Associate Professor Sharon Pattison

Contact Details

Email: sharon.pattison@otago.ac.nz

University Links

Position

Honorary Associate Professor and Medical Oncologist

Department

Department of Pathology (Dunedin)

Qualifications

MBChB BMedSc(Disn) PhD FRACP

Research summary

Gastrointestinal cancers; neuroendocrine tumours; prognostic and predictive variables

Memberships

Translational Research Committee Member, Australasian Gastrointestinal Trials Group (AGITG)
Member, Commonwealth Neuroendocrine Cancer Collaboration (CommNETs), Executive Committee member 2017-2023
Member, ASCO
Member, ESMO
Member, NZSO

Clinical

Gastrointestinal and neuroendocrine cancers

Research

Sharon studied at University of Otago and University of Melbourne.

Sharon is an upper gastrointestinal and neuroendocrine cancer medical oncologist at Wellington Blood and Cancer Centre, and Honorary Associate Professor in the Department of Pathology, Dunedin School of Medicine where her laboratory is based. She is a current HRC Clinical Practitioner Research Fellow.

Sharon has research interests in gastric cancer, colorectal cancer, and neuroendocrine tumours, with a particular interest in understanding the variability that is seen at a clinical, histological, and genomic level.

Publications

Shafaei Pishabad, Z., Sarkar, D., Jeffs, A., Samaratunga, H., Rhodes, J., Costello, R., Highton, A., Wright, D., Pattison, S., Kemp, R., Delahunt, B., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Development of a prognostic tool for identifying high-risk prostate cancer patients. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract

Yap, J., & Pattison, S. (2025). Deficient mismatch repair and BRAF mutations in metastatic colorectal cancer in the South Island of New Zealand. Asia-Pacific Journal of Clinical Oncology. Advance online publication. doi: 10.1111/ajco.14151 Journal - Research Article

Ramachandran, A., Le Quesne Stabej, P., Boyle, V., Elston, M. S., Pattison, S., Lawrence, B., & Print, C. (2024). Alternative splicing generates isoform diversity in MEN1. Endocrine Oncology. Advance online publication. doi: 10.1530/eo-24-0014 Journal - Research Article

Pinkney, H. R., Ross, C. R., Hodgson, T. O., Pattison, S. T., & Diermeier, S. D. (2024). Discovery of prognostic lncRNAs in colorectal cancer using spatial transcriptomics. npj Precision Oncology, 8, 230. doi: 10.1038/s41698-024-00728-1 Journal - Research Article

Mendis, S., Lipton, L., To, Y. H., Ananda, S., Michael, M., McLachlan, S.-A., … Pattison, S., … Lee, B. (2024). Early onset pancreatic cancer: Exploring contemporary treatment and outcomes using real-world data. British Journal of Cancer. Advance online publication. doi: 10.1038/s41416-024-02619-5 Journal - Research Article

2025

Journal - Research Article

Conference Contribution - Published proceedings: Abstract

2024

Journal - Research Article

Ajithkumar, P., Gimenez, G., Stockwell, P. A., Almomani, S., Bowden, S. A., Leichter, A. L., … Pattison, S., … Frizelle, F. A., Eccles, M. R., Purcell, R. V., Rodger, E. J., & Chatterjee, A. (2024). DNA methylome and transcriptome maps of primary colorectal cancer and matched liver metastasis. Data, 9(1), 8. doi: 10.3390/data9010008

Journal - Research Other

Powell, R. M., Moravec, J. C., Jones, G. T., Bhat, B., Lin, S. M., Planer, J. D., … Pattison, S., Morison, I. M., … Eccles, M. R., & Macaulay, E. C. (2024). DNA methylation profiling of heterogeneous sporadic LAM and matched lung tissue. American Journal of Respiratory Cell & Molecular Biology, 70(1), 81-84. doi: 10.1165/rcmb.2023-0300LE

Ajithkumar, P., Vasantharajan, S. S., Pattison, S., McCall, J. L., Rodger, E. J., & Chatterjee, A. (2024). Exploring potential epigenetic biomarkers for colorectal cancer metastasis. International Journal of Molecular Sciences, 25, 874. doi: 10.3390/ijms25020874

2023

Chapter in Book - Research

Vasantharajan, S. S., Barnett, E., Gray, E. S., Rodger, E. J., Eccles, M. R., Pattison, S., Munro, F., & Chatterjee, A. (2023). Size-based method for enrichment of circulating tumor cells from blood of colorectal cancer patients. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 231-248). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_15

