Dr Ana Holley

2023

Journal - Research Article

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2023). Neutrophil-enriched biomarkers and long-term prognosis in acute coronary syndrome: A systematic review and meta-analysis. Journal of Cardiovascular Translational Research. Advance online publication. doi: 10.1007/s12265-023-10425-2

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2023). Increased levels of low density neutrophils (LDNs) in myocardial infarction. Acta Cardiologica, 78(1), 47-54. doi: 10.1080/00015385.2021.2015145

Conference Contribution - Published proceedings: Abstract

Holley, A., Yiu, J., Hally, K., & Larsen, P. (2023). Neutrophil biomarkers and long-term prognosis in acute coronary syndrome: A systematic review and meta-analysis. Heart, Lung & Circulation, 32(Suppl. 3), 678. doi: 10.1016/j.hlc.2023.06.582

Blackshaw, C., Hally, K., Harding, S., Fairley, S., Larsen, P., & Holley, A. (2023). Gender differences in demographics, management, and clinical outcomes in AMI patients. Heart, Lung & Circulation, 32(Suppl. 3), 386. doi: 10.1016/j.hlc.2023.06.382

2022

Journal - Research Article

Brunton-O'Sullivan, M. M., Holley, A. S., Shi, B., Harding, S. A., & Larsen, P. D. (2022). Cluster analysis of extracellular matrix biomarkers predicts the development of impaired systolic function within 1 year of acute myocardial infarction. Heart & Vessels, 37, 2029-2038. doi: 10.1007/s00380-022-02118-8

Brunton-O'Sullivan, M. M., Holley, A. S., Bird, G. K., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2022). Examining variation and temporal dynamics of extracellular matrix biomarkers following acute myocardial infarction. Biomarkers in Medicine, 16(3), 147-161. doi: 10.2217/bmm-2021-0531

Rogan, A., Brunton-O'Sullivan, M., Holley, A., McQuade, D. d., & Larsen, P. (2022). Can serum biomarkers be used to rule out significant intracranial pathology in emergency department patients with mild traumatic brain injury? A systemic review & meta-analysis. Injury, 53, 259-271. doi: 10.1016/j.injury.2021.10.015

Conference Contribution - Published proceedings: Abstract

Whitfield, P., Sword, D., Holley, A., Walsh, E., Weatherall, M., Shepherd, P. R., … Hall, R. M., & Krebs, J. D. (2022). The metabolic effects of a CREBRF gene variant in NZ women. Proceedings of the 45th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. (pp. 46). Retrieved from https://www.ivvy.com.au/event/NZSSD22/welcome.html

Whitfield, P., Sword, D., Holley, A., Walsh, E., Weatherall, M., Shepherd, P., … Hall, R. M., & Krebs, J. D. (2022). The metabolic effects of a CREBRF gene variant in NZ women: Assessment of satiety and incretins. Proceedings of the 45th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. (pp. 22). Retrieved from https://www.ivvy.com.au/event/NZSSD22/welcome.html

2021

Journal - Research Article

Gunawardene, A., Manning, S., Holley, A., Kristono, G., Danielson, K., Shekouh, A., Larsen, P., & Dennett, E. (2021). An IL8-CEA combined score is stage-specific in colorectal cancer. Surgery, Gastroenterology & Oncology, 26(4), 284-290. doi: 10.21614/sgo-26-4-401

Brunton-O'Sullivan, M. M., Holley, A. S., Hally, K. E., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2021). A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction. Scientific Reports, 11, 12705. doi: 10.1038/s41598-021-92108-z

Conference Contribution - Published proceedings: Abstract

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Shi, B., Harding, S., & Larsen, P. (2021). Using principal component analysis to create prognostic cytokine scores for adverse outcome in acute myocardial infarction. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S57-S58). doi: 10.1016/j.hlc.2021.05.003

2020

Journal - Research Article

Kristono, G. A., Holley, A. S., Hally, K. E., Brunton-O'Sullivan, M. M., Shi, B., Harding, S. A., & Larsen, P. D. (2020). An IL-6-IL-8 score derived from principal component analysis is predictive of adverse outcome in acute myocardial infarction. Cytokine: X, 2, 100037. doi: 10.1016/j.cytox.2020.100037

Kristono, G. A., Holley, A. S., Lakshman, P., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2020). Association between inflammatory cytokines and long-term adverse outcomes in acute coronary syndromes: A systematic review. Heliyon, 6(4), e03704. doi: 10.1016/j.heliyon.2020.e03704

Kristono, G. A., Holley, A. S., Harding, S. A., & Larsen, P. D. (2020). White blood cell subtypes as predictors of adverse cardiac events. Coronary Artery Disease, 31(5), 446-450. doi: 10.1097/mca.0000000000000860

