Contact Details
- Phone
- 64 3 479 7014
- p.cooper@otago.ac.nz
University Links
- Position
- Dean of the Faculty of Dentistry, Professor of Oral Biology
- Department
- Department of Oral Sciences
- Qualifications
- BSc(Hons) (Leeds) PhD PGCILTHE (Birmingham)
- Research summary
- Tissue engineering, pulp biology, periodontal inflammation, photobiomodulation
- Teaching
- Oral Biology
- Memberships
- IADR, PBRG
Research
My research is within the field of oral and dental tissue inflammation and repair. Current areas of research interest include:
1. Dentine-Pulp complex biology
Paul has led projects studying the molecular changes which occur in the dentine-pulp complex as a result of disease, dental injury and repair, and in its response to dental materials. PhD projects he has supervised have characterised dental pulp stem cells (DPSC) responses with the aim of developing novel treatment technologies.
2. Molecular and Cellular aspects of Periodontal Disease
Paul has led studies characterising oral epithelial or neutrophil responses to periodontal bacteria. In collaboration his work has shown that elevated systemic levels of IFNs are associated with the disease. Subsequently this has led to further studies on the roles of Neutrophil Extracellular Traps (NETs), auto-immunity/-inflammation, DNAse deficiency, epigenetics and efferocytosis in periodontitis and its comorbidities.
3. Low Level Light/Laser Therapy (LLLT) / photobiomodulation / phototherapy
Recent studies indicate the utility of phototherapies in promoting oral and dental tissue health as well as for disinfection. Different light delivery approaches are being explored to identify delivery parameters which modulate dentine-pulp complex, gingival and immune cell responses relevant to tissue health.
4. Assessment of toothpaste cleaning
Industry funded studies have utilised profilometry, gloss analyses, stain models and SEM to investigate mechanistic actions of dental dentifrices for oral hygiene.
Additional details
Professor Cooper has over 200 research peer reviewed publications and has authored and edited 12 book chapters in oral and pulp biology. He has delivered over 40 invited lectures globally. He has supervised over 40 Doctoral students and been awarded over NZ$10-million (equivalent) in research funding.
In 2010, Paul was awarded the IADR Distinguished Scientist Young Investigator Award and he has recently been the President of the Pulp Biology and Regeneration Group of IADR and he is currently the vice-president of the IADR-ANZ Division.
He has visiting chairs at several universities around the world and serves as editor and on editorial boards for several leading dental journals.
Paul also completed a postgraduate certificate in learning and teaching in higher education (PGCILTHE) in 2003 and is a Fellow of the Higher Education Academy.
Publications
Al-Maswary, A. A., Walmsley, A. D., Cooper, P. R., & Scheven, B. A. (2024). Low-intensity pulsed ultrasound induces proliferation of human neural stem cells. Clinical & Translational Discovery, 4, e259. doi: 10.1002/ctd2.259 Journal - Research Article
Lundy, F. T., Friedlander, L. T., & Cooper, P. R. (2024). Biological basis for vital pulp treatment. In H. F. Duncan & I. A. El-Karim (Eds.), Vital pulp treatment. (pp. 20-46). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781119930419.ch2 Chapter in Book - Research
Hussein, H. R., Abdulkareem, A. A., Milward, M. R., & Cooper, P. R. (2024). E-cadherin and TAC in GCF accurately discriminate periodontal health and disease. Oral Diseases. Advance online publication. doi: 10.1111/odi.14862 Journal - Research Article
Khurshid, Z., Adanir, N., Ratnayake, J., Dias, G., & Cooper, P. R. (2023). Demineralized dentin matrix for bone regeneration in dentistry: A critical update. Saudi Dental Journal. Advance online publication. doi: 10.1016/j.sdentj.2023.11.028 Journal - Research Other
Hussein, H. R., Abdulkareem, A. A., Milward, M. R., & Cooper, P. R. (2023). Ability of gingival crevicular fluid volume, E-cadherin, and total antioxidant capacity levels for predicting outcomes of nonsurgical periodontal therapy for periodontitis patients. Journal of Periodontal Research. Advance online publication. doi: 10.1111/jre.13213 Journal - Research Article
2024
Chapter in Book - Research
Lundy, F. T., Friedlander, L. T., & Cooper, P. R. (2024). Biological basis for vital pulp treatment. In H. F. Duncan & I. A. El-Karim (Eds.), Vital pulp treatment. (pp. 20-46). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781119930419.ch2
Journal - Research Article
Al-Maswary, A. A., Walmsley, A. D., Cooper, P. R., & Scheven, B. A. (2024). Low-intensity pulsed ultrasound induces proliferation of human neural stem cells. Clinical & Translational Discovery, 4, e259. doi: 10.1002/ctd2.259
Hussein, H. R., Abdulkareem, A. A., Milward, M. R., & Cooper, P. R. (2024). E-cadherin and TAC in GCF accurately discriminate periodontal health and disease. Oral Diseases. Advance online publication. doi: 10.1111/odi.14862
2023
Edited Book - Research
Seymour, G. J., Cullinan, M. P., Heng, N. C. K., & Cooper, P. R. (Eds.). (2023). Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588) (3rd ed.). New York, NY: Springer, 528p. doi: 10.1007/978-1-0716-2780-8
Chapter in Book - Research
Arora, S., Ramachandra, S. S., Cooper, P. R., & Hussaini, H. M. (2023). Prospects of passive immunotherapy to treat pulpal inflammation. In M. T. Rahman, W. Teughels & R. J. Lamont (Eds.), Immunology for Dentistry. (pp. 202-214). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781119893035.ch14
Hirschfeld, J., Chicca, I. J., Moonen, C. G. J., White, P. C., Ling, M. R., Wright, H. J., Cooper, P. R., … Chapple, I. L. C. (2023). Characterization, quantification, and visualization of neutrophil extracellular traps. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 451-472). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_27
Journal - Research Article
Hussein, H. R., Abdulkareem, A. A., Milward, M. R., & Cooper, P. R. (2023). Ability of gingival crevicular fluid volume, E-cadherin, and total antioxidant capacity levels for predicting outcomes of nonsurgical periodontal therapy for periodontitis patients. Journal of Periodontal Research. Advance online publication. doi: 10.1111/jre.13213
Friedlander, L. T., Wallace, W. D. A., Broadbent, J. M., Hanlin, S. M., Lyons, K. M., Cannon, R. D., & Cooper, P. R. (2023). Preparedness and competency of New Zealand graduates for general dental practice: Perceptions from the workforce. Australian Dental Journal. Advance online publication. doi: 10.1111/adj.12981
Alsamahi, S., Milne, T. J., Hussaini, H. M., Rich, A. M., Cooper, P. R., & Friedlander, L. T. (2023). Effects of glycation end-products on the dental pulp in patients with type 2 diabetes. International Endodontic Journal, 56, 1373-1384. doi: 10.1111/iej.13966
Khurshid, Z., Alfarhan, M. F. A., Bayan, Y., Mazher, J., Adanir, N., Dias, G. J., Cooper, P. R., & Ratnayake, J. (2023). Development, physicochemical characterization and in-vitro biocompatibility study of dromedary camel dentine derived hydroxyapatite for bone repair. PeerJ. Advance online publication. doi: 10.7717/peerj.15711
Virdee, S. S., Bashir, N. Z., Krstic, M., Camilleri, J., Grant, M. M., Cooper, P. R., & Tomson, P. L. (2023). Periradicular tissue fluid-derived biomarkers for apical periodontitis: An in vitro methodological & in vivo cross-sectional study. International Endodontic Journal, 56, 1222-1240. doi: 10.1111/iej.13956
Kearney, M., Cooper, P. R., Smith, A. J., & Duncan, H. F. (2023). Characterisation of miRNA expression in dental pulp cells during epigenetically-driven reparative processes. International Journal of Molecular Sciences, 24, 8631. doi: 10.3390/ijms24108631
Wongviriya, A., Shelton, R. M., Cooper, P. R., Milward, M. R., & Landini, G. (2023). The relationship between sphingosine-1-phosphate receptor 2 and epidermal growth factor in migration and invasion of oral squamous cell carcinoma. Cancer Cell International, 23, 65. doi: 10.1186/s12935-023-02906-w
Saliem, S. S., Bede, S. Y., Abdulkareem, A. A., Abdullah, B. H., Milward, M. R., & Cooper, P. R. (2023). Gingival tissue samples from periodontitis patients demonstrate epithelial–mesenchymal transition phenotype. Journal of Periodontal Research, 58, 247-255. doi: 10.1111/jre.13086
Zhao, R., Wang, T., Yang, R., Adam, L. A., Zaharic, T., Loch, C., Tompkins, G. R., & Cooper, P. R. (2023). Enhancing the student learning experience: Co-teaching biochemistry and clinical sciences within the dental curriculum. Biochemistry & Molecular Biology Education, 51, 146-154. doi: 10.1002/bmb.21701
Journal - Research Other
Khurshid, Z., Adanir, N., Ratnayake, J., Dias, G., & Cooper, P. R. (2023). Demineralized dentin matrix for bone regeneration in dentistry: A critical update. Saudi Dental Journal. Advance online publication. doi: 10.1016/j.sdentj.2023.11.028
Dohan, Z., Friedlander, L. T., Cooper, P. R., Li, K.-C., Ratnayake, J. T., & Mei, M. L. (2023). In vitro models used in the formation of root caries lesions: A review of the literature. Dentistry Journal, 11, 269. doi: 10.3390/dj11120269
Murad, M., & Cooper, P. R. (2023). Regenerative endodontic procedures: Are they more successful in mature permanent teeth with necrotic pulp than in immature teeth? Evidence-Based Dentistry, 24, 125-126. doi: 10.1038/s41432-023-00916-1
Majeed, R., Elnawawy, H. M., Kutty, M. G., Yahya, N. A., Azami, N. H., Kasim, N. H. A., … Cooper, P. R., … Ahmed, H. M. A. (2023). Physicochemical, mechanical and biological properties of nano-calcium silicate-based cements: A systematic review. Odontology, 111, 759-776. doi: 10.1007/s10266-023-00786-0
Imran, E., Cooper, P. R., Ratnayake, J., Ekambaram, M., & Mei, M. L. (2023). Potential beneficial effects of hydroxyapatite nanoparticles on caries lesions in vitro: A review of the literature. Dentistry Journal, 11, 40. doi: 10.3390/dj11020040
Conference Contribution - Verbal presentation and other Conference outputs
Patel, S., Milne, T. J., Hussaini, H. M., Cooper, P. R., & Friedlander, L. T. (2023, July). Hyperglycaemia and the dental pulp: So what about angiogenesis? Verbal presentation at the Faculty of Dentistry Clinical and Research Excellence Symposium, Dunedin, New Zealand.
