Profile

Contact Details

Phone: +64 3 479 7471
Email: noelyn.hung@otago.ac.nz

University Links

Position

Senior Lecturer

Department

Department of Pathology (Dunedin)

Qualifications

BSc MB ChB FRCPA

Research summary

Anatomical pathologist with subspecialist interest in perinatal medicine, oncology, and autoimmunity

Teaching

Dr Hung teaches into the disciplines of undergraduate and postgraduate medicine, dentistry, pharmacy, physiotherapy, medical laboratory science, and pathology at the University of Otago and Southern District Health Board. Through the Otago Polytechnic she also contributes to midwifery education.

Dr Hung is Curator of the Pathology Department Museum of Human Disease.

Clinical

Anatomical pathologist with subspecialist interest in perinatal medicine, oncology, and autoimmunity.

Research

Since joining the university in late 2004, Dr Hung has continued clinical practice, developed a research programme, enjoyed teaching, and continued her work in the biotechnology industry which emphasises 'good clinical practice' and 'good laboratory practice' (according to International Conference on Harmonisation Guidelines for GCP and GLP standards, and European Medicines Agency Guidelines). Dr Hung has led (as PI) over 500 PK/PD phase 1 and 2 studies.

As an anatomical pathologist Dr Hung's expertise is in the interpretation of human disease, and readily takes the 'bedside to the bench'. Anatomical pathology emerged from morbid anatomy, which in turn emerged from normal anatomy in the 17th century, and embraces all disease with a morphological tissue manifestation. This now extends to the microscopic, proteonomic, epigenetic and genetic levels and as such is a broad discipline in the 'big picture' of human disease.

Oncology, autoimmunity and reproductive medicine may seem disparate interests but a unifying feature is the regulation of cell death, survival and growth. The need to understand the regulation of growth at the start of life in inversely reflected in the need to conquer the immortality of cancer cell growth. Between these are chronic diseases (such as autoimmunity), which also involve deregulated cell death, survival and growth.

Dr Hung works closely with Drs Tania Slatter and Janice Royds as a member of the Molecular Pathology Group. Local collaborators include Dr Celia Devenish (Women's and Children's Health), Professor Rob Walker (Medicine), Dr Ahmad Taha (Neurosurgery), Dr William Clow (Women's and Children's Health), and Professor John Highton (Medicine). Collaborators from outside Dunedin are at the University of Otago, Christchurch; and the universities of Hong Kong, Sydney, Oxford, Manchester, and Umea.

Publications

Wang, D., Hung, N., Hung, T., Eden, K., Chan, W.-K., Kwan, R., … Duffull, S., Glue, P., & Jackson, C. (2024). Oral docetaxel plus encequidar: A phase 1 clinical trial. Cancer Chemotherapy & Pharmacology. Advance online publication. doi: 10.1007/s00280-024-04674-4 Journal - Research Article

Wang, D., Hughes-Medlicott, N., Klingler, L., Wang, Y., Hung, N., Duffull, S., … Glue, P., … Jackson, C. (2024). A sensitive assay for unbound docetaxel using ultrafiltration plus HPLC-MS and its application to a clinical study. Pharmaceutics, 16, 602. doi: 10.3390/pharmaceutics16050602 Journal - Research Article

Wang, D., Jackson, C., Hung, N., Hung, T., Kwan, R., Chan, W.-K., … Hughes-Medlicott, N. J., Glue, P., & Duffull, S. (2024). Oral docetaxel plus encequidar: A pharmacokinetic model and evaluation against IV docetaxel. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-024-09913-y Journal - Research Article

Wang, D., Hung, T., Hung, N., Glue, P., Jackson, C., & Duffull, S. (2023). Optimal sample selection applied to information rich, dense data. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-023-09883-7 Journal - Research Other

Dai, M.-S., Chao, T.-C., Chiu, C.-F., Lu, Y.-S., Shiah, H.-S., Jackson, C. G. C. A., Hung, N., … Chao, T.-Y. (2023). Oral paclitaxel and encequidar in patients with breast cancer: A pharmacokinetic, safety, and antitumor activity study. Therapeutic Advances in Medical Oncology, 15. doi: 10.1177/17588359231183680 Journal - Research Article

