Principal Investigator
Associate Professor Alexander Tups
Associate Professor Alexander Tups' biography
Email alexander.tups@otago.ac.nz
Tel +64 3 479 4862
Fax +64 3 479 7323
Department of Physiology website
Research interests
The focus of our research at the Centre for Neuroendocrinology is on the neuroendocrine regulation of metabolism. In particular we are interested in the central interaction of the adiposity hormones leptin and insulin, which appears crucial for the maintenance of energy and glucose homeostasis. We established that a loss of central leptin action during obesity leads to impaired insulin action, which might explain the striking correlation of obesity and type 2 diabetes.
We investigate neuroendocrine mechanisms that link obesity, diabetes and Alzheimer's disease.
We focus on manipulating these crucial pathways via nutritive, genetherapeutic and pharmacological approaches to potentially avoid the manifestation of nutrition related diseases.
Clinical conditions
- Obesity
- Type 2 diabetes
- Alzheimer's disease
- Bipolar disorder
- Cancer
List of publications for Alexander Tups (Google Scholar)
Tups Laboratory staff and students
Mohammed Rizwan, Research Fellow
Email: mohammed.rizwan@otago.ac.nz