Chao, H. C., Milne, T. J., Cathro, P., Cooper, P. R., & Friedlander, L. T. (2023, July). Hyperglycaemia promotes mineralisation of human dental pulp cells: An exploratory in vitro study. Verbal presentation at the Faculty of Dentistry Clinical and Research Excellence Symposium, Dunedin, New Zealand.
2022
Chapter in Book - Research
Duncan, H. F., & Cooper, P. R. (2022). The bioactive properties of dentine and molecular advances in pulp regeneration. In H. M. A. Ahmed & P. M. H. Dummer (Eds.), Endodontic advances and evidence-based clinical guidelines. (pp. 51-73). Hoboken, NJ: Wiley Blackwell. doi: 10.1002/9781119553939.ch2
Journal - Research Article
Khurshid, Z., Alfarhan, M. F., Mazher, J., Bayan, Y., Cooper, P. R., Dias, G. J., … Ratnayake, J. (2022). Extraction of hydroxyapatite from camel bone for bone tissue engineering application. Molecules, 27(22), 7946. doi: 10.3390/molecules27227946
Al-Maswary, A. A., O'Reilly, M., Holmes, A. P., Walmsley, A. D., Cooper, P. R., & Scheven, B. A. (2022). Exploring the neurogenic differentiation of human dental pulp stem cells. PLoS ONE, 17(11), e0277134. doi: 10.1371/journal.pone.0277134
Bai, Y., Liu, X., Li, J., Wang, Z., Guo, Q., Xiao, M., Cooper, P. R., … He, W. (2022). Stage-dependent regulation of dental pulp stem cell odontogenic differentiation by transforming growth factor-β1. Stem Cells International, 2022, 2361376. doi: 10.1155/2022/2361376
Saliem, S. S., Bede, S. Y., Cooper, P. R., Abdulkareem, A. A., Milward, M. R., & Abdullah, B. H. (2022). Pathogenesis of periodontitis: A potential role for epithelial-mesenchymal transition. Japanese Dental Science Review, 58, 268-278. doi: 10.1016/j.jdsr.2022.09.001
Hewitt, B., Batt, J., Shelton, R. M., Cooper, P. R., Landini, G., Lucas, R. A., … Milward, M. R. (2022). A 3D printed device for in vitro generation of stratified epithelia at the air-liquid interface. Tissue Engineering Part C: Methods, 28(11), 599-609. doi: 10.1089/ten.TEC.2022.0130
Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425
Wang, C., Lucas, R., Milward, M., & Cooper, P. R. (2022). Impact of particle morphology on abrasion, polishing and stain removal efficacy in a tooth cleaning model system. Biotribology, 32, 100218. doi: 10.1016/j.biotri.2022.100218
Li, J., Wang, Z., Wang, J., Guo, Q., Fu, Y., Dai, Z., … Cooper, P. R., … He, W. (2022). Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways. Stem Cell Research & Therapy, 13(1), 304. doi: 10.1186/s13287-022-02971-4
Pelepenko, L. E., Marciano, M. A., Francati, T. M., Bombarda, G., Antunes, T. B. M., Sorrentino, F., … Cooper, P. R., … Camilleri, J. (2022). Can strontium replace calcium in bioactive materials for dental applications? Journal of Biomedical Materials Research Part A, 110, 1892-1911. doi: 10.1002/jbm.a.37421
Mohamad, S. A., Milward, M. R., Hadis, M. A., Kuehne, S. A., & Cooper, P. R. (2022). Blue light photobiomodulation of dental pulp cells. Lasers in Dental Science, 6, 79-87. doi: 10.1007/s41547-022-00152-3
Yong, D., Choi, J. J. E., Cathro, P., Cooper, P. R., Dias, G., Huang, J., & Ratnayake, J. (2022). Development and analysis of a hydroxyapatite supplemented calcium silicate cement for endodontic treatment. Materials, 15(3), 1176. doi: 10.3390/ma15031176
Virdee, S. S., Bashir, N., Cooper, P. R., & Tomson, P. L. (2022). Exploiting dentine matrix proteins in cell-free approaches for periradicular tissue engineering. Tissue Engineering Part B: Reviews, 28(4), 707-732. doi: 10.1089/ten.TEB.2021.0074
Aral, K., Milward, M. R., & Cooper, P. R. (2022). Inflammasome dysregulation in human gingival fibroblasts in response to periodontal pathogens. Oral Diseases, 28, 216-224. doi: 10.1111/odi.13760
Journal - Research Other
Cooper, P. R., Moffat, S. M., & Thomson, W. M. (2022). Te Kaupeka Pūniho: New Zealand's new dental school. British Dental Journal, 233(2), 154-158. doi: 10.1038/s41415-022-4450-0
Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684
Journal - Professional & Other Non-Research Articles
Cooper, P. (2022). A time of change. New Zealand Dental Journal, 118(1), 2. [Editorial].
