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Principal Investigator

Dave Grattan 186x228Professor Dave Grattan

Professor Dave Grattan's biography
Tel +64 3 479 7442
Fax +64 3 479 7254
Department of Anatomy website

Research interests

My group within the Centre for Neuroendocrinology is interested in the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain.

Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and role of prolactin in changes in mood and behaviour in the post-partum period.

Clinical conditions

  • Hyperprolactinaemia
  • Infertility
  • Post-partum anxiety
  • Post-partum depression

List of publications for Dave Grattan (Google Scholar)

Grattan Laboratory staff & students

Shalhd Al-Isawi imageShahd Al-Isawi, PhD student

Jenny Clarkson_webJenny Clarkson, Research Fellow
Neural circuits required for maternal adaptation to pregnancy

charlie fang imageCharlie Fang, PhD student

Teodora Georgescu_webTeodora Georgescu, Research Fellow
Cellular actions of prolactin on neurons

Zin Khant Aung_webZin Khant-Aung, Scientific Officer
Hormonal regulation of metabolism

Pene Knowles_webPene Knowles, Research Technician
Prolactin neuroendocrinology

Sharon Ladyman_webSharon Ladyman, Senior Research Fellow
Regulation of energy homeostasis during pregnancy

Holly Phillipps_webHollian Phillipps, Research Fellow
Prolactin action in adult neurogenesis

Mo Rizwan_webMohammed Rizwan, Research Fellow
Hypothalamic regulation of bodyweight and glucose metabolism

Aliya Cross, Honours student

Lydia Fay, Honours student

Andrew Lee, Honours student

Andy Stewart, Masters student

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Research Funders


Rizwan, M. Z., Kamstra, K., Pretz, D., Shepherd, P. R., Tups, A., & Grattan, D. R. (2024). Conditional deletion of β-catenin in the mediobasal hypothalamus impairs adaptive energy expenditure in response to high fat diet and exacerbates diet-induced obesity. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.1666-23.2024 Journal - Research Article

Stewart, A. M., Grattan, D. R., & Georgescu, T. (2023). The role of lactogenic hormones in suppression of fever responses during late pregnancy. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 268th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours/Postgraduate Diploma Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from Conference Contribution - Published proceedings: Abstract

Grattan, D. (2023, November). How our biology contributes to obesity. Verbal presentation at the Edgar Diabetes and Obesity Research Centre (EDOR) 20th Anniversary Symposium, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R., & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13350 Journal - Research Article

Pal, T., Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2023, August). Dynamics of MPOA prolactin receptor-expressing neurons in freely behaving mice. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

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