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Dr Kirsty Danielson

Contact Details

Email
kirsty.danielson@otago.ac.nz
Position
Senior Lecturer
Department
Department of Surgery and Anaesthesia (Wellington)
Qualifications
BBmedSc PhD
Research summary
Colorectal cancer; disease biomarkers

Research

I completed both my BBMedSc and PhD at Victoria University of Wellington before undertaking a postdoctoral fellowship at Beth Israel Deaconess Medical Centre, Harvard Medical School in Boston, USA. My research during this time focused on the use of extracellular vesicles and small non-coding RNAs in the plasma as functional biomarkers for cardiovascular and metabolic disease. In 2017 I returned to Wellington and joined the University of Otago as a Lecturer in the Department of Surgery and Anaesthesia.

My current research interests include the use of extracellular vesicles and RNA as plasma biomarkers for risk stratification and prediction of response to therapy in patient groups, and their mechanisms of function in cellular models of disease. Working with surgeons based at University of Otago and Wellington Hospital as a part of the Surgical Cancer Research Group, I am involved in several projects investigating novel biomarkers in colorectal cancer.

Publications

Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918

Symonds, E. K. C., Black, B., Brown, A., Meredith, I., Currie, M. J., Hally, K. E., & Danielson, K. M. (2023). Adipose derived stem cell extracellular vesicles modulate primary human macrophages to an anti-inflammatory phenotype in vitro. Journal of Extracellular Biology, 2, e104. doi: 10.1002/jex2.104

Symonds, E. K. C., Wilms, H., Finlayson, C., Hally, K. E., Black, B., Sparks, S. V., … Dennett, E. R., Danielson, K. M., & Meredith, I. (2023). Volumetric assessment of fat graft retention over implant by MRI. Australasian Journal of Plastic Surgery, 6(1), 70234. doi: 10.34239/ajops.70234

Gower, H., Danielson, K., Dennett, E., & Deere, J. (2023). Potential role of volatile organic compound breath testing in the Australasian colorectal cancer pathway. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.18195

Paterson, E., Blenkiron, C., Danielson, K., & Henry, C. (2022). Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context. Translational Oncology, 23, 101478. doi: 10.1016/j.tranon.2022.101478

Bakr, S., Simonson, B., Danielson, K. M., & Das, S. (2018). Extracellular RNA isolation from cell culture supernatant. In T. Patel (Ed.), Extracellular RNA: Methods and protocols: Methods in molecular biology (Vol. 1740). (pp. 23-34). New York, NY: Humana Press. doi: 10.1007/978-1-4939-7652-2_3

Chapter in Book - Research

Kivell, B. M., & Danielson, K. (2016). Neurological effects of nicotine, tobacco, and particulate matter. In V. R. Preedy (Ed.), Neuropathology of drug addictions and substance misuse (Vol. 1: Foundations of understanding, tobacco, alcohol, cannabinoids and opioids). (pp. 115-122). London, UK: Academic Press. doi: 10.1016/B978-0-12-800213-1.00011-0

Chapter in Book - Research

Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918

Journal - Research Article

Symonds, E. K. C., Black, B., Brown, A., Meredith, I., Currie, M. J., Hally, K. E., & Danielson, K. M. (2023). Adipose derived stem cell extracellular vesicles modulate primary human macrophages to an anti-inflammatory phenotype in vitro. Journal of Extracellular Biology, 2, e104. doi: 10.1002/jex2.104

Journal - Research Article

Symonds, E. K. C., Wilms, H., Finlayson, C., Hally, K. E., Black, B., Sparks, S. V., … Dennett, E. R., Danielson, K. M., & Meredith, I. (2023). Volumetric assessment of fat graft retention over implant by MRI. Australasian Journal of Plastic Surgery, 6(1), 70234. doi: 10.34239/ajops.70234