Conference Contribution - Published proceedings: Abstract
Adam, L., Zhao, R., Wang, T., Yang, R., Zaharic, T., Loch, C., Tompkins, G., & Cooper, P. (2022). Linking theory to practice: Co-teaching biochemistry in dental education. New Zealand Dental Journal, 118(4), (pp. 172). [Abstract]
Arora, S., Cooper, P., Friedlander, L., Rizwan, S., Seo, B., Rich, A., & Hussaini, H. (2022). Evaluation of IL-23 inhibitor as a pulp immunomodulating agent: An in vitro and in vivo study. New Zealand Dental Journal, 118(4), (pp. 167). [Abstract]
2021
Journal - Research Article
Ngah, N. A., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., Ratnayake, J., Cooper, P. R., & Hussaini, H. M. (2021). Lyophilised platelet-rich fibrin: Physical and biological characterisation. Molecules, 26(23), 7131. doi: 10.3390/molecules26237131
Jayash, S. N., Cooper, P. R., Shelton, R. M., Kuehne, S. A., & Poologasundarampillai, G. (2021). Novel chitosan-silica hybrid hydrogels for cell encapsulation and drug delivery. International Journal of Molecular Sciences, 22, 12267. doi: 10.3390/ijms222212267
Wang, C., Lucas, R., Milward, M., & Cooper, P. R. (2021). Particle size effects on abrasion, surface polishing and stain removal efficacy in a tooth model system. Biotribology, 28, 100196. doi: 10.1016/j.biotri.2021.100196
Paduano, F., Aiello, E., Cooper, P. R., Marrelli, B., Makeeva, I., Islam, M., … Tatullo, M. (2021). A dedifferentiation strategy to enhance the osteogenic potential of dental derived stem cells. Frontiers in Cell & Developmental Biology, 9, 668558. doi: 10.3389/fcell.2021.668558
Aral, K., Milward, M. R., & Cooper, P. R. (2021). Gene expression profiles of mitochondria-endoplasmic reticulum tethering in human gingival fibroblasts in response to periodontal pathogens. Archives of Oral Biology, 128, 105173. doi: 10.1016/j.archoralbio.2021.105173
Serrage, H. J., Cooper, P. R., Palin, W. M., Horstman, P., Hadis, M., & Milward, M. R. (2021). Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens. Lasers in Medical Science, 36, 1957-1969. doi: 10.1007/s10103-021-03331-z
Mohamad, S. A., Milward, M. R., Kuehne, S. A., Hadis, M. A., Palin, W. M., & Cooper, P. R. (2021). Potential for direct application of blue light for photo-disinfection of dentine. Journal of Photochemistry & Photobiology B, 215, 112123. doi: 10.1016/j.jphotobiol.2021.112123
Gleneadie, H. J., Baker, A. H., Batis, N., Bryant, J., Jiang, Y., Clokie, S. J. H., … Cooper, P. R., … Wiench, M. (2021). The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress. Cancer Letters, 501, 172-186. doi: 10.1016/j.canlet.2020.12.029
Arruda-Vasconcelos, R., Louzada, L. M., Feres, M., Tomson, P. L., Cooper, P. R., & Gomes, B. P. F. A. (2021). Investigation of microbial profile, levels of endotoxin and lipoteichoic acid in teeth with symptomatic irreversible pulpitis: A clinical study. International Endodontic Journal, 54, 46-60. doi: 10.1111/iej.13402
Journal - Research Other
Zhao, R., Yang, R., Cooper, P. R., Khurshid, Z., Shavandi, A., & Ratnayake, J. (2021). Bone grafts and substitutes in dentistry: A review of current trends and developments. Molecules, 26(10), 3007. doi: 10.3390/molecules26103007
Mohamad, S. A., Milward, M. R., Hadis, M. A., Kuehne, S. A., & Cooper, P. R. (2021). Photobiomodulation of mineralisation in mesenchymal stem cells. Photochemical & Photobiological Sciences, 20, 699-714. doi: 10.1007/s43630-021-00047-5
El Karim, I. A., Cooper, P. R., About, I., Tomson, P. L., Lundy, F. T., & Duncan, H. F. (2021). Deciphering reparative processes in the inflamed dental pulp. Frontiers in Dental Medicine, 2(8), 651219. doi: 10.3389/fdmed.2021.651219
Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S., Seo, B., Rich, A. M., & Hussaini, H. M. (2021). Potential application of immunotherapy for modulation of pulp inflammation: Opportunities for vital pulp treatment. International Endodontic Journal, 54, 1263-1274. doi: 10.1111/iej.13524
Ngah, N. A., Ratnayake, J., Cooper, P. R., Dias, G. J., Tong, D. C., Mohd Noor, S. N. F., & Hussaini, H. M. (2021). Potential of lyophilized platelet concentrates for craniofacial tissue regenerative therapies. Molecules, 26, 517. doi: 10.3390/molecules26030517
2020
Journal - Research Article
Heboyan, A., Syed, A. U. Y., Rokaya, D., Cooper, P. R., Manrikyan, M., & Markaryan, M. (2020). Cytomorphometric analysis of inflammation dynamics in the periodontium following the use of fixed dental prostheses. Molecules, 25, 4650. doi: 10.3390/molecules25204650
Virdee, S. S., Ravaghi, V., Camilleri, J., Cooper, P., & Tomson, P. (2020). Current trends in endodontic irrigation amongst general dental practitioners and dental schools within the United Kingdom and Ireland: A cross-sectional survey. British Dental Journal. Advance online publication. doi: 10.1038/s41415-020-1984-x
Aral, K., Milward, M. R., & Cooper, P. R. (2020). Dysregulation of inflammasomes in human dental pulp cells exposed to Porphyromonas gingivalis and Fusobacterium nucleatum. Journal of Endodontics, 46(9), 1265-1272. doi: 10.1016/j.joen.2020.06.008
Aral, K., Milward, M. R., Gupta, D., & Cooper, P. R. (2020). Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells. Molecular Oral Microbiology, 35, 158-167. doi: 10.1111/omi.12302
Aral, K., Milward, M. R., Cooper, P. R., & Guler, O. C. (2020). Evaluation of psychological stress and cortisol levels in males with and without gingivitis. Annals of Medical Research, 27(5), 1459-1464. doi: 10.5455/annalsmedres.2019.11.710
Aral, K., Güler, O. C., Cooper, P. R., Shoker, S., Kuehne, S. A., & Milward, M. R. (2020). Antimicrobial effects of boric acid against periodontal pathogens [Borik Asitin Periodontal Patojenler Üzerine Olan Antimikrobiyal Etkileri]. Ege Üniversitesi Diş Hekimliği Fakültesi Dergisi, 41(1), 20-25. doi: 10.5505/eudfd.2020.04935
Virdee, S. S., Farnell, D. J. J., Silva, M. A., Camilleri, J., Cooper, P. R., & Tomson, P. L. (2020). The influence of irrigant activation, concentration and contact time on sodium hypochlorite penetration into root dentine: An ex vivo experiment. International Endodontic Journal, 53, 986-997. doi: 10.1111/iej.13290
Journal - Research Other
Duncan, H. F., & Cooper, P. R. (2020). Pulp innate immune defense: Translational opportunities. Journal of Endodontics, 46(9, Suppl.), S10-S18. doi: 10.1016/j.joen.2020.06.019
Yamauchi, Y., Cooper, P. R., Shimizu, E., Kobayashi, Y., Smith, A. J., & Duncan, H. F. (2020). Histone acetylation as a regenerative target in the dentine-pulp complex. Frontiers in Genetics, 11, 1. doi: 10.3389/fgene.2020.00001
Aral, K., Milward, M. R., Kapila, Y., Berdeli, A., & Cooper, P. R. (2020). Inflammasomes and their regulation in periodontal disease: A review. Journal of Periodontal Research, 55, 473-487. doi: 10.1111/jre.12733
Journal - Professional & Other Non-Research Articles
Duncan, H. F., & Cooper, P. R. (2020). Réparation des tissus dentaires: Futures possibilités avec les agents biologiques. ENDO: Revue Francophone D'Endodontie, 4(3), 189-200. [Review].
2019
Journal - Research Article
Koutroulis, A., Kuehne, S. A., Cooper, P. R., & Camilleri, J. (2019). The role of calcium ion release on biocompatibility and antimicrobial properties of hydraulic cements. Scientific Reports, 9, 19019. doi: 10.1038/s41598-019-55288-3
Koutroulis, A., Batchelor, H., Kuehne, S. A., Cooper, P. R., & Camilleri, J. (2019). Investigation of the effect of the water to powder ratio on hydraulic cement properties. Dental Materials, 35(8), 1146-1154. doi: 10.1016/j.dental.2019.05.011
Holder, M. J., Wright, H. J., Couve, E., Milward, M. R., & Cooper, P. R. (2019). Neutrophil extracellular traps exert potential cytotoxic and proinflammatory effects in the dental pulp. Journal of Endodontics, 45(5), 513-520.e3. doi: 10.1016/j.joen.2019.02.014
Serrage, H. J., Joanisse, S., Cooper, P. R., Palin, W., Hadis, M., Darch, O., … Milward, M. R. (2019). Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number. Journal of Biophotonics, 12(6), e201800411. doi: 10.1002/jbio.201800411
Journal - Research Other
Duncan, H. F., & Cooper, P. R. (2019). Réparation des tissus dentaires: Futures possibilités avec les agents biologiques. ENDO, 13(4), 295-306. [Review].