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2020). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica, 75(6), 497-502. doi: 10.1080/00015385.2019.1611189

Conference Contribution - Published proceedings: Abstract

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Harding, S., & Larsen, P. (2020). Trends in inflammatory cytokine levels over acute and chronic phases of myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S293). doi: 10.1016/j.hlc.2020.09.574

Brunton-O'Sullivan, M., Holley, A., Hally, K., Kristono, G., Bird, G., Harding, S., & Larsen, P. (2020). Examining the relationship between infarct size and circulating extracellular matrix biomarkers over acute and chronic phases of myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S257-S258). doi: 10.1016/j.hlc.2020.09.495

Yiu, J., Hally, K., Holley, A., & Larsen, P. (2020). Circulating low-density neutrophils in acute myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S242). doi: 10.1016/j.hlc.2020.09.464

Holley, A., Harding, S., & Larsen, P. (2020). An analysis on gender disparities in a contemporary acute myocardial infarction (AMI) cohort. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S235). doi: 10.1016/j.hlc.2020.09.447

Fahmi, H., Laurie, A., Shepherd, P., Bhoothpur, C., Legget, M., Doughty, R., Holley, A., Larsen, P., & Gladding, P. (2020). Clinical applications of polygenic risk scores in coronary artery disease and familial hypercholesterolaemia. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S5-S6). doi: 10.1016/j.hlc.2020.05.017

2019

Journal - Research Other

Thunders, M., Holley, A., Harding, S., Stockwell, P., & Larsen, P. (2019). Using NGS-methylation profiling to understand the molecular pathogenesis of young MI patients who have subsequent cardiac events [Brief report]. Epigenetics, 14(6), 536-544. doi: 10.1080/15592294.2019.1605815

Conference Contribution - Published proceedings: Abstract

Gunawardene, A., Manning, S., Danielson, K., Holley, A., Kristono, G., Shekouh, A., Larsen, P., & Dennett, E. (2019). A combined IL8 and CEA score is an effective marker of metastatic colorectal cancer. ANZ Journal of Surgery, 89(Suppl. 1), (pp. 23). doi: 10.1111/ans.15180

Kristono, G., Holley, A., Lakshman, P., Brunton-O'Sullivan, M., Harding, S., & Larsen, P. (2019). A systematic review of inflammatory cytokines as predictors of long-term outcome in acute coronary syndromes. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S19). doi: 10.1016/j.hlc.2019.05.051

Brunton-O'Sullivan, M., Holley, A., Hally, K., Harding, S., & Larsen, P. (2019). An exploratory factor analysis of circulating extracellular matrix biomarkers in acute myocardial infarction. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S14). doi: 10.1016/j.hlc.2019.05.039

2018

Conference Contribution - Published proceedings: Abstract

Kristono, G., Holley, A., Sasse, A., Harding, S., & Larsen, P. (2018). Neutrophil-lymphocyte ratio as a prognostic marker in acute myocardial infarction. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S332-S333). doi: 10.1016/j.hlc.2018.06.645

Kirby, A., Holley, A., Aitken, A., Larsen, P., & Harding, S. (2018). Family history of premature coronary artery disease: Accuracy and predictor of risk. Heart, Lung & Circulation, 27(Suppl. 1), (pp. S26). doi: 10.1016/j.hlc.2018.05.159

2017

Journal - Research Article

Holley, A., Pitman, J., Miller, J., Harding, S., & Larsen, P. (2017). Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Journal of Investigative Medicine, 65(5), 919-925. doi: 10.1136/jim-2016-000361

Harding, S. A., Holley, A., Wilkins, B., Fairley, S., Simmonds, M., & Larsen, P. D. (2017). Contemporary antiplatelet therapy in acute coronary syndromes: Are there differences in outcomes and discontinuation between clopidogrel and ticagrelor? Internal Medicine Journal, 47(11), 1298-1305. doi: 10.1111/imj.13595

Larsen, P. D., Holley, A. S., Sasse, A., Al-Sinan, A., Fairley, S., & Harding, S. A. (2017). Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes. Thrombosis Research, 152, 14-19. doi: 10.1016/j.thromres.2017.02.006

Matsis, K., Holley, A., Al-Sinan, A., Matsis, P., Larsen, P. D., & Harding, S. A. (2017). Differing clinical characteristics between young and older patients presenting with myocardial infarction. Heart, Lung & Circulation, 26(6), 566-571. doi: 10.1016/j.hlc.2016.09.007

