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Contact Details

Department of Anatomy
MB(Anhui) PhD(Otago)
Research summary
Aging, neurodegenerative and psychiatric disorders


Professor Liu's main research interests are:

  1. Neurobiological basis and intervention of age-related cognitive decline, and neurodegenerative and psychiatric disorders
  2. Biological basis of learning and memory

A combination of behavioural, in vivo microdialysis, neurochemical, molecular biological, immunohistochemical, and electrophysiological approaches are being used.

A growing body of evidence suggests the implications of altered arginine metabolism in the aging and neurodegenerative processes and psychiatric disorders. Professor Liu's research group has been focusing on how central and/or peripheral arginine metabolism is altered, aiming to better understand the neurobiological basis of aging and neurodegenerative (Alzheimer's disease in particular) and psychiatric (e.g., schizophrenia) disorders, to identify biomarkers and to explore the therapeutic target(s). Moreover, her research group has also been investigating the functional role of agmatine, a putative novel neurotransmitter, in learning and memory, and exploring its therapeutic potential for cognitive decline.


Highet, B., Wiseman, J. A., Mein, H., Parker, R., Ryan, B., Turner, C. P., Jing, Y., … Liu, P., … Faull, R. L. M., … Curtis, M. A. (2023). PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization. Journal of Alzheimer's Disease. Advance online publication. doi: 10.3233/jad-220986 Journal - Research Article

Deane, A. R., Jing, Y., Shoorangiz, R., Liu, P., & Ward, R. D. (2023). Cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk. Behavioral Neuroscience, 137(1), 67-77. doi: 10.1037/bne0000540 Journal - Research Article

Mein, H., Jing, Y., Ahmad, F., Zhang, H., & Liu, P. (2022). Altered polyamine system in the P301S (PS19) tauopathy model. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 49). Retrieved from Conference Contribution - Published proceedings: Abstract

Ahmed, S., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2022). Partial endothelial nitric oxide synthase deficiency exacerbates cognitive deficit and amyloid pathology in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease. International Journal of Molecular Sciences, 23(13), 7316. doi: 10.3390/ijms23137316 Journal - Research Article

Li, Z., Zhang, T., Xu, L., Wei, Y., Cui, H., Tang, Y., … Zhang, H., Liu, P., … Wang, J. (2022). Plasma metabolic alterations and potential biomarkers in individuals at clinical high risk for psychosis. Schizophrenia Research, 239, 19-28. doi: 10.1016/j.schres.2021.11.011 Journal - Research Article

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