2024

Journal - Research Article

2023

Journal - Research Article

Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267

Journal - Research Other

2022

Conference Contribution - Verbal presentation and other Conference outputs

Polwatta, S. N., Boix De Jesús, A. N., Wang, D., Taha, A., Kazantseva, M., Zhou, J., Mehta, S., Saraiva, A. M., … Royds, J., … Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2022, August). The Δ 133p53 isoform enhances cell-surface trafficking to promote metastasis. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Wang, D., Jackson, C., Glue, P., Hung, N., Hung, T., & Duffull, S. (2022, August-September). Exploring go/no-go with oral docetaxel plus encequidar. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

2021

Journal - Research Article

Jackson, C. G. C. A., Hung, T., Segelov, E., Barlow, P., Prenen, H., McLaren, B., Hung, N. A., Clarke, K., … Deva, S. (2021). Oral paclitaxel with encequidar compared to intravenous paclitaxel in patients with advanced cancer: A randomised crossover pharmacokinetic study. British Journal of Clinical Pharmacology, 87, 4673-4683. doi: 10.1111/bcp.14886

Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005

2020

Journal - Research Article

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Glue, P., Medlicott, N. J., Neehoff, S., Surman, P., Lam, F., Hung, N., & Hung, C.-T. (2020). Safety and efficacy of extended release ketamine tablets in patients with treatment-resistant depression and anxiety: Open label pilot study. Therapeutic Advances in Psychopharmacology, 10, 1-6. doi: 10.1177/2045125320922474

Fabre, M.-S., Stanton, N. M., Slatter, T. L., Lee, S., Senanayake, D., Gordon, R. M. A., … Taha, A., Royds, J. A., Hung, N., … McConnell, M. J. (2020). The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy. PLoS ONE, 15(4), e0231470. doi: 10.1371/journal.pone.0231470

Reily-Bell, A. L., Fisher, A., Harrison, B., Bowie, S., Ray, S., Hawkes, M., … Fukuzawa, R., Macaulay, E. C., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2020). Human papillomavirus E6/E7 expression in preeclampsia-affected placentae. Pathogens, 9(3), 239. doi: 10.3390/pathogens9030239

Glue, P., Medlicott, N. J., Surman, P., Lam, F., Hung, N., & Hung, C. T. (2020). Ascending-dose study of controlled-release ketamine tablets in healthy volunteers: Pharmacokinetics, pharmacodynamics, safety, and tolerability. Journal of Clinical Pharmacology, 60(6), 751-757. doi: 10.1002/jcph.1573

Conference Contribution - Published proceedings: Abstract

Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Bessemer, B., Chatterjee, A., Alsaleh, A. A., Stockwell, P. A., Ludgate, J. L., Weeks, R. J., Jones, G. T., Day, R. C., Fukazawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2020). The potential power of placental epigenetics [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

2019

Journal - Research Article

Mehta-Mujoo, P. P., Cunliffe, H. E., Hung, N. A., & Slatter, T. L. (2019). Long non-coding RNA ANRIL in the nucleus associates with periostin expression in breast cancer. Frontiers in Oncology, 9, 885. doi: 10.3389/fonc.2019.00885

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Journal - Research Other

Jackson, C. G. C. A., Morris, T., Hung, N., & Hung, T. (2019). Breast milk paclitaxel excretion following intravenous chemotherapy: A case report. British Journal of Cancer, 121, 421-424. doi: 10.1038/s41416-019-0529-z

Conference Contribution - Published proceedings: Abstract

Dai, M.-S., Chao, T.-C., Chiu, C.-F., Lu, Y.-S., Shiah, H.-S., Wu, Y.-Y., … Hung, N., … Chao, T.-Y. (2019). Oral paclitaxel in the treatment of metastatic breast cancer (MBC) patients. Journal of Clinical Oncology, 37(15, Suppl.), 1084. doi: 10.1200/JCO.2019.37.15_suppl.1084

Hung, Y.-P., Chao, Y., Chen, M. H., Cutler, D., Kramer, D., Chan, W. K., … Hung, N. A., … Tenner, L. L. (2019). A phase lb study of oraxol in combination with ramucirumab in patients with gastric or esophageal cancers who failed previous chemotherapy. Journal of Clinical Oncology, 37(15, Suppl.), e15518. doi: 10.1200/JCO.2019.37.15_suppl.e15518

