Biochemistry seminar – Building chains: uncovering how ubiquitin E3 ligases are regulated
Presented by Professor Catherine Day of the Department of Biochemistry.
Protein ubiquitylation is a pervasive post-translational modification that plays a crucial role in most eukaryotic signalling pathways. This is because the addition of ubiquitin can alter protein stability and function, allowing cells to respond to changes in their environment.
In this seminar, I will discuss our efforts to understand the activity of several RING E3 ligases, proteins that play a key role in protein ubiquitylation. By gaining a better understanding of the mechanisms involved in the addition of ubiquitin, we hope to explain how cellular processes are regulated and help account for diseases resulting from dysregulated ubiquitylation.
