Dr Laura Burga

2024

Journal - Research Article

Hills, F. R., Eruera, A.-R., Hodgkinson-Bean, J., Jorge, F., Easingwood, R., Brown, S. H. J., … Burga, L. N., & Bostina, M. (2024). Variation in structural motifs within SARS-related coronavirus spike proteins. PLoS Pathogens, 20(5), e1012158. doi: 10.1371/journal.ppat.1012158

2023

Journal - Research Article

Wierenga, J. R., Grimwood, R., Taylor, H. S., Hunter, S., Argilla, L. S., Webster, T., Lim, L., French, R., … Jorge, F., Bostina, M., Burga, L., … Geoghegan, J. L. (2023). Total infectome investigation of diphtheritic stomatitis in yellow-eyed penguins (Megadyptes antipodes) reveals a novel and abundant megrivirus. Veterinary Microbiology, 286, 109895. doi: 10.1016/j.vetmic.2023.109895

Jadav, N., Velamoor, S., Huang, D., Cassin, L., Hazelton, N., Eruera, A.-R., Burga, L. N., & Bostina, M. (2023). Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy. Journal of Structural Biology, 215, 108035. doi: 10.1016/j.jsb.2023.108035

Waqqar, S., Lee, K., Lawley, B., Bilton, T., Quiñones‑Mateu, M. E., Bostina, M., & Burga, L. N. (2023). Directed evolution of Seneca Valley virus in tumorsphere and monolayer cell cultures of a small-cell lung cancer model. Cancers, 15, 2541. doi: 10.3390/cancers15092541

Wierenga, J. R., Morgan, K. J., Hunter, S., Taylor, H. S., Argilla, L. S., Webster, T., Dubrulle, J., Jorge, F., Bostina, M., Burga, L., … Geoghegan, J. L. (2023). A novel gyrovirus is abundant in yellow-eyed penguin (Megadyptes antipodes) chicks with a fatal respiratory disease. Virology, 579, 75-83. doi: 10.1016/j.virol.2022.12.012

Conference Contribution - Published proceedings: Abstract

Burga, L., Pham, A., Nimick, M., Waqqar, S., Turner, P., Watanabe, E., & Bostina, M. (2023). Developing oncolytic Seneca Valey Virus for cancer treatment. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Jadav, N., Velamoor, S., Huang, D., Hazelton, N., Eruera, A., Burga, L. N., & Bostina, M. (2023). Beyond the Surface: Ultrastructural Investigation of TS vs ML using vEM. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Kumaran, R., Jayawardena, N., Burga, L., Wolf, M., & Bostina, M. (2023). Structural insights into senecavirus genome uncoating mechanism. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Conference Contribution - Edited volume of conference proceedings

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 268th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours/Postgraduate Diploma Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 266th Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

2022

Journal - Research Article

Jayawardena, N., McCarthy, C., Wang, I., Waqqar, S., Burga, L. N., Strauss, M., & Bostina, M. (2022). Characterisation of a Seneca Valley virus thermostable mutant. Virology, 575, 74-82. doi: 10.1016/j.virol.2022.08.015

Conference Contribution - Edited volume of conference proceedings

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 264th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Poster Presentation (not in published proceedings)

Hills, F. R., Burga, L., Watanabe, E., & Bostina, M. (2022, August). Comparison of the structural and phylogenetic evolution of the Coronaviridae spike protein. Poster session presented at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Watanabe, E., Burga, L., Velamoor, S., Nimick, M., Easingwood, R., & Bostina, M. (2022, August). Effects of Seneca Valley virus with clinically available chemotherapeutic drugs on 3D tumour-like cell cultures of triple negative breast cancer cells. Poster session presented at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Waqqar, S., Jayawardena, N. N., McCarthy, C., Lawley, B., Wang, I., Bilton, T., Burga, L. N., Quinones Mateu, M., … Bostina, M. (2022, August). Obtaining Seneca valley virus variants with increased capsid stability under evolutionary pressure. Poster session presented at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Burga, L. N., Pham, A., Nimick, M., Turner, P., Watanabe, E., & Bostina, M. (2022, August). Developing oncolytic Seneca Valley Virus for cancer treatment. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Chapter in Book - Research

Burga, L., & Bostina, M. (2021). Oncolytic Viruses. In D. H. Bamford & M. Zuckerman (Eds.), Encyclopedia of virology (Vol.1). (4th ed.) (pp. 658-661). Amsterdam, The Netherlands: Academic Press. doi: 10.1016/B978-0-12-814515-9.00064-3

Journal - Research Article

Jayawardena, N., Miles, L. A., Burga, L. N., Rudin, C., Wolf, M., Poirier, J. T., & Bostina, M. (2021). N-linked glycosylation on anthrax toxin receptor 1 is essential for Seneca Valley virus infection. Viruses, 13(5), 769. doi: 10.3390/v13050769

Conference Contribution - Published proceedings: Abstract

Watanabe, E., & Burga, L. (2021). Effects of Seneca Valley virus with clinically available chemotherapeutic drugs on 3D tumour-like cell cultures of BT549 triple negative breast cancer cells. New Zealand Medical Journal, 134(1543), (pp. 158). Retrieved from https://www.nzma.org.nz/journal