Journal - Research Article

Clode, N. J., Danielson, K., & Dennett, E. (2021). Perceptions of competency with evidence-based medicine among medical students: Changes through training and alignment with objective measures. New Zealand Medical Journal, 134(1531), 63-75. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Dore, M., Filoche, S., Danielson, K., & Henry, C. (2021). Characterisation of levonorgestrel-resistant endometrial cancer cells. Cancer Management & Research, 13, 7871-7884. doi: 10.2147/CMAR.S327381

Journal - Research Article

Greenwood, A., Keating, J., Kenwright, D., Shekouh, A., Dalzell, A., Dennett, E., & Danielson, K. (2021). Lymph node morphology in stage II colorectal cancer. PLoS ONE, 16(3), e0249197. doi: 10.1371/journal.pone.0249197

Journal - Research Article

Gunawardene, A., Manning, S., Holley, A., Kristono, G., Danielson, K., Shekouh, A., Larsen, P., & Dennett, E. (2021). An IL8-CEA combined score is stage-specific in colorectal cancer. Surgery, Gastroenterology & Oncology, 26(4), 284-290. doi: 10.21614/sgo-26-4-401

Journal - Research Article

Macartney-Coxson, D., Danielson, K., Clapham, J., Benton, M. C., Johnstone, A., Jones, A., … Stubbs, R. S. (2020). MicroRNA profiling in adipose before and after weight loss highlights the role of miR-223-3p and the NLRP3 inflammasome. Obesity, 28(3), 570-580. doi: 10.1002/oby.22722

Journal - Research Article

Murillo, O. D., Thistlethwaite, W., Rozowsky, J., Subramanian, S. L., Lucero, R., Shah, N., … Danielson, K. M., … Milosavljevic, A. (2019). ExRNA Atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids. Cell, 177, 463-477. doi: 10.1016/j.cell.2019.02.018

Journal - Research Article

Srinivasan, S., Yeri, A., Cheah, P. S., Chung, A., Danielson, K., De Hoff, P., … Laurent, L. C. (2019). Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation. Cell, 177, 446-462. doi: 10.1016/j.cell.2019.03.024

Journal - Research Article

Danielson, K. M., Shah, R., Yeri, A., Liu, X., Garcia, F. C., Silverman, M., … Das, S. (2018). Plasma circulating extracellular RNAs in left ventricular remodeling post-myocardial infarction. EBioMedicine, 32, 172-181. doi: 10.1016/j.ebiom.2018.05.013

Journal - Research Article

Manning, S., & Danielson, K. M. (2018). The immunomodulatory role of tumour-derived extracellular vesicles in colorectal cancer. Immunology & Cell Biology, 96(7), 733-741. doi: 10.1111/imcb.12038

Journal - Research Article

Danielson, K. M., Rubio, R., Abderazzaq, F., Das, S., & Wang, Y. E. (2017). High throughput sequencing of extracellular RNA from human plasma. PLoS ONE, 12(1), e0164644. doi: 10.1371/journal.pone.0164644

Journal - Research Article

Jones, A., Danielson, K. M., Benton, M. C., Ziegler, O., Shah, R., Stubbs, R. S., … Macartney-Coxson, D. (2017). miRNA signatures of insulin resistance in obesity. Obesity, 25(10), 1734-1744. doi: 10.1002/oby.21950

Journal - Research Article

Shah, R., Murthy, V., Pacold, M., Danielson, K., Tanriverdi, K., Larson, M. G., … Freedman, J. E. (2017). Extracellular RNAs are associated with insulin resistance and metabolic phenotypes. Diabetes Care, 40(4), 546-553. doi: 10.2337/dc16-1354

Journal - Research Article

Danielson, K. M., Estanislau, J., Tigges, J., Toxavidis, V., Camacho, V., Felton, E. J., … Ghiran, I. (2016). Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry. PLoS ONE, 11(1), e0144678. doi: 10.1371/journal.pone.0144678