Chen, M. H., Chao, Y., Tenner, L., Hung, N. A., Cutler, D., Kramer, D., … Hung, C.-T. (2019). A phase Ib study of oraxol in combination with ramucirumab in patients with gastric or esophageal cancers who failed previous chemotherapy. Annals of Oncology, 30(Suppl. 5), mdz247.126. doi: 10.1093/annonc/mdz247.126

Jackson, C. G. C. A., Deva, S., Bayston, K., McLaren, B., Barlow, P., Hung, N. A., … Hung, C.-T. (2019). An international randomized cross-over bio-equivalence study of oral paclitaxel + HM30181 compared with weekly intravenous (IV) paclitaxel in patients with advanced solid tumours. Annals of Oncology, 30(Suppl. 5), mdz244.039. doi: 10.1093/annonc/mdz244.039

Conference Contribution - Verbal presentation and other Conference outputs

Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Chatterjee, A. C., Stockwell, P. A., Alsaleh, A. A., Wilson, J. L., Weeks, R. J., Day, R. C., Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2019, August-September). The placental potential: Harnessing insights from placental epigenetics to predict disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Menkes, D. B., Glue, P., Gale, C., Lam, F., Hung, C.-T., & Hung, N. (2018). Steady-state clozapine and norclozapine pharmacokinetics in Māori and European patients. EBioMedicine, 27, 134-137. doi: 10.1016/j.ebiom.2017.11.030

Zhou, J., Reddy, M. V., Wilson, B. K. J., Blair, D. A., Taha, A., Frampton, C. M., Eiholzer, R. A., … Hung, N. A., Royds, J. A., & Slatter, T. L. (2018). MR imaging characteristics associate with tumor-associated macrophages in glioblastoma and provide an improved signature for survival prognostication. American Journal of Neuroradiology, 39(2), 252-259. doi: 10.3174/ajnr.A5441

Conference Contribution - Published proceedings: Abstract

Dai, M.-S., Chao, T.-Y., Chiu, C.-F., Lu, Y.-S., Shiah, H.-S., Wu, Y.-Y., … Hung, N., … Hung, T. (2018). Oral paclitaxel and HM30181A demonstrate clinical activity in metastatic breast cancer (MBC) patients. Annals of Oncology, 29(Suppl. 8), mdy272.279. doi: 10.1093/annonc/mdy272.279

Conference Contribution - Poster Presentation (not in published proceedings)

Reily-Bell, A., Fisher, A., Devenish, C. J., Hung, N. A., & Slatter, T. L. (2018, November). Human papillomavirus in the placenta and its relationship to birth complications. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Mehta-Mujoo, P., Landmann, M., Pilbrow, A. P., Currie, M. J., Morrin, H. R., Hung, N. A., & Slatter, T. L. (2018, August). Visualisation of long non-coding RNA ANRIL in breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Reily-Bell, A., Fisher, A., Devenish, C. J., Hung, N. A., Braithwaite, A. W., & Slatter, T. L. (2018, August). Investigating p53 isoforms in HPV positive cervical cancers and in the placenta. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Eiholzer, R. A., Kazantseva, M., Mehta, S., Roth, I., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018, August). The role of the p53 isoform Δ133TPP53 in treatment resistance. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Slatter, T. L., Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., … Royds, J. A., Zhou, J., Hung, N. A., & Braithwaite, A. W. (2018, August). The TP53 isoform Δ133p53β in glioblastoma development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fabre, M. S., Jones, N. M., Slatter, T. L., Rowe, M. R., Gordon, R. A. M., Castro, M. L., Hung, N., … McConnell, M. J. (2018, August). BCL6: An essential role in glioblastoma therapy resistance and survival. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Dias, G. J., Mahoney, P., Hung, N. A., Sharma, L. A., Kalita, P., Smith, R. A., … Ali, A. (2017). Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes. Journal of Biomedical Materials Research Part B, 105(7), 2034-2044. doi: 10.1002/jbm.b.33735

Journal - Research Other

Vardi, L., Paterson, H., & Hung, N. A. (2017). Successful pregnancy following treatment of recurrent chronic histiocytic intervillositis. BMJ Case Reports. doi: 10.1136/bcr-2016-217886

