., Mehlitz, S., Grattan, D. R., & Tups, A. (2017). Temporal and regional onset of leptin resistance in diet-induced obese mice. Journal of Neuroendocrinology, 29(10), e12481. doi: 10.1111/jne.12481
Conference Contribution - Poster Presentation (not in published proceedings)
Skinner, N., Rizwan, M. Z., & Tups, A. (2017, September). Effect of circadian rhythms on leptin and insulin sensitivity. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Rizwan, M. Z., Shepherd, P., Tups, A., & Grattan, D. R. (2017, September). Stabilization of beta-catenin in mouse hypothalamic cell lines. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kaplish, M., Rizwan, M. Z., & Grattan, D. R. (2017, September). The effect of pregnancy-induced adaptations on glucagon like-peptide-1 receptor activation-induced stabilisation of beta-catenin in hypothalamic neurons in female rats. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Boucsein, A., Rizwan, M., & Tups, A. (2017, September). Circadian rhythmicity of leptin sensitivity in the hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2016
Journal - Research Article
Kim, J. S., Rizwan, M. Z., Clegg, D. J., & Anderson, G. M. (2016). Leptin signaling is not required for anorexigenic estradiol effects in female mice. Endocrinology, 157(5), 1991-2001. doi: 10.1210/en.2015-1594
Conference Contribution - Published proceedings: Abstract
Boucsein, A., Rizwan, M., Skinner, N., & Tups, A. (2016). Temporal rhythms of metabolic pathways in the hypothalamus. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. 34, (pp. 64). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Tups, A., Boucsein, A., Skinner, N., & Rizwan, M. (2016). Leptin resistance: Cause or consequence of hypothalamic inflammation? In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 63). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Skinner, N., Rizwan, M. Z., & Tups, A. (2016). Effect of circadian rhythms on leptin sensitivity. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 37). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Rizwan, M. Z., Skinner, N., Mehlitz, S., & Tups, A. (2016). Temporal and regional onset of leptin resistance in diet induced obese mice. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 35). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Conference Contribution - Poster Presentation (not in published proceedings)
Rizwan, M. (2016, August-September). Temporal and regional onset of leptin resistance in diet induced obese mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Carter, K., Rizwan, M., Ladyman, S. R., & Grattan, D. R. (2016, August). Feeding-induced regulation of Wnt/beta catenin signaling in the mouse hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Journal - Research Article
Evans, M. C., Rizwan, M. Z., & Anderson, G. M. (2015). Insulin does not target CamkIIα neurones to critically regulate the neuroendocrine reproductive axis in mice. Journal of Neuroendocrinology, 27(12), 899-910. doi: 10.1111/jne.12330
2014
Journal - Research Article
Evans, M. C., Rizwan, M. Z., & Anderson, G. M. (2014). Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice. Endocrinology, 155(11), 4368-4379. doi: 10.1210/en.2014-1412
Evans, M. C., Rizwan, M., Mayer, C., Boehm, U., & Anderson, G. M. (2014). Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. Journal of Neuroendocrinology, 26(7), 468-479. doi: 10.1111/jne.12166
Rizwan, M. Z., Harbid, A. A., Inglis, M. A., Quennell, J. H., & Anderson, G. M. (2014). Evidence that hypothalamic RFamide related peptide-3 neurones are not leptin-responsive in mice and rats. Journal of Neuroendocrinology, 26(4), 247-257. doi: 10.1111/jne.12140
Conference Contribution - Published proceedings: Abstract
Rizwan, M. Z., Inglis, M. A., & Anderson, G. M. (2014). Deletion of estrogen receptor-α (ERα) from RFamide-related peptide-3 (RFRP-3) neurons disrupts the negative and positive feedback effects of estradiol on gonadotrophin secretion. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Rizwan, M. Z., Inglis, M. A., & Anderson, G. M. (2014). Deletion of estrogen receptor-α (ERα) from RFamide-related peptide-3 (RFRP-3) neurons disrupts the negative and positive feedback effects of estradiol on gonadotrophin secretion. Proceedings of the Medical Sciences Congress (MedSci). (pp. 42). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
2013
Conference Contribution - Published proceedings: Abstract
Kheirabad, M. K., Anderson, G. M., & Rizwan, M. Z. (2013). Hypothalamic RFamide related peptide-3 (RFRP-3) neurons project to oxytocin and vasopressin neurons and stimulate secretion. Endocrine Reviews, 34(3, Suppl.), MON-159. Retrieved from http://press.endocrine.org/series/endo-meetings
Kim, J. S., Quennell, J. H., Rizwan, M. Z., & Anderson, G. M. (2013). Anorexigenic estradial effects do not involve leptin-STAT3 signaling. Endocrine Reviews, 34(3, Suppl.), SAT-709. Retrieved from http://press.endocrine.org/series/endo-meetings
Conference Contribution - Poster Presentation (not in published proceedings)
