Red X iconGreen tick iconYellow tick icon

Contact Details

+64 3 364 0590
Professor and Head of Department
Department of Pathology and Biomedical Science (Christchurch)
BSc (Cant) PhD (Auck)
Research summary
Genetics of human disease


Director of the Carney Centre for Pharmacogenomics and the Gene Structure and Function Lab, Martin's main research interests are psychiatric genetics, pharmacogenomics, and the genetics of complex disease.

His current research largely focuses on pharmacogenomics, which aims to understand how drugs and genes interact with the goal of improving drug treatments and reducing adverse drug reactions. For example, analysis of genetic variation in genes such as those that encode drug metabolising liver enzymes like CYP2D6 and CYP2C19, is helping to determine genetic factors that impact on response to treatments for various diseases.

For a more comprehensive analysis of genetic factors impacting drug response or risks of adverse drug reactions, they are also applying Next Generation DNA sequencing methods including exome sequencing and other genomic approaches to explore drug response phenotypes.

In order to understand severe adverse drug reactions, his lab has developed a biobank for collecting biological samples of people who have suffered such reactions, called UDRUGS. This biobank is growing, and will enhance efforts to understand genetic factors that contribute to severe adverse drug reactions.

Other research interests include work with the Christchurch Health and Development Study looking at genetic contributions to a range of complex human traits, and a study focusing on the genetics of anorexia nervosa. In addition, Martin's laboratory is examining the impact of G-quadruplex DNA structures and their relevance to genomic imprinting and other aspects of genome biology.


Turner, A. J., Nofziger, C., Ramey, B. E., Ly, R. C., Bousman, C. A., Agúndez, J. A. G., … Kennedy, M. A., … Gaedigk, A. (2023). PharmVar tutorial on CYP2D6 structural variation testing and recommendations on reporting [Tutorial]. Clinical Pharmacology & Therapeutics. Advance online publication. doi: 10.1002/cpt.3044 Journal - Research Other

Kee, P. S., Karunanathie, H., Maggo, S. D. S., Kennedy, M. A., & Chua, E. W. (2023). Long-range polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods and protocols: Methods in molecular biology (Vol. 2967). (2nd ed.) (pp. 181-192). New York, NY: Humana. doi: 10.1007/978-1-0716-3358-8_15 Chapter in Book - Research

Morillon, M. B., Nørup, A., Singh, J. A., Dalbeth, N., Taylor, W. J., Kennedy, M. A., … Grainger, R., … Stamp, L. K. (2023). Outcome reporting in randomized trials in Gout: A systematic scoping review from the OMERACT Gout Working Group assessing the uptake of the core outcome set. Seminars in Arthritis & Rheumatism. Advance online publication. doi: 10.1016/j.semarthrit.2023.152191 Journal - Research Article

Kee, P. S., Maggo, S. D. S., Kennedy, M. A., & Chin, P. K. L. (2023). The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses [Brief research report]. Frontiers in Pharmacology, 14, 1080117. doi: 10.3389/fphar.2023.1080117 Journal - Research Article

Cleland, L., Kennedy, H. L., Pettie, M. A., Kennedy, M. A., Bulik, C. M., & Jordan, J. (2023). Eating disorders, disordered eating, and body image research in New Zealand: A scoping review. Journal of Eating Disorders, 11(1), 7. doi: 10.1186/s40337-022-00728-1 Journal - Research Article

Back to top