- Academic background
- Health Sciences, Sciences
- Host campus
- Sarah Hook, Dr Allan Gamble, Associate Professor Joanna Kirman
mRNA vaccines have a number of inherent obstacles to overcome in order to have maximal efficacy. This includes the instability of mRNA and its low penetration across cell membranes. Lipid nanoparticles are currently being used as a method of overcoming these issues with moderate success. In this PhD project the candidate will develop and evaluate alternative and complementary formulation strategies and will then evaluate both in vitro and in vivo their ability to improve the immunogenicity of a model tuberculosis mRNA vaccine.
This research project is cross-disciplinary and will suit students with a background in pharmaceutical sciences, immunology or related areas.
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