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Grattan Laboratory

Research interests

My group within the Centre for Neuroendocrinology is interested in the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain.

Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and role of prolactin in changes in mood and behaviour in the post-partum period.

Clinical conditions

  • Hyperprolactinaemia
  • Infertility
  • Post-partum anxiety
  • Post-partum depression

List of publications for Dave Grattan (Google Scholar)

Grattan Laboratory staff & students

Jenny Clarkson_webJenny Clarkson, Research Fellow
Neural circuits required for maternal adaptation to pregnancy
Email jenny.clarkson@otago.ac.nz

Teodora Georgescu_webTeodora Georgescu, Scientific Officer
Cellular actions of prolactin on neurons
Email teodora.georgescu@otago.ac.nz

Matt Gillett_webMatt Gillett, PhD student
Email: matt.gillett@postgrad.otago.ac.n

Zin Khant Aung_webZin Khant-Aung, Assistant Research Fellow
Hormonal regulation of metabolism
Email zin.khantaung@otago.ac.nz

Pene Knowles_webPene Knowles, Research Technician
Prolactin neuroendocrinology
Email pene.knowles@otago.ac.nz

Ilona Kokay_webIlona Kokay, Honorary Research Fellow
Prolactin receptor expression in the brain
Email ilona.kokay@otago.ac.nz

Sharon Ladyman_webSharon Ladyman, Senior Research Fellow
Regulation of energy homeostasis during pregnancy
Email sharon.ladyman@otago.ac.nz

Chantelle Murrell_webChantelle Murrell, PhD student
Email chantelle.murrell@postgrad.otago.ac.nz

Holly Phillipps_webHollian Phillipps, Research Fellow
Prolactin action in adult neurogenesis
Email holly.phillipps@otago.ac.nz

Mo Rizwan_webMohammed Rizwan, Research Fellow
Hypothalamic regulation of bodyweight and glucose metabolism
Email mohammed.rizwan@otago.ac.nz

Joe Yip_webJoe Yip, Research Fellow
Plasticity of neuroendocrine dopaminergic neurons and prolactin
Email joe.yip@otago.ac.nz

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Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Hassan, M., Grattan, D. R., & Leitch, B. (2023). Developmental inhibitory changes in the primary somatosensory cortex of the stargazer mouse model of absence epilepsy. Biomolecules, 13, 186. doi: 10.3390/biom13010186

Young, C., Grattan, D., & Ladyman, S. (2022). Effect of the Polynesian-specific CREBRF gene variant on lactogenic activity during mouse pregnancy. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 139. Retrieved from https://www.esa-srb-apeg-nzse.org

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2022). Prolactin action is necessary for parental behavior in male mice. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.0558-22.2022

Khant Aung, Z., Kado, E., Young, C., Grattan, D. R., & Ladyman, S. R. (2022, August). Protective role of a Polynesian-specific variant of CREBRF gene against gestational diabetes mellitus (GDM): Mouse model. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Grattan, D. R. (2022, August). Hypothalamic Wnt/b-catenin signalling is required for normal metabolic homeostasis. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.