Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Colin Brown Laboratory

Research interests

Our research group principally uses electrophysiology and immunohistochemistry to determine how the brain controls birth, lactation, and cardiovascular function. Our main focus is on how oxytocin and vasopressin contribute to preterm labour, high blood pressure and heart problems.

Clinical conditions

  • Preterm labour
  • Preeclampsia
  • Hypertension
  • Myocardial infarction

Professor Brown's researcher profile

The Colin Brown Laboratory has a code of conduct.

List of publications for Colin Brown (Google Scholar)

Colin Brown Laboratory staff & students

Mehwish Abbasi_webMehwish Abbasi, PhD Student
Hypothalamic regulation of birth and lactation

Emily Brown_webEmily Brown, PhD Student
Hypothalamic regulation of body fluid balance in pregnancy and lactation

Michael Perkinson_webMichael Perkinson, PhD Student
Hypothalamic regulation of pregnancy and lactation

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.


Brown, C. H., Ludwig, M., Tasker, J. G., & Stern, J. E. (2020). Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation. Journal of Neuroendocrinology, 32, e12856. doi: 10.1111/jne.12856

Brown, C. H., Roy, R. K., Hamm, J. P., & Stern, J. E. (2020). Development of a novel approach for real-time two-photon imaging of the rat hypothalamus in vivo. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.04797

Abbasi, M., Perkinson, M., Brown, C., & Iremonger, K. (2020). Kisspeptin regulation of oxytocin neuron activity in late pregnancy. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.02418

Perkinson, M. R., Kim, J. S., Brown, C. H., & Iremonger, K. J. (2020). Characterisation of an oxytocin-ires-cre mouse model for recording oxytocin neuron bursts in behaving mice. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.03560

Sethi, S., Augustine, R. A., Bouwer, G. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2020). Type 2 diabetes is associated with increased activation of brain regions that regulate sympathetic drive to the heart. New Zealand Medical Journal, 133(1527), (pp. 126). Retrieved from

Chapter in Book - Research

Brown, C. H. (2016). Magnocellular neurons and posterior pituitary function. In D. M. Pollock (Ed.), Comprehensive physiology (Vol. 6). (pp. 1701-1741). American Physiological Society. doi: 10.1002/cphy.c150053

Brown, C. H., Han, S. Y., Moaddab, M., Scott, V., & Schwenke, D. O. (2015). Peptidergic control of oxytocin and vasopressin neurons and its role in reproduction and hypertension-associated plasticity. In W. E. Armstrong & J. G. Tasker (Eds.), Neurophysiology of neuroendocrine neurons. (pp. 63-84). Chichester, UK: Wiley Blackwell. doi: 10.1002/9781118606803.ch3

Brown, C. H. (2005). Autocrine modulation of excitability by dendritic peptide release from magnocellular neurosecretory cells. In M. Ludwig (Ed.), Dendritic neurotransmitter release. (pp. 223-237). New York: Kluwer Academic.

Roper, P., Brown, C. H., Bourque, C. W., & Armstrong, W. E. (2005). Autoregulation of bursting of AVP neurons of the rat hypothalamus. In S. Coombes & P. C. Bressloff (Eds.), Bursting: The genesis of rhythm in the nervous system. (pp. 49-88). Singapore: World Scientific.

^ Top of page

Journal - Research Article

Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2019). Acute myocardial infarction activates magnocellular vasopressin and oxytocin neurons. Journal of Neuroendocrinology, 31, e12808. doi: 10.1111/jne.12808

Korpal, A. K., Han, S. Y., Schwenke, D. O., & Brown, C. H. (2018). A switch from GABA inhibition to excitation of vasopressin neurones exacerbates the development angiotensin II-dependent hypertension. Journal of Neuroendocrinology, 30(8), e12564. doi: 10.1111/jne.12564

Korpal, A. K., Brown, C. H., & Schwenke, D. O. (2018). Assessing the role of hypothalamic microglia and blood vessel disruption in the development of angiotensin II-dependent hypertension in Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 470(6), 883-895. doi: 10.1007/s00424-018-2128-x

Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2018). Activation of oxytocin neurons in the paraventricular nucleus drives cardiac sympathetic nerve activation following myocardial infarction in rats. Communications Biology, 1, 160. doi: 10.1038/s42003-018-0169-5

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Augustine, R. A., Ladyman, S. R., Bouwer, G. T., Alyousif, Y., Sapsford, T. J., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2017). Prolactin regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Physiology, 595(11), 3591-3605. doi: 10.1113/jp273712

Royo, J. M., Brown, C. H., Leng, G., & MacGregor, D. J. (2016). Oxytocin neurones: Intrinsic mechanisms governing the regularity of spiking activity. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12358

Kim, J. S., Brown, C. H., & Anderson, G. M. (2016). Anti-opioid effects of RFRP-3 on magnocellular neuron activity in morphine-naïve and morphine-treated female rats. Endocrinology, 157(10), 4003-4011. doi: 10.1210/en.2016-1374

Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605

Augustine, R. A., Bouwer, G. T., Seymour, A. J., Grattan, D. R., & Brown, C. H. (2016). Reproductive regulation of gene expression in the hypothalamic supraoptic and paraventricular nuclei. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12350

Choe, K. Y., Han, S. Y., Gaub, P., Shell, B., Voisin, D. L., Knapp, B. A., … Brown, C. H., … Bourque, C. W. (2015). High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron, 85(3), 549-560. doi: 10.1016/j.neuron.2014.12.048

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular & Cellular Neuroscience, 68, 323-330. doi: 10.1016/j.mcn.2015.08.013

Han, S. Y., Bouwer, G. T., Seymour, A. J., Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat. European Journal of Neuroscience, 42(9), 2690-2698. doi: 10.1111/ejn.13062

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin enhances the expression of morphine-induced conditioned place preference in rats. Psychoneuroendocrinology, 53, 159-169. doi: 10.1016/j.psyneuen.2015.01.003

Han, S. Y., Gray, E., Hughes, G., Brown, C. H., & Schwenke, D. O. (2014). Increased sympathetic drive during the onset of hypertension in conscious Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 466(3), 459-466. doi: 10.1007/s00424-013-1338-5

Joe, N., Scott, V., & Brown, C. H. (2014). Glial regulation of extrasynaptic NMDA receptor-mediated excitation of supraoptic nucleus neurons during dehydration. Journal of Neuroendocrinology, 26(1), 35-42. doi: 10.1111/jne.12121

Scott, V., & Brown, C. H. (2013). Beyond the GnRH axis: Kisspeptin regulation of the oxytocin system in pregnancy and lactation. Advances in Experimental Medicine & Biology, 784, 201-218. doi: 10.1007/978-1-4614-6199-9_10

Brown, C. H., Bains, J. S., Ludwig, M., & Stern, J. E. (2013). Physiological regulation of magnocellular neurosecretory cell activity: Integration of intrinsic, local and afferent mechanisms. Journal of Neuroendocrinology, 25(8), 678-710. doi: 10.1111/jne.12051

Tasker, J. G., Oliet, S. H. R., Bains, J. S., Brown, C. H., & Stern, J. E. (2012). Glial regulation of neuronal function: From synapse to systems physiology. Journal of Neuroendocrinology, 24(4), 566-576. doi: 10.1111/j.1365-2826.2011.02259.x

Ruan, M., Russell, J. A., & Brown, C. H. (2011). Acute morphine administration and withdrawal from chronic morphine increase afterdepolarization amplitude in rat supraoptic nucleus neurons in hypothalamic explants. Neuropharmacology, 61, 789-797. doi: 10.1016/j.neuropharm.2011.05.025

Scott, V., & Brown, C. H. (2011). Kisspeptin activation of supraoptic nucleus neurons in Vivo. Endocrinology, 152(10), 3862-3870. doi: 10.1210/en.2011-1181

More publications...