Cushley, S., Duncan, H. F., Lappin, M. J., Tomson, P. L., Lundy, F. T., Cooper, P., … El Karim, I. A. (2019). Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review. Journal of Dentistry, 88, 103158. doi: 10.1016/j.jdent.2019.06.005
Duncan, H. F., Bjørndal, L., van der Sluis, L., Rechenberg, D. K., Simon, S., Cooper, P. R., … Galler, K. (2019). Third European Society of Endodontology (ESE) research meeting: ACTA, Amsterdam, The Netherlands, 26th October 2018: Deep caries and the exposed pulp: current and emerging therapeutic perspectives. International Endodontic Journal, 52(2), 135-138. doi: 10.1111/iej.13059
Duncan, H. F., Cooper, P. R., & Smith, A. J. (2019). Dissecting dentine–pulp injury and wound healing responses: Consequences for regenerative endodontics. International Endodontic Journal, 52(3), 261-266. doi: 10.1111/iej.13064
Virdee, S. S., Butt, K., Grant, M., Camilleri, J., Cooper, P. R., & Tomson, P. L. (2019). A systematic review of methods used to sample and analyse periradicular tissue fluid during root canal treatment. International Endodontic Journal, 52(8), 1108-1127. doi: 10.1111/iej.13104
2018
Journal - Research Article
Okamoto, M., Takahashi, Y., Komichi, S., Cooper, P. R., & Hayashi, M. (2018). Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases. Scientific Reports, 8, 10690. doi: 10.1038/s41598-018-29112-3
Abdulkareem, A., Shelton, R. M., Landini, G., Cooper, P. R., & Milward, M. R. (2018). Periodontal pathogens promote epithelial-mesenchymal transition in oral squamous carcinoma cells in vitro. Cell Adhesion & Migration, 12(2), 127-137. doi: 10.1080/19336918.2017.1322253
Luo, Z., Wang, Z., He, X., Liu, N., Liu, B., Sun, L., … Cooper, P. (2018). Effects of histone deacetylase inhibitors on regenerative cell responses in human dental pulp cells. International Endodontic Journal, 51(7), 767-778. doi: 10.1111/iej.12779
Robinson, J. P., Macedo, R. G., Verhaagen, B., Versluis, M., Cooper, P. R., van der Sluis, L. W. M., & Walmsley, A. D. (2018). Cleaning lateral morphological features of the root canal: The role of streaming and cavitation. International Endodontic Journal, 51(Suppl. 1), e55-e64. doi: 10.1111/iej.12804
Flight, R., Landini, G., Styles, I. B., Shelton, R. M., Milward, M. R., & Cooper, P. R. (2018). Automated noninvasive epithelial cell counting in phase contrast microscopy images with automated parameter selection. Journal of Microscopy, 271(3), 345-354. doi: 10.1111/jmi.12726
White, P. C., Hirschfeld, J., Milward, M. R., Cooper, P. R., Wright, H. J., Matthews, J. B., & Chapple, I. L. C. (2018). Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. Journal of Periodontal Research, 53(4), 525-535. doi: 10.1111/jre.12542
Chicca, I. J., Milward, M. R., Chapple, I. L. C., Griffiths, G., Benson, R., Dietrich, T., & Cooper, P. R. (2018). Development and application of high-content biological screening for modulators of NET production. Frontiers in Immunology, 9, 337. doi: 10.3389/fimmu.2018.00337
Journal - Research Other
Kearney, M., Cooper, P. R., Smith, A. J., & Duncan, H. F. (2018). Epigenetic approaches to the treatment of dental pulp inflammation and repair: Opportunities and obstacles. Frontiers in Genetics, 9, 311. doi: 10.3389/fgene.2018.00311
Marrelli, M., Codispoti, B., Shelton, R. M., Scheven, B. A., Cooper, P. R., Tatullo, M., & Paduano, F. (2018). Dental pulp stem cell mechanoresponsiveness: Effects of mechanical stimuli on dental pulp stem cell behavior. Frontiers in Physiology, 9, 1685. doi: 10.3389/fphys.2018.01685
2017
Journal - Research Article
Castro, S. A., Collighan, R., Lambert, P. A., Dias, I. H. K., Chauhan, P., Bland, C. E., … Cooper, P. R., & Devitt, A. (2017). Porphyromonas gingivalis gingipains cause defective macrophage migration towards apoptotic cells and inhibit phagocytosis of primary apoptotic neutrophils. Cell Death & Disease, 8, e2644. doi: 10.1038/cddis.2016.481
He, X., Jiang, W., Luo, Z., Qu, T., Wang, Z., Liu, N., … Cooper, P. R., & He, W. (2017). IFN-γ 3 regulates human dental pulp stem cells behavior via NF-κB and MAPK signaling. Scientific Reports, 7, 40681. doi: 10.1038/srep40681
Andreev, P. S., Coates, M. I., Karatajūtė-Talimaa, V., Shelton, R. M., Cooper, P. R., & Sansom, I. J. (2017). Elegestolepis and its kin, the earliest monodontode chondrichthyans. Journal of Vertebrate Paleontology, 37(1), e1245664. doi: 10.1080/02724634.2017.1245664
Gao, Q., Cooper, P. R., Walmsley, A. D., & Scheven, B. A. (2017). Role of Piezo channels in ultrasound-stimulated dental stem cells. Journal of Endodontics, 43(7), 1130-1136. doi: 10.1016/j.joen.2017.02.022
Duncan, H. F., Smith, A. J., Fleming, G. J. P., Reid, C., Smith, G., & Cooper, P. R. (2017). Release of bio-active dentine extracellular matrix components by histone deacetylase inhibitors (HDACi). International Endodontic Journal, 50(1), 24-38. doi: 10.1111/iej.12588
Tomson, P. L., Lumley, P. J., Smith, A. J., & Cooper, P. R. (2017). Growth factor release from dentine matrix by pulp-capping agents promotes pulp tissue repair-associated events. International Endodontic Journal, 50(3), 281-292. doi: 10.1111/iej.12624
Wang, C., Lucas, R., Smith, A. J., & Cooper, P. R. (2017). An in vitro screening assay for dental stain cleaning. BMC Oral Health, 17, 37. doi: 10.1186/s12903-016-0328-3
Hadis, M. A., Cooper, P. R., Milward, M. R., Gorecki, P. C., Tarte, E., Churm, J., & Palin, W. M. (2017). Development and application of LED arrays for use in phototherapy research. Journal of Biophotonics, 10(11), 1514-1525. doi: 10.1002/jbio.201600273
Conference Contribution - Published proceedings: Full paper
Smith, A. J., & Cooper, P. R. (2017). Regenerative endodontics: Burning questions. Journal of Endodontics, 43(9, Suppl.), (pp. S1-S6). doi: 10.1016/j.joen.2017.06.002
Cooper, P. R., Chicca, I. J., Holder, M. J., & Milward, M. R. (2017). Inflammation and regeneration in the dentin-pulp complex: Net gain or net loss? Journal of Endodontics, 43(9, Suppl.), (pp. S87-S94). doi: 10.1016/j.joen.2017.06.011
2016
Journal - Research Article
Salehi, S., Cooper, P., Smith, A., & Ferracane, J. (2016). Dentin matrix components extracted with phosphoric acid enhance cell proliferation and mineralization. Dental Materials, 32(3), 334-342. doi: 10.1016/j.dental.2015.11.004
Gao, Q., Walmsley, A. D., Cooper, P. R., & Scheven, B. A. (2016). Ultrasound stimulation of different dental stem cell populations: Role of mitogen-activated protein kinase signaling. Journal of Endodontics, 42(3), 425-431. doi: 10.1016/j.joen.2015.12.019
White, P., Sakellari, D., Roberts, H., Risafi, I., Ling, M., Cooper, P., … Chapple, I. (2016). Peripheral blood neutrophil extracellular trap production and degradation in chronic periodontitis. Journal of Clinical Periodontology, 43(12), 1041-1049. doi: 10.1111/jcpe.12628
Andreev, P., Coates, M. I., Karatajūtė-Talimaa, V., Shelton, R. M., Cooper, P. R., Wang, N.-Z., & Sansom, I. J. (2016). The systematics of the Mongolepidida (Chondrichthyes) and the Ordovician origins of the clade. PeerJ, 4, e1850. doi: 10.7717/peerj.1850
Duncan, H. F., Smith, A. J., Fleming, G. J. P., Partridge, N. C., Shimizu, E., Moran, G. P., & Cooper, P. R. (2016). The histone-deacetylase-inhibitor suberoylanilide hydroxamic acid promotes dental pulp repair mechanisms through modulation of matrix metalloproteinase-13 activity. Journal of Cellular Physiology, 231(4), 798-816. doi: 10.1002/jcp.25128
