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Translational pharmacogenomics research from molecule to bedside

The Carney Centre for Pharmacogenomics is a collaboration between research groups based at the University of Otago, Christchurch.

Together, we span a wide range of clinical, pharmacological and genetic expertise. As a result we have a strongly collaborative, multidisciplinary approach to pharmacogenomic research.

Our research

Our current research programmes focus on several aspects of pharmacogenetics, pharmacogenomics and related topics. For example, we are studying:

  • Potential genetic factors underlying serious adverse reactions, or unusual responses to drugs
  • Genome-wide gene expression effects of the mood stabiliser drug sodium valproate, in a brain cell line
  • Epigenetic effects of drugs
  • Molecular basis of micronutrient treatment in mental disorders

We use a range of methods for these projects, including DNA sequence analysis of specific pharmacogenes, application of genome-wide methods such as whole exome and whole genome sequencing, as well as RNA-sequencing, methylome analysis, and application of novel technologies such as nanopore DNA sequencing.

Learn more about the research undertaken by the Carney Centre for Pharmacogenomics.


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