Conference Contribution - Published proceedings: Abstract

Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio

Ray, S., Fisher, A., Bowie, S., Devenish, C., Slatter, T., & Hung, N. (2017). Human papilloma virus in the placenta: The role of p53. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 766. Retrieved from http://gen2017.w.events4you.currinda.com

Kazantseva, M., Mehta, S., Eiholzer, R. A., Roth, I., Bowie, S., Joruiz, S., Royds, J. A., Taha, A., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2017). Elevated Δ133p53β in prostate tumours correlates with an immune suppressive signature and poorer outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 29). Retrieved from http://www.uib.no/en/ccbio

Jackson, C. G. C. A., Deva, S., Bayston, K., Barlow, P., Eden, K., Hung, N., … Hung, T. (2017). An open-label, randomized cross-over bioavailability study of oral paclitaxel and HM30181 compared with weekly intravenous (IV) paclitaxel in patients with advanced solid tumours. Annals of Oncology, 28(Suppl. 10), mdx568. doi: 10.1093/annonc/mdx658

Almomani, S., Morison, I., Hung, N., Slatter, T., & Macaulay, E. (2017). Predicting altered methylation patterns in early pre-eclampsia. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 778. Retrieved from http://gen2017.w.events4you.currinda.com

Harrison, B., Hung, N., Ussher, J., Slatter, T., & Devenish, C. (2017). A new peripheral blood test for HPV to predict perinatal disease. New Zealand Medical Journal, 130(1461), (pp. 88-89). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Momani, S., Morison, I. M., Hung, N. A., Slatter, T. L., & Macaulay, E. C. (2017, September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Macaulay, E. C., Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2017, September). Profiling the placental epigenome in pre-eclampsia to predict pregnancy outcomes. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Journal - Research Article

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379

Glue, P., Cape, G., Tunnicliff, D., Lockhart, M., Lam, F., Hung, N., … Harland, S., … Friedhoff, L. (2016). Ascending single-dose, double-blind, placebo-controlled safety study of noribogaine in opioid-dependent patients. Clinical Pharmacology in Drug Development, 5(6), 460-468. doi: 10.1002/cpdd.254

Hung, N. A., Eiholzer, R. A., Kirs, S., Zhou, J., Ward-Hartstonge, K., Wiles, A. K., Frampton, C. M., Taha, A., Royds, J. A., & Slatter, T. L. (2016). Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma. Modern Pathology, 29, 212-226. doi: 10.1038/modpathol.2015.156

Glue, P., Cape, G., Tunnicliff, D., Lockhart, M., Lam, F., Gray, A., Hung, N., … Harland, S., … Friedhoff, L. (2016). Switching opioid-dependent patients from methadone to morphine: Safety, tolerability, and methadone pharmacokinetics. Journal of Clinical Pharmacology, 56(8), 960-965. doi: 10.1002/jcph.704

Royds, J. A., Pilbrow, A. P., Morrin, H. R., Frampton, C., Russell, I. A., Moravec, C. S., … Currie, M. J., Hung, N. A., & Slatter, T. L. (2016). The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16^INK4a expression. Frontiers in Oncology, 5, 306. doi: 10.3389/fonc.2015.00306

Conference Contribution - Published proceedings: Full paper

Moskal, A. C. M., Loke, S.-K., & Hung, N. (2016). Challenges implementing social constructivist learning approaches: The case of Pictation. Proceedings of the 33rd Australasian Society for Computers in Learning in Tertiary Education (ASCILITE) Conference: Show Me The Learning. (pp. 446-454). Retrieved from http://2016conference.ascilite.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Macaulay, E. C., Chatterjee, A., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., & Morison, I. M. (2016, March). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Poster session presented at the Keystone Symposia on Molecular and Cellular Biology: Chromatin and Epigenetics, Whistler, Canada.

Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2016, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kazantseva, M., Hung, N., Mehta, S., Roth, I., Baird, M., Braithwaite, A., & Slatter, T. (2016, October). Mutant p53 promotes incorrect B cell differentiation and adverse outcome in DLBCL. Verbal presentation at the 7th International Mutant p53 Workshop, Melbourne, Australia.