Journal - Research Article

Freedman, J. E., Gerstein, M., Mick, E., Rozowsky, J., Levy, D., Kitchen, R., … Danielson, K., … Tanriverdi, K. (2016). Diverse human extracellular RNAs are widely detected in human plasma. Nature Communications, 7, 11106. doi: 10.1038/ncomms11106

Journal - Research Article

Shah, R. V., Murthy, V. L., Allison, M. A., Ding, J., Budoff, M., Frazier-Wood, A. C., … Danielson, K., … Mozaffarian, D. (2016). Diet and adipose tissue distributions: The Multi-Ethnic Study of Atherosclerosis. Nutrition, Metabolism & Cardiovascular Diseases, 26(3), 185-193. doi: 10.1016/j.numecd.2015.12.012

Journal - Research Article

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., … Das, S. (2015). Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study. Circulation, 131(25), 2202-2216. doi: 10.1161/CIRCULATIONAHA.114.013220

Journal - Research Article

Danielson, K., Putt, F., Truman, P., & Kivell, B. M. (2014). The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain. Synapse, 68(2), 45-60. doi: 10.1002/syn.21715

Journal - Research Article

Danielson, K., Truman, P., & Kivell, B. M. (2011). The effects of nicotine and cigarette smoke on the monoamine transporters. Synapse, 65(9), 866-879. doi: 10.1002/syn.20914

Journal - Research Article

Gower, H., Danielson, K., Dennett, E., & Deere, J. (2023). Potential role of volatile organic compound breath testing in the Australasian colorectal cancer pathway. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.18195

Journal - Research Other

Paterson, E., Blenkiron, C., Danielson, K., & Henry, C. (2022). Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context. Translational Oncology, 23, 101478. doi: 10.1016/j.tranon.2022.101478

Journal - Research Other

Dore, M., Filoche, S., Danielson, K., & Henry, C. (2021). Efficacy of the LNG-IUS for treatment of endometrial hyperplasia and early stage endometrial cancer: Can biomarkers predict response? Gynecologic Oncology Reports, 36, 100732. doi: 10.1016/j.gore.2021.100732

Journal - Research Other

Desmond, B. J., Dennett, E. R., & Danielson, K. M. (2019). Circulating extracellular vesicle microRNA as diagnostic biomarkers in early colorectal cancer: A review. Cancers, 12(1), 52. doi: 10.3390/cancers12010052

Journal - Research Other

Hally, K. E., Danielson, K. M., & Larsen, P. D. (2018). Looking to the future: Spotlight on emerging biomarkers for predicting cardiovascular risk. Current Epidemiology Reports, 5, 230-242. doi: 10.1007/s40471-018-0158-8

Journal - Research Other

Yeri, A., Courtright, A., Danielson, K., Hutchins, E., Alsop, E., Carlson, E., … Van Keuren-Jensen, K. (2018). Evaluation of commercially available small RNASeq library preparation kits using low input RNA. BMC Genomics, 19, 331. doi: 10.1186/s12864-018-4726-6

Journal - Research Other

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., … Das, S. (2016). Response to letter regarding article, "Circulating MicroRNA-30d is Associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study". Circulation, 133(6), e389-e390. doi: 10.1161/CIRCULATIONAHA.115.019228

Journal - Research Other

Laurent, L. C., Abdel-Mageed, A. B., Adelson, P. D., Arango, J., Balaj, L., Breakefield, X., … Danielson, K., … Gould, S. (2015). Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles, 4(1), 26533. doi: 10.3402/jev.v4.26533

Journal - Research Other

Quesenberry, P. J., Aliotta, J., Camussi, G., Abdel-Mageed, A. B., Wen, S., Goldberg, L., … Danielson, K., … Dooner, M. (2015). Potential functional applications of extracellular vesicles: A report by the NIH Common Fund Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles, 4(1), 27575. doi: 10.3402/jev.v4.27575

Journal - Research Other

Danielson, K. M., & Das, S. (2014). Extracellular vesicles in heart disease: Excitement for the future? Exosomes & Microvesicles, 2, 1. doi: 10.5772/58390

Journal - Research Other

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