Conference Contribution - Published proceedings: Abstract

Holley, A., Northcott, H., Gladding, P., Harding, S., & Larsen, P. (2017). Significant differences in genetic risk profiles between Maori and European presenting with myocardial infarction. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S307-S308). doi: 10.1016/j.hlc.2017.06.612

Holley, A., Wilkins, B., Fairley, S., Ranchord, A., Larsen, P., & Harding, S. (2017). Prior myocardial infarction an independent predictor of adverse cardiovascular events. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S91). doi: 10.1016/j.hlc.2017.06.110

Fake, A., Holley, A., Kirby, A., Sasse, A., Larsen, P., & Harding, S. (2017). Evaluating the ability of bleeding risk scores and platelet reactivity to predict bleeding risk in those presenting with myocardial infarction. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S77). doi: 10.1016/j.hlc.2017.06.078

Harding, S., Holley, A., Fairley, S., Wilkins, B., Simmonds, M., & Larsen, P. (2017). Contemporary antiplatelet therapy in acute coronary syndromes: Are there differences in outcomes and complications between clopidogrel and ticagrelor? Heart, Lung & Circulation, 26(Suppl. 2), (pp. S292-S293). doi: 10.1016/j.hlc.2017.06.576

Lim, R. Y., Holley, A., Fairley, S., Sasse, A., Larsen, P., & Harding, S. (2017). Ticagrelor use and platelet reactivity in Maori and diabetic patients with acute coronary syndromes. Heart, Lung & Circulation, 26(Suppl. 1), (pp. S5). doi: 10.1016/j.hlc.2017.05.012

Wilkins, B., Matsis, P., Simmonds, M., Holley, A., Larsen, P., & Harding, S. (2017). Ticagrelor use and the “treatment risk paradox” in elderly patients with acute coronary syndromes. Heart, Lung & Circulation, 26(Suppl. 1), (pp. S7). doi: 10.1016/j.hlc.2017.05.018

O'Connor, M., Ranchord, A., Holley, A., Larsen, P., & Harding, S. (2017). What are the clinical and demographic characteristics of patients prescribed less than 12 months of Dual Anti-Platelet Therapy (DAPT) after an Acute Coronary Syndrome (ACS) event? Heart, Lung & Circulation, 26(Suppl. 1), (pp. S20). doi: 10.1016/j.hlc.2017.05.052

Kirby, A., Aitken, A., Simmonds, M., Holley, A., Larsen, P., & Harding, S. (2017). Readmission rates 30 days following myocardial infarction. Heart, Lung & Circulation, 26(Suppl. 1), (pp. S17-S18). doi: 10.1016/j.hlc.2017.05.045

2016

Journal - Research Article

Holley, A., Harding, S., Sasse, A., Miller, J., & Larsen, P. (2016). Reduced glutathione peroxidase activity predicts increased cardiovascular risk following an acute coronary syndrome. International Cardiovascular Forum Journal, 6, 61-65. doi: 10.17987/icfj.v6i0.241

Holley, A. S., Miller, J. H., Larsen, P. D., & Harding, S. A. (2016). Relationship between glutathione peroxidase, platelet reactivity, and reactive oxygen species in an acute coronary syndrome population. Annals of Clinical & Laboratory Science, 46(6), 639-644.

Conference Contribution - Published proceedings: Abstract

Holley, A., Al-Sinan, A., Fairley, S., Simmonds, M., Larsen, P., & Harding, S. (2016). Residual platelet reactivity measured by VerifyNow® is more predictive than Multiplate® of one year outcomes following acute coronary syndromes (ACS). Heart, Lung & Circulation, 25(Suppl. 2), (pp. S62). doi: 10.1016/j.hlc.2016.06.140

Holley, A., Matsis, K., Northcott, H., Gladding, P., Harding, S., & Larsen, P. (2016). Genetic risk scoring in a young myocardial infarction (MI) population. Heart, Lung & Circulation, 25(Suppl. 2), (pp. S283-S284). doi: 10.1016/j.hlc.2016.06.664

2015

Journal - Research Article

Larsen, P. D., Johnston, L. R., Holley, A., La Flamme, A., Smyth, L., Chua, E. W., Kennedy, M. A., & Harding, S. A. (2015). Prevalence and significance of CYP2C19*2 and CYP2C19*17 alleles in a New Zealand acute coronary syndrome population. Internal Medicine Journal, 45(5), 537-545. doi: 10.1111/imj.12698

Conference Contribution - Published proceedings: Abstract

Holley, A., Miller, J., Harding, S., & Larsen, P. (2015). Characterisation of the glutathione peroxidase system in coronary artery disease. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S140). doi: 10.1016/j.hlc.2015.06.064