Kazantseva, M., Hung, N., Mehta, S., Baird, M., Slatter, T., & Braithwaite, A. (2016, August-September). Investigating the association of Δ133p53 isoform expression and the inflammatory microenvironment in prostate tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Eiholzer, R., Zhou, J., Taha, A., Kirs, S., Wang, D., Ziad, F., … Wilson, B., … Fulton, J., … Ward-Hartstonge, K., Wiles, A., Frampton, C., Hung, N., & Slatter, T. (2016, August-September). Surgical success and response to adjuvant therapy in glioblastoma depends on telomere maintenance associated markers. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Slatter, T. L., Hung, N. G. L. Y., Clow, W. M., Royds, J. A., Devenish, C. J., & Hung, N. A. (2015). A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications. Modern Pathology, 28, 1369-1382. doi: 10.1038/modpathol.2015.88

Slatter, T. L., Hung, N., Bowie, S., Campbell, H., Rubio, C., Speidel, D., Wilson, M., Baird, M., Royds, J. A., & Braithwaite, A. W. (2015). Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease, 6, e1783. doi: 10.1038/cddis.2015.149

Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015). Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE, 10(2), e0116270. doi: 10.1371/journal.pone.0116270

Slatter, T. L., Hsia, H., Samaranayaka, A., Sykes, P., Clow, W., Devenish, C. J., … Royds, J. A., … Hung, N. A. (2015). Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. Journal of Pathology: Clinical Research, 1(2), 95-105. doi: 10.1002/cjp2.11

Glue, P., Lockhart, M., Lam, F., Hung, N., Hung, C.-T., & Friedhoff, L. (2015). Ascending-dose study of noribogaine in healthy volunteers: Pharmacokinetics, pharmacodynamics, safety, and tolerability. Journal of Clinical Pharmacology, 55(2), 189-194. doi: 10.1002/jcph.404

Conference Contribution - Published proceedings: Full paper

Macaulay, E. C., Roberts, H. E., Al-Momani, S., Hung, N. A., Slatter, T. L., Devenish, C., & Morison, I. M. (2015). Methylome meets maternity ward: Predicting pre-eclampsia in early pregnancy. Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics (BCB). (pp. 484-485). New York: ACM. doi: 10.1145/2808719.2811419

Conference Contribution - Published proceedings: Abstract

Nolan, A., de Silva, H., Royds, J., & Hung, N. (2015). A pilot study of HPV related sialadenitis. Scandinavian Journal of Immunology, 81, (pp. 353). doi: 10.1111/sji.12291

Kirs, S., Taha, A., Royds, J., Slatter, T., & Hung, N. (2015). The repair protein MGMT and scavenger receptor CD163 are independent prognostic factors for metastatic brain tumours. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Momani, S., Macaulay, E., Roberts, H., Hung, N., Slatter, T., Devenish, C., & Morison, I. (2015, August-September). Predicting altered methylation patterns in early pre-eclampsia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kazantseva, M., Slatter, T., Hung, N., & Braithwaite, A. (2015, September). Altered regulation of Δ133p53 isoforms expression in prostate tumours. Verbal presentation at the 2nd International p53 Isoform Workshop, Aix-en-Provence, France.

Devenish, C. J., Hung, N., & Slatter, T. (2015, July). What is the evidence that HPV effects pregnancy outcomes? Verbal presentation at the Perinatal Society of New Zealand (PSNZ) 35th Annual Scientific Meeting, Dunedin, New Zealand.

2014

Journal - Research Article

Berney-Meyer, L., Hung, N., Slatter, T., Schollum, J. B. W., Kitching, A. R., & Walker, R. J. (2014). Omeprazole-induced acute interstitial nephritis: A possible Th1–Th17-mediated injury? Nephrology, 19(6), 359-365. doi: 10.1111/nep.12226

Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159

Slatter, T. L., Park, L., Anderson, K., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J. A., Devenish, C., & Hung, N. A. (2014). Smoking during pregnancy causes double-strand DNA break damage to the placenta. Human Pathology, 45(1), 17-26. doi: 10.1016/j.humpath.2013.07.024

Journal - Research Other

Lindström, A.-C., Hung, N. A., Duncan, W., & Kieser, J. (2014). Detection of gunshot residues (GSR) on a self-inflicted gunshot wound. Pathology, 46(3), 260-263. doi: 10.1097/pat.0000000000000083

Conference Contribution - Published proceedings: Abstract

Ward-Hartstonge, K., Taha, A., Hung, N., Kemp, R., & Slatter, T. (2014). Increased CD163 expression defines a subgroup of glioblastoma multiforme. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

Knarston, I., Macaulay, E., Roberts, H., Slatter, T., Hung, N., Devenish, C., & Morison, I. (2014). Validation of DNA methylation biomarkers for pre-eclampsia. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Hung, N. A. (2014, October). Telomere maintenance mechanism identifies poor prognosis uterine sarcoma. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Tauranga, New Zealand.