Journal - Research Article

Anaka, M., Chan, D., Pattison, S., Thawer, A., Franco, B., Moody, L., Jackson, C., … Singh, S. (2023). Patient priorities concerning treatment decisions for advanced neuroendocrine tumors identified by discrete choice experiments. Oncologist, oyad312. Advance online publication. doi: 10.1093/oncolo/oyad312

Rodger, E. J., Gimenez, G., Ajithkumar, P., Stockwell, P. A., Almomani, S., Bowden, S. A., Leichter, A. L., Ahn, A., Pattison, S., McCall, J. L., … Frizelle, F. A., Eccles, M. R., Purcell, R. V., & Chatterjee, A. (2023). An epigenetic signature of advanced colorectal cancer metastasis. iScience, 26(6), 106986. doi: 10.1016/j.isci.2023.106986

Journal - Research Other

Shanika, L. G. T., Reynolds, A., Pattison, S., & Braund, R. (2023). Proton pump inhibitor use: Systematic review of global trends and practices. European Journal of Clinical Pharmacology, 79, 1159-1172. doi: 10.1007/s00228-023-03534-z

2022

Journal - Research Article

Vasantharajan, S. S., Barnett, E., Gray, E. S., McCall, J. L., Rodger, E. J., Eccles, M. R., Munro, F., Pattison, S., & Chatterjee, A. (2022). Assessment of a size-based method for enriching circulating tumour cells in colorectal cancer. Cancers, 14, 3446. doi: 10.3390/cancers14143446

Powell, R. M., Pattison, S., Moravec, J. C., Bhat, B., Guirguis, N., Markie, D., Jones, G. T., … Print, C. G., Morison, I. M., Gavryushkin, A., … Eccles, M. R., & Macaulay, E. C. (2022). Tuberous sclerosis complex: A complex case. Molecular Case Studies, 8, a006182. doi: 10.1101/mcs.a006182

Conference Contribution - Verbal presentation and other Conference outputs

Vasantharajan, S. S., Barnett, E., Eccles, M. R., Pattison, S., Rodger, E. J., McCall, J. L., … Munro, F., & Chatterjee, A. (2022, September). Evaluation of a membrane-based method for enriching circulating tumour cells from the blood of colorectal cancer patients. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

Shyam, S., Eccles, M. R., Pattison, S., Rodger, E. J., McCall, J. L., Gray, E. S., & Chatterjee, A. (2022, August). Evaluation of a membrane-based method for enriching circulating tumour cells from the blood of colorectal cancer patients. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Elston, M. S., Love, A., Kevat, D., Carroll, R., Siow, Z. R., Pattison, S., … the Commonwealth Neuroendocrine Tumour Collaboration (CommNETs). (2021). Pituitary function following peptide receptor radionuclide therapy for neuroendocrine tumours. Cancer Medicine, 10, 8405-8411. doi: 10.1002/cam4.4345

Shyam, S., Eccles, M. R., Rodger, E. J., Pattison, S., McCall, J. L., Gray, E. S., … Chatterjee, A. (2021). The epigenetic landscape of circulating tumour cells. Biochimica et Biophysica Acta: Reviews on Cancer, 1875(188514). doi: 10.1016/j.bbcan.2021.188514

Busuttil, R. A., George, J., House, C. M., Lade, S., Mitchell, C., Di Costanzo, N. S., Pattison, S., … Boussioutas, A. (2021). SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence. Gastric Cancer, 24, 589-601. doi: 10.1007/s10120-020-01143-8

Journal - Research Other

Sohail, S., Zuk, V., Halfdanarson, T., Chan, D., Pattison, S., Vasdev, R., … Hallett, J. (2021). The quality of online information for an uncommon malignancy: Neuroendocrine tumours (NETs) [Communication]. Current Oncology, 28, 842-846. doi: 10.3390/curroncol28010082

Conference Contribution - Published proceedings: Abstract

Shyam, S., Eccles, M., Pattison, S., Rodger, E., McCall, J., Gray, E., & Chatterjee, A. (2021). Identification of tumour specific-epigenetic signatures in circulating tumour cells to understand their role in colorectal cancer metasis. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2020

Journal - Research Article

Wang, K., Li, E., Busuttil, R. A., Kong, J. C., Pattison, S., Sung, J. J. Y., … Boussioutas, A. (2020). A cohort study and meta-analysis of the evidence for consideration of Lauren subtype when prescribing adjuvant or palliative chemotherapy for gastric cancer. Therapeutic Advances in Medical Oncology, 12, 1-22. doi: 10.1177/1758835920930359

