Profile

Contact Details

Email: judith.marsman@otago.ac.nz

University Links

Position: Postdoctoral Fellow
Department: Department of Surgical Sciences (Dunedin)
Research summary: Cardiovascular disease genetics

Research

My research is on understanding the mechanism by which genetic variants contribute to cardiovascular diseases. Numerous genetic variants that are associated with a range of cardiovascular diseases have been identified, however, many of these are located in non-coding DNA and have no assignable target gene. I aim to investigate which genes are affected by these genetic variants, and how the variants regulate the expression of these genes.

Research areas:

Gene regulation
Cardiovascular diseases
3D chromatin interactions
Zebrafish as an animal model

Publications

Horsfield, J., & Marsman, J. (Eds.). (2022). Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). New York, NY: Springer, 379p. doi: 10.1007/978-1-0716-2140-0 Edited Book - Research

Marsman, J., Day, R. C., & Gimenez, G. (2022). Circular chromosome conformation capture sequencing (4C-Seq ) in primary adherent cells. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 301-320). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_16 Chapter in Book - Research

Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175 Journal - Research Article

Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. New Zealand Medical Journal, 133(1518), (pp. 98). Retrieved from https://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract

Jones, G. T., Marsman, J., Bhat, B., Phillips, V. L., Chatterjee, A., Rodger, E. J., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2020). DNA methylation profiling identifies a high effect genetic variant for lipoprotein(a) levels. Epigenetics, 15(9), 949-958. doi: 10.1080/15592294.2020.1739797 Journal - Research Article

2022

Edited Book - Research

Horsfield, J., & Marsman, J. (Eds.). (2022). Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). New York, NY: Springer, 379p. doi: 10.1007/978-1-0716-2140-0

Chapter in Book - Research

2021

Journal - Research Article

2020

Journal - Research Article

Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256

Conference Contribution - Published proceedings: Abstract

2019

Journal - Research Article

Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

2018

Conference Contribution - Published proceedings: Abstract

Marsman, J., Millier, M. J., Highton, J., Stamp, L. K., & Hessian, P. A. (2018). Transcriptional profiling of the subcutaneous rheumatoid nodule: An insight into pathogenic mechanisms and cellular content. Arthritis & Rheumatology, 70(9, Suppl.), 929. doi: 10.1002/art.40700

2017

Journal - Research Article

Marsman, J., Thomas, A., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2017). A DNA contact map for the mouse Runx1 gene identifies novel haematopoietic enhancers. Scientific Reports, 7, 13347. doi: 10.1038/s41598-017-13748-8

Conference Contribution - Published proceedings: Abstract

Marsman, J., Thomas, A., Osato, M., O'Sullivan, J., & Horsfield, J. A. (2017). Identifying functional roles for novel cis-regulatory elements predicted to regulate the Runx1 gene. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 789. Retrieved from http://gen2017.w.events4you.currinda.com

Conference Contribution - Verbal presentation and other Conference outputs

Marsman, J. (2017, June). Understanding the genetics of cardiovascular diseases: Into the third dimension. Invited presentation at the Southern Health Symposium, Dunedin, New Zealand.

Marsman, J., Phillips, V. L., Horsfield, J. A., & Jones, G. T. (2017, September). Finding a function for genetic variants associated with abdominal aortic aneurysm. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Conference Contribution - Published proceedings: Abstract

Marsman, J., Thomas, A. L., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2016). A Runx1 interactome identifies novel hematopoietic enhancers. Blood, 128(22), 726. Retrieved from http://www.bloodjournal.org

van Huffel, S., Day, R. C., Antony, J., Marsman, J., Horsfield, J. A., & Dunbier, A. K. (2016). 4CSeq analysis of a breast cancer susceptibility locus on 6q25.1. Cancer Research, 76(14, Suppl.), 4518. doi: 10.1158/1538-7445.AM2016-4518

Conference Contribution - Verbal presentation and other Conference outputs

Marsman, J. (2016, March). A loopy story of Runx1 gene regulation. Verbal presentation at the Genetics Otago Symposium, Dunedin, New Zealand.

Awarded Doctoral Degree

Marsman, J. (2016). Transcriptional regulation of the Runx1 gene (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/6329

2015

Journal - Research Article

Voets, E., Marsman, J., Demmers, J., Beijersbergen, R., & Wolthuis, R. (2015). The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Scientific Reports, 5, 14798. doi: 10.1038/srep14798

Conference Contribution - Poster Presentation (not in published proceedings)

Marsman, J. (2015, May). Cohesin and CTCF contact regulatory elements to control runx1 expression. Poster session presented at the European Molecular Biology Organization (EMBO) Conference: Chromatin and Epigenetics, Heidelberg, Germany.

2014

Journal - Research Article

Leeke, B., Marsman, J., O'Sullivan, J. M., & Horsfield, J. A. (2014). Cohesin mutations in myeloid malignancies: Underlying mechanisms. Experimental Hematology & Oncology, 3, 13. doi: 10.1186/2162-3619-3-13

Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Meier, M., Antony, J., Mönnich, M., & Horsfield, J. A. (2014). Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1839(1), 50-61. doi: 10.1016/j.bbagrm.2013.11.007

Conference Contribution - Verbal presentation and other Conference outputs

Marsman, J. (2014, November). Cohesin and CTCF regulate unx1 expression. Verbal presentation at the Genetics Otago Annual Symposium & Workshop, Dunedin, New Zealand.

2013

Conference Contribution - Verbal presentation and other Conference outputs

Marsman, J. (2013, February). Cohesin and CTCF control runx1 expression at the onset of zebrafish haematopoiesis. Verbal presentation at the 14th Annual Australia and New Zealand Zebrafish Conference, Queenstown, New Zealand.

Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Mönnich, M., & Horsfield, J. A. (2013, August). Cohesin and CTCF contact cis regulatory elements to control spatiotemporal runx1 expression during zebrafish development. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

Marsman, J., & Horsfield, J. A. (2012). Long distance relationships: Enhancer-promoter communication and dynamic gene transcription. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1819(11-12), 1217-1227. doi: 10.1016/j.bbagrm.2012.10.008

Conference Contribution - Poster Presentation (not in published proceedings)

Marsman, J., O'Neill, A., Kao, B., More, H., Rhodes, J., Mönnich, M., Young, S., & Horsfield, J. (2012, September). Cohesin and CTCF cooperate to initiate haematopoietic expression of RUNXI in zebrafish. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Marsman, J., O'Neill, A., Kao, B., More, H., Rhodes, J., Mönnich, M., Young, S., & Horsfield, J. (2012, September). Cohesin and CTCF cooperate to initiate haematopoietic expression of runx1 in zebrafish. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

2011

Conference Contribution - Verbal presentation and other Conference outputs

Kao, B. R., Marsman, J., & Horsfield, J. A. (2011, September). A cohesin–dependent mechanism of runx1 regulation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.