2013

Chapter in Book - Research

Hung, N., & Slatter, T. (2013). Histopathology in biomolecular research. In A. Divan & J. Royds (Eds.), Tools and techniques in biomolecular science. (pp. 418-437). Oxford, UK: Oxford University Press.

Journal - Research Article

Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225

Hung, N. A., Royds, J. A., & Slatter, T. L. (2013). Molecular markers of glioblastoma and the potential for integration with imaging: The future for assigning prognosis and best treatment strategy. Current Molecular Imaging, 2(2), 107-116. doi: 10.2174/2211555211302020001

Ferrandon, S., Saultier, P., Carras, J., Battiston-Montagne, P., Alphonse, G., Beuve, M., … Slatter, T., Hung, N., Royds, J., … Poncet, D. (2013). Telomere profiling: Toward glioblastoma personalized medicine. Molecular Neurobiology, 47(1), 64-76. doi: 10.1007/s12035-012-8363-9

Hung, N. A., Hsia, H., Royds, J. A., & Slatter, T. L. (2013). Telomere maintenance mechanisms: Prognostic and therapeutic implications for the pathologist and oncologist. Open Journal of Pathology, 3(1), 10-20. doi: 10.4236/ojpathology.2013.31003

Kazantseva, M. G., Hung, N. A., Highton, J., & Hessian, P. A. (2013). MMP expression in rheumatoid inflammation: The rs11568818 polymorphism is associated with MMP-7 expression at an extra-articular site. Genes & Immunity, 14(3), 162-169. doi: 10.1038/gene.2012.65

Journal - Research Other

Hung, N. A. (2013). A difficult conversation: Dusting off the bedside manner of pathologists. BJOG, 120(5), 649. doi: 10.1111/1471-0528.12084

Conference Contribution - Published proceedings: Abstract

Macaulay, E. C., Roberts, H. E., Hung, N. A., & Morison, I. M. (2013). Epigenetic markers for pre-eclampsia. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/

Slatter, T., Park, L., Anderson, K., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J., Devenish, C., & Hung, N. (2013). Smoking during pregnancy causes double strand DNA break damage to the placenta. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/

Roberts, H., Macaulay, E., Hung, N., & Morison, I. (2013). Epigenetic profiling of pre-eclamptic placentas. Placenta, 34(9), (pp. A66). doi: 10.1016/j.placenta.2013.06.199

Conference Contribution - Poster Presentation (not in published proceedings)

Macaulay, E. C., Roberts, H. E., Hung, N. A., & Morison, I. M. (2013, July). Epigenetic markers for pre-eclampsia. Poster session presented at the EpiCongress, Boston, USA.

Roberts, H. E., Macaulay, E. C., Hung, N. A., & Morison, I. M. (2013, August). Epigenetic profiling of pre-eclamptic placentas. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Menkes, D. B., Glue, P., Gale, C., & Hung, N. (2013, September). Steady-state clozapine pharmacokinetics in Maori and European patients. Verbal presentation at the Royal Australian and New Zealand College of Psychiatrists (RANZCP) Conference: The Shifting Strands of Psychiatry, Auckland, New Zealand.

2012

Journal - Research Article

Glue, P., Gale, C., Menkes, D. B., & Hung, N. (2012). Evaluation of bioequivalence between clozapine suspension and tablet formulations : A multiple-dose, fed and fasted Study. Clinical Drug Investigation, 32(11), 723-727. doi: 10.1007/s40261-012-0004-6

Slatter, T. L., Tan, X., Yuen, Y. C., Gunningham, S., Ma, S. S., Daly, E., Packer, S., Devenish, C., Royds, J. A., & Hung, N. A. (2012). The alternative lengthening of telomeres pathway operates in non-neoplastic human cells. Journal of Pathology, 226(3), 509-518. doi: 10.1002/path.2981

Conference Contribution - Poster Presentation (not in published proceedings)