Journal - Research Other
Smith, A. J., Duncan, H. F., Diogenes, A., Simon, S., & Cooper, P. R. (2016). Exploiting the bioactive properties of the dentin-pulp complex in regenerative endodontics. Journal of Endodontics, 42(1), 47-56. doi: 10.1016/j.joen.2015.10.019
Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2016). Epigenetic modulation of dental pulp stem cells: Implications for regenerative endodontics. International Endodontic Journal, 49(5), 431-446. doi: 10.1111/iej.12475
Hadis, M. A., Zainal, S. A., Holder, M. J., Carroll, J. D., Cooper, P. R., Milward, M. R., & Palin, W. M. (2016). The dark art of light measurement: Accurate radiometry for low-level light therapy. Lasers in Medical Science, 31(4), 789-809. doi: 10.1007/s10103-016-1914-y
2015
Chapter in Book - Research
Smith, A. J., & Cooper, P. R. (2015). Cellular signaling in dentin repair and regeneration. In A. Vishwakarma, P. Sharpe, S. Shi & M. Ramalingam (Eds.), Stem cell biology and tissue engineering in dental sciences. (pp. 405-417). London, UK: Elsevier. doi: 10.1016/B978-0-12-397157-9.00036-9
Journal - Research Article
Zhang, J., Wang, Z., Jiang, Y., Niu, Z., Fu, L., Luo, Z., Cooper, P. R., … He, W. (2015). Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro. Experimental Cell Research, 332(2), 259-266. doi: 10.1016/j.yexcr.2015.01.020
Wang, Z., Ma, F., Wang, J., Zhou, Z., Liu, B., He, X., … Cooper, P. R. (2015). Extracellular signal-regulated kinase mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling are required for lipopolysaccharide-mediated mineralization in murine odontoblast-like cells. Journal of Endodontics, 41(6), 871-876. doi: 10.1016/j.joen.2015.01.006
Andreev, P. S., Coates, M. I., Shelton, R. M., Cooper, P. R., Smith, M. P., & Sansom, I. J. (2015). Upper Ordovician chondrichthyan-like scales from North America. Palaeontology, 58(4), 691-704. doi: 10.1111/pala.12167
Davies, O. G., Cooper, P. R., Shelton, R. M., Smith, A. J., & Scheven, B. A. (2015). Isolation of adipose and bone marrow mesenchymal stem cells using CD29 and CD90 modifies their capacity for osteogenic and adipogenic differentiation. Journal of Tissue Engineering, 6, 1-10. doi: 10.1177/2041731415592356
Spengler, J., Lugonja, B., Ytterberg, A. J., Zubarev, R. A., Creese, A. J., Pearson, M. J., … Cooper, P. R., … Scheel-Toellner, D. (2015). Release of active peptidyl arginine deiminases by neutrophils can explain production of extracellular citrullinated autoantigens in rheumatoid arthritis synovial fluid. Arthritis & Rheumatology, 67(12), 3135-3145. doi: 10.1002/art.39313
He, W., Wang, Z., Luo, Z., Yu, Q., Jiang, Y., Zhang, Y., … Cooper, P. R. (2015). LPS promote the odontoblastic differentiation of human dental pulp stem cells via MAPK signaling pathway. Journal of Cellular Physiology, 230(3), 554-561. doi: 10.1002/jcp.24732
Davies, O. G., Cooper, P. R., Shelton, R. M., Smith, A. J., & Scheven, B. A. (2015). A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue, bone marrow and dental pulp. Journal of Bone & Mineral Metabolism, 33(4), 371-382. doi: 10.1007/s00774-014-0601-y
Journal - Research Other
Duncan, H. F., Smith, A. J., Fleming, G. J. P., Moran, G. P., & Cooper, P. R. (2015). Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points. Genomics Data, 5, 391-393. doi: 10.1016/j.gdata.2015.07.013
Farges, J.-C., Alliot-Licht, B., Renard, E., Ducret, M., Gaudin, A., Smith, A. J., & Cooper, P. R. (2015). Dental pulp defence and repair mechanisms in dental caries. Mediators of Inflammation, 2015, 230251. doi: 10.1155/2015/230251
Smith, J. G., Smith, A. J., Shelton, R. M., & Cooper, P. R. (2015). Dental pulp cell behavior in biomimetic environments [Research report]. Journal of Dental Research, 94(11), 1552-1559. doi: 10.1177/0022034515599767
Conference Contribution - Published proceedings: Full paper
Palin, W. M., Hadis, M. A., Milward, M. R., Carroll, J. D., & Cooper, P. R. (2015). Beam profile measurements for dental phototherapy: The effect of distance, wavelength and tissue thickness. Proceedings of SPIE (Vol. 9309): Mechanisms for Low-Light Therapy X. 9309, 930905. doi: 10.1117/12.2077628
Hadis, M. A., Cooper, P. R., Milward, M. R., Gorecki, P., Tarte, E., Churm, J., & Palin, W. M. (2015). The effect of UV-Vis to near-infrared light on the biological response of human dental pulp cells. Proceedings of SPIE (Vol. 9309): Mechanisms for Low-Light Therapy X. 9309, 930906. doi: 10.1117/12.2077645
Milward, M. R., Hadis, M. A., Cooper, P. R., Gorecki, P., Carroll, J. D., & Palin, W. M. (2015). Biomodulatory effects of laser irradiation on dental pulp cells in vitro. Proceedings of SPIE (Vol. 9309): Mechanisms for Low-Light Therapy X. 930908. doi: 10.1117/12.2077717
2014
Chapter in Book - Research
Cooper, P. R., & Smith, A. J. (2014). Inflammatory processes in the dental pulp. In M. Goldberg (Ed.), The dental pulp: Biology, pathology, and regenerative therapies. (pp. 97-112). Berlin, Germany: Springer. doi: 10.1007/978-3-642-55160-4_7
Journal - Research Article
He, W., Wang, Z., Zhou, Z., Zhang, Y., Zhu, Q., Wei, K., … Cooper, P. R., … Yu, Q. (2014). Lipopolysaccharide enhances Wnt5a expression through toll-like receptor 4, myeloid differentiating factor 88, phosphatidylinositol 3-OH kinase/AKT and nuclear factor kappa B pathways in human dental pulp stem cells. Journal of Endodontics, 40(1), 69-75. doi: 10.1016/j.joen.2013.09.011
Li, D., Fu, L., Zhang, Y., Yu, Q., Ma, F., Wang, Z., … Cooper, P. R., & He, W. (2014). The effects of LPS on adhesion and migration of human dental pulp stem cells in vitro. Journal of Dentistry, 42(10), 1327-1334. doi: 10.1016/j.jdent.2014.07.007
Macedo, R. G., Robinson, J. P., Verhaagen, B., Walmsley, A. D., Versluis, M., Cooper, P. R., & van der Sluis, L. W. M. (2014). A novel methodology providing insights into removal of biofilm-mimicking hydrogel from lateral morphological features of the root canal during irrigation procedures. International Endodontic Journal, 47(11), 1040-1051. doi: 10.1111/iej.12246
He, W., Zhang, J., Niu, Z., Yu, Q., Wang, Z., Zhang, R., … Cooper, P. R. (2014). Regulatory interplay between NFIC and TGF-β1 in apical papilla-derived stem cells. Journal of Dental Research, 93(5), 496-501. doi: 10.1177/0022034514525200
Nicolae, L. C., Shelton, R. M., Cooper, P. R., Martin, R. A., & Palin, W. M. (2014). The effect of Bioglass addition on mechanical and physical properties of photoactive UDMA-TEGDMA resin composites. Key Engineering Materials, 587, 215-221. doi: 10.4028/www.scientific.net/KEM.587.215
Milward, M. R., Holder, M. J., Palin, W. M., Hadis, M. A., Carroll, J. D., & Cooper, P. R. (2014). Low Level Light Therapy (LLLT) for the treatment and management of dental and oral diseases. Dental Update, 41(9), 763-772. doi: 10.12968/denu.2014.41.9.763
Yu, Y., Wang, L., Yu, J., Lei, G., Yan, M., Smith, G., Cooper, P. R., … Smith, A. J. (2014). Dentin matrix proteins (DMPs) enhance differentiation of BMMSCs via ERK and P38 MAPK pathways. Cell & Tissue Research, 356(1), 171-182. doi: 10.1007/s00441-013-1790-8
Asif, I. M., Shelton, R. M., Cooper, P. R., Addison, O., & Martin, R. A. (2014). In vitro bioactivity of titanium-doped bioglass. Journal of Materials Science: Materials in Medicine, 25(8), 1865-1873. doi: 10.1007/s10856-014-5230-4
Journal - Research Other
