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Grattan Laboratory

Research interests

My group within the Centre for Neuroendocrinology is interested in the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain.

Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and role of prolactin in changes in mood and behaviour in the post-partum period.

Clinical conditions

  • Hyperprolactinaemia
  • Infertility
  • Post-partum anxiety
  • Post-partum depression

List of publications for Dave Grattan (Google Scholar)

Grattan Laboratory staff & students

Jenny Clarkson_webJenny Clarkson, Research Fellow
Neural circuits required for maternal adaptation to pregnancy
Email jenny.clarkson@otago.ac.nz

Teodora Georgescu_webTeodora Georgescu, Scientific Officer
Cellular actions of prolactin on neurons
Email teodora.georgescu@otago.ac.nz

Matt Gillett_webMatt Gillett, PhD student
Email: matt.gillett@postgrad.otago.ac.nz

Eleni Hackwell_webEleni Hackwell, PhD Student
The role of prolactin in lactational infertility
Email hacel029@student.otago.ac.nz

Zin Khant Aung_webZin Khant-Aung, Assistant Research Fellow
Hormonal regulation of metabolism
Email zin.khantaung@otago.ac.nz

Pene Knowles_webPene Knowles, Research Technician
Prolactin neuroendocrinology
Email pene.knowles@otago.ac.nz

Ilona Kokay_webIlona Kokay, Honorary Research Fellow
Prolactin receptor expression in the brain
Email ilona.kokay@otago.ac.nz

Sharon Ladyman_webSharon Ladyman, Senior Research Fellow
Regulation of energy homeostasis during pregnancy
Email sharon.ladyman@otago.ac.nz

Chantelle Murrell_webChantelle Murrell, PhD student
Email chantelle.murrell@postgrad.otago.ac.nz

Holly Phillipps_webHollian Phillipps, Research Fellow
Prolactin action in adult neurogenesis
Email holly.phillipps@otago.ac.nz

Mo Rizwan_webMohammed Rizwan, Research Fellow
Hypothalamic regulation of bodyweight and glucose metabolism
Email mohammed.rizwan@otago.ac.nz

Judith Swart_webJudith Swart, PhD Student
Involvement of the reward circuitry in prolactin’s regulation of maternal behaviour
Email swaju179@student.otago.ac.nz

Joe Yip_webJoe Yip, Research Fellow
Plasticity of neuroendocrine dopaminergic neurons and prolactin
Email joe.yip@otago.ac.nz

Cameron Young, Honours student

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Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Gillett, M. L., Grattan, D. R., & Ladyman, S. R. (2022). The role of prolactin in the small intestine during pregnancy and lactation. New Zealand Medical Journal, 135(1557), (pp. 102). Retrieved from https://journal.nzma.org.nz/

Radecki, K. C., Ford, M. J., Phillipps, H. R., Lorenson, M. Y., Grattan, D. R., Yamanaka, Y., & Walker, A. M. (2022). Multiple Cell Types in the Oviduct Express the Prolactin Receptor. FASEB BioAdvances. Advance online publication. doi: 10.1096/fba.2022-00004

Phillipps, H. R., Khant Aung, Z., & Grattan, D. R. (2022). Elevated prolactin secretion during proestrus in mice: Absence of a defined surge. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13129

Kamstra, K., Rizwan, M. Z., Grattan, D. R., Horsfield, J. A., & Tups, A. (2022). Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB Journal, 36, e22207. doi: 10.1096/fj.202101764R

Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. PNAS, 119(6), e2116972119. doi: 10.1073/pnas.2116972119