Harding, S., Fairley, S., Al-Sinan, A., Holley, A., Howard, C., Matsis, P., Aitken, A., & Larsen, P. (2015). Bleeding, dyspnoea and discontinuation in a real world ACS cohort treated with ticagrelor. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S376). doi: 10.1016/j.hlc.2015.06.615

Howard, C., Holley, A., Sasse, A., Harding, S., & Larsen, P. (2015). Is the incidence of high on treatment platelet reactivity (HOTPR) reduced in acute coronary syndrome (ACS) patients treated with ticagrelor? Heart, Lung & Circulation, 24(Suppl. 2), (pp. S100). doi: 10.1016/j.hlc.2015.04.126

2014

Conference Contribution - Published proceedings: Abstract

Plunkett, S., Ranchord, A., Matsis, P., Holley, A., Larsen, P., & Harding, S. (2014). "Normal" coronary arteries in the setting of acute coronary syndromw: Frequency and outcomes. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e36-e37). doi: 10.1016/j.hlc.2014.04.222

Legge, C., Al-Sinan, A., Holley, A., Johnston, L., Larsen, P., & Harding, S. (2014). Does timing of platelet function testing (PFT) contribute to variability in residual on-treatment platelet reactivity in patients with acute coronary syndrome (ACS)? Heart, Lung & Circulation, 23(Suppl. 1), (pp. e31). doi: 10.1016/j.hlc.2014.04.205

Holley, A., Miller, J., Harding, S., & Larsen, P. (2014). Variability and prognostic significance of antioxidant enzymes in acute coronary syndromes (ACS). Heart, Lung & Circulation, 23(Suppl. 1), (pp. e27). doi: 10.1016/j.hlc.2014.04.196

Hally, K., Johnston, L., Holley, A., Larsen, P., & Harding, S. (2014). Platelet count and platelet function testing in acute coronary syndromes. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e26). doi: 10.1016/j.hlc.2014.04.192

2013

Conference Contribution - Published proceedings: Abstract

Holley, A., Johnston, L., Harding, S., & Larsen, P. (2013). High levels of reactive oxygen species (ROS) are associated with reduced glutathione peroxidase (GPx) activity in acute coronary syndrome (ACS). Heart, Lung & Circulation, 22(Suppl. 1), (pp. S41). doi: 10.1016/j.hlc.2013.05.098

Johnston, L., Smyth, L., Kennedy, M., Holley, A., Sasse, A., La Flamme, A., Larsen, P., & Harding, S. (2013). High on treatment platelet reactivity is associated with a higher risk of MACE in ACS patients: Diabetes and loss of function genotype the driving forces. Heart, Lung & Circulation, 22(7), (pp. 561). doi: 10.1016/j.hlc.2013.04.035

Holley, A. S., Johnston, L. R., Harding, S. A., & Larsen, P. D. (2013). Reduced glutathione peroxidase (GPx) activity in acute coronary syndrome (ACS) is correlated with high levels of reactive oxygen species (ROS). Heart, Lung & Circulation, 22(7), (pp. 560-561). doi: 10.1016/j.hlc.2013.04.033

Conference Contribution - Poster Presentation (not in published proceedings)

Holley, A. S., Johnston, L. R., Harding, S. A., & Larsen, P. D. (2013, August). Prognostic significance of antioxidant enzymes in acute coronary syndrome patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Conference Contribution - Published proceedings: Abstract

Johnston, L., Holley, A., Chen-Xu, M., Larsen, P., & Harding, S. (2012). Significant disagreement between the VerifyNow and Multiplate assays in the classification of high platelet reactivity on clopidogrel. Heart, Lung & Circulation, 21(Suppl. 1), (pp. S174-S175). doi: 10.1016/j.hlc.2012.05.434

Chen-Xu, M., Johnston, L., Holley, A., Sasse, A., Larsen, P. D., & Harding, S. A. (2012). Comparison of the Multiplate and VerifyNow assays for monitoring residual platelet reactivity after clopidogrel. Heart, Lung & Circulation, 21(8), (pp. 483-484). doi: 10.1016/j.hlc.2012.03.025

Johnston, L. R., Holley, A. S., Chen-Xu, M., La Flamme, A. C., Larsen, D., & Harding, S. A. (2012). High residual platelet reactivity on aspirin in a New Zealand ACS population. Heart, Lung & Circulation, 21(8), (pp. 491-492). doi: 10.1016/j.hlc.2012.03.043

Holley, A. S., Johnston, L. R., Chen-Xu, M., Sasse, A., Larsen, P. D., & Harding, S. A. (2012). Plasma antioxidant enzyme levels in acute coronary syndrome. Heart, Lung & Circulation, 21(8), (pp. 490). doi: 10.1016/j.hlc.2012.03.040