Davies, O. G., Smith, A. J., Cooper, P. R., Shelton, R. M., & Scheven, B. A. (2014). The effects of cryopreservation on cells isolated from adipose, bone marrow and dental pulp tissues [Brief communication]. Cryobiology, 69(2), 342-347. doi: 10.1016/j.cryobiol.2014.08.003
Carroll, J. D., Milward, M. R., Cooper, P. R., Hadis, M., & Palin, W. M. (2014). Developments in low level light therapy (LLLT) for dentistry. Dental Materials, 30(5), 465-475. doi: 10.1016/j.dental.2014.02.006
Conference Contribution - Published proceedings: Full paper
Cooper, P. R., Holder, M. J., & Smith, A. J. (2014). Inflammation and regeneration in the dentin-pulp complex: A double-edged sword. Journal of Endodontics, 40(4, Suppl.), (pp. S46-S51). doi: 10.1016/j.joen.2014.01.021
2013
Journal - Research Article
Tomson, P. L., Lumley, P. J., Alexander, M. Y., Smith, A. J., & Cooper, P. R. (2013). Hepatocyte growth factor is sequestered in dentine matrix and promotes regeneration-associated events in dental pulp cells. Cytokine, 61(2), 622-629. doi: 10.1016/j.cyto.2012.11.009
Robinson, J. P., Lumley, P. J., Cooper, P. R., Grover, L. M., & Walmsley, A. D. (2013). Reciprocating root canal technique induces greater debris accumulation than a continuous rotary technique as assessed by 3-dimensional micro-computed tomography. Journal of Endodontics, 39(8), 1067-1070. doi: 10.1016/j.joen.2013.04.003
Zhang, J., Zhang, Y., Lv, H., Yu, Q., Zhou, Z., Zhu, Q., … Cooper, P. R., … He, W. (2013). Human stem cells from the apical papilla response to bacterial lipopolysaccharide exposure and anti-inflammatory effects of nuclear factor I C. Journal of Endodontics, 39(11), 1416-1422. doi: 10.1016/j.joen.2013.07.018
Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2013). Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. Experimental Cell Research, 319(10), 1534-1543. doi: 10.1016/j.yexcr.2013.02.022
Zhang, J., Zhu, Q. L., Huang, P., Yu, Q., Wang, Z. H., Cooper, P. R., … He, W. (2013). CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-κB signalling pathways in odontoblast cells. International Endodontic Journal, 46(7), 666-674. doi: 10.1111/iej.12043
Cooper, P. R., Palmer, L. J., & Chapple, I. L. C. (2013). Neutrophil extracellular traps as a new paradigm in innate immunity: Friend or foe? Periodontology 2000, 63(1), 165-197. doi: 10.1111/prd.12025
Milward, M. R., Chapple, I. L. C., Carter, K., Matthews, J. B., & Cooper, P. R. (2013). Micronutrient modulation of NF-κB in oral keratinocytes exposed to periodontal bacteria. Innate Immunity, 19(2), 140-151. doi: 10.1177/1753425912454761
Ferracane, J. L., Cooper, P. R., & Smith, A. J. (2013). Dentin matrix component solubilization by solutions at pH relevant to self-etching dental adhesives. Journal of Adhesive Dentistry, 15(5), 407-412. doi: 10.3290/j.jad.a29536
Lei, G., Yu, Y., Jiang, Y., Wang, S., Yan, M., Smith, A. J., … Cooper, P. R., … Yu, J. (2013). Differentiation of BMMSCs into odontoblast-like cells induced by natural dentine matrix. Archives of Oral Biology, 58(7), 862-870. doi: 10.1016/j.archoralbio.2013.01.002
2012
Chapter in Book - Research
Simon, S., Smith, A. J., Lumley, P. J., Cooper, P. R., & Berdal, A. (2012). The pulp healing process: From generation to regeneration. In H. Larjava (Ed.), Oral wound healing: Cell biology and clinical management. (pp. 313-332). Oxford, UK: Wiley Blackwell. doi: 10.1002/9781118704509.ch13
Journal - Research Article
Smith, A. J., Smith, J. G., Shelton, R. M., & Cooper, P. R. (2012). Harnessing the natural regenerative potential of the dental pulp. Dental Clinics of North America, 56(3), 589-601. doi: 10.1016/j.cden.2012.05.011
Gale, Z., Cooper, P. R., & Scheven, B. A. (2012). Glial cell line-derived neurotrophic factor influences proliferation of osteoblastic cells. Cytokine, 57(2), 276-281. doi: 10.1016/j.cyto.2011.10.023
Robinson, J. P., Lumley, P. J., Claridge, E., Cooper, P. R., Grover, L. M., Williams, R. L., & Walmsley, A. D. (2012). An analytical Micro CT methodology for quantifying inorganic dentine debris following internal tooth preparation. Journal of Dentistry, 40(11), 999-1005. doi: 10.1016/j.jdent.2012.08.007
Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2012). Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. Journal of Endodontics, 38(3), 339-345. doi: 10.1016/j.joen.2011.12.014
Man, J., Shelton, R. M., Cooper, P. R., & Scheven, B. A. (2012). Low-intensity low-frequency ultrasound promotes proliferation and differentiation of odontoblast-like cells. Journal of Endodontics, 38(5), 608-613. doi: 10.1016/j.joen.2012.01.015
Smith, J. G., Smith, A. J., Shelton, R. M., & Cooper, P. R. (2012). Recruitment of dental pulp cells by dentine and pulp extracellular matrix components. Experimental Cell Research, 318(18), 2397-2406. doi: 10.1016/j.yexcr.2012.07.008
Palmer, L. J., Cooper, P. R., Ling, M. R., Wright, H. J., Huissoon, A., & Chapple, I. L. C. (2012). Hypochlorous acid regulates neutrophil extracellular trap release in humans. Clinical & Experimental Immunology, 167(2), 261-268. doi: 10.1111/j.1365-2249.2011.04518.x
Smith, J. G., Smith, A. J., Shelton, R. M., & Cooper, P. R. (2012). Antibacterial activity of dentine and pulp extracellular matrix extracts. International Endodontic Journal, 45(8), 749-755. doi: 10.1111/j.1365-2591.2012.02031.x
Palmer, L. J., Chapple, I. L. C., Wright, H. J., Roberts, A., & Cooper, P. R. (2012). Extracellular deoxyribonuclease production by periodontal bacteria. Journal of Periodontal Research, 47(4), 439-445. doi: 10.1111/j.1600-0765.2011.01451.x
Holder, M. J., Milward, M. R., Palin, W. M., Hadis, M. A., & Cooper, P. R. (2012). Effects of red light-emitting diode irradiation on dental pulp cells. Journal of Dental Research, 91(10), 961-966. doi: 10.1177/0022034512456040
Khan, E., Shelton, R. M., Cooper, P. R., Hamburger, J., & Landini, G. (2012). Architectural characterization of Organotypic cultures of H400 and primary rat keratinocytes. Journal of Biomedical Materials Research Part A, 100A(12), 3227-3238. doi: 10.1002/jbm.a.34263
Journal - Research Other
Man, J., Shelton, R. M., Cooper, P. R., Landini, G., & Scheven, B. A. (2012). Low intensity ultrasound stimulates osteoblast migration at different frequencies [Short communication]. Journal of Bone & Mineral Metabolism, 30(5), 602-607. doi: 10.1007/s00774-012-0368-y
Smith, A. J., Scheven, B. A., Takahashi, Y., Ferracane, J. L., Shelton, R. M., & Cooper, P. R. (2012). Dentine as a bioactive extracellular matrix. Archives of Oral Biology, 57(2), 109-121. doi: 10.1016/j.archoralbio.2011.07.008
2011
Chapter in Book - Research
Simon, S., Cooper, P., & Berdal, I. A. (2011). Tissue engineering and endodontics. In J. Ferri & E. B. Hunziker (Eds.), Preprosthetic and maxillofacial surgery: Biomaterials, bone grafting and tissue engineering. (pp. 336-362). Cambridge, UK: Woodhead. doi: 10.1016/B978-1-84569-589-7.50018-3
Journal - Research Article
Zhang, R., Cooper, P. R., Smith, G., Nör, J. E., & Smith, A. J. (2011). Angiogenic activity of dentin matrix components. Journal of Endodontics, 37(1), 26-30. doi: 10.1016/j.joen.2010.08.042
Wright, H. J., Chapple, I. L. C., Matthews, J. B., & Cooper, P. R. (2011). Fusobacterium nucleatum regulation of neutrophil transcription. Journal of Periodontal Research, 46(1), 1-12. doi: 10.1111/j.1600-0765.2010.01299.x