Journal - Research Other

Woodall, M. J., Neumann, S., Campbell, K., Pattison, S. T., & Young, S. L. (2020). The effects of obesity on anti-cancer immunity and cancer immunotherapy. Cancers, 12(5), 1230. doi: 10.3390/cancers12051230

Conference Contribution - Published proceedings: Abstract

Vasantharajan, S. S., Chatterjee, A., Eccles, M., Pattison, S., McCall, J., Gray, E., & Warkiani, M. (2020). Circulating tumour cells (CTCs) as a model to identify tumour-specific epigenetic signatures of metastasis in colorectal cancer. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Powell, R. M., Merrilees, M. J., Pattison, S., Gray, B., Jones, G. T., Eccles, M. R., & Macaulay, E. C. (2020). Epigenetic investigations in LAM: Using heritable biomarkers to trace cell lineage. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Ajithkumar, P., McCall, J., Guilford, P., Pattison, S., Rodger, E., & Chatterjee, A. (2020). Epigenetic profiling of colorectal cancer to predict patients at high risk of metastasis. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Shyam, S., Eccles, M., Pattison, S., McCall, J., Gray, E., & Chatterjee, A. (2020). Circulating tumour cells as a model to identify tumour-speciﬁc epigenetic signatures of colorectal cancer metastasis. Proceedings of the Genetics Otago (GO) Zoom Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Chatterjee, A., McCall, J., Guilford, P., Pattison, S., Rodger, E., & Ajithkumar, P. (2020). Epigenomic profiling of colorectal cancer to predict patients at high risk of metastasis. Cancer Research, 80(16, Suppl.), 2434. doi: 10.1158/1538-7445.Am2020-2434

2019

Chapter in Book - Research

Neumann, S., Peyroux, E. M., Woodall, M. J., Shields, N. J., Young, S. L., & Pattison, S. T. (2019). The Influence of microbial metabolites in the gastrointestinal microenvironment on anticancer immunity. In M. Rajer & E. Segelov (Eds.), Current cancer treatment. London, UK: IntechOpen. doi: 10.5772/intechopen.88137

Journal - Research Article

Woodhouse, B., Pattison, S., Segelov, E., Singh, S., Parker, K., Kong, G., … Koea, J., … and on behalf of the Commonwealth Neuroendocrine Tumour Collaboration (CommNETs), including Carroll, R. (2019). Consensus-derived quality performance indicators for neuroendocrine tumour care. Journal of Clinical Medicine, 8, 1455. doi: 10.3390/jcm8091455

Conference Contribution - Published proceedings: Abstract

Lee, B., Walpole, I., Shapiro, J., Thomson, B., Lipton, L., Ananda, S., … Pattison, S., … Gibbs, P. (2019). Use and outcomes from neoadjuvant chemotherapy in borderline resectable pancreatic ductal adenocarcinoma in an Australasian population. Asia-Pacific Journal of Clinical Oncology, 15(Suppl. 9), (pp. 175). doi: 10.1111/ajco.13263

Lee, B., Shapiro, J., Thomson, B., Ananda, S., Lipton, L., McLachlan, S.-A., … Pattison, S., … Gibbs, P. (2019). How can digital health be used to improve outcomes in pancreatic ductal adenocarcinoma (PDAC)? Examining the potential of the PURPLE translational pancreatic cancer platform. Asia-Pacific Journal of Clinical Oncology, 15(Suppl. 9), (pp. 73-74). doi: 10.1111/ajco.13262

Alfadhel, M., Pemberton, J., Williams, M. J. A., Pattison, S., McDiarmid, B., Pemberton, L., Whalley, G., & Coffey, S. (2019). Imaging guidelines adherence for chemotherapy-related cardiotoxicity: A retrospective study. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S25). doi: 10.1016/j.hlc.2019.05.065

Conference Contribution - Verbal presentation and other Conference outputs

Cochrane, O., Hull, A., Conroy, S., Perry, T., & Pattison, S. (2019, September). Identifying nutritional concerns and dietary support requirements for patients with Neuroendocrine Tumours. Verbal presentation at the Dietitians New Zealand Conference: Closing the Gap, Auckland, New Zealand.

