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Grattan Laboratory

Research interests

My group within the Centre for Neuroendocrinology is interested in the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain.

Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and role of prolactin in changes in mood and behaviour in the post-partum period.

Clinical conditions

  • Hyperprolactinaemia
  • Infertility
  • Post-partum anxiety
  • Post-partum depression

List of publications for Dave Grattan (Google Scholar)

Grattan Laboratory staff & students

Jenny Clarkson_webJenny Clarkson, Research Fellow
Neural circuits required for maternal adaptation to pregnancy
Email jenny.clarkson@otago.ac.nz

Teodora Georgescu_webTeodora Georgescu, Postdoctoral Fellow
Cellular actions of prolactin on neurons
Email teodora.georgescu@otago.ac.nz

Eleni Hackwell_webEleni Hackwell, PhD Student
The role of prolactin in lactational infertility
Email hacel029@student.otago.ac.nz

Zin Khant Aung_webZin Khant-Aung, Assistant Research Fellow
Hormonal regulation of metabolism
Email zin.khantaung@otago.ac.nz

Pene Knowles_webPene Knowles, Research Technician
Prolactin neuroendocrinology
Email pene.knowles@otago.ac.nz

Ilona Kokay_webIlona Kokay, Honorary Research Fellow
Prolactin receptor expression in the brain
Email ilona.kokay@otago.ac.nz

Sharon Ladyman_webSharon Ladyman, Senior Research Fellow
Regulation of energy homeostasis during pregnancy
Email sharon.ladyman@otago.ac.nz

Chantelle Murrell_webChantelle Murrell, PhD student
Email chantelle.murrell@postgrad.otago.ac.nz

Holly Phillipps_webHollian Phillipps, Postdoctoral Fellow
Prolactin action in adult neurogenesis
Email holly.phillipps@otago.ac.nz

Yeri Rim_webYeri Rim, Assistant Research Fellow
Email yeri.rim@otago.ac.nz

Mo Rizwan_webMohammed Rizwan, Postdoctoral Fellow
Hypothalamic regulation of bodyweight and glucose metabolism
Email mohammed.rizwan@otago.ac.nz

Kristina Smiley_webKristina Smiley, Postdoctoral Fellow
Neuroendocrine regulation of paternal behaviour
Email kristina.smiley@otago.ac.nz

Judith Swart_webJudith Swart, PhD Student
Involvement of the reward circuitry in prolactin’s regulation of maternal behaviour
Email swaju179@student.otago.ac.nz

Joe Yip_webJoe Yip, Postdoctoral Fellow
Plasticity of neuroendocrine dopaminergic neurons and prolactin
Email joe.yip@otago.ac.nz

Charlie Fang, Honours student

Matt Gillet, Honours student

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Ladyman, S. R., Carter, K. M., Gillett, M. L., Khant Aung, Z., & Grattan, D. R. (2021). A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin. eLIFE, 10, e62260. doi: 10.7554/eLife.62260

Porteous, R., Haden, P., Hackwell, E. C. R., Singline, A. J., Herde, M. K., Desai, R., … Grattan, D. R., & Herbison, A. E. (2021). Reformulation of PULSAR for analysis of pulsatile LH secretion and a revised model of estrogen negative feedback in mice. Endocrinology, 162(11). doi: 10.1210/endocr/bqab165

Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2021). Changes in maternal motivation across reproductive states in mice: A role for prolactin receptor activation on GABA neurons. Hormones & Behavior, 135, 105041. doi: 10.1016/j.yhbeh.2021.105041

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972

Grattan, D. R., & Andrews, Z. B. (2021). Insulin as a neuroendocrine hormone. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12966