Profile

Contact Details

Phone: 64 3 364 1478
Email: janice.chew-harris@otago.ac.nz

University Links

Position: Research Fellow
Department: Department of Medicine (Christchurch)
Qualifications: BMLSc (Otago), PgDipMLSc (Dist) (Otago), PhD (Otago)
Research summary: Cardioendocrinology and Clinical Biochemistry

Research

Research Interests:

Novel biomarker identification, performance and measurement
Cardiovascular disease
Estimates of kidney function
Clinical Biochemistry
Endocrinology
Protein chemistry

Publications

Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082 Journal - Research Article

Montecillo, J., Pirker, T., Richards, M., Pemberton, C., & Chew-Harris, J. (2023). Protein glycosylation influences soluble urokinase Plasminogen Activator Receptor (suPAR) measurements. Heart, Lung & Circulation, 32(Suppl. 2), P16. doi: 10.1016/j.hlc.2023.04.237 Conference Contribution - Published proceedings: Abstract

Pirker, T., Keys, T., Pham, T., Montecillo, J., Byers, M., Pemberton, C., Richards, M., & Chew-Harris, J. (2023). Soluble urokinase Plasminogen Activator Receptor (suPAR) promotes cardioprotective intracellular signalling in myocardial ischaemia. Heart, Lung & Circulation, 32(Suppl. 2), O02. doi: 10.1016/j.hlc.2023.04.208 Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Appleby, S., Frampton, C., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2022). Comparative performances of soluble urokinase plasminogen activator receptor and Mid-regional proADM to predict composite death and new heart failure rehospitalisation in acutely breathless patients. European Heart Journal, 43(Suppl. 2), (pp. 1087). doi: 10.1093/eurheartj/ehac544.1087 Conference Contribution - Published proceedings: Abstract

Keys, T., Chew-Harris, J., Pemberton, C., Adamson, P., Troughton, R., Doughty, R., & Richards, A. M. (2022). Soluble urokinase plasminogen activator receptor predicts mortality and adverse cardiovascular outcomes following acute coronary syndrome. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S28-S29). doi: 10.1016/j.hlc.2022.05.020 Conference Contribution - Published proceedings: Abstract

2023

Journal - Research Article

Conference Contribution - Published proceedings: Abstract

2022

Conference Contribution - Published proceedings: Abstract

2021

Conference Contribution - Published proceedings: Abstract

Holdaway, M., Lewis, L., Chew-Harris, J., Richards, M., Pemberton, C., & Appleby, S. (2021). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2021.05.044

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S85-S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Prognostic performance of soluble urokinase plasminogen activator receptor (suPAR) in predicting mortality in Asian and Western patients with acute breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in patients with acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.069

2020

Journal - Research Article

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) can predict long-term mortality in patients with acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1695). doi: 10.1093/ehjci/ehaa946.1695

Chew-Harris, J., Appleby, S., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., … Frampton, C., Troughton, R. W., … Richards, A. M., & Pemberton, C. J. (2020). Prognostic performance of soluble urokinase plasminogen activator receptor for 1-year mortality in Asian and Western patients with acute breathlessness. European Heart Journal, 41(Suppl. 2), (pp. 1202). doi: 10.1093/ehjci/ehaa946.1202

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1696). doi: 10.1093/ehjci/ehaa946.1696

2019

Journal - Research Article

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry, 69, 36-44. doi: 10.1016/j.clinbiochem.2019.05.010

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Lee, J. A., Aldous, S., Appleby, S., Chew-Harris, J., Than, M., Troughton, R. W., & Richards, A. M. (2019). The signal peptide of CNP is a novel predictor of MI, MACE and bleeding risk in chest pain patients. European Heart Journal, 40(Suppl. 1), (pp. 2029). doi: 10.1093/eurheartj/ehz745.0283

Chew-Harris, J. S., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Soluble urokinase plasminogen activator receptor (suPAR) predicts 1 year mortality in patients with acute breathlessness. European Heart Journal, 40(Suppl. 1), (pp. 1573). doi: 10.1093/eurheartj/ehz748.0939

2018

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Circulation, 138(Suppl. 1), A11125. [Abstract]

Appleby, S., Chew-Harris, J., Troughton, R., Richards, M., & Pemberton, C. (2018). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Circulation, 138(Suppl. 1), A11094. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018, August). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Other