Simon, S. R. J., Berdal, A., Cooper, P. R., Lumley, P. J., Tomson, P. L., & Smith, A. J. (2011). Dentin-pulp complex regeneration: From lab to clinic. Advances in Dental Research, 23(3), 340-345. doi: 10.1177/0022034511405327
Cooper, P. R., McLachlan, J. L., Simon, S., Graham, L. W., & Smith, A. J. (2011). Mediators of inflammation and regeneration. Advances in Dental Research, 23(3), 290-295. doi: 10.1177/0022034511405389
Duncan, H. F., Smith, A. J., Fleming, G. J. P., & Cooper, P. R. (2011). HDACi: Cellular effects, opportunities for restorative dentistry. Journal of Dental Research, 90(12), 1377-1388. doi: 10.1177/0022034511406919
Gale, Z., Cooper, P. R., & Scheven, B. A. A. (2011). Effects of glial cell line-derived neurotrophic factor on dental pulp cells. Journal of Dental Research, 90(10), 1240-1245. doi: 10.1177/0022034511417443
Journal - Research Other
Holder, M. J., & Cooper, P. R. (2011). Species identification and authentification of human and rodent cell cultures using polymerase chain reaction analysis of vomeronasal receptor genes [Brief report]. Cytotechnology, 63(6), 553-558. doi: 10.1007/s10616-011-9394-1
Conference Contribution - Published proceedings: Abstract
Tomson, P. L., Lumley, P. J., Yan, J., Alexander, M. Y., Smith, A. J., & Cooper, P. R. (2011). Pulp capping agents release hepatocyte growth factor from dentine which may contribute to mineralised tissue repair in the dentine-pulp complex [Extended abstract]. European Cells & Materials, 22(Suppl. 2), (pp. 95). [Abstract]
2010
Journal - Research Article
Simon, S., Smith, A. J., Berdal, A., Lumley, P. J., & Cooper, P. R. (2010). The MAP kinase pathway is involved in odontoblast stimulation via p38 phosphorylation. Journal of Endodontics, 36(2), 256-259. doi: 10.1016/j.joen.2009.09.019
Musson, D. S., McLachlan, J. L., Sloan, A. J., Smith, A. J., & Cooper, P. R. (2010). Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biology of the Cell, 102(3), 145-157. doi: 10.1042/BC20090122
Wylie, C. M., Davenport, A. J., Cooper, P. R., & Shelton, R. M. (2010). Oral keratinocyte responses to nickel-based dental casting alloys in vitro. Journal of Biomaterials Applications, 25(3), 251-267. doi: 10.1177/0885328209349870
Journal - Research Other
Cooper, P. R., Takahashi, Y., Graham, L. W., Simon, S., Imazato, S., & Smith, A. J. (2010). Inflammation-regeneration interplay in the dentine-pulp complex. Journal of Dentistry, 38(9), 687-697. doi: 10.1016/j.jdent.2010.05.016
Simon, S., Lumley, P. J., Cooper, P. R., Berdal, A., Machtou, P., & Smith, A. J. (2010). Trauma and dentinogenesis: A case report. Journal of Endodontics, 36(2), 342-344. doi: 10.1016/j.joen.2009.09.021
Ferracane, J. L., Cooper, P. R., & Smith, A. J. (2010). Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration? Odontology, 98(1), 2-14. doi: 10.1007/s10266-009-0116-5
2009
Journal - Research Article
Simon, S., Smith, A. J., Lumley, P. J., Berdal, A., Smith, G., Finney, S., & Cooper, P. R. (2009). Molecular characterization of young and mature odontoblasts. Bone, 45(4), 693-703. doi: 10.1016/j.bone.2009.06.018
Scheven, B. A. A., Shelton, R. M., Cooper, P. R., Walmsley, A. D., & Smith, A. J. (2009). Therapeutic ultrasound for dental tissue repair. Medical Hypotheses, 73(4), 591-593. doi: 10.1016/j.mehy.2009.05.032
Baker, S. M., Sugars, R. V., Wendel, M., Smith, A. J., Waddington, R. J., Cooper, P. R., & Sloan, A. J. (2009). TGF-β/extracellular matrix interactions in dentin matrix: A role in regulating sequestration and protection of bioactivity. Calcified Tissue International, 85(1), 66-74. doi: 10.1007/s00223-009-9248-4
Scheven, B. A., Man, J., Millard, J. L., Cooper, P. R., Lea, S. C., Walmsley, A. D., & Smith, A. J. (2009). VEGF and odontoblast-like cells: Stimulation by low frequency ultrasound. Archives of Oral Biology, 54(2), 185-191. doi: 10.1016/j.archoralbio.2008.09.008
Patel, M., Smith, A. J., Sloan, A. J., Smith, G., & Cooper, P. R. (2009). Phenotype and behaviour of dental pulp cells during expansion culture. Archives of Oral Biology, 54(10), 898-908. doi: 10.1016/j.archoralbio.2009.06.008
2008
Journal - Research Article
Fleming, G. J. P., Awan, M., Cooper, P. R., & Sloan, A. J. (2008). The potential of a resin-composite to be cured to a 4 mm depth. Dental Materials, 24(4), 522-529. doi: 10.1016/j.dental.2007.05.016
Simon, S., Cooper, P., Smith, A., Picard, B., Naulin Ifi, C., & Berdal, A. (2008). Evaluation of a new laboratory model for pulp healing: Preliminary study. International Endodontic Journal, 41(9), 781-790. doi: 10.1111/j.1365-2591.2008.01433.x
Wright, H. J., Matthews, J. B., Chapple, I. L. C., Ling-Mountford, N., & Cooper, P. R. (2008). Periodontitis associates with a type 1 IFN signature in peripheral blood neutrophils. Journal of Immunology, 181(8), 5775-5784. doi: 10.4049/jimmunol.181.8.5775
Journal - Research Other
Smith, A. J., Lumley, P. J., Tomson, P. L., & Cooper, P. R. (2008). Dental regeneration and materials: A partnership. Clinical Oral Investigations, 12(2), 103-108. doi: 10.1007/s00784-008-0189-5
Conference Contribution - Published proceedings: Full paper
Liu, Y., Barralet, J., Cooper, P., & Shelton, R. (2008). Effects of octacalcium phosphate on the development of bone marrow derived stromal cells: Comparison of osteogenic medium/OCP induced osteocalcin expression. Key Engineering Materials, II, (pp. 1009-1012). [Full Paper]
2007
Journal - Research Article
Liu, Y., Cooper, P. R., Barralet, J. E., & Shelton, R. M. (2007). Influence of calcium phosphate crystal assemblies on the proliferation and osteogenic gene expression of rat bone marrow stromal cells. Biomaterials, 28(7), 1393-1403. doi: 10.1016/j.biomaterials.2006.11.019
Tomson, P. L., Grover, L. M., Lumley, P. J., Sloan, A. J., Smith, A. J., & Cooper, P. R. (2007). Dissolution of bio-active dentine matrix components by mineral trioxide aggregate. Journal of Dentistry, 35(8), 636-642. doi: 10.1016/j.jdent.2007.04.008
Scheven, B. A., Millard, J. L., Cooper, P. R., Lea, S. C., Walmsley, A. D., & Smith, A. J. (2007). Short-term in vitro effects of low frequency ultrasound on odontoblast-like cells. Ultrasound in Medicine & Biology, 33(9), 1475-1482. doi: 10.1016/j.ultrasmedbio.2007.03.010
Matthews, J. B., Wright, H. J., Roberts, A., Cooper, P. R., & Chapple, I. L. C. (2007). Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clinical & Experimental Immunology, 147(2), 255-264. doi: 10.1111/j.1365-2249.2006.03276.x
Milward, M. R., Chapple, I. L. C., Wright, H. J., Millard, J. L., Matthews, J. B., & Cooper, P. R. (2007). Differential activation of NF-κB and gene expression in oral epithelial cells by periodontal pathogens. Clinical & Experimental Immunology, 148(2), 307-324. doi: 10.1111/j.1365-2249.2007.03342.x
Milward, M. R., & Cooper, P. R. (2007). Competency assessment for infection control in the undergraduate dental curriculum. European Journal of Dental Education, 11(3), 148-154. doi: 10.1111/j.1600-0579.2007.00439.x
Journal - Research Other
Matthews, J. B., Wright, H. J., Roberts, A., Ling-Mountford, N., Cooper, P. R., & Chapple, I. L. C. (2007). Neutrophil hyper-responsiveness in periodontitis. Journal of Dental Research, 86(8), 718-722. doi: 10.1177/154405910708600806
2006
Journal - Research Article
Graham, L., Cooper, P. R., Cassidy, N., Nor, J. E., Sloan, A. J., & Smith, A. J. (2006). The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components. Biomaterials, 27(14), 2865-2873. doi: 10.1016/j.biomaterials.2005.12.020