Rizwan, M. Z., Kheirabad, M. K., & Anderson, G. M. (2013, August). Hypothalamic RFamide related peptide-3 (RFRP-3) neurons project to oxytocin and vasopressin neurons and stimulate secretion. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kim, J. S., Rizwan, M. Z., Quennell, J. H., & Anderson, G. M. (2013, August). Evidence that anorexigenic estradiol effects do not involve leptin-STAT3 signalling. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2012
Journal - Research Article
Rizwan, M. Z., Poling, M. C., Corr, M., Cornes, P. A., Augustine, R. A., Quennell, J. H., … Anderson, G. M. (2012). RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology, 153(8), 3770-3779. doi: 10.1210/en.2012-1133
Conference Contribution - Published proceedings: Abstract
Quennell, J. H., Khant Aung, Z., Augustine, R. A., Rizwan, M. Z., Inglis, M. A., Bunn, S. J., & Anderson, G. M. (2012). Evidence for direct estrogenic upregulation of suppressor of cytokine signaling-3 in the mouse brain. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Rizwan, M. Z., Cornes, P. A., & Anderson, G. M. (2012). Evidence that hypothalamic rfamide related peptide-3 (rfrp-3) neurons play a key role in regulating ovulatory function. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Awarded Doctoral Degree
Rizwan, M. Z. (2012). Role of RFamide-related peptide-3 in the neuroendocrine regulation of the reproductive and stress axes (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/2391
2011
Conference Contribution - Published proceedings: Abstract
Rizwan, M. Z., Crampton, J. R., Grattan, D. R., & Anderson, G. M. (2011). Changes in RFamide-related peptide-3 (RFRP-3) gene expression during lactation. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 150). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf
Anderson, G. M., Augustine, R. A., Rizwan, M. Z., & Cornes, P. A. (2011). RFamide-related peptide-3 (RFRP-3) regulates LH secretion exclusively via a GnRH-dependent mechanism in the rat. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main
Rizwan, M. Z., Bergin, D. H., Grattan, D. R., & Anderson, G. M. (2011). Evidence that hypothalamic rfamide related peptide-3 (rfrp-3) neurons act as a conduit between prolactin and the stress axis. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main
Rizwan, M. Z., Bergin, D. H., Grattan, D. R., & Anderson, G. M. (2011). Hypothalamic RFamide related peptide-3 (RFRP-3) neurons respond to the anxiolytic hormone prolactin and modulate the stress axis. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 4.7. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Rizwan, M., Bergin, D., Grattan, D., & Anderson, G. (2011). RFamide related peptide-3: The missing link between prolactin and the stress axis? New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf
2010
Journal - Research Article
Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. (2010). Both p110α and p110β isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology, 22(6), 534-542. doi: 10.1111/j.1365-2826.2010.01975.x
Quennell, J. H., Rizwan, M. Z., Relf, H.-L., & Anderson, G. M. (2010). Developmental and steroidogenic effects on the gene expression of RFRP and its receptor in the rat brain and pituitary gland. Journal of Neuroendocrinology, 22, 309-316. doi: 10.1111/j.1365-2826.2010.01963.x
Conference Contribution - Verbal presentation and other Conference outputs
Rizwan, M., Crampton, J., Grattan, D., & Anderson, G. (2010, November-December). Changes in RFamide-related peptide-3 (RFRP-3) gene expression during lactation. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2009
Journal - Research Article
Anderson, G. M., Relf, H.-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359
Rizwan, M. Z., Porteous, R., Herbison, A. E., & Anderson, G. M. (2009). Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology, 150(3), 1413-1420. doi: 10.1210/en.2008-1287
Conference Contribution - Published proceedings: Abstract
Anderson, G. M., Rizwan, M. Z., Relf, H. L., & Quennell, J. H. (2009). Gene expression of RFamide related peptide and its receptor in rodent brain, pituitary gland and GnRH neurons. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
2008
Conference Contribution - Verbal presentation and other Conference outputs
Rizwan, M., & Anderson, G. M. (2008, November). Levels of Rfamide-related peptide (RFRP) mRNA in rat hypothalamus are affected by age and sex, but not treatment with sex steroids. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
2007
Conference Contribution - Published proceedings: Abstract
Anderson, G. M., & Rizwan, M. Z. (2007). RFRP-3 inhibits GnRH neuronal activation during the estradiol-induced LH surge. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp
Rizwan, M., Porteous, R., Herbison, A., & Anderson, G. (2007). Evidence that RFRP, the mammalian homologue of avian gonadotropin inhibitory hormone, projects outside the blood-brain barrier in rodents. Endocrine Journal. 54(Suppl.), (pp. 185). [Abstract]
2006
Conference Contribution - Verbal presentation and other Conference outputs
Rizwan, M., Porteous, R., Herbison, A., & Anderson, G. (2006, November-December). Evidence that RFRP, the mammalian homologue of avian gonadotropin inhibitory hormone, projects outside the blood-brain barrier in rodents. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.