Chew-Harris, J. S. C., Brennan, S. O., Florkowski, C. M., Troughton, R., & George, P. M. (2017). Deciphering a macro-troponin I complex: A case report. Clinical Chemistry & Laboratory Medicine, 55(4), e77-e79. doi: 10.1515/cclm-2016-0490

2016

Awarded Doctoral Degree

Chew-Harris, J. (2016). Biomarkers of kidney function: Validity of estimates in clinical practice (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/6883

2015

Journal - Research Article

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., & Endre, Z. H. (2015). Comparative performances of the new chronic kidney disease epidemiology equations incorporating cystatin C for use in cancer patients. Asia-Pacific Journal of Clinical Oncology, 11(2), 142-151. doi: 10.1111/ajco.12312

Journal - Research Other

Chew-Harris, J. S. C., Pickering, J. W., George, P. M., Endre, Z. H., & Florkowski, C. M. (2015). Beware the dog that didn't bark: A tale of creatinine in acute kidney injury. Internal Medicine Journal, 45(8), 878-879. doi: 10.1111/imj.12826

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J. S. C., Florkowski, C. M., Elmslie, J. L., Livesey, J. H., Endre, Z. H., & George, P. M. (2015). Lean mass and age are strong determinants of glomerular filtration rate in healthy men. Pathology, 47(Suppl. 1), (pp. S82-S83). doi: 10.1097/01.PAT.0000461558.08084.7f

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P. M., & Endre, Z. H. (2015). Accounting for individual body surface area does improve estimation of absolute GFR using the CKD-EPI equation. Pathology, 47(Suppl. 1), (pp. S82). doi: 10.1097/01.PAT.0000461557.00460.df

2014

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., Elmslie, J. L., Livesey, J., Endre, Z. H., & George, P. M. (2014). Lean mass modulates glomerular filtration rate in males of normal and extreme body composition. Internal Medicine Journal, 44(8), 749-756. doi: 10.1111/imj.12479

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., & Endre, Z. H. (2014). Does cystatin C improve prediction of glomerular filtration rate? Validation in routine use. Pathology, 46(Suppl. 1), (pp. S84-S85). doi: 10.1097/01.PAT.0000443629.15453.e6

2013

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., Elmslie, J. L., & Endre, Z. H. (2013). The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Annals of Clinical Biochemistry, 50(1), 39-46. doi: 10.1258/acb.2012.011241

2011

Journal - Research Other

Florkowski, C., & Chew-Harris, J. S. C. (2011). Methods of estimating GFR: Different equations including CKD-EPI. Clinical Biochemist Reviews, 32(2), 75-79. [Review].

Conference Contribution - Published proceedings: Abstract

Florkowski, C., Chew-Harris, J. S. C., Endre, Z. H., Elmslie, J., & George, P. M. (2011). Renal function in extremes of body composition is influenced by muscle mass but not fat mass nor dietary protein intake. Clinical Biochemist Reviews, 34(Suppl. 4), (pp. S25). [Abstract]

Florkowski, C., Chew-Harris, J. S. C., Endre, Z. H., Elmslie, J., & George, P. M. (2011). Bodyfat is a significant determinant of cystatin-C and a confounding factor for interpretation of renal function. Clinical Biochemist Reviews, 34(Suppl. 4), (pp. S25). [Abstract]

2010

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Saleem, M., Florkowski, C., Sies, C., & George, P. (2010). Estimating GFR in children with cancer. Clinical Biochemist Reviews, 31(Suppl. 4), (pp. S26). [Abstract]

Chew-Harris, J., Saleem, M., Florkowski, C., Sies, C., & George, P. (2010). Estimating GFR: CKD-EPI or MDRD equation? Clinical Biochemist Reviews, 31(Suppl. 4), (pp. S25). [Abstract]

2009

Journal - Research Other

Chew, J. S. C., Saleem, M., Florkowski, C. M., & George, P. M. (2009). Estimating renal function in oncology patients using cystatin C-based equations [Letter]. Clinical Oncology, 21, 425-426. doi: 10.1016/j.clon.2009.01.012

2008

Journal - Research Article

Chew, J. S. C., Saleem, M., Florkowski, C. M., & George, P. M. (2008). Cystatin C: A paradigm of evidence based laboratory medicine. Clinical Biochemist Reviews, 29(2), 47-62.

Conference Contribution - Published proceedings: Abstract

Chew, J. S. C., Saleem, M., Florkowski, C. M., & George, P. M. (2008). Assessment of cystatin C as a renal marker in oncology patients. Clinical Biochemist Reviews, 29(3), (pp. S132). [Abstract]