Anderson, K., Slatter, T., Park, L., Lailai-Tasmania, V., Herbison, P., Clow, W., Royds, J., Devenish, C., & Hung, N. (2012, September). The smoking gun: Cigarette smoking in pregnancy. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Braithwaite, A. W., Baird, M. A., Campbell, H. G., Hung, N. A., Jeffs, A. R., Print, C. G., & Slatter, T. L. (2012, August). Isoforms of the p53 tumour suppressor, inflammation, and cancer. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737

Woolley, A. G., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N. A., … Royds, J. A., Perez, D., Yoon, H.-S., … Braithwaite, A. W. (2011). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. PLoS ONE, 6(6), e20603. doi: 10.1371/journal.pone.0020603

Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851

Conference Contribution - Published proceedings: Abstract

Royds, J. A., Al Nadaf, S., Ahn, A., Chen, Y.-J., Wiles, A., Jellinek, D., Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). Older patients with glioma have a high frequency of a rare CDKN2A P14/16 allele. Neuro-Oncology, 13(Suppl. 2), 50, (pp. ii10). doi: 10.1093/neuonc/nor144

2010

Journal - Research Article

Slatter, T., Gifford-Garner, J., Wiles, A., Tan, X., Chen, Y.-J., MacFarlane, M., Sullivan, M., Royds, J., & Hung, N. (2010). Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. American Journal of Pathology, 177(6), 2694-2700. doi: 10.2353/ajpath.2010.100468

Fitches, A. C., Yousem, S., Cieply, K., Stebbings, S., Highton, J., & Hung, N. A. (2010). PCR detectable Y chromosome-specific DNA but no intact Y chromosome-bearing cells in polymyositis biopsies of two women with male offspring. Pathology, 42(2), 160-164. doi: 10.3109/00313020903494953

2008

Journal - Research Article

Leigh, W., O'Grady, P., Lawson, E. M., Hung, N. A., Theis, J.-C., & Matheson, J. (2008). Pelvic pseudotumor: An unusual presentation of an extra-articular granuloma in a well-fixed total hip arthroplasty. Journal of Arthroplasty, 23(6), 934-938. doi: 10.1016/j.arth.2007.08.003

Gwynne-Jones, D., Lyall, P., Hung, N. A., & Meikle, G. (2008). Accidental human injection of Excenel RTU^TM: Ceftiofur hydrochloride in cottonseed oil. Clinical Toxicology, 46, 908-910. doi: 10.1080/15563650801955278

2007

Journal - Research Article

Highton, J., Hung, N., Hessian, P., & Wilsher, M. (2007). Pulmonary rheumatoid nodules demonstrating features usually associated with rheumatoid synovial membrane. Rheumatology, 46, 811-814.

Connor, A., Stebbings, S., Hung, N. A., Hammond-Tooke, G., Meikle, G., & Highton, J. (2007). STIR MRI to direct muscle biopsy in suspected idiopathic inflammatory myopathy. Journal of Clinical Rheumatology, 13(6), 341-345.

Journal - Research Other

Connor, A., Highton, J., Hung, N. A., Dunbar, J., MacGinley, R., & Walker, R. (2007). Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A: A case report and literature review. American Journal of Kidney Diseases, 50(4), 649-654. doi: 10.1053/j.ajkd.2007.06.014

2006

Journal - Research Article

Hung, N. A., Jackson, C., Nicholson, M., & Highton, J. (2006). Pregnancy-related polymyositis and massive perivillous fibrin deposition in the placenta: Are they pathogenetically related? Arthritis & Rheumatism, 55(1), 154-156. doi: 10.1002/art.21710

2005

Journal - Research Article

Hung, N. A. (2005). Congenital ″clear cell sarcoma of the kidney″. Virchows Archiv, 446(5), 566-568.

Gwynne-Jones, D. P., Theis, J. C., Jeffery, A. K., & Hung, N. A. (2005). Long-term follow-up of a recurrent multifocal desmoid tumour treated with tamoxifen: A case report. Journal of Orthopaedic Surgery, 13(2), 174-177.