2020

Journal - Research Article

Velamoor, S., Mitchell, A., Humbel, B. M., Kim, W., Pushparajan, C., Visnovsky, G., Burga, L. N., & Bostina, M. (2020). Visualizing nudivirus assembly and egress. mBio, 11(4), e01333-20. doi: 10.1128/mBio.01333-20

Journal - Research Other

Jayawardena, N., Poirier, J. T., Burga, L. N., & Bostina, M. (2020). Virus-receptor interactions and virus neutralization: Insights for oncolytic virus development. Oncolytic Virotherapy, 9, 1-15. doi: 10.2147/ov.S186337

2019

Journal - Research Article

McCarthy, C., Jayawardena, N., Burga, L. N., & Bostina, M. (2019). Developing picornaviruses for cancer therapy. Cancers, 11(5), 685. doi: 10.3390/cancers11050685

Journal - Research Other

Jayawardena, N., Burga, L. N., Poirier, J. T., & Bostina, M. (2019). Virus-receptor interactions: Structural insights for oncolytic virus development. Oncolytic Virotherapy, 8, 39-56. doi: 10.2147/ov.S218494

2018

Journal - Research Article

Jayawardena, N., Burga, L. N., Easingwood, R. A., Takizawa, K., Wolf, M., & Bostina, M. (2018). Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus. PNAS, 115(46), E10934-E10940. doi: 10.1073/pnas.1810664115

Strauss, M., Jayawardena, N., Sun, E., Easingwood, R. A., Burga, L. N., & Bostina, M. (2018). Cryo-electron microscopy structure of Seneca Valley Virus procapsid. Journal of Virology, 92(6), e01927-17. doi: 10.1128/jvi.01927-17

Conference Contribution - Published proceedings: Abstract

McCarthy, C., Burga, L., & Bostina, M. (2018). Thermal selection of Seneca Valley Virus to reveal residues important for capsid stability. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 93-94). Retrieved from https://www.nzmsconference.org.nz

Strauss, M., Jayawardena, N., Sun, E., Easingwood, R. A., Burga, L. N., & Bostina, M. (2018). Cryo-electron microscopy structure of Seneca Valley Virus procapsid. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 72). Retrieved from https://www.nzmsconference.org.nz

2017

Journal - Research Article

Miles, L. A., Burga, L. N., Gardner, E. E., Bostina, M., Poirier, J. T., & Rudin, C. M. (2017). Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus. Journal of Clinical Investigation, 127(8), 2957-2967. doi: 10.1172/jci93472

Conference Contribution - Published proceedings: Abstract

Jayawardena, N., Burga, L., Easingwood, R., & Bostina, M. (2017). Cryo-electron microscopy investigation of a novel oncolytic virus-receptor complex. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 37-38). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Burga, L., McCarthy, C., Rosengren, R., & Bostina, M. (2017). Targeting triple negative breast cancer with the oncolytic Seneca Valley Virus. Proceedings of the New Zealand Microbiological Society (NZMS) Annual Conference. 193. Retrieved from http://www.nzmsconference.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Jayawardena, N., Burga, L., Easingwood, R., & Bostina, M. (2017, September). Cryo-electron microscopy investigation of a novel oncolytic picornavirus-receptor complex. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Conference Contribution - Verbal presentation and other Conference outputs

Bostina, M., Strauss, M., & Burga, L. (2016, November). Genome-capsid interaction in Seneca Valley virus. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

2013

Journal - Research Article

Israelsen, W. J., Dayton, T. L., Davidson, S. M., Fiske, B. P., Hosios, A. M., Bellinger, G., … Burga, L. N., … Vander Heiden, M. G. (2013). PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell, 155, 397-409. doi: 10.1016/j.cell.2013.09.025

2012

Journal - Research Article

Juvekar, A., Burga, L. N., Hu, H., Lunsford, E. P., Ibrahim, Y. H., Balmaña, J., … Wulf, G. M. (2012). Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discovery, 2(11), 1048-1063. doi: 10.1158/2159-8290.CD-11-0336

2011

Journal - Research Article

Yuan, T. L., Wulf, G., Burga, L., & Cantley, L. C. (2011). Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Current Biology, 21(3), 173-183. doi: 10.1016/j.cub.2010.12.047

Burga, L. N., Hu, H., Juvekar, A., Tung, N. M., Troyan, S. L., Hofstatter, E. W., & Wulf, G. M. (2011). Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Research, 13, R30. doi: 10.1186/bcr2850

2009

Journal - Research Article

Burga, L. N., Tung, N. M., Troyan, S. L., Bostina, M., Konstantinopoulos, P. A., Fountzilas, H., … Wulf, G. M. (2009). Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers. Cancer Research, 69(4), 1273-1278. doi: 10.1158/0008-5472.can-08-2954

2008

Journal - Research Article

Lam, P. B., Burga, L. N., Wu, B. P., Hofstatter, E. W., Lu, K. P., & Wulf, G. M. (2008). Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. Molecular Cancer, 7, 91. doi: 10.1186/1476-4598-7-91

2005

Journal - Research Article

Burga, L., Wellmann, F., Lukačin, R., Witte, S., Schwab, W., Schröder, J., & Matern, U. (2005). Unusual pseudosubstrate specificity of a novel 3,5-dimethoxyphenol O-methyltransferase cloned from Ruta graveolens L. Archives of Biochemistry & Biophysics, 440(1), 54-64. doi: 10.1016/j.abb.2005.05.026