Shelton, R. M., Liu, Y., Cooper, P. R., Gbureck, U., German, M. J., & Barralet, J. E. (2006). Bone marrow cell gene expression and tissue construct assembly using octacalcium phosphate microscaffolds. Biomaterials, 27(14), 2874-2881. doi: 10.1016/j.biomaterials.2005.12.031
Wright, H. J., Chapple, I. L. C., Cooper, P., & Matthews, J. B. (2006). Platelet-derived growth factor (PDGF) isoform and PDGF receptor expression in drug-induced gingival overgrowth and hereditary gingival fibrosis. Oral Diseases, 12(3), 315-323. doi: 10.1111/j.1601-0825.2005.01201.x
2005
Journal - Research Article
McLachlan, J. L., Smith, A. J., Bujalska, I. J., & Cooper, P. R. (2005). Gene expression profiling of pulpal tissue reveals the molecular complexity of dental caries. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1741(3), 271-281. doi: 10.1016/j.bbadis.2005.03.007
Dhopatkar, A. A., Sloan, A. J., Rock, W. P., Cooper, P. R., & Smith, A. J. (2005). British Orthodontic Society, Chapman Prize Winner 2003: A novel in vitro culture model to investigate the reaction of the dentine-pulp complex to orthodontic force. Journal of Orthodontics, 32(2), 122-132. doi: 10.1179/146531205225020979
Milward, M., & Cooper, P. (2005). Periodontal disease and the ageing patient. Dental Update, 32(10), 598-600, 602-604. doi: 10.12968/denu.2005.32.10.598
Barralet, J. E., Wang, L., Lawson, M., Triffitt, J. T., Cooper, P. R., & Shelton, R. M. (2005). Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels. Journal of Materials Science: Materials in Medicine, 16(6), 515-519. doi: 10.1007/s10856-005-0526-z
2004
Journal - Research Article
McLachlan, J. L., Sloan, A. J., Smith, A. J., Landini, G., & Cooper, P. R. (2004). S100 and cytokine expression in caries. Infection & Immunity, 72(7), 4102-4108. doi: 10.1128/IAI.72.7.4102-4108.2004
2003
Journal - Research Article
McLachlan, J. L., Smith, A. J., Sloan, A. J., & Cooper, P. R. (2003). Gene expression analysis in cells of the dentine-pulp complex in healthy and carious teeth. Archives of Oral Biology, 48(4), 273-283. doi: 10.1016/S0003-9969(03)00003-7
Wang, L., Shelton, R. M., Cooper, P. R., Lawson, M., Triffitt, J. T., & Barralet, J. E. (2003). Evaluation of sodium alginate for bone marrow cell tissue engineering. Biomaterials, 24(20), 3475-3481. doi: 10.1016/S0142-9612(03)00167-4
Journal - Research Other
McLachlan, J. L., Smith, A. J., & Cooper, P. R. (2003). Piezo-power microdissection of mature human dental tissue [Short communication]. Archives of Oral Biology, 48(10), 731-736. doi: 10.1016/S0003-9969(03)00152-3
2001
Journal - Research Article
Caldwell, G. M., Eddy, R. L., Day, C. D., Haley, L. H., Cooper, P. R., Sait, S. S. J., … Shows, T. B. (2001). Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1 → p14. Cytogenetics & Cell Genetics, 92(1-2), 103-107. doi: 10.1159/000056877
Cooper, P., Potter, S., Mueck, B., Yousefi, S., & Jarai, G. (2001). Identification of genes induced by inflammatory cytokines in airway epithelium. American Journal of Physiology: Lung Cellular & Molecular Physiology, 280(5), L841-L852. doi: 10.1152/ajplung.2001.280.5.L841
Yousefi, S., Cooper, P. R., Potter, S. L., Mueck, B., & Jarai, G. (2001). Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes. Journal of Leukocyte Biology, 69(6), 1045-1052. doi: 10.1189/jlb.69.6.1045
2000
Journal - Research Article
Cooper, P., Mueck, B., Yousefi, S., Potter, S., & Jarai, G. (2000). cDNA-RDA of genes expressed in fetal and adult lungs identifies factors important in development and function. American Journal of Physiology: Lung Cellular & Molecular Physiology, 278(2), L284-L293. doi: 10.1152/ajplung.2000.278.2.L284
Yousefi, S., Cooper, P. R., Mueck, B., Potter, S. L., & Jarai, G. (2000). cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. Biochemical & Biophysical Research Communications, 277(2), 401-409. doi: 10.1006/bbrc.2000.3678
1999
Journal - Research Article
Smilinich, N. J., Day, C. D., Fitzpatrick, G. V., Caldwell, G. M., Lossie, A. C., Cooper, P. R., … Higgins, M. J. (1999). A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. PNAS, 96(14), 8064-8069. doi: 10.1073/pnas.96.14.8064
1998
Journal - Research Article
Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., … Cooper, P. R., … Reis, A. (1998). Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell, 93(3), 467-476. doi: 10.1016/S0092-8674(00)81174-5
Cooper, P. R., Smilinich, N. J., Day, C. D., Nowak, N. J., Reid, L. H., Pearsall, R. S., … Higgins, M. J. (1998). Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Genomics, 49(1), 38-51. doi: 10.1006/geno.1998.5221
Cooper, P. R., Nowak, N. J., Higgins, M. J., Church, D. M., & Shows, T. B. (1998). Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. Genomics, 49(3), 419-429. doi: 10.1006/geno.1998.5291
Journal - Research Other
Stöhr, H., Marquardt, A., Rivera, A., Cooper, P. R., Nowak, N. J., Shows, T. B., … Weber, B. H. F. (1998). A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1. Genome Research, 8(1), 48-56. doi: 10.1101/gr.8.1.48
Higgins, M. J., Day, C. D., Smilinich, N. J., Ni, L., Cooper, P. R., Nowak, N. J., … Shows, T. (1998). Contig maps and genomic sequencing identify candidate genes in the usher 1C locus. Genome Research, 8(1), 57-68. doi: 10.1101/gr.8.1.57
1997
Journal - Research Article
Stankovic, T., Byrd, P. J., Cooper, P. R., McConville, C. M., Munroe, D. J., Riley, J. H., … Taylor, A. M. R. (1997). Construction of a transcription map around the gene for ataxia telangiectasia: Identification of at least four novel genes. Genomics, 40(2), 267-276. doi: 10.1006/geno.1996.4595
Cooper, P. R., Nowak, N. J., Higgins, M. J., Simpson, S. A., Marquardt, A., Stoehr, H., … Shows, T. B. (1997). A sequence-ready high-resolution physical map of the best macular dystrophy gene region in 11q12-q13. Genomics, 41(2), 185-192. doi: 10.1006/geno.1997.4660
Reid, L. H., Davies, C., Cooper, P. R., Crider-Miller, S. J., Sait, S. N. J., Nowak, N. J., … Higgins, M. J. (1997). A 1-Mb physical map and PAC contig of the imprinted domain in 11p15.5 that contains TAPA1 and the BWSCR1/WT2 region. Genomics, 43(3), 366-375. doi: 10.1006/geno.1997.4826
Journal - Research Other
Byrd, P. J., Stankovic, T., McConville, C. M., Smith, A. D., Cooper, P. R., & Taylor, A. M. R. (1997). Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. Genome Research, 7(1), 71-75. doi: 10.1101/gr.7.1.71
1996
Journal - Research Article
Byrd, P. J., McConville, C. M., Cooper, P., Parkhill, J., Stankovic, T., McGuire, G. M., … Taylor, A. M. R. (1996). Mutations revealed by sequencing the 5′ half of the gene for ataxia telangiectasia. Human Molecular Genetics, 5(1), 145-149. doi: 10.1093/hmg/5.1.145
Byrd, P. J., Cooper, P. R., Stankovic, T., Kullar, H. S., Watts, G. D. J., Robinson, P. J., & Taylor, A. M. R. (1996). A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: Amino acid sequence, structure and expression studies. Human Molecular Genetics, 5(11), 1785-1791. doi: 10.1093/hmg/5.11.1785
1994
Journal - Research Article
Ambrose, H. J., Byrd, P. J., McConville, C. M., Cooper, P. R., Stankovic, T., Riley, J. H., … Taylor, A. M. R. (1994). A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia. Genomics, 21(3), 612-619. doi: 10.1006/geno.1994.1321