Journal - Research Other

Stott, V., Manning, P., & Hung, N. (2005). Idiopathic granulomatous hypophysitis [Case report]. New Zealand Medical Journal, 118(1211). Retrieved from http://journal.nzma.org.nz/journal/118-1211/1355/content.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Highton, J., Hung, N., & Hessian, P. (2005, May). Pulmonary rheumatoid nodules share inflammatory features with rheumatoid synovial membrane. Poster session presented at the Australian Rheumatology Association 47th Annual Scientific Meeting, Melbourne, Australia.

Conference Contribution - Verbal presentation and other Conference outputs

Highton, J., Hung, N., & Hessian, P. (2005, September). Pulmonary rheumatoid nodules show features usually found only in synovial membrane. Verbal presentation at the New Zealand Rheumatology Association Annual Scientific Meeting, Palmerston North, New Zealand.

2004

Journal - Research Other

Gwynne Jones, D. P., Hodgson, B. F., & Hung, N. A. (2004). Bilateral, uncemented total hip arthroplasty in osteopetrosis. Journal of Bone & Joint Surgery (Br), 86-B(2), 276-278.

Hung, N. A., Strack, M., van Rij, A., North, C. J., & Blennerhassett, J. B. (2004). Spontaneous acroangiodermatitis in a young woman. Dermatology Online Journal, 10(2), 8. Retrieved from http://dermatology.cdlib.org/102/case_reports/acroangiodermatitis/hung.html

Conference Contribution - Verbal presentation and other Conference outputs

Hung, N. (2004, September). When things go wrong in obstetrics and infancy. Verbal presentation at the New Zealand Obstetrics and Gynaecology Miniconference, Christchurch, New Zealand.

2002

Journal - Research Article

Teixeira, F., Devlin, M., Hung, N., & Yun, K. (2002). An atrophic plaque on the chest. Australian Family Physician, 31, 359-360.

2000

Journal - Research Other

Mathur, S., Law, A. J. J., & Hung, N. (2000). Late intramedullary spinal cord metastasis in a patient with lymphoblastic lymphoma: Case report. Journal of Clinical Neuroscience, 7(3), 264-268. doi: 10.1054/jocn.1999.0197

1999

Journal - Research Article

Thomas, M. C., Walker, R. J., & Hung, N. (1999). Tuberculosis: Still the great pretender. Hospital Medicine, 60, 214-215.

1998

Journal - Research Article

Holmes, M., Hung, N., & Hunter, M. (1998). Hematuria and death secondary to aortoureteric fistula. Urology, 52(4), 720-722.

IJsselstijn, H., Hung, N., de Jongste, J. C., Tibboel, D., & Cutz, D. (1998). Calcitonin gene-related peptide expression is altered in pulmonary neuroendocrine cells in developing lungs of rats with congenital diaphragmatic hernia. American Journal of Respiratory Cell & Molecular Biology, 19(2), 278-285. doi: 10.1165/ajrcmb.19.2.2853

Hung, N. A., Silver, M. M., Chitayat, D., Provias, J., Toi, A., Jay, V., & Becker, L. E. (1998). Gonadoblastoid testicular dysplasia in Walker-Warburg syndrome. Pediatric & Developmental Pathology, 1(5), 393-404. doi: 10.1007/s100249900054

1993

Journal - Research Other

Delany, S. G., Doyle, T. C. A., Bunton, R. W., Hung, N. A., Joblin, L. U., & Taylor, D. R. (1993). Pulmonary artery sarcoma mimicking pulmonary embolism [Case report]. Chest, 103(5), 1631-1633. doi: 10.1378/chest.103.5.1631

Parry, B. R., Hung, N. A., McCall, J. L., & Phipps, R. F. (1993). Apparent regression of rectal polyps in a patient with Gardner's syndrome receiving concomitant tamoxifen therapy [Case report]. Australian & New Zealand Journal of Surgery, 63(7), 578-579. doi: 10.1111/j.1445-2197.1993.tb00460.x

1991

Journal - Research Article

Frizelle, F. A., Hung, N. A., Heslop, J. H., & Parry, B. R. (1991). Obscure gastrointestinal bleeding: Idiopathic aortoduodenal fistula. Journal of the Royal College of Surgeons of Edinburgh, 36(5), 331-333.

1988

Journal - Research Article

Buisman, N., Mow, A. C., Currie, T., Devereux, F., Hawkins, T., & Holden, H. (1988). AIDS: Knowledge and attitudes in Otago. New Zealand Medical Journal, 101(845), 241-243.