2018

Conference Contribution - Published proceedings: Abstract

Rhodes, J., McCall, J., Pattison, S., Ward-Hartstonge, K., Sandford, S., Munro, F., Black, M., & Kemp, R. (2018). Refining multiplex immunohistochemistry to quantify in situ immune infiltrate: Improving survival of colorectal cancer patients. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Conference Contribution - Verbal presentation and other Conference outputs

Rhodes, J. L., McCall, J. L., Pattison, S. T., Ward-Hartstonge, K. A., Sandford, S. K., Munro, F. M., Black, M. A., & Kemp, R. A. (2018, August). Refining multiplex immunohistochemistry to quantify in situ immune infiltrate: Improving survival of colorectal cancer patients. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

2017

Journal - Research Article

Pattison, S., Mitchell, C., Lade, S., Leong, T., Busuttil, R. A., & Boussioutas, A. (2017). Early relapses after adjuvant chemotherapy suggests primary chemoresistance in diffuse gastric cancer. PLoS ONE, 12(9), e0183891. doi: 10.1371/journal.pone.0183891

Conference Contribution - Published proceedings: Abstract

Pattison, S., Leong, T., Busuttil, R. A., & Boussioutas, A. (2017). MAGEA family gene expression influences survival in intestinal gastric cancer. Annals of Oncology, 28(Suppl. 10), 210P. doi: 10.1093/annonc/mdx660.017

2016

Journal - Research Article

Wang, M., Busuttil, R. A., Pattison, S., Neeson, P. J., & Boussioutas, A. (2016). Immunological battlefield in gastric cancer and role of immunotherapies. World Journal of Gastroenterology, 22(28), 6373-6384. doi: 10.3748/wjg.v22.i28.6373

Pattison, S., Mann, G. B., Crosthwaite, G., Lade, S., Mitchell, C., Leong, T., … Boussioutas, A. (2016). Predictors of outcome after surgery for gastric cancer in a Western cohort. ANZ Journal of Surgery, 86(6), 469-474. doi: 10.1111/ans.12915

Awarded Doctoral Degree

Pattison, S. T. (2016). Heterogeneity in gastric cancer and the impact on patient survival (PhD). University of Melbourne, Melbourne, Australia. Retrieved from http://hdl.handle.net/11343/112437

2015

Chapter in Book - Other

Pattison, S., & Boussioutas, A. (2015). Pathophysiology of hereditary diffuse gastric cancer. In V. E. Strong (Ed.), Gastric cancer: Principles and practice. (pp. 91-109). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-15826-6_6

Conference Contribution - Published proceedings: Abstract

Pattison, S., Di Costanzo, N., Mitchell, C., Murray, W., Leong, T., Busuttil, R., & Boussioutas, A. (2015). MMR loss, inflammatory score and prognosis in gastric cancer. European Journal of Cancer, 51(Suppl. 3), (pp. S465). doi: 10.1016/S0959-8049(16)31300-4

2014

Journal - Research Other

Pattison, S., & Zalcberg, J. R. (2014). Bespoke treatment: Drivers beware! Asia-Pacific Journal of Clinical Oncology, 10(4), 378-380. doi: 10.1111/ajco.12265

2013

Journal - Research Article

Lei, Z., Tan, I. B., Das, K., Deng, N., Zouridis, H., Pattison, S., … Rozen, S. G. (2013). Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. Gastroenterology, 145, 554-565. doi: 10.1053/j.gastro.2013.05.010

Journal - Research Other

Pattison, S. T., & McLaren, B. R. (2013). Triple negative breast cancer in a male-to-female transsexual [Brief communication]. Internal Medicine Journal, 43(2), 203-205. doi: 10.1111/imj.12047

Conference Contribution - Published proceedings: Abstract

Pattison, S., Holt, B., Lade, S., Mitchell, C., Crosthwaite, G., Mann, B., … Boussioutas, A. (2013). Predictors of outcome after surgery for gastric cancer in a Western cohort. Asia-Pacific Journal of Clinical Oncology, 9(Suppl. 3), (pp. 133). doi: 10.1111/ajco.12145

2002

Journal - Research Article

Futschik, M., Jeffs, A., Pattison, S., Kasabov, N., Sullivan, M., Merrie, A., & Reeve, A. (2002). Gene expression profiling of metastatic and nonmetastatic colorectal cancer cell lines. Genome Letters, 1(1), 26-34. doi: 10.1166/gl.2002.005

2001

Journal - Research Article

Pattison, S. T., & Reeve, A. E. (2001). From molecule to malady. The future of high speed molecular biology in medicine. New Zealand Medical Journal, 114, 70-72.

Conference Contribution - Published proceedings: Abstract

Jeffs, A., Pattison, S., Xu, J., & Reeve, A. (2001). Microarray analysis of colorectal cancer cell lines. Nature Genetics, 27, (pp. 62). doi: 10.1038/87138